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1. 发明授权

US6121264A Imidazole-substituted quinoxalinedione derivatives 失效
标题翻译：咪唑取代的喹喔啉二酮衍生物
公开(公告)号：US6121264A
公开(公告)日：2000-09-19
申请号：US194750
申请日：1998-12-02
申请人： Shuichi Sakamoto , Junya Ohmori , Jun-ichi Shishikura , Masamichi Okada , Masao Sasamata
发明人： Shuichi Sakamoto , Junya Ohmori , Jun-ichi Shishikura , Masamichi Okada , Masao Sasamata
IPC分类号： C07D403/04 , A61K31/495 , C07D521/00 , A61K31/498 , C07D403/10 , C07D403/14
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Imidazole-substituted quinoxalinedione derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof and pharmaceutical compositions useful as glutamate receptor antagonists and the like, which comprise said compounds or salts thereof and pharmaceutically acceptable carriers. ##STR1## (Each symbol in the formula has the following meaning: A: a group represented by a formula (CH.sub.2).sub.m or a group represented by a formula Ph--(CH.sub.2).sub.p (Ph: a phenyl group),X: an oxygen atom or a group represented by a formula NR.sup.4,R.sup.1 : a hydrogen atom, a hydroxyl group or a triazolyl group, with the proviso that X may be a bond when R.sup.1 is a triazolyl group,R.sup.2 : a hydrogen atom, a nitro group, a halogeno-lower alkyl group, a cyano group, an amino group, a mono- or di-lower alkylamino group or a halogen atom,R.sup.3 and R.sup.4 : may be the same or different from each other and each represents a hydrogen atom or a lower alkyl group,n: 0, 1 or 2,m: an integer of 2 to 6, andp: an integer of 1 to 6.
摘要翻译： PCT No.PCT / JP97 / 01905 Sec。 371日期1998年12月2日第 102（e）日期1998年12月2日PCT提交1997年6月5日PCT公布。公开号WO97 / 46555 日期：1997年12月11日由以下通式（I）表示的咪唑取代的喹喔啉二酮衍生物或其药学上可接受的盐以及用作谷氨酸受体拮抗剂等的药物组合物，其包含所述化合物或其盐和药学上可接受的载体。（式中的每个符号具有以下含义：A：由式（CH 2）m表示的基团或由式Ph-（CH 2）p（Ph：苯基）表示的基团，X：氧原子或由式NR4表示的基团，R1：氢原子，羟基或三唑基，条件是当R 1为三唑基时，X可以为键，R 2为氢原子，硝基，卤代低级烷基，氰基，氨基，一或二低级烷基氨基或卤素原子，R 3和R 4可以相同或不同，表示氢原子或低级烷基基团，n：0,1或2，m为2〜6的整数，p为1〜6的整数。

2. 发明授权

US6096743A 1,2,3,4-tetrahydroquinoxalinedione derivative 失效
标题翻译： 1,2,3,4-四氢喹喔啉二酮衍生物
公开(公告)号：US6096743A
公开(公告)日：2000-08-01
申请号：US809087
申请日：1997-03-05
申请人： Jun-ichi Shishikura , Hiroshi Inami , Shuichi Sakamoto , Shin-ichi Tsukamoto , Masao Sasamata , Masamichi Okada , Mitsuo Fujii
发明人： Jun-ichi Shishikura , Hiroshi Inami , Shuichi Sakamoto , Shin-ichi Tsukamoto , Masao Sasamata , Masamichi Okada , Mitsuo Fujii
IPC分类号： C07D403/04 , A61K31/498 , A61K31/4985 , A61P25/14 , A61P25/28 , C07D241/44 , C07D471/04 , C07D521/00 , C07D403/10
CPC分类号： C07D231/12 , C07D233/56 , C07D241/44 , C07D249/08
摘要： A 1,2,3,4-tetrahydroquinoxalinedione derivative represented by the following formula (I) or salt thereof, an NMDA-glycine receptor and/or AMPA receptor antagonist or kainic acid neurotoxicity inhibitor containing the derivative or salt. In addition, a pharmaceutical composition comprising said compound and a pharmaceutically acceptable carrier: ##STR1## wherein the substituents are as described in the specification.
摘要翻译： PCT No.PCT / JP95 / 01922 Sec。 371日期1997年3月5日 102（e）1997年3月5日PCT PCT 1995年9月25日PCT公布。公开号WO96 / 10023 日本1996年4月4日由下式（I）表示的1,2,3,4-四氢喹喔啉二酮衍生物或其盐，含有该衍生物或盐的NMDA-甘氨酸受体和/或AMPA受体拮抗剂或红藻氨酸神经毒性抑制剂。此外，包含所述化合物和药学上可接受的载体的药物组合物：其中取代基如说明书中所述。

