专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4789740A Halogenation process for preparing 2-(oxoazetidinyl)-3-chloromethyl-3-butenoate 失效
标题翻译：制备2-（氧代氮杂环丁烷基）-3-氯甲基-3-丁烯酸酯的卤化方法
公开(公告)号：US4789740A
公开(公告)日：1988-12-06
申请号：US23970
申请日：1987-03-09
申请人： Sigeru Torii , Hideo Tanaka , Yuzuru Ogata , Michio Sasaoka , Norio Saito , Shigemitsu Nagao
发明人： Sigeru Torii , Hideo Tanaka , Yuzuru Ogata , Michio Sasaoka , Norio Saito , Shigemitsu Nagao
IPC分类号： C07D205/08 , C07D205/095 , C07B39/00
CPC分类号： C07D205/095 , Y02P20/55
摘要： A process for preparing an azetidinone derivative represented by the formula (I) ##STR1## wherein R.sup.1 represents an aryl group, arylmethyl group or aryloxymethyl group, R.sup.2 represents hydrogen atom or a carboxyl-protecting group and R.sup.3 represents an alkyl group or aryl group, the process comprising reacting an azetidinone derivative represented by the formula (II) ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above with a chlorinating agent.
摘要翻译：制备由式（I）表示的氮杂环丁酮衍生物的方法其中R 1表示芳基，芳基甲基或芳氧基甲基，R 2表示氢原子或羧基保护基，R 3表示烷基或芳基，该方法包括使由式（II）表示的氮杂环丁酮衍生物（II）（其中R 1，R 2和R 3如上定义）与氯化剂反应。

2. 发明授权

US4958018A Method for production of 3-exomethylenecepham derivatives 失效
标题翻译： 3-甲磺酰头孢衍生物的生产方法
公开(公告)号：US4958018A
公开(公告)日：1990-09-18
申请号：US347319
申请日：1989-05-04
申请人： Sigeru Torii , Hideo Tanaka , Masatoshi Taniguchi , Michio Sasaoka , Norio Saito , Takashi Shiroi , Shigemitsu Nagao , Ryo Kikuchi , Yutaka Kameyama
发明人： Sigeru Torii , Hideo Tanaka , Masatoshi Taniguchi , Michio Sasaoka , Norio Saito , Takashi Shiroi , Shigemitsu Nagao , Ryo Kikuchi , Yutaka Kameyama
IPC分类号： B01J23/14 , C07B61/00 , C07D501/04 , C07D501/22
CPC分类号： C07D501/04 , Y02P20/55
摘要： Disclosed is a method of producing a 3-exomethylenecepham of the formula ##STR1## wherein R.sup.1 is amino or substituted amino and R.sup.2 is a carboxy-protecting group comprising reacting a cephem of the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and X is halogen with lead metal while maintaining the pH of the reaction system at about 0.1 to 8. The cephem (I) may be reacted with a catalytic amount of lead metal or a lead compound in the presence of a metal having a greater ionization tendency than lead.

3. 发明授权

US4740596A Process for preparation of 4-sulfonylthio azetidinone derivatives 失效
标题翻译： 4-磺酰硫基氮杂环丁酮衍生物的制备方法
公开(公告)号：US4740596A
公开(公告)日：1988-04-26
申请号：US089947
申请日：1987-08-26
申请人： Sigeru Torii , Hideo Tanaka , Michio Sasaoka , Shigemitsu Nagao
发明人： Sigeru Torii , Hideo Tanaka , Michio Sasaoka , Shigemitsu Nagao
IPC分类号： C07D205/08 , A61K31/395 , A61K31/397 , A61P31/04 , C07D205/09 , C07D205/095 , C07D417/12 , C07B45/00 , C07D401/12
CPC分类号： C07D205/09 , C07D205/095
摘要： A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formulaR.sup.3 SO.sub.2 SR.sup.9 (VII)wherein R.sup.3 and R.sup.9 are as defined above.
摘要翻译：制备式（I）表示的氮杂环丁酮衍生物的方法，其中R 1是氢，卤素或低级烷氧基，R 2是氢，卤素，低级烷氧基，氨基或基团（其中R 5是取代的或未取代的苯基，取代或未取代的苯基甲基，取代或未取代的苯氧基甲基或取代或未取代的苯甲酰基），或R 1和R 2一起为羰基，R 3为取代或未取代的苯基，且R 4为氢，任选取代的烃残基或酰基，衍生自无机酸或有机酸的甲硅烷基，磺酰基或膦酰基，该方法包括使由式（VI）表示的二硫代氮杂环丁酮衍生物（其中R 1，R 2和R 4如上所定义）和R 9是取代或未取代的，含有由式R3SO2SR9（VII）表示的化合物的芳族杂环残基，其中R3和R9如上定义。

