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1. 发明申请

US20100159605A1 Method of Correction of Particle Interference to Hemoglobin Measurement 有权
标题翻译：血红蛋白测量的粒子干扰校正方法
公开(公告)号：US20100159605A1
公开(公告)日：2010-06-24
申请号：US12616273
申请日：2009-11-11
申请人： Shuliang ZHANG , Jiuliu Lu , Min Zheng , Eric M. Grace , Jing Li , Maritza Lavernia , Ted W. Britton
发明人： Shuliang ZHANG , Jiuliu Lu , Min Zheng , Eric M. Grace , Jing Li , Maritza Lavernia , Ted W. Britton
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/25 , Y10T436/25125
摘要： A method of correction of particle interference to hemoglobin measurement of a blood sample on a hematology analyzer is provided. The method includes mixing an aliquot of a blood sample with a lytic reagent to lyse red blood cells and forming a sample mixture; measuring absorbance of the sample mixture at a predetermined wavelength of a hemoglobin chromogen formed in the sample mixture, and obtaining an apparent hemoglobin concentration of the blood sample using obtained absorbance; measuring concentration and size of cellular particles remaining in the sample mixture; removing contribution of the cellular particles to the apparent hemoglobin concentration using the concentration and the size of the cellular particles to obtain a corrected hemoglobin concentration of the blood sample; and reporting the corrected hemoglobin concentration of the blood sample.
摘要翻译：提供了一种在血液分析仪上校正血液样品的血红蛋白测量的粒子干扰的方法。该方法包括将血样的等分试样与裂解试剂混合以溶解红细胞并形成样品混合物; 测量在样品混合物中形成的血红蛋白色原子的预定波长处的样品混合物的吸光度，并使用所获得的吸光度获得血液样品的表观血红蛋白浓度; 测量残留在样品混合物中的细胞颗粒的浓度和尺寸; 使用细胞颗粒的浓度和大小去除细胞颗粒对表观血红蛋白浓度的贡献，以获得血液样品的校正血红蛋白浓度; 并报告血样的校正血红蛋白浓度。

2. 发明授权

US08192995B2 Method of correction of particle interference to hemoglobin measurement 有权
标题翻译：校正颗粒干扰血红蛋白测量方法
公开(公告)号：US08192995B2
公开(公告)日：2012-06-05
申请号：US12616273
申请日：2009-11-11
申请人： Shuliang Zhang , Jiuliu Lu , Min Zheng , Eric M. Grace , Jing Li , Maritza Lavernia , Ted W. Britton
发明人： Shuliang Zhang , Jiuliu Lu , Min Zheng , Eric M. Grace , Jing Li , Maritza Lavernia , Ted W. Britton
IPC分类号： G01N33/72 , G01N33/48
CPC分类号： G01N33/721 , G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/25 , Y10T436/25125
摘要： A method of correction of particle interference to hemoglobin measurement of a blood sample on a hematology analyzer is provided. The method includes mixing an aliquot of a blood sample with a lytic reagent to lyse red blood cells and forming a sample mixture; measuring absorbance of the sample mixture at a predetermined wavelength of a hemoglobin chromogen formed in the sample mixture, and obtaining an apparent hemoglobin concentration of the blood sample using obtained absorbance; measuring concentration and size of cellular particles remaining in the sample mixture; removing contribution of the cellular particles to the apparent hemoglobin concentration using the concentration and the size of the cellular particles to obtain a corrected hemoglobin concentration of the blood sample; and reporting the corrected hemoglobin concentration of the blood sample.
摘要翻译：提供了一种在血液分析仪上校正血液样品的血红蛋白测量的粒子干扰的方法。该方法包括将血样的等分试样与裂解试剂混合以溶解红细胞并形成样品混合物; 测量在样品混合物中形成的血红蛋白色原子的预定波长处的样品混合物的吸光度，并使用所获得的吸光度获得血液样品的表观血红蛋白浓度; 测量残留在样品混合物中的细胞颗粒的浓度和尺寸; 使用细胞颗粒的浓度和大小去除细胞颗粒对表观血红蛋白浓度的贡献，以获得血液样品的校正血红蛋白浓度; 并报告血样的校正血红蛋白浓度。