3. 发明授权

US5283244A Fused pyrazine derivatives 失效
标题翻译：稠合吡嗪衍生物
公开(公告)号：US5283244A
公开(公告)日：1994-02-01
申请号：US50225
申请日：1993-05-03
申请人： Shuichi Sakamoto , Junya Ohmori , Hirokazu Kubota , Masao Sasamata , Masamichi Okada , Kazuyuki Hidaka
发明人： Shuichi Sakamoto , Junya Ohmori , Hirokazu Kubota , Masao Sasamata , Masamichi Okada , Kazuyuki Hidaka
IPC分类号： C07D241/44 , A61K31/495 , C07D241/52 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D521/00 , A61K31/535 , C07D403/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D403/04
摘要： The present invention is a pyrazine derivative which has glutamate receptor antagonizing activity, represented by formula: ##STR1## wherein Z represents C or N, provided that two Zs are not N atoms at the same time; R.sup.1 represents: ##STR2## wherein ##STR3## represents ##STR4## R.sup.6 represents H or alkyl, and R.sup.7 and R.sup.8 represent each H, alkyl, nitro or phenyl, or alternatively R.sup.7 and R.sup.8 are combined together to represent butadienylene or 1,4-butylene; R.sup.2 and R.sup.3 represent each H, F, cyano, acyl, nitro, alkyl, morpholino or one of said species of R.sup.1 ; R.sup.4 and R.sup.5 represent each H, hydroxyl, alkyl, cycloalkyl, heterocycle, phenyl, or Y-substituted alkyl; Y represents hydroxyl, acyloxy, F-substituted methyl, cycloalkyl, tetrahydrofuryl, carboxyl, alkoxycarbonyl or ##STR5## R.sup.9 and R.sup.10 represent each H or alkyl, or alternatively R.sup.9 and R.sup.10 are combined together to represent a 5- or 6-membered cyclic group which may contain oxygen atom(s).
摘要翻译： PCT No.PCT / JP91 / 01498 Sec。 371日期：1993年5月5日 102（e）日期1993年5月5日PCT 1991年11月1日PCT PCT。出版物WO92 / 07847 本发明是具有谷氨酸受体拮抗活性的吡嗪衍生物，其由下式表示：（*化学结构*）其中Z表示C或N，条件是两个Z不同时为N原子; R1表示：（*化学结构*）其中（*化学结构*）表示（*化学结构*）R6表示H或烷基，R7和R8表示H，烷基，硝基或苯基，或者R7和R8组合一起代表丁二烯或1,4-丁烯; R 2和R 3表示每个H，F，氰基，酰基，硝基，烷基，吗啉代或所述R1的一种; R4和R5代表H，羟基，烷基，环烷基，杂环，苯基或Y-取代的烷基; Y表示羟基，酰氧基，F取代的甲基，环烷基，四氢呋喃基，羧基，烷氧基羰基或（*化学结构*）R9和R10表示每个H或烷基，或者R9和R10组合在一起代表5-或6- 可以含有氧原子的多元环状基团。

