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1. 发明申请

US20070259881A1 Substituted Imidazo Ring Systems and Methods 审中-公开
标题翻译：取代的咪唑环系统和方法
公开(公告)号：US20070259881A1
公开(公告)日：2007-11-08
申请号：US11570715
申请日：2005-06-17
申请人： Joseph Dellaria , Tushar Kshirsagar , Shri Niwas , William Moser , Joan Moseman , Kyle Lindstrom , Azim Celebi , John Gerster , Philip Heppner , Joshua Wurst
发明人： Joseph Dellaria , Tushar Kshirsagar , Shri Niwas , William Moser , Joan Moseman , Kyle Lindstrom , Azim Celebi , John Gerster , Philip Heppner , Joshua Wurst
IPC分类号： A61K31/44 , A61K31/437 , A61K31/496 , A61P31/12 , A61P35/00 , C07D401/02 , C07D401/14 , C07D471/02
CPC分类号： C07D471/04
摘要： Imidazo ring systems, which include, for example, imidazopyridine, imidazoquinoline, 6,7,8,9-tetrahydroimidazoquinoline, imidazonaphthyridine, and 6,7,8,9-tetrahydroimidazonaphthyridine compounds substituted at the 1-position and/or the 2-position, pharmaceutical compositions containing these compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：咪唑环体系，其包括例如咪唑并吡啶，咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和6,7,8,9-四氢咪唑并吡啶化合物，其在1-位和/或2-位上被取代公开了含有这些化合物的药物组合物，制备这些化合物的方法，以及这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

2. 发明申请

US20060100229A1 Pyrazolopyridines and analogs thereof 有权
公开(公告)号：US20060100229A1
公开(公告)日：2006-05-11
申请号：US11097715
申请日：2005-04-01
申请人： David Hays , Michael Danielson , John Gerster , Shri Niwas , Ryan Prince , Tushar Kshirsagar , Philip Heppner , William Moser , Joan Moseman , Matthew Radmer , Maureen Kavanagh , Sarah Strong , Jason Bonk
发明人： David Hays , Michael Danielson , John Gerster , Shri Niwas , Ryan Prince , Tushar Kshirsagar , Philip Heppner , William Moser , Joan Moseman , Matthew Radmer , Maureen Kavanagh , Sarah Strong , Jason Bonk
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04 , C07D471/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

3. 发明申请

US20050047993A1 METHOD OF PREPARING METAL CONTAINING COMPOUNDS USING HYDRODYNAMIC CAVITATION 有权
标题翻译：使用水力气蚀制备含金属化合物的方法
公开(公告)号：US20050047993A1
公开(公告)日：2005-03-03
申请号：US10615309
申请日：2003-07-08
申请人： William Moser , Oleg Kozyuk , Josef Find , Sean Emerson , Ivo Krausz
发明人： William Moser , Oleg Kozyuk , Josef Find , Sean Emerson , Ivo Krausz
IPC分类号： B01J19/00 , B01J37/03 , B22F1/00 , B22F9/30 , C01B13/36 , C01G23/053 , C01G49/00 , C01G51/00 , B01J3/06
CPC分类号： B82Y30/00 , B01J19/008 , B01J37/031 , B22F1/0018 , B22F9/30 , B22F2999/00 , C01B13/363 , C01G23/053 , C01G39/00 , C01G49/0054 , C01G51/00 , C01G53/00 , C01P2002/34 , C01P2002/60 , C01P2002/72 , C01P2004/64 , C01P2006/82 , B22F2202/01
摘要： A process for the preparation of nanostructured materials in high phase purities using cavitation is disclosed. The method comprises mixing a metal containing solution with a precipitating agent and passing the mixture into a cavitation chamber. The chamber consists of a first element to produce cavitation bubbles, and a second element that creates a pressure zone sufficient to collapse the bubbles. The process is useful for the preparation of mixed metal oxide catalysts and materials for piezoelectrics and superconductors.
摘要翻译：公开了一种使用空化制备高相纯度的纳米结构材料的方法。该方法包括将含金属溶液与沉淀剂混合并将混合物送入空化室。该室由产生空化气泡的第一元件和产生足以压缩气泡的压力区的第二元件组成。该方法可用于制备用于压电和超导体的混合金属氧化物催化剂和材料。

