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1. 发明授权

US07977461B2 Anti-platelet membrane glycoprotein VI monoclonal antibody 有权
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US07977461B2
公开(公告)日：2011-07-12
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

2. 发明授权

US07264967B2 Anti-CD14 monoclonal antibody having effect of inhibiting CD14/TLR binding 失效
标题翻译：具有抑制CD14 / TLR结合作用的抗CD14单克隆抗体
公开(公告)号：US07264967B2
公开(公告)日：2007-09-04
申请号：US10432236
申请日：2001-09-28
申请人： Shoji Furusako , Kamon Shirakawa , Sadao Mori
发明人： Shoji Furusako , Kamon Shirakawa , Sadao Mori
IPC分类号： C12N5/06
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/34 , G01N2500/00
摘要： The present invention provides an antibody which specifically recognizes an epitope containing a part of a domain based on a finding that the domain ranging from the 269- to 315-positions of human CD14 represented by SEQ ID NO:1 is a site capable of interacting with another protein, an antibodies provided. This antibody can inhibit the interaction between human CD14 and another protein and thus suppress cell activation. And also, the present invention provides hybridomas producing the above antibody or its fragment; a peptide containing the amino acids in the domain as specified above; a method of constructing an antibody with the use of this peptide as an immunogen; and a method of screening a medicament for sepsis involving the step of bringing a test substance into contact with CD14 and TLR.
摘要翻译：本发明提供了一种抗体，其特异性识别含有部分结构域的表位，基于以下发现：由SEQ ID NO：1表示的人CD14的269位至315位的结构域是能够与另一种蛋白质，提供抗体。该抗体可抑制人CD14与另一种蛋白质之间的相互作用，从而抑制细胞活化。而且，本发明提供了产生上述抗体或其片段的杂交瘤; 含有如上所述的结构域中的氨基酸的肽; 使用该肽作为免疫原构建抗体的方法; 以及筛选涉及使测试物质与CD14和TLR接触的步骤的败血症药物的方法。

3. 发明授权

US08124722B2 Soluble CD14 antigen 有权
标题翻译：可溶性CD14抗原
公开(公告)号：US08124722B2
公开(公告)日：2012-02-28
申请号：US12395298
申请日：2009-02-27
申请人： Shoji Furusako , Kamon Shirakawa , Jiro Hirose
发明人： Shoji Furusako , Kamon Shirakawa , Jiro Hirose
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N33/6893 , G01N2333/70596 , G01N2800/26
摘要： There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAGE under non-reducing conditions; 2) an amino acid sequence in which the amino acid sequence of SEQ ID NO:1 is present on its N terminal; and 3) ability to specifically bind to an antibody prepared by using a peptide comprising 16 amino acid residues described in SEQ ID NO:2 for the antigen; and a recombinant soluble CD14 fragment.
摘要翻译：提供可溶性CD14抗原，其是用作诊断败血症的标志物的新型体内蛋白质，具有以下特征1）至3）：1）当通过SDS-PAGE测定时，分子量为13±2kDa 非还原条件; 2）其N末端存在SEQ ID NO：1的氨基酸序列的氨基酸序列; 和3）通过使用包含SEQ ID NO：2中所述的16个氨基酸残基的肽作为抗原而特异性结合抗体的能力; 和重组可溶性CD14片段。

4. 发明授权

US07901900B2 Assay kit and antibody for human low molecular weight CD14 有权
标题翻译：用于人类低分子量CD14的测定试剂盒和抗体
公开(公告)号：US07901900B2
公开(公告)日：2011-03-08
申请号：US11987746
申请日：2007-12-04
申请人： Shoji Furusako , Kamon Shirakawa
发明人： Shoji Furusako , Kamon Shirakawa
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N2800/26
摘要： The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid sequence at a position among the positions 1 to 68. An assay kit for human low-molecular-weight CD14 using the antibody and an assay method of the present invention, preferably a sandwich method, are able to quantitatively or qualitatively determine human low-molecular-weight CD14 with high sensitivity and specificity in a simple manner, so that they are useful for the diagnosis of a patient suffering from sepsis.
摘要翻译：本发明提供使用肽作为抗原制备的抗体，所述肽具有选自人高分子量CD14的1至68位的氨基酸序列的8-30个氨基酸残基，或与在位置1至68之间的位置具有特定氨基酸序列的肽。使用抗体的人类低分子量CD14测定试剂盒和本发明的测定方法，优选夹心法可以定量地或以简单的方式定性测定人体低分子量CD14，具有高灵敏度和特异性，因此它们可用于诊断患有败血症的患者。

5. 发明授权

US07608684B2 Soluble CD14 antigen 有权
标题翻译：可溶性CD14抗原
公开(公告)号：US07608684B2
公开(公告)日：2009-10-27
申请号：US11126344
申请日：2005-05-11
申请人： Shoji Furusako , Kamon Shirakawa , Jiro Hirose
发明人： Shoji Furusako , Kamon Shirakawa , Jiro Hirose
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N33/6893 , G01N2333/70596 , G01N2800/26
摘要： There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAGE under non-reducing conditions; 2) an amino acid sequence in which the amino acid sequence of SEQ ID NO:1 is present on its N terminal; and 3) ability to specifically bind to an antibody prepared by using a peptide comprising 16 amino acid residues described in SEQ ID NO:2 for the antigen; and a recombinant soluble CD14 fragment.
摘要翻译：提供可溶性CD14抗原，其是用作诊断败血症的标志物的新型体内蛋白质，具有以下特征1）至3）：1）当通过SDS-PAGE测定时，分子量为13±2kDa 非还原条件; 2）其N末端存在SEQ ID NO：1的氨基酸序列的氨基酸序列; 和3）通过使用包含SEQ ID NO：2中所述的16个氨基酸残基的肽作为抗原而特异性结合抗体的能力; 和重组可溶性CD14片段。

6. 发明申请

US20090092612A1 ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY 有权
公开(公告)号：US20090092612A1
公开(公告)日：2009-04-09
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.