4. 发明授权

US6133258A Inhibitor of kainic acid neurotoxicity and pyridothiazine derivative 失效
标题翻译：红藻氨酸神经毒性抑制剂和吡啶并噻嗪衍生物
公开(公告)号：US6133258A
公开(公告)日：2000-10-17
申请号：US68534
申请日：1998-05-13
申请人： Jun-ichi Shishikura , Hiroshi Inami , Tomoyuki Yasunaga , Masaaki Hirano , Shuichi Sakamoto , Kazushige Ohno , Masamichi Okada , Shin-ichi Tsukamoto
发明人： Jun-ichi Shishikura , Hiroshi Inami , Tomoyuki Yasunaga , Masaaki Hirano , Shuichi Sakamoto , Kazushige Ohno , Masamichi Okada , Shin-ichi Tsukamoto
IPC分类号： A61K31/5415 , A61K31/542 , C07D513/04
CPC分类号： A61K31/5415
摘要： Neuroprotective agents based on inhibition of kainic acid neurotoxicity and compounds useful as neuroprotective agents based on inhibition of kainic acid neurotoxicity. An inhibitors of kainic acid neurotoxicity, comprising as an active ingredient a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, and a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein symbols in the formula have the following respective meanings: the ring A: a pyridine ring; ##STR2## R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or a lower alkyl, cycloalkyl, alkenyl, aryl, carboxyl or lower alkoxycarbonyl group which may have substituent(s), or are not present, with the proviso that R.sup.2 and R.sup.3 may together form a nitrogen-containing heterocyclic group which may have nitrogen atoms as another hetero atom, may be fused with a benzene ring and may have a lower alkyl group as a substituent.
摘要翻译： PCT No.PCT / JP96 / 03339 Sec。 371日期1998年5月13日 102（e）日期1998年5月13日PCT 1996年11月14日PCT PCT。出版物WO97 / 17970 日期1997年5月22日基于抑制红藻氨酸神经毒性的神经保护剂和基于抑制红藻氨酸神经毒性作用的神经保护剂的化合物。作为活性成分的红藻氨酸神经毒性抑制剂，含有下述通式（I）所示的吡哆噻嗪衍生物或其药学上可接受的盐，以及下述通式（I）表示的吡哒嗪衍生物或其药学上可接受的盐其中式中的符号具有以下各自的含义：环A：吡啶环; R 1，R 2，R 3，R 4和R 5可以相同或不同，各自表示氢原子或可以具有取代基或不存在的低级烷基，环烷基，烯基，芳基，羧基或低级烷氧基羰基，条件是R2和R3可以一起形成可以具有氮原子作为另一个杂原子的含氮杂环基，可以与苯环稠合并且可以具有低级烷基作为取代基。

5. 发明授权

US06642264B1 Thiazolobenzoimidazole derivatives 失效
标题翻译：噻唑并苯并咪唑衍生物
公开(公告)号：US06642264B1
公开(公告)日：2003-11-04
申请号：US09958174
申请日：2001-10-05
申请人： Satoshi Hayashibe , Hirotsune Itahana , Masamichi Okada , Atsuyuki Kohara , Kyoichi Maeno , Kiyoshi Yahiro , Itsuro Shimada , Kazuhito Tanabe , Kenji Negoro , Takashi Kamikubo , Shuichi Sakamoto
发明人： Satoshi Hayashibe , Hirotsune Itahana , Masamichi Okada , Atsuyuki Kohara , Kyoichi Maeno , Kiyoshi Yahiro , Itsuro Shimada , Kazuhito Tanabe , Kenji Negoro , Takashi Kamikubo , Shuichi Sakamoto
IPC分类号： A61K31425
CPC分类号： C07D513/04 , A61K31/429
摘要： This invention relates to novel thiazolo[3,2-a]benzoimidazole derivatives represented by the following general formula (I). The compounds provided by the invention act specifically on metabotropic glutamate receptors and are used as medicaments. The invention also provides novel compounds useful as intermediates for the synthesis of the compounds of the invention. (Symbols in the formula represent the following meanings. R1: carbamoyl, carbonyl, oxy, amino, carbonylamino or the like which may be substituted; R2: hydrogen, lower alkyl or the like; and R3, R4 and R5: hydrogen, lower alkyl and the like which may be the same or different from one another.)
摘要翻译：本发明涉及由以下通式（I）表示的新型噻唑并[3,2-a]苯并咪唑衍生物。本发明提供的化合物特异性地代表代谢型谷氨酸受体并用作药物。本发明还提供了可用作合成本发明化合物的中间体的新化合物（式中的符号表示以下含义：R 1：可以被取代的氨基甲酰基，羰基，氧基，氨基，羰基氨基等 R 2：氢，低级烷基等; R 3，R 4和R 5：氢，低级烷基等可以彼此相同或不同。）

