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    • 4. 发明申请
    • ß-HEXOSAMINIDASE PROTEIN VARIANTS AND ASSOCIATED METHODS FOR TREATING GM2 GANGLIOSIDOSES
    • ß-HEXOSAMINIDASE蛋白变体及相关方法治疗GM2 GANGLIOSIDOSES
    • US20150258180A1
    • 2015-09-17
    • US14660412
    • 2015-03-17
    • Don MahuranBrian Mark
    • Don MahuranBrian Mark
    • A61K38/47C12N9/24
    • C12N9/2402A61K38/00A61K38/47C12Y302/01052
    • Embodiments herein include variants of β-hexosaminidase that are useful for hydrolyzing GM2 ganglioside, polynucleotides encoding the same, and related methods. In various embodiments, a variant β-hexosaminidase subunit is included wherein the variant β-hexosaminidase subunit forms a homodimer under physiological conditions and wherein the variant β-hexosaminidase subunit associates with GM2 activator protein to hydrolyze GM2 ganglioside. In some embodiments, an isolated or recombinant polynucleotide encoding such a variant β-hexosaminidase subunit is included. In some embodiments, a method of treating a subject exhibiting an abnormal cellular accumulation of GM2 ganglioside is included wherein the method includes administering a composition including a protein variant of β-hexosaminidase or a polynucleotide encoding the same. Other embodiments are included herein.
    • 本文的实施方案包括可用于水解GM2神经节苷脂,编码它们的多核苷酸和相关方法的变体。 在各种实施方案中,包括变体& - 己糖胺酶亚基,其中变体& - 己糖胺酶亚基在生理条件下形成同二聚体,并且其中所述变体和半胱氨酸酶亚基与GM2激活蛋白结合以水解GM2神经节苷脂。 在一些实施方案中,包括编码这种变体& - 己糖胺酶亚基的分离的或重组的多核苷酸。 在一些实施方案中,包括治疗表现出GM2神经节苷脂异常细胞积累的受试者的方法,其中所述方法包括施用包含β-半乳糖苷酶的蛋白质变体的组合物或其编码的多核苷酸。 本文还包括其它实施例。
    • 5. 发明申请
    • Cellular network handoff decision mechanism
    • 蜂窝网切换决策机制
    • US20050181795A1
    • 2005-08-18
    • US11075983
    • 2005-03-10
    • Brian MarkAlexe Leu
    • Brian MarkAlexe Leu
    • H04W36/08H04W36/18H04W36/32H04Q7/20
    • H04W36/32H04W36/18H04W36/30
    • Disclosed is a cellular network handoff decision mechanism which comprising the steps of: determining a sampling interval using a carrier wavelength; determining a local averaging interval that is larger than the sampling interval; determining a handoff decision interval that is larger than the local averaging interval; selecting at least two base stations from a multitude of base stations having a pilot signal from a reference cellular network using a selection criterion; determining a received signal strength from the pilot signal strength for each of the selected base stations once during every sampling interval; calculating a local average signal strength value using each of the received signal strengths once during every local averaging interval; determining an assignment region in which the local average signal strength value lies using a hysteresis range; and calculating a handoff decision once during every handoff decision interval using a handoff calculation.
