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1. 发明申请

US20070093086A1 Method and apparatus for fixed and replaceable module architecture 失效
标题翻译：固定和可替换模块架构的方法和装置
公开(公告)号：US20070093086A1
公开(公告)日：2007-04-26
申请号：US11253081
申请日：2005-10-17
申请人： Simon Davis , Denis King , Dion Pike , Joey Chow , Mark Megarity
发明人： Simon Davis , Denis King , Dion Pike , Joey Chow , Mark Megarity
IPC分类号： H05K1/00
CPC分类号： H05K1/14 , H04Q1/023 , H04Q1/03 , H04Q1/035 , H04Q2201/12 , H05K1/0295 , H05K2201/044 , H05K2201/09954 , H05K2201/10189 , H05K2201/2027 , Y10T29/49128 , Y10T29/49133
摘要： A method and apparatus for an electrical system architecture capable of providing fixed or modular components, for example, interface connectors, is provided. Fixed components allow product cost to be minimized. Modular components provide flexible configurability of products. In accordance with at least one embodiment of the present invention, an electrical system architecture capable of providing fixed or modular components minimizes costs such as design, production, and customer support costs while being able to provide a range of product variants.
摘要翻译：提供了一种能够提供固定或模块化组件（例如，接口连接器）的电气系统结构的方法和装置。固定组件允许产品成本最小化。模块化组件提供灵活的产品配置性。根据本发明的至少一个实施例，能够提供固定或模块化部件的电气系统结构使得诸如设计，生产和客户支持成本之类的成本最小化，同时能够提供一系列的产品变型。

2. 发明申请

US20070086175A1 Configurable chassis guidance system and method 有权
标题翻译：可配置的底盘引导系统和方法
公开(公告)号：US20070086175A1
公开(公告)日：2007-04-19
申请号：US11437965
申请日：2006-05-19
申请人： Simon Davis , Mark Megarity , Joey Chow , Dion Pike
发明人： Simon Davis , Mark Megarity , Joey Chow , Dion Pike
IPC分类号： H05K7/14 , H05K1/00
CPC分类号： H05K7/1435 , H05K7/186
摘要： A configurable chassis guidance system and method are described. The system may be practiced as a chassis and/or a module or an element thereof (e.g., a mating guide). The system and method allow reconfiguration of multiple modules of various module widths without the need for removal or reinstallation of module guides mounted on the chassis. As an example, a single-width module may be removed and replaced by a double-width module or quadruple-width module without removing module guides used to engage the single-width module. As another example, a double-width module or quadruple-width module may be removed and replaced by a single-width module without removing module guides used to engage the double-width module or quadruple-width module. The system and method may be practiced so as not to impair compatibility of modules with card edge module guides that engage an edge of a circuit board of a module.
摘要翻译：描述了可配置的底盘引导系统和方法。该系统可以实现为底盘和/或模块或其元件（例如，配合引导件）。该系统和方法允许重新配置各种模块宽度的多个模块，而无需拆卸或重新安装安装在机箱上的模块导板。作为示例，单宽模块可以被移除并由双宽度模块或四倍宽度模块代替，而不去除用于接合单宽度模块的模块引导件。作为另一示例，双宽度模块或四倍宽度模块可以被移除并由单宽度模块代替，而不去除用于接合双宽度模块或四倍宽度模块的模块引导件。该系统和方法可以被实践为不损害与接合模块的电路板的边缘的卡边缘模块引导件的模块的兼容性。

3. 发明授权

US08927697B2 PD-1 specific antibodies and uses thereof 有权
标题翻译： PD-1特异性抗体及其用途
公开(公告)号：US08927697B2
公开(公告)日：2015-01-06
申请号：US13062559
申请日：2009-09-14
申请人： Simon Davis , Kerry Louise Tyson
发明人： Simon Davis , Kerry Louise Tyson
IPC分类号： C12P21/08 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/56972 , G01N2333/70503
摘要： One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.
摘要翻译：本公开的一个方面提供可以作为PD-1的激动剂的抗体，从而调节由PD-1调节的免疫应答。本公开的另一方面提供包含PD-1特异性抗体的组合物及其在下调免疫应答的方法中的用途。这些方法可以在包括人或动物在内的任何对象上实施。在本发明的另一方面，本文公开的抗PD-1抗体可用于检测生物样品中的PD-1或其片段。检测到的PD-1的量可以与PD-1的表达水平相关，并且与受试者中免疫细胞（例如，活化的T细胞，B细胞和/或单核细胞）的活化状态相关。