7. 发明授权

US07465547B2 Methods for detecting human low molecular weight CD14 有权
标题翻译：检测人类低分子量CD14的方法
公开(公告)号：US07465547B2
公开(公告)日：2008-12-16
申请号：US10534257
申请日：2003-11-12
申请人： Shoji Furusako , Kamon Shirakawa
发明人： Shoji Furusako , Kamon Shirakawa
IPC分类号： C07K16/28 , C12P21/08 , G01N33/50 , G01N33/543 , G01N33/577
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N2800/26
摘要： The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid sequence at a position among the positions 1 to 68. An assay kit for human low-molecular-weight CD14 using the antibody and an assay method of the present invention, preferably a sandwich method, are able to quantitatively or qualitatively determine human low-molecular-weight CD14 with high sensitivity and specificity in a simple manner, so that they are useful for the diagnosis of a patient suffering from sepsis.
摘要翻译：本发明提供使用肽作为抗原制备的抗体，所述肽具有选自人高分子量CD14的1至68位的氨基酸序列的8-30个氨基酸残基，或与在位置1至68之间的位置具有特定氨基酸序列的肽。使用抗体的人类低分子量CD14测定试剂盒和本发明的测定方法，优选夹心法可以定量地或以简单的方式定性测定人体低分子量CD14，具有高灵敏度和特异性，因此它们可用于诊断患有败血症的患者。

8. 发明申请

US20090203052A1 NOVEL SOLUBLE CD14 ANTIGEN 有权
标题翻译：新型可溶性CD14抗原
公开(公告)号：US20090203052A1
公开(公告)日：2009-08-13
申请号：US12395298
申请日：2009-02-27
申请人： Shoji FURUSAKO , Kamon Shirakawa , Jiro Hirose
发明人： Shoji FURUSAKO , Kamon Shirakawa , Jiro Hirose
IPC分类号： G01N33/53
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N33/6893 , G01N2333/70596 , G01N2800/26
摘要： There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAGE under non-reducing conditions; 2) an amino acid sequence in which the amino acid sequence of SEQ ID NO:1 is present on its N terminal; and 3) ability to specifically bind to an antibody prepared by using a peptide comprising 16 amino acid residues described in SEQ ID NO:2 for the antigen; and a recombinant soluble CD14 fragment.
摘要翻译：提供可溶性CD14抗原，其是用作诊断败血症的标志物的新型体内蛋白质，具有以下特征1）至3）：1）当通过SDS-PAGE测定时，分子量为13±2kDa 非还原条件; 2）其N末端存在SEQ ID NO：1的氨基酸序列的氨基酸序列; 和3）通过使用包含SEQ ID NO：2中所述的16个氨基酸残基的肽作为抗原而特异性结合抗体的能力; 和重组可溶性CD14片段。

9. 发明申请

US20090041783A1 ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY 审中-公开
标题翻译：抗血小板膜糖蛋白VI单克隆抗体
公开(公告)号：US20090041783A1
公开(公告)日：2009-02-12
申请号：US11816233
申请日：2006-01-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C07K14/00 , A61P43/00 , G01N33/566 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译：本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。

10. 发明申请

US20090029396A1 Assay kit and antibody for human low molecular weight CD14 有权
标题翻译：用于人类低分子量CD14的测定试剂盒和抗体
公开(公告)号：US20090029396A1
公开(公告)日：2009-01-29
申请号：US11987746
申请日：2007-12-04
申请人： Shoji Furusako , Kamon Shirakawa
发明人： Shoji Furusako , Kamon Shirakawa
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C07K14/70596 , C07K16/2896 , C07K2317/34 , G01N2800/26
摘要： The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid sequence at a position among the positions 1 to 68. An assay kit for human low-molecular-weight CD14 using the antibody and an assay method of the present invention, preferably a sandwich method, are able to quantitatively or qualitatively determine human low-molecular-weight CD14 with high sensitivity and specificity in a simple manner, so that they are useful for the diagnosis of a patient suffering from sepsis.
摘要翻译：本发明提供使用肽作为抗原制备的抗体，所述肽具有选自人高分子量CD14的1至68位的氨基酸序列的8-30个氨基酸残基，或与在位置1至68之间的位置具有特定氨基酸序列的肽。使用抗体的人类低分子量CD14测定试剂盒和本发明的测定方法，优选夹心法可以定量地或以简单的方式定性测定人体低分子量CD14，具有高灵敏度和特异性，因此它们可用于诊断患有败血症的患者。

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