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1. 发明申请

US20070239205A1 Plasma-treated vascular occlusion devices and methods 有权
标题翻译：血浆治疗血管闭塞装置及方法
公开(公告)号：US20070239205A1
公开(公告)日：2007-10-11
申请号：US11395474
申请日：2006-03-31
申请人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Davis , Darren Sherman
发明人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Davis , Darren Sherman
IPC分类号： A61B17/03 , H05H1/24
CPC分类号： A61L31/14 , A61L31/10 , A61L31/146 , A61L2400/18 , A61L2430/36 , Y10T428/1355 , Y10T428/1376 , C08L27/20
摘要： Vaso-occlusive devices are provided that have a polymer foam disposed about them. The polymer is treated with a plasma to facilitate thrombogenicity. A method for making and using such devices also is provided. The preferred polymer is a copolymer of a halogenated vinylidene and a halogenated alkene.
摘要翻译：提供具有围绕它们设置聚合物泡沫的血管闭塞装置。用等离子体处理聚合物以促进血栓形成。还提供了制造和使用这种装置的方法。优选的聚合物是卤代亚乙烯基和卤代烯烃的共聚物。

2. 发明申请

US20060058834A1 Foam matrix embolization device 有权
标题翻译：泡沫基质栓塞装置
公开(公告)号：US20060058834A1
公开(公告)日：2006-03-16
申请号：US11171560
申请日：2005-11-18
申请人： Hiep Do , Richard Davis , Donald Jones , Juan Lorenzo , Vladimir Mitelberg , Darren Sherman , Murty Vyakarnam
发明人： Hiep Do , Richard Davis , Donald Jones , Juan Lorenzo , Vladimir Mitelberg , Darren Sherman , Murty Vyakarnam
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12181 , A61B17/1219 , A61B2017/0053 , A61B2017/1205 , A61L31/10 , A61L31/146 , A61L2430/36 , C08L67/04
摘要： The present invention relates to a medical device for placement at a predetermined location within a passageway of the human body, and more particularly, relates to a flexible embolization device which may be delivered by a catheter to a pre-selected position within a blood vessel to thereby embolize a blood vessel or a blood vessel defect, such as an aneurysm or fistula. Specifically, the embolization device comprises an elongated coil having a lumen, the coil and lumen being at least partially embedded in an elongated foam member comprising, in some embodiments, a flexible, biodegradable, water insoluble, open, interconnecting-cell foam material having embolic characteristics, and capable of allowing cell proliferation into the open cell foam interior.
摘要翻译：本发明涉及一种用于放置在人体通道内的预定位置处的医疗装置，更具体地涉及一种柔性栓塞装置，其可以由导管递送到血管内的预先选定的位置，从而栓塞血管或血管缺损，例如动脉瘤或瘘。具体地，栓塞装置包括具有内腔的细长线圈，线圈和内腔至少部分地嵌入细长的泡沫构件，其在一些实施例中包括具有栓塞的柔性，可生物降解的水不溶性，开放的互连泡沫材料特征，并且能够允许细胞增殖进入开孔泡沫内部。

3. 发明申请

US20060200190A1 Embolic coil with twisted wire 审中-公开
标题翻译：带绞线的栓塞线圈
公开(公告)号：US20060200190A1
公开(公告)日：2006-09-07
申请号：US11070727
申请日：2005-03-02
申请人： Juan Lorenzo , Darren Sherman , Robert Farnan , Mark Pomeranz
发明人： Juan Lorenzo , Darren Sherman , Robert Farnan , Mark Pomeranz
IPC分类号： A61M29/00
CPC分类号： A61B17/12145 , A61B17/12022
摘要： An embolic element may be manufactured by twisting a length of wire about a longitudinal axis thereof, the wire having at least one flat portion along its length, to cause the flat portion to form a generally helical shape. The length of wire is then optionally wound onto a mandrel by bending of the wire to form a three-dimensional shape.
摘要翻译：栓塞元件可以通过围绕其纵向轴线扭转一段电线来制造，该线材沿着其长度具有至少一个平坦部分，以使平坦部分形成大致螺旋形状。然后，线的长度可选地通过弯曲导线缠绕在心轴上以形成三维形状。

