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1. 发明申请

US20090232771A1 Method of controlling cell functions 审中-公开
标题翻译：控制细胞功能的方法
公开(公告)号：US20090232771A1
公开(公告)日：2009-09-17
申请号：US11632459
申请日：2005-07-12
申请人： Shuji Hinuma , Masaki Hosoya , Rie Kunisada
发明人： Shuji Hinuma , Masaki Hosoya , Rie Kunisada
IPC分类号： A61K35/12 , C12Q1/68 , C12N5/10 , A01N1/02 , C07K14/47 , C07H21/04 , C12N5/06 , C12N5/08
CPC分类号： G01N33/5073 , A61K38/00 , C07K14/4702 , G01N33/5023
摘要： The present invention provides methods of screening genes associated with cell regeneration, growth and differentiation and regulators for cell regeneration, growth or differentiation; regulators for cell regeneration, growth or differentiation; and so on. More specifically, the present invention provides methods of screening genes associated with cell regeneration, growth and differentiation, which comprises the step of quantitatively analyzing expression levels of multiple genes collectively in a cell having a regeneration, differentiation or growth capability to thereby identify the genes associated with the regeneration, growth or differentiation of the cell; methods of screening genes associated with cell regeneration, growth and differentiation, which comprises the step of quantitatively analyzing expression levels of multiple genes collectively in a cell having a regeneration, differentiation or growth capability to thereby identify one or more genes that show higher expression levels in the cell or are specific in expression as compared to the other cells; and, the step of contacting at least one candidate substance capable of regulating the functions of the identified genes or their gene products with the cell and comparing changes before and after the contact; and so on.
摘要翻译：本发明提供筛选与细胞再生，生长和分化相关的基因以及用于细胞再生，生长或分化的调节剂的方法; 细胞再生，生长或分化的调节剂; 等等。更具体地，本发明提供筛选与细胞再生，生长和分化相关的基因的方法，其包括在具有再生，分化或生长能力的细胞中统一地定量分析多个基因的表达水平从而鉴定相关基因的步骤与细胞的再生，生长或分化; 筛选与细胞再生，生长和分化相关基因的方法，其包括在具有再生，分化或生长能力的细胞中统计分析多个基因的表达水平的步骤，从而鉴定一种或多种在与其他细胞相比，细胞或表达特异性; 以及将能够调节所识别的基因或其基因产物的功能的至少一种候选物质与细胞接触并比较接触前后的变化的步骤; 等等。

2. 发明申请

US20070202550A1 Novel G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译：新型G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US20070202550A1
公开(公告)日：2007-08-30
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07H21/04 , C07K14/47 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

3. 发明授权

US06492324B1 APJ ligand polypeptides 失效
标题翻译： APJ配体多肽
公开(公告)号：US06492324B1
公开(公告)日：2002-12-10
申请号：US09255518
申请日：1999-02-22
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： C07K400
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译：本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物，例如艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。

4. 发明授权

US06228984B1 Polypeptides their production and use 失效
标题翻译：多肽的生产和使用
公开(公告)号：US06228984B1
公开(公告)日：2001-05-08
申请号：US08776971
申请日：1997-02-07
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K1447
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选的药物候选化合物。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

5. 发明申请

US20090075334A1 POLYPEPTIDES, THEIR PRODUCTION AND USE 失效
标题翻译：聚氨酯，其生产和使用
公开(公告)号：US20090075334A1
公开(公告)日：2009-03-19
申请号：US12166444
申请日：2008-07-02
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： C12P21/02 , C07K7/08 , C07K14/47 , C07K7/06 , C07K5/10 , G01N33/68 , C07K16/18 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译：本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物，例如艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。

6. 发明授权

US07192723B2 G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译： G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US07192723B2
公开(公告)日：2007-03-20
申请号：US10719587
申请日：2003-11-21
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： C07K7/08 , C07K14/47 , G01N33/566
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

7. 发明授权

US07172876B2 Method of screening therapeutic agents for nerve degeneration associated diseases 有权
标题翻译：筛选神经变性相关疾病的治疗剂的方法
公开(公告)号：US07172876B2
公开(公告)日：2007-02-06
申请号：US10517956
申请日：2003-06-12
申请人： Shuji Hinuma , Ryo Fujii , Masataka Harada , Masaki Hosoya
发明人： Shuji Hinuma , Ryo Fujii , Masataka Harada , Masaki Hosoya
IPC分类号： G01N33/567
CPC分类号： G01N33/74 , C07K14/4747 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： By using a G protein-coupled receptor protein containing an amino acid sequence, which is the same or the substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:10, SEQ ID NO:12 or SEQ ID NO:14, or its salt together with humanin, a compound or its salt capable of changing the binding properties of the above receptor protein or its salt to humanin can be efficiently screened.
摘要翻译：通过使用含有与SEQ ID NO：1，SEQ ID NO：10，SEQ ID NO：12或SEQ ID NO：12表示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白可以有效地筛选能够改变上述受体蛋白质或其盐对人源的结合特性的化合物或其盐与人源化合物或其盐。

8. 发明授权

US07041789B2 RFRP-3 and DNA thereof 失效
标题翻译： RFRP-3及其DNA
公开(公告)号：US07041789B2
公开(公告)日：2006-05-09
申请号：US10487634
申请日：2002-08-22
申请人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
发明人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
IPC分类号： A61K38/00 , A61K38/04 , C07K16/00 , C07K17/00 , C07K5/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.
摘要翻译：作为促进催乳素分泌的药剂的本发明的RFRP-3肽可用作与催乳素分泌有关的各种疾病的预防和/或治疗剂，例如低血浆病，精囊发育不全，绝经综合征和甲状腺机能减退。

9. 发明申请

US20060073516A1 Novel screening method 审中-公开
标题翻译：新型筛选方法
公开(公告)号：US20060073516A1
公开(公告)日：2006-04-06
申请号：US10509484
申请日：2003-03-27
申请人： Yasuaki Ito , Tokuyuki Shinohara , Masaki Hosoya , Shuji Hinuma , Yuko Noguchi
发明人： Yasuaki Ito , Tokuyuki Shinohara , Masaki Hosoya , Shuji Hinuma , Yuko Noguchi
IPC分类号： G01N33/53 , A61K38/17 , C07H21/04 , C12P21/06 , A61K31/195 , C07K14/705
CPC分类号： C07K14/705
摘要： Using a novel G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same amino acid sequence as an amino acid sequence represented by SEQ ID NO: 2 or its salt together with β-alanine or L-carnosine, an agonist or an antagonist to the receptor protein or its salt can be efficiently screened.
摘要翻译：使用具有与SEQ ID NO：2表示的氨基酸序列相同或基本相同的氨基酸序列的氨基酸序列的新型G蛋白偶联受体蛋白或其盐与β-丙氨酸或L-肌肽一起使用，可以有效地筛选受体蛋白质或其盐的激动剂或拮抗剂。

10. 发明申请

US20060035332A1 Novel RFRP-3 and DNA thereof 失效
标题翻译：新型RFRP-3及其DNA
公开(公告)号：US20060035332A1
公开(公告)日：2006-02-16
申请号：US11223294
申请日：2005-09-09
申请人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
发明人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.
摘要翻译：作为促进催乳素分泌的药剂的本发明的RFRP-3肽可用作与催乳素分泌相关的各种疾病的预防和/或治疗剂，例如低血浆病，精囊发育不全，绝经期综合征和甲状腺机能减退。

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