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1. 发明申请

US20070219228A1 Aryl substituted imidazonaphthyridines 有权
标题翻译：芳基取代的咪唑并萘啶
公开(公告)号：US20070219228A1
公开(公告)日：2007-09-20
申请号：US11570703
申请日：2005-06-17
申请人： Shri Niwas , Bryon Merrill , Philip Heppner , Tushar Kshirsagar , Gregory Lundquist , David Amos , Kyle Lindstrom
发明人： Shri Niwas , Bryon Merrill , Philip Heppner , Tushar Kshirsagar , Gregory Lundquist , David Amos , Kyle Lindstrom
IPC分类号： A61K31/4745 , C07D471/14
CPC分类号： C07D471/14
摘要： Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：公开了用芳基取代基取代的咪唑并萘啶环体系，含有这些化合物的药物组合物，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

2. 发明申请

US20080015184A1 Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines 审中-公开
标题翻译：脲取代的咪唑并吡啶，咪唑并喹啉和咪唑并萘啶
公开(公告)号：US20080015184A1
公开(公告)日：2008-01-17
申请号：US11570567
申请日：2005-06-14
申请人： Tushar Kshirsagar , George Griesgraber , Sarah Johannessen , Azim Celebi , Philip Heppner , Gregory Lundquist Jr. , David Amos , Bernhard ZImmermann , Scott Langer
发明人： Tushar Kshirsagar , George Griesgraber , Sarah Johannessen , Azim Celebi , Philip Heppner , Gregory Lundquist Jr. , David Amos , Bernhard ZImmermann , Scott Langer
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P31/12 , A61P35/00 , C07D243/08 , C07D279/12 , C07D401/14 , C07D413/14 , C07D471/04
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物在2-位上具有尿素取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗公开了包括病毒和肿瘤疾病在内的疾病。

3. 发明申请

US20070066639A1 Oxime substituted imidazoquinolines 失效
标题翻译：肟取代的咪唑并喹啉
公开(公告)号：US20070066639A1
公开(公告)日：2007-03-22
申请号：US10595065
申请日：2004-08-12
申请人： Tushar Kshirsagar , David Amos , Joseph Dellaria Jr , Philip Heppner , Scott Langer , Bernhard Zimmermann
发明人： Tushar Kshirsagar , David Amos , Joseph Dellaria Jr , Philip Heppner , Scott Langer , Bernhard Zimmermann
IPC分类号： A61K31/4745 , C07D471/14 , C07D471/02
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在1位具有肟取代基的含咪唑的化合物（例如咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法用于在动物中诱导细胞因子生物合成公开了包括病毒和肿瘤疾病在内的疾病的治疗。

4. 发明申请

US20070099901A1 Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines 有权
标题翻译：羟胺和肟取代的咪唑并喹啉，咪唑并吡啶和咪唑并吡啶类
公开(公告)号：US20070099901A1
公开(公告)日：2007-05-03
申请号：US10595895
申请日：2004-11-24
申请人： Larry Krepski , Joseph Dellaria , Daniel Duffy , David Amos , Bernhard Zimmermann , David Squire , Gregory Marszalek , Philip Heppner , Tushar Kshirsagar
发明人： Larry Krepski , Joseph Dellaria , Daniel Duffy , David Amos , Bernhard Zimmermann , David Squire , Gregory Marszalek , Philip Heppner , Tushar Kshirsagar
IPC分类号： A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在1-位取代的咪唑并喹啉，吡啶和萘啶环体系，含有这些化合物的化合物，中间体和使用方法作为免疫调节剂的药物组合物，用于在动物中诱导细胞因子生物合成和治疗疾病，包括公开了病毒和肿瘤疾病。

5. 发明申请

US20070072893A1 Substituted imidazo ring systems and methods 有权
标题翻译：取代的咪唑环体系和方法
公开(公告)号：US20070072893A1
公开(公告)日：2007-03-29
申请号：US10595959
申请日：2004-11-24
申请人： Larry Krepski , Joseph Dellaria , Daniel Duffy , Matthew Radmer , David Amos
发明人： Larry Krepski , Joseph Dellaria , Daniel Duffy , Matthew Radmer , David Amos
IPC分类号： A61K31/4745 , C07D471/14 , C07D471/02
CPC分类号： C07D471/04 , C07D213/74 , C07D255/02 , C07D471/14
摘要： Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, inter-mediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：在1位置取代的咪唑环体系，含有化合物的药物组合物，介导体，制备化合物的方法以及这些化合物作为免疫调节剂的使用方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒的疾病并发现肿瘤性疾病。