3. 发明申请

US20070143033A1 Systems and methods for particle counting 有权
标题翻译：粒子计数的系统和方法
公开(公告)号：US20070143033A1
公开(公告)日：2007-06-21
申请号：US11312722
申请日：2005-12-20
申请人： Shuliang Zhang , Min Zheng , Dongqing Lin , Ziling Huo
发明人： Shuliang Zhang , Min Zheng , Dongqing Lin , Ziling Huo
IPC分类号： G06F19/00
CPC分类号： G01N15/12 , G01N35/00584 , G01N2015/1062 , G01N2015/1068 , G01N2015/1081 , G01N2015/1087
摘要： Systems and methods consistent with embodiments of the present invention provide a method for the measurement and analysis of particle counts in flow cytometry and hematology instruments. In some methods for the measurement and analysis of particle counts, a corrected histogram of particle distributions is calculated and used to obtain an accurate count of particles and an accurate measurement of other particle parameters.
摘要翻译：与本发明的实施方案一致的系统和方法提供了流式细胞术和血液学仪器中的颗粒计数的测量和分析方法。在一些用于测量和分析颗粒计数的方法中，计算颗粒分布的校正直方图并用于获得精确的颗粒计数和其他颗粒参数的精确测量。

4. 发明授权

US07457709B2 Systems and methods for particle counting 有权
标题翻译：粒子计数的系统和方法
公开(公告)号：US07457709B2
公开(公告)日：2008-11-25
申请号：US11312722
申请日：2005-12-20
申请人： Shuliang Zhang , Min Zheng , Dongqing Lin , Ziling Huo
发明人： Shuliang Zhang , Min Zheng , Dongqing Lin , Ziling Huo
IPC分类号： G06F19/00
CPC分类号： G01N15/12 , G01N35/00584 , G01N2015/1062 , G01N2015/1068 , G01N2015/1081 , G01N2015/1087
摘要： Systems and methods consistent with embodiments of the present invention provide a method for the measurement and analysis of particle counts in flow cytometry and hematology instruments. In some methods for the measurement and analysis of particle counts, a corrected histogram of particle distributions is calculated and used to obtain an accurate count of particles and an accurate measurement of other particle parameters.
摘要翻译：与本发明的实施方案一致的系统和方法提供了流式细胞术和血液学仪器中的颗粒计数的测量和分析方法。在一些用于测量和分析颗粒计数的方法中，计算颗粒分布的校正直方图并用于获得精确的颗粒计数和其他颗粒参数的精确测量。

5. 发明授权

US06472215B1 Method of analyzing nucleated red blood cells in a blood sample 有权
标题翻译：分析血样中有核红细胞的方法
公开(公告)号：US06472215B1
公开(公告)日：2002-10-29
申请号：US09917450
申请日：2001-07-27
申请人： Ziling Huo , Jaesang Park , Wei Yao , Shuliang Zhang , Min Zheng
发明人： Ziling Huo , Jaesang Park , Wei Yao , Shuliang Zhang , Min Zheng
IPC分类号： G01N3100
CPC分类号： G01N15/12 , G01N15/1456 , G01N21/47 , G01N33/491 , G01N2015/1037 , Y10T436/10 , Y10T436/101666 , Y10T436/107497
摘要： A method of analyzing nucleated red blood cells (NRBCs) in a blood sample and further enumerating NRBCs is disclosed. The method includes lysing a first aliquot and a second aliquot of a blood sample separately with a first lysing reagent system and a second lysing reagent system; measuring the first sample mixture in a flow cell by DC, RF, and light scatter measurements; measuring cell distributions and counting remaining blood cells in the second sample mixture by DC impedance measurements in a non-focused flow aperture; analyzing blood cell distribution patterns obtained from measuring the first sample mixture and from measuring the second sample mixture respectively; and further performing a combined analysis to differentiate NRBCs from other cell types and determine numbers of NRBCs in the blood sample.
摘要翻译：公开了一种在血液样品中分析有核红细胞（NRBC）并进一步列举NRBC的方法。该方法包括用第一裂解试剂系统和第二裂解试剂系统分别裂解血液样品的第一等分试样和第二等分试样; 通过DC，RF和光散射测量来测量流动池中的第一个样品混合物; 通过在非聚焦流动孔径中的DC阻抗测量来测量细胞分布并计数第二样品混合物中的剩余血细胞; 分析从测量第一样品混合物获得的血细胞分布模式和分别测量第二样品混合物; 并进一步进行组合分析以区分NRBC与其他细胞类型并确定血液样品中NRBC的数目。