6. 发明申请

US20120069294A1 IMAGE VIEWING GLASSES 有权
标题翻译：图像查看玻璃
公开(公告)号：US20120069294A1
公开(公告)日：2012-03-22
申请号：US13231057
申请日：2011-09-13
申请人： Hiroshi Ohno , Tatsuya Sakata , Masamichi Okada , Nobuyuki Hara , Naoto Shimizu
发明人： Hiroshi Ohno , Tatsuya Sakata , Masamichi Okada , Nobuyuki Hara , Naoto Shimizu
IPC分类号： G02C5/22
CPC分类号： G02B27/0176 , G02B2027/0178 , G02C5/2263 , G02C2200/18
摘要： A glasses-type shutter holder may include left and right temple parts connected respectively to left and right frame end parts of frame. The left and right temple parts may be foldable respectively with respect to the left and right frame end parts in accordance with movement, for each frame end part and temple part pair, of a contact position at which a movement part provided with one of the temple part and the frame end part of the pair is in contact with a contact part of the other of the temple part and the frame end part of the pair. For each of the pairs, the contact part is in contact with the movement part when the temple part is unfolded to a maximum degree, and a maximum degree of opening of the temple part is varied in accordance with the movement of the movable part.
摘要翻译：眼镜型快门保持器可以包括分别连接到框架的左框架和右框架端部的左右镜腿部分。根据对于每个框架端部和镜腿部对的移动，左右镜腿部分可以分别相对于左框架和右框架端部折叠，该接触位置处设置有一个镜腿的移动部件所述一对的所述框架端部与所述一对的所述镜腿部的另一方的接触部与所述一对的所述框的端部接触。对于每一对，当镜腿部分展开最大程度时，接触部分与运动部分接触，并且根据可移动部件的移动来改变镜腿部分的最大开度。

7. 发明授权

US06566796B2 Steel sheet for tension mask, making method thereof and tension mask 失效
标题翻译：用于张力罩的钢板，其制造方法和张力罩
公开(公告)号：US06566796B2
公开(公告)日：2003-05-20
申请号：US09929850
申请日：2001-08-14
申请人： Satoshi Kodama , Reiko Sugihara , Hideki Matsuoka , Yasushi Tanaka , Tatsuhiko Hiratani , Kenji Tahara , Kenichi Mitsuzuka , Kenichiro Takayanagi , Masamichi Okada , Hiroaki Kato , Chohachi Sato
发明人： Satoshi Kodama , Reiko Sugihara , Hideki Matsuoka , Yasushi Tanaka , Tatsuhiko Hiratani , Kenji Tahara , Kenichi Mitsuzuka , Kenichiro Takayanagi , Masamichi Okada , Hiroaki Kato , Chohachi Sato
IPC分类号： H01J2907
CPC分类号： C22C38/04 , C21D8/0236 , C21D8/1233 , C22C38/001 , C22C38/004 , C22C38/02 , C22C38/12 , H01J9/142 , H01J2229/0733
摘要： A method of making a steel sheet for a tension mask, including the steps of: hot rolling a steel consisting essentially of, by weight %, C: less than 0.1%, Si: 0.05% or less, Mn: 0.4 to 2%, P: 0.03% or less, S: 0.03% or less, sol.Al: 0.01% or less, N: 0.010% or more, and the balance of Fe; and annealing the cold rolled steel sheet, followed by a secondary cold rolling at a reduction rate of 35% or higher. The steel sheet produced by this method shows excellent creep resistance during blackening treatment and excellent magnetic shielding property with an anhysteretic permeability of 3400 or more at a DC bias magnetic field of 0.35 Oe, and therefore causes no color-deviation when applied to the tension mask.
摘要翻译：一种制造张力掩模用钢板的方法，包括以下步骤：将基本上由C：小于0.1％，Si：0.05％以下，Mn：0.4〜2％的重量％组成的钢进行热轧， P：0.03％以下，S：0.03％以下，sol.Al：0.01％以下，N：0.010％以上，余量为Fe; 对冷轧钢板进行退火，然后以35％以上的还原率进行二次冷轧。通过该方法制造的钢板在0.35Oe的直流偏压磁场下显示优异的抗蠕变性，并且在0.35Oe的直流偏置磁场下具有优异的磁阻屏蔽性，具有3400以上的非磁滞渗透性，因此当施加到张力掩模时不会产生颜色偏差。

8. 发明授权

US5855237A Casting method with improved resin core removing step and apparatus for performing the method 失效
标题翻译：具有改进的树脂芯去除步骤的铸造方法和用于执行该方法的装置
公开(公告)号：US5855237A
公开(公告)日：1999-01-05
申请号：US826767
申请日：1997-04-07
申请人： Yuji Okada , Hirokazu Shirakawa , Shuichi Tomitaka , Masamichi Okada , Takayuki Kato
发明人： Yuji Okada , Hirokazu Shirakawa , Shuichi Tomitaka , Masamichi Okada , Takayuki Kato
IPC分类号： B22C9/10 , B22D29/00 , F02F1/24 , B22C1/00
CPC分类号： B22D29/001 , B22C9/10 , F02F1/24
摘要： In a casting process using a resin core, sometimes molten resin remains in a cast product after the steps of withdrawal of the resin core from the cast product. In order to solve the problem, as a material of the resin core, a resin which is hard and not deformed against high temperature and high pressure of molten metal until the molten metal is solidified and is softened with an increase of temperature beyond the temperature at which the metal is solidified is used. The resin core is withdrawn from the cast product after it is softened but before it is melted. The softened core is pulled out from the cast product without being broken apart.
摘要翻译：在使用树脂芯的铸造工艺中，在将树脂芯从铸造产品中取出的步骤之后，有时熔融树脂残留在铸造产品中。为了解决这个问题，作为树脂芯的材料，在熔融金属凝固之前，耐高温高压的熔融金属硬化而不变形的树脂，随着温度的升高而超过温度而软化使用金属固化。树脂芯在软化之后但在熔化之前从铸造产品中取出。软化的芯从铸造产品中拉出而不会分开。

