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    • 1. 发明授权
    • Inhibitor of kainic acid neurotoxicity and pyridothiazine derivative
    • 红藻氨酸神经毒性抑制剂和吡啶并噻嗪衍生物
    • US6133258A
    • 2000-10-17
    • US68534
    • 1998-05-13
    • Jun-ichi ShishikuraHiroshi InamiTomoyuki YasunagaMasaaki HiranoShuichi SakamotoKazushige OhnoMasamichi OkadaShin-ichi Tsukamoto
    • Jun-ichi ShishikuraHiroshi InamiTomoyuki YasunagaMasaaki HiranoShuichi SakamotoKazushige OhnoMasamichi OkadaShin-ichi Tsukamoto
    • A61K31/5415A61K31/542C07D513/04
    • A61K31/5415
    • Neuroprotective agents based on inhibition of kainic acid neurotoxicity and compounds useful as neuroprotective agents based on inhibition of kainic acid neurotoxicity. An inhibitors of kainic acid neurotoxicity, comprising as an active ingredient a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, and a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein symbols in the formula have the following respective meanings: the ring A: a pyridine ring; ##STR2## R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or a lower alkyl, cycloalkyl, alkenyl, aryl, carboxyl or lower alkoxycarbonyl group which may have substituent(s), or are not present, with the proviso that R.sup.2 and R.sup.3 may together form a nitrogen-containing heterocyclic group which may have nitrogen atoms as another hetero atom, may be fused with a benzene ring and may have a lower alkyl group as a substituent.
    • PCT No.PCT / JP96 / 03339 Sec。 371日期1998年5月13日 102(e)日期1998年5月13日PCT 1996年11月14日PCT PCT。 出版物WO97 / 17970 日期1997年5月22日基于抑制红藻氨酸神经毒性的神经保护剂和基于抑制红藻氨酸神经毒性作用的神经保护剂的化合物。 作为活性成分的红藻氨酸神经毒性抑制剂,含有下述通式(I)所示的吡哆噻嗪衍生物或其药学上可接受的盐,以及下述通式(I)表示的吡哒嗪衍生物或其药学上可接受的盐 其中式中的符号具有以下各自的含义:环A:吡啶环; R 1,R 2,R 3,R 4和R 5可以相同或不同,各自表示氢原子或可以具有取代基或不存在的低级烷基,环烷基,烯基,芳基,羧基或低级烷氧基羰基, 条件是R2和R3可以一起形成可以具有氮原子作为另一个杂原子的含氮杂环基,可以与苯环稠合并且可以具有低级烷基作为取代基。
    • 7. 发明授权
    • Catalyst carrier and exhaust gas treatment apparatus
    • 催化剂载体和废气处理装置
    • US08034299B2
    • 2011-10-11
    • US11942559
    • 2007-11-19
    • Takahiko IdoKazushige Ohno
    • Takahiko IdoKazushige Ohno
    • B01D50/00
    • F01N3/2828B01D53/9454B01D2255/9202B01J32/00B01J35/04C04B38/0009F01N3/2853F01N2450/28Y02A50/2324Y02T10/22Y10T428/24149C04B35/00
    • A catalyst carrier including a ceramic block having two open faces, an outer peripheral surface, and multiple cells divided by a cell wall and extending between the open faces. The ceramic block has multiple honeycomb units combined by interposing an adhesive layer, where the honeycomb units include an outer-peripheral-side honeycomb unit and a center-side honeycomb unit combined to form the outer peripheral part and the center part, respectively, of the block. The outer-peripheral-side honeycomb unit has an outer peripheral cell wall forming the outer peripheral surface of the outer-peripheral-side honeycomb unit. The outer peripheral cell wall includes an outermost peripheral cell wall forming part of the outer peripheral surface of the block. A cell of the outer-peripheral-side honeycomb unit in contact with the outermost peripheral cell wall thereof has a corner part having a curved surface, where the corner part is on the side contacting the outermost peripheral cell wall.
    • 一种催化剂载体,其包括具有两个开放面的陶瓷块,外周表面和由细胞壁分隔并在开放面之间延伸的多个细胞。 陶瓷块具有多个蜂窝单元,其通过插入粘合剂层而组合,其中蜂窝单元包括外周侧蜂窝单元和组合以形成外周侧蜂窝单元的中心侧蜂窝单元的中心侧蜂窝单元 块。 外周侧蜂窝单元具有形成外周侧蜂窝单元的外周面的外周电池壁。 外周细胞壁包括形成块的外周面的一部分的最外周细胞壁。 与外周侧细胞壁接触的外周侧蜂窝单元的单元具有具有弯曲面的角部,其中角部位于与最外周细胞壁接触的一侧。