6. 发明授权

US07482165B2 Method of preventing white blood cell interferences to red blood cell measurements of a blood sample 有权
标题翻译：防止白细胞干扰血液样本红细胞测量的方法
公开(公告)号：US07482165B2
公开(公告)日：2009-01-27
申请号：US11210346
申请日：2005-08-24
申请人： Min Zheng , Jing Li , Yi Li , Michael J. Switzer
发明人： Min Zheng , Jing Li , Yi Li , Michael J. Switzer
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： Methods of prevention and correction of white blood cell interferences to the measurements of mean cell volume (MCV), red blood cell concentration (RBC) and hematocrit (Hct) of a blood sample are disclosed. The interference to MCV can be prevented by identifying a valley between the red blood cell and white blood cell modes on the red blood cell distribution histogram, defining a red blood cell region using the valley and calculating MCV within the defined region. Alternatively, a curve fit of the white blood cell population on the red blood cell distribution histogram can be used to exclude the white blood cells. RBC can be corrected by subtracting the white blood cell concentration obtained from the analysis of a second aliquot sample, when the white blood cell concentration (WBC) exceeds a predetermined criterion. Hct of the blood sample can be calculated using the obtained MCV and RBC.
摘要翻译：公开了对血液样本的平均细胞体积（MCV），红细胞浓度（RBC）和血细胞比容（Hct）的测量的白细胞干扰的预防和校正方法。通过在红细胞分布直方图上识别红细胞和白细胞模式之间的谷，可以防止对MCV的干扰，使用谷定义红细胞区域并计算定义区域内的MCV。或者，可以使用白细胞群体对红细胞分布直方图的曲线拟合来排除白细胞。当白细胞浓度（WBC）超过预定标准时，可通过减去从第二等份样品的分析获得的白细胞浓度来校正RBC。可以使用获得的MCV和RBC计算血液样品的Hct。

7. 发明申请

US20070054403A1 Method of preventing white blood cell interferences to red blood cell measurements of a blood sample 有权
标题翻译：防止白细胞干扰血液样本红细胞测量的方法
公开(公告)号：US20070054403A1
公开(公告)日：2007-03-08
申请号：US11210346
申请日：2005-08-24
申请人： Min Zheng , Jing Li , Yi Li , Michael Switzer
发明人： Min Zheng , Jing Li , Yi Li , Michael Switzer
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： Methods of prevention and correction of white blood cell interferences to the measurements of mean cell volume (MCV), red blood cell concentration (RBC) and hematocrit (Hct) of a blood sample are disclosed. The interference to MCV can be prevented by identifying a valley between the red blood cell and white blood cell modes on the red blood cell distribution histogram, defining a red blood cell region using the valley and calculating MCV within the defined region. Alternatively, a curve fit of the white blood cell population on the red blood cell distribution histogram can be used to exclude the white blood cells. RBC can be corrected by subtracting the white blood cell concentration obtained from the analysis of a second aliquot sample, when the white blood cell concentration (WBC) exceeds a predetermined criterion. Hct of the blood sample can be calculated using the obtained MCV and RBC.
摘要翻译：公开了对血液样本的平均细胞体积（MCV），红细胞浓度（RBC）和血细胞比容（Hct）的测量的白细胞干扰的预防和校正方法。通过在红细胞分布直方图上识别红细胞和白细胞模式之间的谷，可以防止对MCV的干扰，使用谷定义红细胞区域并计算定义区域内的MCV。或者，可以使用白细胞群体对红细胞分布直方图的曲线拟合来排除白细胞。当白细胞浓度（WBC）超过预定标准时，可通过减去从第二等份样品的分析获得的白细胞浓度来校正RBC。可以使用获得的MCV和RBC计算血液样品的Hct。

8. 发明申请

US20130292161A1 METHODS FOR IMPROVING CORROSION RESISTANCE AND APPLICATIONS IN ELECTRICAL CONNECTORS 有权
标题翻译：改善电连接器耐腐蚀性和应用的方法
公开(公告)号：US20130292161A1
公开(公告)日：2013-11-07
申请号：US13461135
申请日：2012-05-01
申请人： Zhengwei Liu , Min Zheng , Rod Martens
发明人： Zhengwei Liu , Min Zheng , Rod Martens
IPC分类号： H05K1/09 , B05D5/12 , C25D5/02 , B82Y40/00 , B82Y30/00
CPC分类号： C23C16/45555 , C23C16/04 , C23C18/1605 , C23C18/54 , C25D5/022 , H01B1/02 , H01B1/04 , H05K3/24 , H05K3/244 , H05K2201/0323 , Y10T29/49155
摘要： A method of manufacturing an electrical conductor includes providing a substrate layer, depositing a graphene layer on the substrate layer and selectively depositing boundary cappings on defects of the graphene layer to inhibit corrosion of the substrate layer at the defects. Optionally, the boundary cappings may include nano-sized crystals deposited only at the defects. The selectively depositing may include electrodepositing boundary cappings on exposed portions of the substrate layer at the defects. The selectively depositing may include reacting boundary capping material with exposed portions of the substrate layer at the defects to deposit the boundary cappings only at the defects.
摘要翻译：制造电导体的方法包括提供衬底层，在衬底层上沉积石墨烯层，并且在石墨烯层的缺陷上选择性地沉积边界帽以抑制缺陷处的衬底层的腐蚀。任选地，边界覆盖物可以包括仅在缺陷处沉积的纳米尺寸的晶体。选择性沉积可以包括在缺陷处在基底层的暴露部分上电沉积边界覆盖物。选择性沉积可以包括使边界覆盖材料与衬底层的暴露部分处于缺陷处，以仅在缺陷处沉积边界覆盖层。