4. 发明申请

US20080188854A1 Surgical Anchor Delivery System 审中-公开
标题翻译：外科手术输送系统
公开(公告)号：US20080188854A1
公开(公告)日：2008-08-07
申请号：US11969595
申请日：2008-01-04
申请人： Michael William Moser
发明人： Michael William Moser
IPC分类号： A61B17/16 , A61B17/17
CPC分类号： A61B17/1684 , A61B17/0401 , A61B17/1631 , A61B17/1633 , A61B2017/0409
摘要： Embodiments of the present invention relate to systems and methods for assisting a user during delivery of a labral anchor. For example, one embodiment provides a labral anchor delivery system that includes a drill sleeve having a proximal end and a distal end that is cannulated therebetween. At least a portion of the drill sleeve proximate to the distal end is curved such that the distal end is configured to be positioned substantially perpendicular to a surface of a glenoid. The labral anchor delivery system includes a drill bit having a proximal end and a distal end and configured to be positioned within the cannulated drill sleeve and into engagement with the surface of the glenoid. In addition, at least a portion of the drill bit between the proximal and distal ends of the drill bit is flexible for conforming to the curved portion of the drill sleeve.
摘要翻译：本发明的实施例涉及用于在递送拉帕尔锚的过程中辅助用户的系统和方法。例如，一个实施例提供了一种唇部锚定器传送系统，其包括具有近端和在其间插管的远端的钻套筒。靠近远端的钻孔套筒的至少一部分是弯曲的，使得远端构造成基本上垂直于关节盂的表面定位。唇部锚固器输送系统包括具有近端和远端的钻头，并且被配置为定位在套管钻套内并与关节盂的表面接合。此外，钻头的近端和远端之间的钻头的至少一部分是柔性的，以便与钻套筒的弯曲部分一致。

5. 发明申请

US20080072948A1 Thermoelectric system 失效
标题翻译：热电系统
公开(公告)号：US20080072948A1
公开(公告)日：2008-03-27
申请号：US11803402
申请日：2007-05-14
申请人： Andrew McGilvray , John Vachon , William Moser
发明人： Andrew McGilvray , John Vachon , William Moser
IPC分类号： H01L35/30
CPC分类号： F02B63/04 , F01N5/025 , H01L35/30 , Y02T10/16 , Y02T10/166
摘要： An internal combustion engine that includes a block, a cylinder head having an intake valve port and exhaust valve port formed therein, a piston, and a combustion chamber defined by the block, the piston, and the head. At least one thermoelectric device is positioned within either or both the intake valve port and the exhaust valve port. Each of the valves is configured to move within a respective intake and exhaust valve port thereby causing said valves to engage the thermoelectric devices resulting in heat transfer from the valves to the thermoelectric devices. The intake valve port and exhaust valve port are configured to fluidly direct intake air and exhaust gas, respectively, into the combustion chamber and the thermoelectric device is positioned within the intake valve port, and exhaust valve port, such that the thermoelectric device is in contact with the intake air and exhaust gas.
摘要翻译：一种内燃机，其包括块体，具有形成在其中的进气门口和排气阀口的气缸盖，活塞和由所述块，所述活塞和所述头部限定的燃烧室。至少一个热电装置位于进气门口和排气阀口内的一个或两个内。每个阀构造成在相应的进气和排气阀口内移动，从而使得所述阀与热电装置接合，导致从阀到热电装置的热传递。进气门口和排气门口分别将进气和废气流体地引导到燃烧室中，并且热电装置位于进气阀口和排气阀口内，使得热电装置接触与进气和废气。

6. 发明申请

US20070219196A1 AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES 有权
标题翻译：酰胺取代的咪唑吡啶，咪唑啉和咪唑并吡啶
公开(公告)号：US20070219196A1
公开(公告)日：2007-09-20
申请号：US10599159
申请日：2005-03-24
申请人： Larry Krepski , Joseph Dellaria Jr. , Daniel Duffy , David Amos , Bernhard Zimmermann , William Moser
发明人： Larry Krepski , Joseph Dellaria Jr. , Daniel Duffy , David Amos , Bernhard Zimmermann , William Moser
IPC分类号： A61K31/4353 , A61K31/5377 , C07D413/14 , C07D471/02 , C07D471/12
CPC分类号： C07D471/04 , C07D413/14 , C07D471/02 , C07D471/12 , C07D471/14
摘要： Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译：咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，其在1-位具有酰胺基取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗公开了包括病毒和肿瘤疾病在内的疾病。

7. 发明申请

US20070155767A1 Sulfone substituted imidazo ring ethers 失效
标题翻译：砜取代的咪唑环醚
公开(公告)号：US20070155767A1
公开(公告)日：2007-07-05
申请号：US10596117
申请日：2004-12-03
申请人： Matthew Radmer , William Moser , Joan Moseman , Joseph Dellaria
发明人： Matthew Radmer , William Moser , Joan Moseman , Joseph Dellaria
IPC分类号： A61K31/4745 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9-tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl-containing ether substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译：咪唑环化合物（例如，咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和6,7,8,9-四氢咪唑并萘啶）与1-位硫醚基，亚磺酰基或磺酰基醚取代基公开了含有化合物的药物组合物，中间体，制备该化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

