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1. 发明申请

US20050075574A1 Devices for vulnerable plaque detection 有权
标题翻译：易损斑块检测装置
公开(公告)号：US20050075574A1
公开(公告)日：2005-04-07
申请号：US10668012
申请日：2003-09-22
申请人： Simon Furnish , Jay Caplan , Andres Zuluaga , Daniel McNulty
发明人： Simon Furnish , Jay Caplan , Andres Zuluaga , Daniel McNulty
IPC分类号： A61B5/00 , A61B8/12 , G01S15/89 , A61B8/14
CPC分类号： A61B5/02007 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/445 , G01S15/899
摘要： An intravascular probe includes a sheath with a distal portion and a proximal portion. The intravascular probe includes a first optical waveguide extending along the sheath, the first optical waveguide being configured to carry optical radiation between the distal and proximal portions, and a first beam redirector disposed at the distal portion in optical communication with the first optical waveguide. The intravascular probe also includes an optical detector configured to receive optical radiation from the first optical waveguide, and an ultrasound transducer disposed at the distal portion. The ultrasound transducer is configured to couple ultrasound energy between the intravascular probe and a transmission medium. A wire extends along the sheath in electrical communication with the ultrasound transducer.
摘要翻译：血管内探针包括具有远侧部分和近端部分的鞘。血管内探针包括沿护套延伸的第一光波导，第一光波导被配置为在远端和近端部分之间承载光辐射，以及布置在远端部分处的与第一光波导光学通信的第一光束重定向器。血管内探针还包括被配置为接收来自第一光波导的光辐射的光学检测器和设置在远端部分处的超声波换能器。超声换能器配置成在血管内探针和传播介质之间耦合超声波能量。电线沿着护套延伸，与超声换能器电连通。

2. 发明授权

US06949072B2 Devices for vulnerable plaque detection 有权
公开(公告)号：US06949072B2
公开(公告)日：2005-09-27
申请号：US10668012
申请日：2003-09-22
申请人： Simon Furnish , Jay Caplan , Andres Zuluaga , Daniel E. McNulty
发明人： Simon Furnish , Jay Caplan , Andres Zuluaga , Daniel E. McNulty
IPC分类号： A61B5/00 , A61B8/12 , G01S15/89
CPC分类号： A61B5/02007 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/445 , G01S15/899
摘要： An intravascular probe includes a sheath with a distal portion and a proximal portion. The intravascular probe includes a first optical waveguide extending along the sheath, the first optical waveguide being configured to carry optical radiation between the distal and proximal portions, and a first beam redirector disposed at the distal portion in optical communication with the first optical waveguide. The intravascular probe also includes an optical detector configured to receive optical radiation from the first optical waveguide, and an ultrasound transducer disposed at the distal portion. The ultrasound transducer is configured to couple ultrasound energy between the intravascular probe and a transmission medium. A wire extends along the sheath in electrical communication with the ultrasound transducer.

3. 发明申请

US20050107706A1 Intraluminal spectroscope with wall-contacting probe 审中-公开
标题翻译：管腔内分光镜与壁接触探针
公开(公告)号：US20050107706A1
公开(公告)日：2005-05-19
申请号：US10940468
申请日：2004-09-14
申请人： Andres Zuluaga , Simon Furnish , Jay Caplan
发明人： Andres Zuluaga , Simon Furnish , Jay Caplan
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/6885 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/6858
摘要： An apparatus for detecting vulnerable plaque within a lumen defined by an intraluminal wall includes a probe through which an optical fiber extends. An coupler in optical communication with the fiber is configured to atraumatically contact the intraluminal wall. A light source provides light to the fiber for illuminating the wall and a detector coupled to the fiber receives light from within the wall.
摘要翻译：用于检测由腔内壁限定的腔内的易损斑块的装置包括光纤延伸穿过的探针。与纤维光学连通的耦合器被配置为不可靠地接触管腔内壁。光源向光纤提供光以照射壁，并且耦合到光纤的检测器从墙壁内接收光。

4. 发明申请

US20100022891A1 INTRALUMINAL SPECTROSCOPE WITH WALL CONTACTING PROBE 审中-公开
标题翻译：具有壁面接触探针的内部光谱
公开(公告)号：US20100022891A1
公开(公告)日：2010-01-28
申请号：US12568431
申请日：2009-09-28
申请人： Andres ZULUAGA , Simon Furnish , Jay Caplan
发明人： Andres ZULUAGA , Simon Furnish , Jay Caplan
IPC分类号： A61B5/00
CPC分类号： A61B5/6885 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/6858
摘要： A spectroscope for detecting vulnerable plaque within a lumen defined by an intraluminal wall includes a probe through which an optical fiber extends. An coupler in optical communication with the fiber is configured to atraumatically contact the intraluminal wall. A light source provides light to the fiber for illuminating the wall and a detector coupled to the fiber receives light from within the wall.
摘要翻译：用于检测由腔内壁限定的腔内的易损斑块的分光镜包括光纤延伸穿过的探针。与纤维光学连通的耦合器被配置为不可靠地接触管腔内壁。光源向光纤提供光以照射壁，并且耦合到光纤的检测器从墙壁内接收光。

