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1. 发明申请

US20150168388A1 Multiplexed Analyses of Test Samples 审中-公开
标题翻译：测试样本的多路复用分析
公开(公告)号：US20150168388A1
公开(公告)日：2015-06-18
申请号：US14569241
申请日：2014-12-12
申请人： SomaLogic, Inc.
发明人： James R. Heil , Daniel J. Schneider , Daniel T. Nieuwlandt , Sheri K. Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
IPC分类号： G01N33/543
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).
摘要翻译：本公开描述了用于检测可能存在于测试样品中的一种或多种靶分子的方法，装置，试剂和试剂盒。在一个实施方案中，将测试样品与包含标签的适体接触并对靶分子具有特异性亲和力。允许形成包含与其靶分子结合的适体的适体亲和复合体。如果测试样品含有目标分子，通常将在测试样品中形成适体亲和复合体。适体亲和复合物任选地转化为适体共价复合物，其包括与其靶分子共价结合的适体。然后可以使用本领域技术人员已知的各种方法中的任一种检测和/或定量适体亲和复合物（或任选的适体共价复合物），包括使用固体支持物，使用质谱法和使用定量聚合酶链反应（Q-PCR）。

2. 发明授权

US11111495B2 Method for generating aptamers with improved off-rates 有权
公开(公告)号：US11111495B2
公开(公告)日：2021-09-07
申请号：US16414026
申请日：2019-05-16
申请人： SomaLogic, Inc.
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
IPC分类号： C12N15/115 , C12Q1/6816 , C12Q1/6832 , C12Q1/6834 , G01N33/53 , G01N33/58 , C12Q1/6811 , C12N9/74 , C12N15/10
摘要： The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

3. 发明申请

US20190264208A1 Method for Generating Aptamers with Improved Off-Rates 审中-公开
公开(公告)号：US20190264208A1
公开(公告)日：2019-08-29
申请号：US16413989
申请日：2019-05-16
申请人： SomaLogic, Inc.
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
IPC分类号： C12N15/115 , C12Q1/6816 , C12Q1/6832 , C12Q1/6834 , G01N33/53 , G01N33/58 , C12N9/74 , C12Q1/6811 , C12N15/10
摘要： The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

4. 发明申请

US20180275143A1 Lung Cancer Biomarkers and Uses Thereof 审中-公开
公开(公告)号：US20180275143A1
公开(公告)日：2018-09-27
申请号：US15993132
申请日：2018-05-30
申请人： SomaLogic, Inc.
发明人： Sheri K. Wilcox , Deborah Ayers , Nebojsa Janjic , Larry Gold , Michael Riel-Mehan , Thale Jarvis
IPC分类号： G01N33/68 , G01N33/574 , C12Q1/6886 , G06F19/10 , G06F19/18 , G06F19/20 , G06F19/24
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , G01N33/57423 , G16B20/00 , G16B25/00 , G16B40/00 , G16B99/00
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 18, Table 20, or Table 21, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

5. 发明授权

US11221340B2 Lung cancer biomarkers and uses thereof 有权
公开(公告)号：US11221340B2
公开(公告)日：2022-01-11
申请号：US15993132
申请日：2018-05-30
申请人： SomaLogic, Inc.
发明人： Sheri K. Wilcox , Deborah Ayers , Nebojsa Janjic , Larry Gold , Michael Riel-Mehan , Thale Jarvis
IPC分类号： G01N33/68 , C12Q1/6886 , G01N33/574 , G16B20/00 , G16B99/00 , G16B20/20 , G16B25/10 , G16B40/30 , G16B25/00 , G16B40/00
摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 18, Table 20, or Table 21, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

6. 发明授权

US10648972B2 Multiplexed analyses of test samples 有权
公开(公告)号：US10648972B2
公开(公告)日：2020-05-12
申请号：US15878021
申请日：2018-01-23
申请人： SomaLogic, Inc.
发明人： James R. Heil , Daniel J. Schneider , Daniel T. Nieuwlandt , Sheri K. Wilcox , Dominic Zichi , Todd Gander , Bruce Eaton , Larry Gold
IPC分类号： G01N33/543 , G01N33/58 , C40B40/00 , C12Q1/6834 , C12Q1/6837 , C12Q1/6832
摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).

7. 发明申请

US20140081011A1 Aptamers to 4-1BB and Their Use in Treating Diseases and Disorders 有权
标题翻译：适应4-1BB及其在治疗疾病和疾病中的应用
公开(公告)号：US20140081011A1
公开(公告)日：2014-03-20
申请号：US14084411
申请日：2013-11-19
申请人： SomaLogic, Inc.
发明人： Jonathan Vaught , Daniel I. Resnicow , Sheela Waugh , Sheri K. Wilcox , Daniel J. Schneider
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , A61K31/7115 , C07H19/073 , C07H19/10 , C07H21/04
摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to 4-1BB; pharmaceutical compositions comprising such 4-1BB aptamers; and methods of making and using the same.
摘要翻译：本公开一般涉及核酸领域，更具体地涉及能够结合4-1BB的适体; 包含这种4-1BB适体的药物组合物; 以及制作和使用它们的方法。

8. 发明申请

US20180155725A1 Method for Generating Aptamers with Improved Off-Rates 审中-公开
公开(公告)号：US20180155725A1
公开(公告)日：2018-06-07
申请号：US15878161
申请日：2018-01-23
申请人： SomaLogic, Inc.
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
IPC分类号： C12N15/115 , C12N15/10 , G01N33/53
CPC分类号： C12N15/115 , C12N9/6429 , C12N15/1048 , C12N2310/16 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2330/31 , C12Q1/6811 , C12Q1/6816 , C12Q1/6832 , C12Q1/6834 , G01N33/5308 , G01N33/58 , C12Q2525/205 , C12Q2565/514 , C12Q2525/161 , C12Q2537/101 , C12Q2523/313
摘要： The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

9. 发明申请

US20170137819A1 Method for Generating Aptamers with Improved Off-Rates 审中-公开
公开(公告)号：US20170137819A1
公开(公告)日：2017-05-18
申请号：US15410414
申请日：2017-01-19
申请人： SomaLogic, Inc.
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
IPC分类号： C12N15/115 , C12N15/10 , G01N33/53
CPC分类号： C12N15/115 , C12N9/6429 , C12N15/1048 , C12N2310/16 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2330/31 , C12Q1/6811 , C12Q1/6816 , C12Q1/6832 , C12Q1/6834 , G01N33/5308 , G01N33/58 , C12Q2525/205 , C12Q2565/514 , C12Q2525/161 , C12Q2537/101 , C12Q2523/313
摘要： The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. In addition, the disclosure describes aptamer constructs that include a variety of functionalities, including a cleavable element, a detection element, and a capture or immobilization element.

10. 发明授权

US09382533B2 Method for generating aptamers with improved off-rates 有权
公开(公告)号：US09382533B2
公开(公告)日：2016-07-05
申请号：US14606134
申请日：2015-01-27
申请人： SomaLogic, Inc.
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold , Thale C. Jarvis , Jeffrey D. Carter
IPC分类号： C12N15/115 , C12N15/10 , G01N33/53 , C12Q1/68
CPC分类号： C12N15/1048 , C12N15/115 , C12N2310/16 , C12Q1/6811 , G01N33/5308 , C12Q2525/117 , C12Q2525/205 , C12Q2541/101
摘要： The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods.

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