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    • 3. 发明申请
    • Polymer for Controlling Delivery of Bioactive Agents and Method of Use
    • 用于控制生物活性剂递送的聚合物和使用方法
    • US20120258238A1
    • 2012-10-11
    • US13525762
    • 2012-06-18
    • Hiep DoJoel Rosenblatt
    • Hiep DoJoel Rosenblatt
    • B05D7/00B05D5/00
    • A61L29/16A61L29/06A61L2300/206A61L2300/404C08L83/04
    • A medical device includes a base material and chlorhexidine or a pharmaceutically acceptable salt thereof disposed in the base material sufficient to reduce microbial growth. The base material includes a polymer having a silicone monomer and a urethane monomer. To make the medical device having an antimicrobial agent, a silicone-urethane-carbonate polymer is dissolved in Dimethylformamide/Tetrahydrofuran (DMF/THF) to generate a coating solution, a chlorhexidine or a pharmaceutically acceptable salt thereof is mixed into the coating solution, a base material is coated with the coating solution, and the coating solution is dried to remove the solvent. The chlorhexidine is present in concentration sufficient to reduce microbial growth.
    • 医疗装置包括基材和设置在基材中的氯己定或其药学上可接受的盐,足以减少微生物生长。 基材包括具有硅氧烷单体和聚氨酯单体的聚合物。 为了使具有抗微生物剂的医疗装置,将硅氧烷 - 氨基甲酸酯 - 碳酸酯聚合物溶解在二甲基甲酰胺/四氢呋喃(DMF / THF)中以产生涂布溶液,洗必泰或其药学上可接受的盐混合到涂布溶液中, 将基材涂布在涂布溶液中,并将涂布溶液干燥以除去溶剂。 洗必泰以足以减少微生物生长的浓度存在。