    • 公开了一种蜂窝网络切换判定机制,其包括以下步骤:使用载波波长确定采样间隔; 确定大于采样间隔的局部平均间隔; 确定大于所述局部平均间隔的切换判定间隔; 使用选择标准从具有来自参考蜂窝网络的导频信号的多个基站中选择至少两个基站; 在每个采样间隔期间,每个所选基站的导频信号强度确定接收信号强度; 在每个局部平均间隔期间使用每个接收信号强度一次计算局部平均信号强度值; 使用滞后范围确定局部平均信号强度值所在的分配区域; 以及使用切换计算在每个切换判定间隔期间计算一次切换决定。
    • 6. 发明授权
    • Cellular network handoff decision mechanism
    • 蜂窝网切换决策机制
    • US07218933B2
    • 2007-05-15
    • US11075983
    • 2005-03-10
    • Brian MarkAlexe E. Leu
    • Brian MarkAlexe E. Leu
    • H04Q7/20
    • H04W36/32H04W36/18H04W36/30
    • Disclosed is a cellular network handoff decision mechanism which comprising the steps of: determining a sampling interval using a carrier wavelength; determining a local averaging interval that is larger than the sampling interval; determining a handoff decision interval that is larger than the local averaging interval; selecting at least two base stations from a multitude of base stations having a pilot signal from a reference cellular network using a selection criterion; determining a received signal strength from the pilot signal strength for each of the selected base stations once during every sampling interval; calculating a local average signal strength value using each of the received signal strengths once during every local averaging interval; determining an assignment region in which the local average signal strength value lies using a hysteresis range; and calculating a handoff decision once during every handoff decision interval using a handoff calculation.
    • 公开了一种蜂窝网络切换判定机制,其包括以下步骤:使用载波波长确定采样间隔; 确定大于采样间隔的局部平均间隔; 确定大于所述局部平均间隔的切换判定间隔; 使用选择标准从具有来自参考蜂窝网络的导频信号的多个基站中选择至少两个基站; 在每个采样间隔期间,每个所选基站的导频信号强度确定接收信号强度; 在每个局部平均间隔期间使用每个接收信号强度一次计算局部平均信号强度值; 使用滞后范围确定局部平均信号强度值所在的分配区域; 以及使用切换计算在每个切换判定间隔期间计算一次切换决定。
    • 7. 发明授权
    • Optimal buffer management scheme with dynamic queue length thresholds for ATM switches
    • ATM交换机动态队列长度阈值的最优缓冲管理方案
    • US06424622B1
    • 2002-07-23
    • US09249324
    • 1999-02-12
    • Ruixue FanAlexander IshiiBrian MarkGopalakrishnan RamamurthyQiang Ren
    • Ruixue FanAlexander IshiiBrian MarkGopalakrishnan RamamurthyQiang Ren
    • H04L1226
    • H04L49/3081H04L2012/5679H04L2012/5681H04L2012/5682H04Q11/0478
    • A buffer management scheme for an ATM switch where the static and dynamic thresholds are applied appropriately at different levels to ensure efficient and fair usage of buffer memory. A novel dynamic threshold mechanism which, while ensuring fair sharing of memory, maximizes the overall memory utilization. An ATM switch using a dynamic queue threshold scheme, said ATM switch comprising K output port queues and a buffer of B cells sharing said K output port queues, wherein a common threshold is dynamically set for the K output port queues, the common threshold being changed to a new value from an old value when a new cell arrives at any of said K output queues, said new value being a maximum of a length of said any of said K output queues plus one and said old value when total queue length is less than a preset value times B and, said new value being a maximum of a said old value minus one and a statically set minimum buffer threshold when total queue length is greater than or equal to a preset value times B, wherein said preset value is greater than or equal to 0.
    • 一种用于ATM交换机的缓冲器管理方案,其中静态和动态阈值在不同级别适当地应用以确保缓冲存储器的有效和合理使用。 一种新颖的动态阈值机制,在确保公平共享内存的同时,最大限度地提高了内存利用率。 一种使用动态队列阈值方案的ATM交换机,所述ATM交换机包括K个输出端口队列和共享所述K个输出端口队列的B个小区的缓冲器,其中为所述K个输出端口队列动态地设置公共阈值,所述公共阈值被改变 当新单元到达所述K个输出队列中的任一个时,从旧值到新值,所述新值是所述K个输出队列中的任何一个的长度的最大值加上当总队列长度较少时的所述旧输出队列的长度 比预设值乘以B,并且当总队列长度大于或等于预设值乘以B时,所述新值是所述旧值减1的最大值和静态设置的最小缓冲器阈值,其中所述预设值更大 大于等于0。