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    • 5. 发明授权
    • Hydrophilic polymers, pressure sensitive adhesives and coatings
    • 亲水聚合物,压敏粘合剂和涂料
    • US06653427B2
    • 2003-11-25
    • US09757980
    • 2001-01-10
    • Daniel L. Holguin
    • Daniel L. Holguin
    • C08F22068
    • A61K8/8152A61K9/7023A61Q17/00A61Q19/00B41M5/508B41M5/52B41M5/5227B41M5/5245B41M5/5254C08F220/28C08F2220/281Y02P20/582C08F2222/1013
    • A method for the preparation of gel-free poly 2-hydroxyethyl methacrylate substantially in the absence of a chain transfer agent, comprising introducing monomeric 2-hydroxyethyl methacrylate containing ethylene glycol dimethacrylate impurities in the range of about 0.05 to 0.1% by weight into a solution of alcohol and water and polymerizing. The present invention also provides a method for the preparation of gel-free homopolymer of 4-hydroxybutyl acrylate substantially in the absence of a chain transfer agent in an alcohol or in solution of alcohol and water. The present invention also provides a method for the preparation of gel-free copolymer of 2-hydroxyethyl methacrylate and 4-hydroxybutyl acrylate substantially in the absence of a chain transfer agent, comprising introducing monomeric 2-hydroxyethyl methacrylate containing ethylene glycol dimethacrylate impurities in the range of about 0.05 to 0.1% by weight with monomeric 4-hydroxybutyl acrylate into a solution of alcohol and water.
    • 一种在不存在链转移剂的情况下制备无凝胶的聚2-羟乙基甲基丙烯酸酯的方法,包括将含有约0.05至0.1重量%的乙二醇二甲基丙烯酸酯杂质的单体2-羟乙基甲基丙烯酸酯引入到溶液 的酒精和水和聚合。 本发明还提供一种制备基于在醇或醇和水的溶液中不存在链转移剂的丙烯酸4-羟基丁酯的无凝胶均聚物的方法。 本发明还提供了一种制备基本上不存在链转移剂的甲基丙烯酸2-羟基乙酯和丙烯酸4-羟基丁酯的无凝胶共聚物的方法,包括将含有乙二醇二甲基丙烯酸酯杂质的单体2-羟乙基甲基丙烯酸酯引入范围内 约0.05至0.1重量%,与单体4-羟基丁基丙烯酸酯反应制成醇和水的溶液。
    • 10. 发明授权
    • Hydrophilic polymers and methods of preparation
    • 亲水聚合物及其制备方法
    • US06743880B2
    • 2004-06-01
    • US10133808
    • 2002-04-26
    • Daniel L. Holguin
    • Daniel L. Holguin
    • C08F22068
    • A61K9/7023A61K8/042A61K8/8152A61Q17/00A61Q19/00B41M5/508B41M5/52B41M5/5227B41M5/5236B41M5/5245B41M5/5254C08F220/28C08F2220/281Y02P20/582Y10T428/167C08F2222/1013
    • The present invention provides a method for the preparation of hydrophilic water insoluble, gel-free copolymers of 2-hydroxyethyl methacrylate and at least one of acrylic acid or methacrylic acid, and 2-hydroxyethyl methacrylate, 4-hydroxybutyl acrylate and acrylic or methacrylic acid, where the copolymers are prepared in a solution of water and alcohol using monomeric 2-hydroxyethyl methacrylate containing ethylene glycol dimethacrylate impurities up to about 0.15% by weight and substantially in the absence of a chain transfer agent. The copolymers are convertible to water soluble copolymers by pH adjustment. The invention also provides a method for the preparation of a copolymer of 2-hydroxyethyl methacrylate and 4-hydroxybutyl acrylate, and a homopolymer of 2-hydroxyethyl methacrylate in a solution of water and either a monoalcohol or a polyhydric alcohol. The polymers are useful in topical skin applications, including use as cosmetic compositions, dermatological compositions, and flexible skin coatings, and as pressure sensitive adhesives.
    • 本发明提供了制备亲水不溶性的甲基丙烯酸2-羟乙酯与丙烯酸或甲基丙烯酸和甲基丙烯酸2-羟乙酯,丙烯酸4-羟基丁酯和丙烯酸或甲基丙烯酸中的至少一种的亲水不溶性凝胶型共聚物的方法, 其中共聚物在水和醇的溶液中制备,使用含有高达约0.15重量%的乙二醇二甲基丙烯酸酯杂质的单体2-羟乙基甲基丙烯酸酯,基本上不存在链转移剂。 通过pH调节,共聚物可转化成水溶性共聚物。 本发明还提供了在水和一元醇或多元醇的溶液中制备甲基丙烯酸2-羟乙酯和丙烯酸4-羟基丁酯的共聚物和甲基丙烯酸2-羟乙酯的均聚物的方法。 聚合物可用于局部皮肤应用,包括用作化妆品组合物,皮肤病学组合物和柔性皮肤涂层,以及作为压敏粘合剂。