4. 发明申请

US20110171215A1 PD-1 SPECIFIC ANTIBODIES AND USES THEREOF 有权
标题翻译： PD-1特异性抗体及其用途
公开(公告)号：US20110171215A1
公开(公告)日：2011-07-14
申请号：US13062559
申请日：2009-09-14
申请人： Simon Davis , Kerry Louise Tyson
发明人： Simon Davis , Kerry Louise Tyson
IPC分类号： A61K39/395 , C12N5/00 , C12N5/10 , C12N15/63 , C07K7/06 , C07K14/435 , C07K16/00 , C07H21/04 , A61P41/00 , A61P37/08 , A61P1/00
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/56972 , G01N2333/70503
摘要： One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.
摘要翻译：本公开的一个方面提供可以作为PD-1的激动剂的抗体，从而调节由PD-1调节的免疫应答。本公开的另一方面提供包含PD-1特异性抗体的组合物及其在下调免疫应答的方法中的用途。这些方法可以在包括人或动物在内的任何对象上实施。在本发明的另一方面，本文公开的抗PD-1抗体可用于检测生物样品中的PD-1或其片段。检测到的PD-1的量可以与PD-1的表达水平相关，并且与受试者中免疫细胞（例如，活化的T细胞，B细胞和/或单核细胞）的活化状态相关。

5. 发明授权

US07851598B2 Receptor modulators 有权
标题翻译：受体调节剂
公开(公告)号：US07851598B2
公开(公告)日：2010-12-14
申请号：US10585491
申请日：2005-01-10
申请人： Simon Davis
发明人： Simon Davis
IPC分类号： C07K16/28
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/70521 , C07K14/70532 , C07K16/2818 , C07K2299/00 , C07K2317/55 , C07K2317/75 , C07K2319/00 , G06F19/16 , G06F19/18
摘要： Method of identifying a modulator of CD28 comprising comparing a structural model of a candidate modulator with a structural model of CD28 to thereby determine whether the modulator will bind to CD28, wherein the structural model is derived from, or comprises, structural coordinates of a crystal of: (i) CD28, (ii) a fragment of CD28, or (iii) a homologue of (i) or (ii). The crystal of CD28 in a soluble form complexed with the Fab fragment of a mitogenic (superagonistic) antibody has been obtained and used for the determination of the 3D-structure of the receptor. The application also relates to modulators of superagonistic signalling for any receptor of the CD28 family, i.e. to superagonistic antibodies and chimeric proteins thereof, and to the screening of the superagonistic modulators. In the methods of screening, the binding of the candidate modulators to a portion of the receptor proximal to the cell membrane is investigated.
摘要翻译：识别CD28调节剂的方法，包括将候选调节剂的结构模型与CD28的结构模型进行比较，从而确定调节剂是否结合CD28，其中结构模型是衍生自或包含结构模型的结构坐标：（i）CD28，（ii）CD28的片段，或（iii）（i）或（ii）的同源物。已经获得了与促有丝分裂（超抗原）抗体的Fab片段复合的可溶形式的CD28晶体，并用于测定受体的3D结构。本申请还涉及CD28家族的任何受体的超强信号调节剂，即其超强抗体及其嵌合蛋白，以及对超调调节剂的筛选。在筛选方法中，研究了候选调节剂与接近细胞膜的受体的一部分的结合。

6. 发明申请

US20070058601A1 Method of authenticating access points on a wireless network 审中-公开
标题翻译：在无线网络上验证接入点的方法
公开(公告)号：US20070058601A1
公开(公告)日：2007-03-15
申请号：US11512258
申请日：2006-08-30
申请人： Simon Davis , Ian Phillips
发明人： Simon Davis , Ian Phillips
IPC分类号： H04Q7/24
CPC分类号： H04L63/08 , H04L63/1466 , H04W12/06 , H04W12/12
摘要： A method of authenticating access points (1, 2, 3) on a wireless network (4) comprises sending a list of nearest neighbours (2, 3) from a trusted access point (1) to a controller (6). At the trusted access point (1), test data related to each of the listed nearest neighbours is received from the controller. Each neighbour (2, 3) is interrogated using its respective test data and the response compared with an expected response. A reliability indication is returned to the controller (6).
摘要翻译：一种在无线网络（4）上认证接入点（1,2,3）的方法包括将最近邻居（2,3）的列表从可信接入点（1）发送到控制器（6）。在受信任的接入点（1），从控制器接收与列出的最近邻居中的每一个相关的测试数据。使用其各自的测试数据询问每个邻居（2,3），并且响应与预期响应进行比较。可靠性指示返回到控制器（6）。

7. 发明授权

US08447227B2 Jukebox system 有权
标题翻译：自动点唱机系统
公开(公告)号：US08447227B2
公开(公告)日：2013-05-21
申请号：US12735413
申请日：2009-01-14
申请人： Simon Davis
发明人： Simon Davis
IPC分类号： H04H40/00
CPC分类号： H04L67/025 , G06F17/30044 , G06F17/30053 , G11B27/002 , G11B27/105 , G11B27/11 , H04L65/4084 , H04L67/04 , H04L67/06
摘要： A jukebox is described where users having mobile telephones can access a server (2) located remote from the jukebox location and select tracks for playing on the jukebox at the user's location. The user's mobile telephone communicates on WAP or WEB on a mobile with the server (2) thereby allowing the user to view any information relating to the tracks selectable on the jukebox at the user's location. The user's selection is transmitted to the jukebox via a wireless communications network and the track played at the user's location. The communication between the remote server (2) and the jukebox allows information such as track lists selectable and information relating to the tracks to be remotely accessed by owners to allow suitable track lists to be provided for selection for different venues or different times of the day or of the year. For example, all rock songs could be removed from the selection list after 11 pm at night.
摘要翻译：描述了一种点播机，其中具有移动电话的用户可以访问位于远离点播机位置的服务器（2），并且在用户位置处选择用于在自动存储塔上播放的轨道。用户的移动电话与服务器（2）在移动设备上的WAP或WEB上进行通信，从而允许用户在用户的位置查看与自动存储塔上可选择的轨道有关的任何信息。用户的选择通过无线通信网络和在用户位置播放的轨道传送到自动点唱机。远程服务器（2）和自动存储器之间的通信允许可选择的轨道列表等信息和与轨道相关的信息被业主远程访问，以允许提供适合的轨道列表，供不同场地或当天不同时间选择或一年。例如，所有的摇滚歌曲可以在晚上11点之后从选择列表中删除。