8. 发明申请

US20070066480A1 METHOD OF PREPARING COMPOUNDS USING CAVITATION AND COMPOUNDS FORMED THEREFROM 审中-公开
标题翻译：使用孔和化合物制备化合物的方法
公开(公告)号：US20070066480A1
公开(公告)日：2007-03-22
申请号：US11556019
申请日：2006-11-02
申请人： William Moser , Oleg Kozyuk , Ivo Krausz , Sean Emerson , Josef Find
发明人： William Moser , Oleg Kozyuk , Ivo Krausz , Sean Emerson , Josef Find
IPC分类号： B01J23/38
CPC分类号： B01J19/008 , B01J23/002 , B01J23/44 , B01J23/50 , B01J23/80 , B01J23/83 , B01J23/882 , B01J35/002 , B01J35/023 , B01J37/031 , B01J2523/00 , B22F1/0044 , B22F2998/00 , B82Y30/00 , C01G9/006 , C01G23/053 , C01G25/006 , C01G39/00 , C01G49/0018 , C01G49/009 , C01G51/00 , C01P2002/34 , C01P2002/60 , C01P2002/72 , C01P2002/74 , C01P2004/62 , C01P2004/64 , C01P2006/80 , B22F9/24 , B22F9/02 , B01J2523/31 , B01J2523/48 , B01J2523/824 , B01J2523/17 , B01J2523/27 , B01J2523/24 , B01J2523/3706 , B01J2523/842 , B01J2523/68 , B01J2523/845 , B01J2523/18 , B01J2523/47 , B01J2523/19 , B01J2523/41 , B01J2523/54
摘要： Nanostructured materials and processes for the preparation of these nanostructured materials in high phase purities using cavitation is disclosed. The method preferably comprises mixing a metal containing solution with a precipitating agent and passing the mixture into a cavitation chamber. The chamber consists of a first element to produce cavitation bubbles, and a second element that creates a pressure zone sufficient to collapse the bubbles. The process is useful for the preparation of catalysts and materials for piezoelectrics and superconductors.
摘要翻译：公开了纳米结构材料和使用空化制备高相纯度的这些纳米结构材料的方法。该方法优选包括将含金属溶液与沉淀剂混合并将混合物通入空化室。该室由产生空化气泡的第一元件和产生足以压缩气泡的压力区的第二元件组成。该方法可用于制备用于压电和超导体的催化剂和材料。

9. 发明授权

US07498434B2 Two-phase method for the synthesis of selected pyrazolopyrimidines 失效
标题翻译：合成选择的吡唑并嘧啶的两相方法
公开(公告)号：US07498434B2
公开(公告)日：2009-03-03
申请号：US10585006
申请日：2004-12-02
申请人： Gary Lee Cantrell , Frank William Moser , Robert Edward Halvachs
发明人： Gary Lee Cantrell , Frank William Moser , Robert Edward Halvachs
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： An improved method of making a substituted pyrazolopyrimidine. The method comprises reacting a aminopyrazole compound or a salt thereof with a substituted 1-oxo-2-propenyl-arene(-heterocycle) or a salt thereof under acidic conditions in a reaction medium including a two-phase mixture of an aqueous solution and a water-immiscible organic liquid. Specific substituted pyrazolopyrimidines include N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide and N-methyl-N-(3-{3-[2-thienyl-carbonyl]-pyrazolo[1,5-a]-pyrimidin-7-yl}phenyl)acetamide.
摘要翻译：一种制备取代吡唑并嘧啶的改进方法。该方法包括在酸性条件下将氨基吡唑化合物或其盐与取代的1-氧代-2-丙烯基 - 芳烃（ - 杂环）或其盐在包括水溶液和与水不混溶的有机液体。特异取代的吡唑并嘧啶包括N- [3-（3-氰基吡唑并[1,5-a]嘧啶-7-基）苯基] -N-乙基乙酰胺和N-甲基-N-（3- {3- [2-噻吩基] 羰基] - 吡唑并[1,5-a]嘧啶-7-基}苯基）乙酰胺。

10. 发明申请

US20060252792A1 ETHER SUBSTITUTED IMIDAZOPYRIDINES 失效
标题翻译：其他替代的咪唑吡啶
公开(公告)号：US20060252792A1
公开(公告)日：2006-11-09
申请号：US11459489
申请日：2006-07-24
申请人： Joseph Dellaria , Kyle Lindstrom , Luke Dressel , Philip Heppner , John Jacobsen , Joan Moseman , William Moser , Matthew Radmer , Doris Stoermer
发明人： Joseph Dellaria , Kyle Lindstrom , Luke Dressel , Philip Heppner , John Jacobsen , Joan Moseman , William Moser , Matthew Radmer , Doris Stoermer
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译：在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。还公开了制备可用于制备化合物的化合物和中间体的方法。

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