4. 发明授权

US4853468A Process for the preparation of cephem derivatives 失效
标题翻译：头孢烯衍生物的制备方法
公开(公告)号：US4853468A
公开(公告)日：1989-08-01
申请号：US166918
申请日：1988-03-11
申请人： Sigeru Torii , Kenji Uneyama , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi
发明人： Sigeru Torii , Kenji Uneyama , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi
IPC分类号： C07D205/095 , C07D403/12 , C07D501/02 , C07D501/08 , C07F9/568
CPC分类号： C07D403/12 , C07D205/095 , C07F9/568
摘要： This invention provides azetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The azetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.
摘要翻译：本发明提供由式“IMAGE”表示的氮杂环丁酮衍生物及其制备方法。氮杂环丁酮衍生物用作生产用作抗生素剂的头孢菌素化合物的中间体。

5. 发明授权

US4784734A Azetidinone derivatives and process for the preparation of the same 失效
标题翻译：氮杂环丁酮衍生物及其制备方法相同
公开(公告)号：US4784734A
公开(公告)日：1988-11-15
申请号：US71664
申请日：1987-07-09
申请人： Sigeru Torii , Kenji Uneyama , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi
发明人： Sigeru Torii , Kenji Uneyama , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi
IPC分类号： C07D205/095 , C07D403/12 , C07F9/568 , C25B3/06
CPC分类号： C07D403/12 , C07D205/095 , C07F9/568
摘要： This invention provides azetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The azetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.
摘要翻译：本发明提供由式“IMAGE”表示的氮杂环丁酮衍生物及其制备方法。氮杂环丁酮衍生物用作生产用作抗生素剂的头孢菌素化合物的中间体。

6. 发明授权

US4801720A Azetidinone disulfides and a ring opening process for preparing the same 失效
标题翻译：氮杂环丁酮二硫化物及其制备方法
公开(公告)号：US4801720A
公开(公告)日：1989-01-31
申请号：US46444
申请日：1987-05-06
申请人： Sigeru Torii , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Siroi
发明人： Sigeru Torii , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Siroi
IPC分类号： C07D205/08 , C07D205/095 , C07D403/12 , C07D417/12 , C07D417/14 , C07D501/20 , C07D501/36 , C07B43/06 , C07B45/00 , C07D401/12
CPC分类号： C07D403/12 , C07D205/095 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： An azetidinone derivative represented by the formula (I) ##STR1## wherein R.sup.1 is substituted or unsubstituted phenyl or substituted or unsubstituted phenoxy, R.sup.2 is hydrogen, optionally substituted hydrocarbon residue or amino-protecting group selected from acyl, silyl, sulfonyl and phosphonyl derived from organic or inorganic acid, ##STR2## is >C.dbd.O or>C.dbd.N--OR.sup.3 (wherein R.sup.3 is hydrogen or lower alkyl), X.sup.1 and X.sup.2 are the same or different and are halogen, hydroxyl, alkoxy, acyloxy, SR.sup.4 (wherein R.sup.4 is straight chain or branched chain lower alkyl substituted or unsubstituted, substituted or unsubstituted phenyl or substituted or unsubstituted heterocyclic group), amino or hydrogen, one of X.sup.1 and X.sup.2 being hydrogen when the other is not, and R.sup.5 is substituted or unsubstituted phenyl or substituted or unsubstituted heterocyclic group, and a process for preparing the same.
摘要翻译：由式（I）表示的氮杂环丁酮衍生物其中R1是取代或未取代的苯基或取代或未取代的苯氧基，R2是氢，任选取代的烃残基或氨基保护基，其选自酰基，甲硅烷基，磺酰基和衍生自有机或无机酸的膦酰基是C = O或C = N-OR 3（其中R 3为氢或低级烷基），X 1和X 2相同或不同，为卤素，羟基，烷氧基，酰氧基，SR4（其中R4是直链或支链低级烷基取代或未取代的，取代或未取代的苯基或取代或未取代的杂环基），氨基或氢，当另一个未被取代时，X 1和X 2之一为氢，R 5为取代基或未取代的苯基或取代或未取代的杂环基，及其制备方法。

7. 发明授权

US4689411A 4-thio azetidinone intermediates and process for the preparation of the same 失效
标题翻译： 4-硫代氮杂环丁酮中间体及其制备方法相同
公开(公告)号：US4689411A
公开(公告)日：1987-08-25
申请号：US865651
申请日：1986-05-15
申请人： Sigeru Torii , Kenji Uneyama , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi
发明人： Sigeru Torii , Kenji Uneyama , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi
IPC分类号： C07D205/095 , C07D403/12 , C07D501/02 , C07D501/08 , C07F9/568 , C07D205/08 , C07F9/65
CPC分类号： C07D403/12 , C07D205/095 , C07F9/568
摘要： This invention provides azetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The azetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.
摘要翻译：本发明提供由式“IMAGE”表示的氮杂环丁酮衍生物及其制备方法。氮杂环丁酮衍生物用作生产用作抗生素剂的头孢菌素化合物的中间体。