4. 发明申请

US20050137623A1 Activatable foam expandable implantable medical device and method of use 审中-公开
标题翻译：可活化泡沫塑料可植入医疗器械及其使用方法
公开(公告)号：US20050137623A1
公开(公告)日：2005-06-23
申请号：US10868303
申请日：2004-06-15
申请人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
发明人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
IPC分类号： A61B17/12 , A61F2/00 , A61L31/00 , A61L31/10 , A61L31/16 , A61M29/00
CPC分类号： A61L31/16 , A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/1219 , A61B2017/12054 , A61L31/10 , A61L2300/216
摘要： A medial device such as a vascular occlusive device which includes a support structure and a bioactive expansible coating disposed on the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive expansible foam coating and bodily fluids until the outer barrier is activated and removed by applying an external agent to the outer barrier thereby permitting expansion of the bioactive foam coating.
摘要翻译：中间装置，例如血管闭塞装置，其包括支撑结构和设置在支撑结构上的生物活性可扩展涂层和外部阻隔涂层，其用于防止生物活性可膨胀泡沫涂层与体液之间的反应，直到外屏障被激活并通过将外部剂施加到外部阻挡层从而允许生物活性泡沫涂层膨胀来除去。

5. 发明申请

US20050137569A1 Activatable bioactive implantable medical device and method of use 审中-公开
标题翻译：可活化生物活性植入式医疗器械及其使用方法
公开(公告)号：US20050137569A1
公开(公告)日：2005-06-23
申请号：US10868152
申请日：2004-06-15
申请人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
发明人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
IPC分类号： A61B17/12 , A61F2/00 , A61L31/00 , A61L31/10 , A61L31/16 , A61M31/00
CPC分类号： A61L31/16 , A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/1219 , A61B2017/12054 , A61L31/10 , A61L2300/216
摘要： A medial device such as a vascular occlusive device which includes a support structure and a bioactive expansible coating disposed on the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive expansible coating and bodily fluids until the outer barrier is activated and removed by applying an external agent to the outer barrier thereby permitting expansion of the bioactive coating.
摘要翻译：中间装置如血管闭塞装置，其包括支撑结构和设置在支撑结构上的生物活性可扩展涂层和外部阻隔涂层，其用于防止生物活性可膨胀涂层和体液之间的反应，直到外屏障被激活，通过将外部剂施用到外部阻挡层从而允许生物活性涂层的膨胀来除去。

6. 发明申请

US20050137568A1 Activatable bioactive implantable medical device and method of use 审中-公开
标题翻译：可活化生物活性植入式医疗器械及其使用方法
公开(公告)号：US20050137568A1
公开(公告)日：2005-06-23
申请号：US10738477
申请日：2003-12-17
申请人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
发明人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
IPC分类号： A61B17/12 , A61F2/00 , A61L31/00 , A61L31/10 , A61L31/16 , A61M29/00
CPC分类号： A61L31/16 , A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/1219 , A61B2017/12054 , A61L31/10 , A61L2300/216
摘要： A medial device which includes a support structure and a bioactive coating disposed onto the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive agent and bodily fluids until the outer barrier is activated by applying an external agent to the outer barrier.
摘要翻译：一种内部装置，其包括支撑结构和设置在支撑结构上的生物活性涂层和外部阻隔涂层，其用于防止生物活性剂和体液之间的反应，直到外部屏障通过将外部剂施加到外部屏障。