8. 发明申请

US20100311400A1 JUKEBOX SYSTEM 有权
标题翻译： JUKEBOX系统
公开(公告)号：US20100311400A1
公开(公告)日：2010-12-09
申请号：US12735413
申请日：2009-01-14
申请人： Simon Davis
发明人： Simon Davis
IPC分类号： H04W4/00 , G06F15/16
CPC分类号： H04L67/025 , G06F17/30044 , G06F17/30053 , G11B27/002 , G11B27/105 , G11B27/11 , H04L65/4084 , H04L67/04 , H04L67/06
摘要： A jukebox is described where users having mobile telephones can access a server (2) located remote from the jukebox location and select tracks for playing on the jukebox at the user's location. The user's mobile telephone communicates on WAP or WEB on a mobile with the server (2) thereby allowing the user to view any information relating to the tracks selectable on the jukebox at the user's location. The user's selection is transmitted to the jukebox via a wireless communications network and the track played at the user's location. The communication between the remote server (2) and the jukebox allows information such as track lists selectable and information relating to the tracks to be remotely accessed by owners to allow suitable track lists to be provided for selection for different venues or different times of the day or of the year. For example, all rock songs could be removed from the selection list after 11 pm at night.
摘要翻译：描述了一种点播机，其中具有移动电话的用户可以访问位于远离点播机位置的服务器（2），并且在用户位置处选择用于在自动存储塔上播放的轨道。用户的移动电话与服务器（2）在移动设备上的WAP或WEB上进行通信，从而允许用户在用户的位置查看与自动存储塔上可选择的轨道有关的任何信息。用户的选择通过无线通信网络和在用户位置播放的轨道传送到自动点唱机。远程服务器（2）和自动存储器之间的通信允许可选择的轨道列表等信息和与轨道相关的信息被业主远程访问，以允许提供适合的轨道列表，供不同场地或当天不同时间选择或一年。例如，所有的摇滚歌曲可以在晚上11点之后从选择列表中删除。

9. 发明申请

US20080044837A1 Receptor Modulators 有权
标题翻译：受体调节剂
公开(公告)号：US20080044837A1
公开(公告)日：2008-02-21
申请号：US10585491
申请日：2005-01-10
申请人： Simon Davis
发明人： Simon Davis
IPC分类号： G01N33/53 , G06F19/00 , C07K16/28
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/70521 , C07K14/70532 , C07K16/2818 , C07K2299/00 , C07K2317/55 , C07K2317/75 , C07K2319/00 , G06F19/16 , G06F19/18
摘要： Method of identifying a modulator of CD28 comprising comparing a structural model of a candidate modulator with a structural model of CD28 to thereby determine whether the modulator will bind to CD28, wherein the structural model is derived from, or comprises, structural coordinates of a crystal of: (i) CD28, (ii) a fragment of CD28, or (iii) a homologue of (i) or (ii).
摘要翻译：识别CD28调节剂的方法，包括将候选调节剂的结构模型与CD28的结构模型进行比较，从而确定调节剂是否结合CD28，其中结构模型是衍生自或包含结构模型的结构坐标：（i）CD28，（ii）CD28的片段，或（iii）（i）或（ii）的同源物。

10. 发明申请

US20070281697A1 Method of Packet Switched Handover 有权
标题翻译：分组交换切换方法
公开(公告)号：US20070281697A1
公开(公告)日：2007-12-06
申请号：US10592356
申请日：2005-02-24
申请人： Simon Davis
发明人： Simon Davis
IPC分类号： H04Q7/20
CPC分类号： H04W36/18 , H04W36/12
摘要： A method of packet switched handover in a mobile communication system comprising a terminal, a source node and a destination node comprises negotiating protocol parameters for the destination node on behalf of a new network entity, by communicating with an old network entity whilst the terminal is still connected to the source node; and completing the packet switched handover, such that service interruption on handover is reduced.
摘要翻译：在包括终端，源节点和目的地节点的移动通信系统中的分组交换切换的方法包括：代表新网络实体通过与旧网络实体通信来协商目的地节点的协议参数，同时终端仍然连接到源节点; 并完成分组交换切换，使得切换时的业务中断减少。

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