8. 发明授权

US4566996A Process for preparing azetidinone derivatives 失效
标题翻译：制备氮杂环丁酮衍生物的方法
公开(公告)号：US4566996A
公开(公告)日：1986-01-28
申请号：US567736
申请日：1984-01-03
申请人： Sigeru Torii , Hideo Tanaka , Takashi Shiroi , Michio Sasaoka , Norio Saito , Kiyotoshi Matsumura
发明人： Sigeru Torii , Hideo Tanaka , Takashi Shiroi , Michio Sasaoka , Norio Saito , Kiyotoshi Matsumura
IPC分类号： C07D205/08 , C07D205/095 , C07D405/12
CPC分类号： C07D205/095 , Y02P20/55
摘要： A process for preparing an azetidinone derivative represented by the formula (1) ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted phenylmethyl group or a substituted or unsubstituted phenoxymethyl group, R.sup.2 represents a hydrogen atom or a group for protecting carboxylic acid and Ar represents a substituted or unsubstituted phenyl group, the process comprising reacting a thiazolineazetidinone derivative represented by the formula (2) ##STR2## wherein R.sup.1 and R.sup.2 are as defined above with a sulfonyl bromide represented by the formula (3)Ar--SO.sub.2 --Br (3)wherein Ar is as defined above in water-containing organic solvent.
摘要翻译：制备由式（1）表示的氮杂环丁酮衍生物的方法其中R1表示取代或未取代的芳基，取代或未取代的苯基甲基或取代或未取代的苯氧基甲基，R2表示氢原子或用于保护羧酸和Ar的基团代表取代或未取代的苯基，该方法包括使式（2）表示的噻唑啉氮杂环丁酮衍生物（2）其中R1和R2如上定义，式（3）Ar-SO 2-Br（3）其中Ar如上所述在含水有机溶剂中。

9. 发明授权

US4499265A Process for preparing 3-exo-methylenecepham derivatives 失效
标题翻译： 3-异喹喔啉衍生物的制备方法
公开(公告)号：US4499265A
公开(公告)日：1985-02-12
申请号：US406568
申请日：1982-08-09
申请人： Sigeru Torii , Hideo Tanaka , Junzo Nokami , Takashi Shiroi , Norio Saito , Michio Sasaoka
发明人： Sigeru Torii , Hideo Tanaka , Junzo Nokami , Takashi Shiroi , Norio Saito , Michio Sasaoka
IPC分类号： C07D501/08 , C07D501/14 , C07D513/04
CPC分类号： C07D513/04 , Y02P20/55
摘要： This invention provides a process for preparing a 3-exo-methylenecepham derivative represented by the formula ##STR1## wherein R.sup.1 represents an aralkyl or aryloxymethyl group both of which may be substituted on the aromatic ring, and R.sup.2 represents a carboxyl-protecting group, the process comprising subjecting a compound represented by the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, to a cyclization reaction in an acidic water-containing solvent.
摘要翻译：本发明提供一种制备由式（III）表示的3-外 - 亚甲基头孢衍生物的方法，其中R 1表示可在芳环上被取代的芳烷基或芳氧基甲基，R2表示羧基保护基该方法包括将其中R 1和R 2如上所定义的式Ⅺ（II）表示的化合物在酸性含水溶剂中进行环化反应。

10. 发明授权

US4482491A Thiazolinoazetidinone derivatives and process for the preparation of the same 失效
标题翻译：噻唑并氮杂环丁酮衍生物及其制备方法相同
公开(公告)号：US4482491A
公开(公告)日：1984-11-13
申请号：US370034
申请日：1982-04-20
申请人： Sigeru Torii , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi , Akira Tanaka
发明人： Sigeru Torii , Hideo Tanaka , Junzo Nokami , Michio Sasaoka , Norio Saito , Takashi Shiroi , Akira Tanaka
IPC分类号： C07D205/095 , C07D417/12 , C07D501/08 , C07D501/22 , C07D501/24 , C07D501/36 , C07D513/04 , C07D205/08 , C07D403/12
CPC分类号： C07D417/12 , C07D205/095 , C07D513/04
摘要： This invention provides thiazolinoazetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The thiazolinoazetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.
摘要翻译：本发明提供由式＆lt; IMAGE＆gt;表示的噻唑并氮杂环丁酮衍生物及其制备方法。噻唑烷基氮杂环丁酮衍生物用作生产用作抗生素剂的头孢菌素化合物的中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式