7. 发明授权

US6010500A Telescoping apparatus and method for linear lesion ablation 失效
标题翻译：用于线性病变消融的伸缩装置和方法
公开(公告)号：US6010500A
公开(公告)日：2000-01-04
申请号：US897567
申请日：1997-07-21
申请人： Darren Sherman , Mark L. Pomeranz , Troy J. Chapman , N. Parker Willis , Dale Rieb , Robert B. West
发明人： Darren Sherman , Mark L. Pomeranz , Troy J. Chapman , N. Parker Willis , Dale Rieb , Robert B. West
IPC分类号： A61B18/14 , A61B17/39
CPC分类号： A61B18/1492 , A61B2018/1472 , A61B2218/002
摘要： A catheter device for creating linear lesions in endocardial tissue or other body tissue is described. The catheter includes an inner shaft telescopically received within an outer shaft. The inner shaft has one or more spaced apart electrodes along its distal section. The outer shaft member includes a fluid permeable window positionable to selectively overlay some or all of the electrodes when the relative positioning of the inner and outer shaft members is adjusted. During use, the window is positioned adjacent to the body tissue which is to be ablated and at least a portion of the electrodes are exposed through the window. RF energy is delivered to the electrodes while saline or other conductive fluid is simultaneously delivered through the infusion tube. The conductive fluid passes into contact with the electrodes, and through the window into contact with the body tissue, thereby improving the coupling of the RF energy from the electrodes to the tissue and improving the efficiency of the ablation of the tissue.
摘要翻译：描述了用于在心内膜组织或其他身体组织中产生线性损伤的导管装置。导管包括可伸缩地容纳在外轴内的内轴。内轴沿其远端部分具有一个或多个间隔开的电极。外轴构件包括可流体渗透的窗口，其可调节内和外轴构件的相对定位时可选择地覆盖部分或全部电极。在使用期间，窗口被定位成邻近待烧蚀的身体组织，并且至少一部分电极通过窗户暴露。 RF能量被传送到电极，而盐水或其它导电流体同时通过输液管输送。导电流体与电极接触并且通过窗口与身体组织接触，从而改善从电极到组织的RF能量的耦合并提高组织消融的效率。

8. 发明授权

US07294123B2 Activatable bioactive vascular occlusive device and method of use 有权
标题翻译：可活化生物活性血管闭塞装置及其使用方法
公开(公告)号：US07294123B2
公开(公告)日：2007-11-13
申请号：US10738473
申请日：2003-12-17
申请人： Donald K. Jones , Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
发明人： Donald K. Jones , Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12186 , A61B2017/00004 , A61B2017/00831
摘要： A vascular occlusive device which includes a support structure and a bioactive coating disposed onto the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive agent and bodily fluids until the outer barrier is activated by applying an external agent to the outer barrier.
摘要翻译：一种血管闭塞装置，其包括支撑结构和设置在支撑结构上的生物活性涂层和外部阻隔涂层，其用于防止生物活性剂和体液之间的反应，直到外部屏障通过将外部剂施用于外部屏障。

9. 发明申请

US20070255253A1 Activatable bioactive vascular occlusive device and method of use 审中-公开
标题翻译：可活化生物活性血管闭塞装置及其使用方法
公开(公告)号：US20070255253A1
公开(公告)日：2007-11-01
申请号：US11821340
申请日：2007-06-22
申请人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
发明人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
IPC分类号： A61M31/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12186 , A61B2017/00004 , A61B2017/00831
摘要： A vascular occlusive device which includes a vascular occlusive embolic coil, a bioactive coating disposed onto the embolic coil, and an outer barrier coating which serves to prevent a reaction between the bioactive agent in the bioactive coating and bodily fluids, until the outer barrier is activated by applying an external agent to the outer barrier.
摘要翻译：一种血管闭塞装置，其包括血管闭塞栓塞线圈，设置在栓塞线圈上的生物活性涂层和用于防止生物活性涂层中的生物活性剂与体液之间的反应的外部阻隔涂层，直到外部屏障被激活通过将外部剂施加到外部屏障。

10. 发明授权

US07247159B2 Activatable bioactive vascular occlusive device 有权
标题翻译：可活化生物活性血管闭塞装置
公开(公告)号：US07247159B2
公开(公告)日：2007-07-24
申请号：US10820967
申请日：2004-04-08
申请人： Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
发明人： Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
IPC分类号： A61B17/08
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B2017/00004 , A61B2017/00336 , A61B2017/00831
摘要： A vascular occlusive device, such as an embolic coil, having thrombogenic fibers extending from the coil and having an outer barrier which encapsulates and flattens the fibers along the sides of the embolic coil for preventing activation of the coil until the outer barrier has been dissolved, or removed, from the embolic coil.
摘要翻译：血管闭塞装置，例如栓塞线圈，具有从线圈延伸的血栓形成纤维，并且具有外阻挡件，其沿着栓塞线圈的侧面封装并平坦化纤维，以防止线圈激活直到外屏障已经溶解，或从栓塞线圈移除。

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