9. 发明授权

US08421852B2 Method for manufacturing stereoscopic image display apparatus and stereoscopic image display apparatus 失效
标题翻译：立体图像显示装置和立体图像显示装置的制造方法
公开(公告)号：US08421852B2
公开(公告)日：2013-04-16
申请号：US12460690
申请日：2009-07-23
申请人： Hideo Niyomura , Hiroshi Ohno , Joji Karasawa , Osamu Horie , Takayuki Kobayashi , Masamichi Okada , Atsushi Sakata , Hiromichi Abe
发明人： Hideo Niyomura , Hiroshi Ohno , Joji Karasawa , Osamu Horie , Takayuki Kobayashi , Masamichi Okada , Atsushi Sakata , Hiromichi Abe
IPC分类号： H04N13/04 , H04N9/47
CPC分类号： G02B27/26 , H04N13/337 , H04N2213/001
摘要： A method for manufacturing a stereoscopic image display apparatus includes a bonding step of bonding an image display panel and a phase difference element by disposing an adhesive layer between the entire surfaces thereof, the image display panel displaying a right-eye image and a left-eye image by regularly mixing them in a plane, the phase difference element including a right-eye image display section corresponding to the right-eye image and a left-eye image display section corresponding to the left-eye image, the phase difference element achieving different polarizations between the right-eye image display section and the left-eye image display section, the adhesive layer being composed of a transparent gel acrylic adhesive with a thickness of 25 to 100 μm, hardness of the adhesive being more than 0 and 350000 μN or less, holding strength of the adhesive at 40° C. after bonding being 8 to 20 N/20 mm.
摘要翻译：一种用于制造立体图像显示装置的方法包括：通过在其整个表面之间设置粘合剂层来接合图像显示面板和相位差元件的接合步骤，显示右眼图像和左眼图像的图像显示面板图像通过在平面中定期混合，所述相位差元件包括对应于右眼图像的右眼图像显示部分和与左眼图像相对应的左眼图像显示部分，所述相位差元素实现不同右眼图像显示部和左眼图像显示部之间的极化，粘合层由厚度为25〜100μm的透明凝胶型丙烯酸粘合剂构成，粘合剂的硬度为大于0且为350000μN，粘合后的粘合剂的保持强度在8〜20N / 20mm之间。

10. 发明申请

US20120121760A1 METHOD FOR IMPROVEMENT OF FOODS UTILIZING BETA-AMYLASE 有权
标题翻译：用于改善利用β-淀粉酶的食物的方法
公开(公告)号：US20120121760A1
公开(公告)日：2012-05-17
申请号：US13383661
申请日：2009-12-22
申请人： Akiko Matsunaga , Masamichi Okada , Shotaro Yamaguchi
发明人： Akiko Matsunaga , Masamichi Okada , Shotaro Yamaguchi
IPC分类号： C12N9/26 , A21D8/04 , A21D13/00 , A23L1/10
CPC分类号： A21D8/042 , A23G3/48 , A23L7/104 , A23L7/196 , A23L27/35 , A23L29/35 , C12N9/2411 , C12N9/2417 , C12N9/2425 , C12Y302/01002
摘要： A novel β-amylase having excellent practical applicability is found, and an object is to provide a practical use of the β-amylase. Provided is a method for improving a food, which is characterized in that a β-amylase derived from Bacillus flexus is acted on a food containing a polysaccharide or an oligosaccharide having an α-1,4 bond of glucose as the main chain.
摘要翻译：发现具有优异实用性的新颖的淀粉酶，其目的是提供淀粉酶的实际应用。本发明提供一种改善食品的方法，其特征在于，将来自弯曲芽孢杆菌的淀粉酶作用于含有以葡萄糖的α-1,4-键为主链的多糖或寡糖的食品。

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