9. 发明申请

US20090009907A1 Laminated film for head applications 有权
标题翻译：用于头部应用的层压膜
公开(公告)号：US20090009907A1
公开(公告)日：2009-01-08
申请号：US11825034
申请日：2007-07-03
申请人： Kunliang Zhang , Min Zheng , Min Li , Chen-Jung Chien , Cherng-Chyi Han
发明人： Kunliang Zhang , Min Zheng , Min Li , Chen-Jung Chien , Cherng-Chyi Han
IPC分类号： G11B5/127 , G11B5/147
CPC分类号： G11B5/3116 , G11B5/1278
摘要： A laminated main pole layer is disclosed in which a non-AFC scheme is used to break the magnetic coupling between adjacent high moment layers and reduce remanence in a hard axis direction while maintaining a high magnetic moment and achieving low values for Hch, Hce, and Hk. An amorphous material layer with a thickness of 3 to 20 Angstroms and made of an oxide, nitride, or oxynitride of one or more of Hf, Zr, Ta, Al, Mg, Zn, or Si is inserted between adjacent high moment stacks. The laminated structure also includes an alignment layer below each high moment layer within each stack. In one embodiment, a Ru coupling layer is inserted between two high moment layers in each stack to introduce an AFC scheme. An uppermost Ru layer is used as a CMP stop layer. A post annealing process may be employed to further reduce the anisotropy field (Hk).
摘要翻译：公开了一种层叠主极层，其中使用非AFC方案来破坏相邻的高力矩层之间的磁耦合，并且在保持高磁矩的同时降低硬轴方向的剩磁，并实现Hch，Hce和 Hk。由Hf，Zr，Ta，Al，Mg，Zn或Si中的一种或多种的氧化物，氮化物或氧氮化物形成的厚度为3〜20埃的无定形材料层插入相邻的高强度叠层之间。层叠结构还包括在每个堆叠内的每个高力矩层下面的对准层。在一个实施例中，Ru耦合层插入每个堆叠中的两个高矩层之间以引入AFC方案。使用最上层的Ru层作为CMP停止层。可以采用后退火工艺来进一步降低各向异性场（Hk）。

10. 发明授权

US07399533B2 Polyvinylidene fluoride coating for metal substrates 有权
标题翻译：金属基材用聚偏二氟乙烯涂层
公开(公告)号：US07399533B2
公开(公告)日：2008-07-15
申请号：US11039979
申请日：2005-01-21
申请人： Min Zheng , Kurt Wood , Scott Gaboury
发明人： Min Zheng , Kurt Wood , Scott Gaboury
IPC分类号： B32B1/08 , B32B15/08 , B32B27/26 , C08L27/12 , C08L27/16
CPC分类号： C09D127/16 , C08K5/42 , C08L33/06 , C08L61/32 , C08L63/00 , Y10T428/12569 , Y10T428/1355 , Y10T428/1393 , Y10T428/31511 , Y10T428/31529 , Y10T428/3154 , Y10T428/31678 , Y10T428/31935 , C08L2666/02
摘要： The invention relates to a one-step fluoropolymer, especially polyvinylidene fluoride (PVDF), coating for use on metals, especially use on metal fuel line and brake tubes, etc, to provide a protective barrier with superior chemical resistance, impact resistance and heat resistance as well as good flexibility. The coating composition contains, on a resin solids basis, 75-94 percent polyvinylidene fluoride resin, 5-20 percent acrylic resin, and 1-15 percent polyepoxide resin. The coating has excellent adhesion on metal substrates, particularly on non-pretreated galvanized steel, without the need for a primer coating.
摘要翻译：本发明涉及一步氟聚合物，特别是聚偏二氟乙烯（PVDF），用于金属的涂料，尤其用于金属燃料管线和制动管等，以提供具有优异的耐化学性，耐冲击性和耐热性的保护屏障以及良好的灵活性。该涂料组合物含有75-94％聚偏二氟乙烯树脂，5-20％丙烯酸树脂和1-15％聚环氧树脂。该涂层对金属基材，特别是未经预处理的镀锌钢板具有优异的粘附性，而不需要底漆涂层。

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