6. 发明申请

US20090135598A1 ELECTRICAL LAMP SYSTEM 审中-公开
标题翻译：电灯系统
公开(公告)号：US20090135598A1
公开(公告)日：2009-05-28
申请号：US12175412
申请日：2008-07-17
申请人： David Amos
发明人： David Amos
IPC分类号： F21V21/00
CPC分类号： F21V25/04 , F21S8/033 , F21V15/005 , F21V21/03
摘要： An electrical lamp system is provided that comprises a base unit and a lamp unit for attachment to the base unit. The base unit includes a housing to be fixed to a wall or ceiling and a plurality of contact terminals that are arranged to contact corresponding contact terminals of the lamp unit when attached. A plurality of connection terminals secured to the base housing are adapted for connection to wires fed to the base unit such that wires connected to the connection terminals can power the lamp unit via the base unit contact terminals. The lamp unit includes a lamp housing an electrical lamp secured to the housing, a plurality of contact terminals arranged to contact said contact terminals of the base unit. The system includes locating means arranged to locate the lamp unit in a first position against the base unit in which the lamp unit is permitted to be separated from the base unit by translation of the lamp unit in a direction away from the base unit along a separation axis. The system also includes guide means that guide rotation of the lamp unit against the base unit about said axis from said first position to a second position, the second position being a position in which said contact terminals of the base unit are in electrical contact with said contact terminals of the lamp unit. In the second position, attachment means attaches the lamp unit to the base unit by preventing separation of the lamp unit from the base unit by translation of the lamp unit along said axis.
摘要翻译：提供一种电灯系统，其包括基座单元和用于附接到基座单元的灯单元。基座单元包括固定到墙壁或天花板的壳体和多个接触端子，其被布置成在附接时与灯单元的相应接触端子接触。固定到基座的多个连接端子适于连接到馈送到基座单元的导线，使得连接到连接端子的电线可以经由基座单元接触端子为灯单元供电。灯单元包括容纳固定到壳体的电灯的灯，布置成接触基座单元的接触端子的多个接触端子。该系统包括定位装置，其布置成将灯单元定位在第一位置抵靠基座单元，其中灯单元允许通过沿着分离的方向沿着远离基本单元的方向平移灯单元而与基座分离轴。所述系统还包括引导装置，其引导灯单元绕所述轴线从所述第一位置转动到第二位置，所述第二位置是所述基座单元的所述接触端子与所述第一位置电接触的位置，灯单元的接触端子。在第二位置，附接装置通过防止灯单元沿着所述轴的平移而防止灯单元与基座单元分离，从而将灯单元附接到基座单元。

7. 发明申请

US20070219196A1 AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES 有权
标题翻译：酰胺取代的咪唑吡啶，咪唑啉和咪唑并吡啶
公开(公告)号：US20070219196A1
公开(公告)日：2007-09-20
申请号：US10599159
申请日：2005-03-24
申请人： Larry Krepski , Joseph Dellaria Jr. , Daniel Duffy , David Amos , Bernhard Zimmermann , William Moser
发明人： Larry Krepski , Joseph Dellaria Jr. , Daniel Duffy , David Amos , Bernhard Zimmermann , William Moser
IPC分类号： A61K31/4353 , A61K31/5377 , C07D413/14 , C07D471/02 , C07D471/12
CPC分类号： C07D471/04 , C07D413/14 , C07D471/02 , C07D471/12 , C07D471/14
摘要： Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，其在1-位具有酰胺基取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗公开了包括病毒和肿瘤疾病在内的疾病。

8. 发明申请

US20070287724A1 Substituted Imidazoquinolines, Imidazopyridines, and Imidazonaphthyridines 有权
标题翻译：取代的咪唑并喹啉，咪唑并吡啶和咪唑并萘啶
公开(公告)号：US20070287724A1
公开(公告)日：2007-12-13
申请号：US11570707
申请日：2005-06-17
申请人： Doris Stoermer , Joseph Dellaria , David Amos , Bernhard Zimmermann , Luke Dressel , Jason Bonk , Matthew Radmer
发明人： Doris Stoermer , Joseph Dellaria , David Amos , Bernhard Zimmermann , Luke Dressel , Jason Bonk , Matthew Radmer
IPC分类号： A61K31/4745 , A61K31/437 , A61P31/12 , A61P35/00 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, 1,5-naphthyridines, 1,5-tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：咪唑并喹啉，吡啶和萘啶环体系（特别是在1位被环状取代基取代的喹啉，四氢喹啉，吡啶，1,5-萘啶，1,5-四氢萘并吡啶），含有这些化合物的药物组合物和公开了这些化合物作为免疫调节剂的用途，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。

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