5. 发明授权

US07310357B2 Providing low-coherence light 有权
标题翻译：提供低相干光
公开(公告)号：US07310357B2
公开(公告)日：2007-12-18
申请号：US11071120
申请日：2005-03-02
申请人： Andres Zuluaga , Jay Caplan
发明人： Andres Zuluaga , Jay Caplan
IPC分类号： H01S3/10 , H01S3/08
CPC分类号： H01S5/146 , A61B18/24 , H01S5/0652 , H01S5/141 , H01S5/143 , H01S5/4068
摘要： The invention features an apparatus and an associated method for illuminating a target area. The apparatus includes reflectors defining a first optical cavity. The first optical cavity defines a first set of longitudinal modes. The apparatus includes a first gain medium defining a first gain band. The first gain medium is configured to cause a plurality of the longitudinal modes of the first set to oscillate over an oscillation band within the first gain band when the first gain medium is pumped at an operative level. The apparatus includes a first optical waveguide positioned within the first optical cavity. The first optical waveguide has a length selected to cause a temporal coherence length of light emitted from the first optical cavity to be shorter than a scattering distance associated with the target area.
摘要翻译：本发明的特征在于用于照亮目标区域的装置和相关联的方法。该装置包括限定第一光学腔的反射器。第一光学腔定义第一组纵向模式。该装置包括限定第一增益带的第一增益介质。第一增益介质被配置为当第一增益介质被泵浦在操作电平时，使第一组的多个纵向模式在第一增益频带内的振荡频带上振荡。该装置包括位于第一光腔内的第一光波导。第一光波导具有被选择为使得从第一光学腔发射的光的时间相干长度短于与目标区域相关联的散射距离的长度。

6. 发明申请

US20060198400A1 Providing low-coherence light 有权
标题翻译：提供低相干光
公开(公告)号：US20060198400A1
公开(公告)日：2006-09-07
申请号：US11071120
申请日：2005-03-02
申请人： Andres Zuluaga , Jay Caplan
发明人： Andres Zuluaga , Jay Caplan
IPC分类号： H01S3/10 , H01S3/13
CPC分类号： H01S5/146 , A61B18/24 , H01S5/0652 , H01S5/141 , H01S5/143 , H01S5/4068
摘要： The invention features an apparatus and an associated method for illuminating a target area. The apparatus includes reflectors defining a first optical cavity. The first optical cavity defines a first set of longitudinal modes. The apparatus includes a first gain medium defining a first gain band. The first gain medium is configured to cause a plurality of the longitudinal modes of the first set to oscillate over an oscillation band within the first gain band when the first gain medium is pumped at an operative level. The apparatus includes a first optical waveguide positioned within the first optical cavity. The first optical waveguide has a length selected to cause a temporal coherence length of light emitted from the first optical cavity to be shorter than a scattering distance associated with the target area.
摘要翻译：本发明的特征在于用于照亮目标区域的装置和相关联的方法。该装置包括限定第一光学腔的反射器。第一光学腔定义第一组纵向模式。该装置包括限定第一增益带的第一增益介质。第一增益介质被配置为当第一增益介质被泵浦在操作电平时，使第一组的多个纵向模式在第一增益频带内的振荡频带上振荡。该装置包括位于第一光腔内的第一光波导。第一光波导具有被选择为使得从第一光学腔发射的光的时间相干长度短于与目标区域相关联的散射距离的长度。

7. 发明申请

US20080097158A1 Noise Suppression System and Method in Catheter Pullback and Rotation System 审中-公开
标题翻译：导管回退和旋转系统中的噪声抑制系统和方法
公开(公告)号：US20080097158A1
公开(公告)日：2008-04-24
申请号：US11875621
申请日：2007-10-19
申请人： Charles Abele , Jay Caplan
发明人： Charles Abele , Jay Caplan
IPC分类号： A61B1/07
CPC分类号： A61B5/0066 , A61B1/00172 , A61B1/00177 , A61M25/0113
摘要： An optical catheter system comprising an intraluminal catheter that provides optical signals to a patient and carries optical signals from the patient, an outer housing, and an inner carriage that moves longitudinally relative to the outer housing and rotates relative to the outer housing during operation when the catheter system is being driven by a pullback and rotation system. The optical catheter system has an interlock system that prevents rotation and longitudinal movement of the inner carriage in the outer housing until attached to the pullback and rotation system. The pullback and rotation system comprises a frame and a catheter system interface, attached to the frame, to which the catheter system is coupled. A carriage drive system is further provided that moves longitudinally and rotates relative to the frame to provide rotation and longitudinal drive to the catheter system. A longitudinal drive system has a drive motor for advancing and/or withdrawing the carriage drive system and a manual drive input enabling a user to manually advance or withdrawal the carriage drive system. A latching system holds the carriage drive system when the catheter system is being attached to the pullback system.
摘要翻译：一种光学导管系统，其包括管腔内导管，其向患者提供光信号并且携带来自患者的光信号，外壳和内托架，所述光信号在操作期间相对于所述外壳在纵向相对运动时相对于所述外壳旋转，导管系统由拉回和旋转系统驱动。光学导管系统具有互锁系统，其防止内部托架在外部壳体中的旋转和纵向运动，直到附接到回拉和旋转系统。回拉和旋转系统包括附接到框架的框架和导管系统接口，导管系统连接到框架和导管系统接口。还提供了一种托架驱动系统，该托架驱动系统纵向移动并相对于框架旋转以向导管系统提供旋转和纵向驱动。纵向驱动系统具有用于前进和/或退出托架驱动系统的驱动马达和使用户能够手动前进或退出托架驱动系统的手动驱动输入。当导管系统连接到回拉系统时，闩锁系统保持托架驱动系统。

8. 发明申请

US20090270815A1 Catheter Priming System 审中-公开
标题翻译：导管启动系统
公开(公告)号：US20090270815A1
公开(公告)日：2009-10-29
申请号：US12111457
申请日：2008-04-29
申请人： Andrea Stamp , Richard Gambale , Jay Caplan , Robert McNeil , Jerry Brightbill
发明人： Andrea Stamp , Richard Gambale , Jay Caplan , Robert McNeil , Jerry Brightbill
IPC分类号： A61M25/14
CPC分类号： A61M39/06 , A61M25/0075 , A61M39/0693 , A61M39/24 , A61M2025/0018 , A61M2025/018 , A61M2025/0183 , A61M2039/062 , A61M2039/0633 , A61M2039/2426 , A61M2039/244 , A61M2039/248
摘要： A catheter includes a longitudinally extending catheter body having proximal and distal ends. The catheter body defines a lumen extending longitudinally from a first port defined at the proximal end, through the body, to a second port defined at the distal end. The catheter includes a valve for controlling fluid flow through the second port.
摘要翻译：导管包括具有近端和远端的纵向延伸的导管主体。导管主体限定了从限定在近端的第一端口，通过主体纵向延伸到限定在远端处的第二端口的内腔。导管包括用于控制通过第二端口的流体流动的阀。

9. 发明申请

US20050043637A1 Method and system for spectral examination of vascular walls through blood during cardiac motion 有权
标题翻译：心脏运动期间通过血液进行血管壁光谱检查的方法和系统
公开(公告)号：US20050043637A1
公开(公告)日：2005-02-24
申请号：US10646271
申请日：2003-08-22
申请人： Jay Caplan , Barbara Marshik-Geurts
发明人： Jay Caplan , Barbara Marshik-Geurts
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086 , A61B5/7285
摘要： A method for improving the treatment and/or examination of vessel walls through fluid, such as blood, functions by identifying the points in time when the catheter is closest to the vessel wall or farthest from the vessel wall. Identification of this relative location enables improved spectral readings in larger vessels. In short, instead of trying to overcome motion (e.g., by centering the catheter), this approach takes advantage of motion by identify times when the catheter is closer to the vessel wall, in order to gather more useful spectral information or improve the efficacy of the treatment of the vessel walls. In the specific example, the invention is used for near infrared (NIR) spectroscopy. In some embodiments, the catheter head is designed to induce relative movement between the head and the vessel walls.
摘要翻译：通过识别当导管最靠近血管壁或离血管壁最远的时间点来改善对血管壁的治疗和/或检查的方法，例如通过流体，例如血液。识别该相对位置可以改善较大容器中的光谱读数。简而言之，代替克服运动（例如通过导管对中），这种方法通过识别导管更靠近血管壁的时间来利用运动，以便收集更有用的光谱信息或提高其功效治疗血管壁。在具体实例中，本发明用于近红外（NIR）光谱。在一些实施例中，导管头被设计成引起头部和血管壁之间的相对运动。

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