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1. 发明授权

US4952717A Myoinositol derivatives and preparation process thereof 失效
标题翻译：肌醇衍生物及其制备方法
公开(公告)号：US4952717A
公开(公告)日：1990-08-28
申请号：US131049
申请日：1987-10-20
申请人： Shoichiro Ozaki , Yutaka Watanabe , Akira Awaya , Yusaku Ishizuka
发明人： Shoichiro Ozaki , Yutaka Watanabe , Akira Awaya , Yusaku Ishizuka
IPC分类号： C07C29/00 , C07C35/16 , C07C43/18 , C07C43/188 , C07C43/196 , C07C43/235 , C07D317/46 , C07D317/72 , C07D493/04 , C07F9/117 , C07F9/24
CPC分类号： C07C43/196 , C07C43/188 , C07F9/117
摘要： Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.

2. 发明授权

US5292913A Myoinositol derivatives and preparation process thereof 失效
标题翻译：肌醇衍生物及其制备方法
公开(公告)号：US5292913A
公开(公告)日：1994-03-08
申请号：US950760
申请日：1992-09-24
申请人： Shoichiro Ozaki , Yutaka Watanabe , Akira Awaya , Yusaku Ishizuka
发明人： Shoichiro Ozaki , Yutaka Watanabe , Akira Awaya , Yusaku Ishizuka
IPC分类号： C07F9/117
CPC分类号： C07F9/117
摘要： Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.
摘要翻译：本文公开了由以下通式（I）表示的肌醇的磷酸酯：（*化学结构*）（I）及其盐，以及其制备方法。肌醇衍生物各自可以通过使磷酸化剂作用于除了希望被磷酸残基取代的那些位置以外的位置上用催化还原可除去取代基取代的肌醇衍生物，然后催化还原由此磷酸化的肌醇来获得。

3. 发明授权

US5252707A Inositol derivative and method for preparing same 失效
标题翻译：肌醇衍生物及其制备方法
公开(公告)号：US5252707A
公开(公告)日：1993-10-12
申请号：US700152
申请日：1991-05-15
申请人： Shoichiro Ozaki , Yutaka Watanabe , Masato Hirata , Akira Awaya
发明人： Shoichiro Ozaki , Yutaka Watanabe , Masato Hirata , Akira Awaya
IPC分类号： A61K31/66 , A61P3/00 , A61P9/00 , A61P43/00 , C07F9/117 , C07F9/6561 , C07F9/6574 , A61K37/02 , C07K17/02 , C12N9/00
CPC分类号： C07F9/117 , C07F9/6561 , C07F9/65744
摘要： There are disclosed a novel inositol-1,4,5-triphosphoric acid derivative, inositol-1,3,4-triphosphoric acid derivative, inositol-1,3,4,5-tetraphosphoric acid derivative, and a bonded substance of the same and a protein. They control the metabolic process of an organism concerned with calcium ions to thereby exert a medicinal virtue.

4. 发明授权

US5264605A Myoinsitol derivatives, process for preparing same, phosphorylating agent, and its utilization 失效
标题翻译：肉豆蔻醇衍生物，其制备方法，磷酸化剂及其利用
公开(公告)号：US5264605A
公开(公告)日：1993-11-23
申请号：US651368
申请日：1991-02-20
申请人： Shoichiro Ozaki , Yutaka Watanabe
发明人： Shoichiro Ozaki , Yutaka Watanabe
IPC分类号： C07C69/013 , C07C69/03 , C07C69/70 , C07F7/18 , C07F9/117 , C07F9/6571 , C07F7/08
CPC分类号： C07F9/117 , C07C69/013 , C07C69/70 , C07F7/1856 , C07F7/1864 , C07F9/657154
摘要： A process for preparing myoinositol polyphosphoric acid from myoinositol via a polyacylmyoinositol, a process for preparing a polysilyl-polyacylmyoinositol from a polyacylmyoinositol, and a process for preparing an optically active myoinositol polyphosphoric acid from the above product or a polysilylmyoinositol.

5. 发明授权

US4376768A Benzothiazine derivative 失效
标题翻译：苯并噻嗪衍生物
公开(公告)号：US4376768A
公开(公告)日：1983-03-15
申请号：US274229
申请日：1981-06-16
申请人： Shoichiro Ozaki , Hideya Kobayashi , Haruki Mori , Takafumi Kitano , Hiroshi Kawazura , Yutaka Okazaki
发明人： Shoichiro Ozaki , Hideya Kobayashi , Haruki Mori , Takafumi Kitano , Hiroshi Kawazura , Yutaka Okazaki
IPC分类号： C07D417/12 , A61K31/54 , A61P29/00 , C07D213/73
CPC分类号： C07D213/73
摘要： N-(6-chloro-2-pyridyl)-3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide that is a novel benzothiazine derivative. The compound is characterized by a low degree of toxicity and a low incidence of gastric disorders and useful as an anti-inflammatory agent.
摘要翻译：作为新的苯并噻嗪衍生物的N-（6-氯-2-吡啶基）-3,4-二氢-2-甲基-4-氧代-2H-1,2-苯并噻嗪-3-甲酰胺1,1-二氧化物。该化合物的特征在于毒性低，胃疾病发生率低，可用作抗炎剂。

6. 发明授权

US08017809B2 Bisboron compound 有权
标题翻译： Bisboron化合物
公开(公告)号：US08017809B2
公开(公告)日：2011-09-13
申请号：US12094968
申请日：2006-11-24
申请人： Katsuhiko Mikoshiba , Shoichiro Ozaki , Akinobu Suzuki , Takeshi Nakamura , Kyoko Nakamura, legal representative , Aiko Nakamura, legal representative
发明人： Katsuhiko Mikoshiba , Shoichiro Ozaki , Akinobu Suzuki , Takeshi Nakamura
IPC分类号： C07F5/02 , A61K31/69
CPC分类号： C07F5/025
摘要： A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, R1 and R2 independently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, R3 represents a hydrogen atom; —(CH2)m—NR4R5; —CO—(CH2)m—NR4R5; —COCH(NH2)R6; —CHR7R8; —CH2CH(NH2)—R9; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from R1 and R2, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH2, S, SO2, CH2OCH2, OCH2, OCH2CH2OCH2, OCH2OCH2CH2 and CH2OCH2CH2, or a salt thereof, and a composition for controlling the intracellular calcium concentration, which comprises the compound or salt thereof as an active ingredient.
摘要翻译：由通式（I）表示的双硼化合物：其中B表示硼原子，Y表示氧或硫原子，R1和R2独立地表示单环芳基，多环芳基或含有至少一个选自氧，氮和硫原子的杂原子，R 3表示氢原子; - （CH 2）m -NR 4 R 5; -CO-（CH 2）m -NR 4 R 5; -COCH（NH 2）R 6; -CHR7R8; -CH 2 CH（NH 2）-R 9; 被C1-C4烷基取代的喹啉基; 或被吡啶基，哌啶子基或吡咯烷基取代的C1-C4烷基，X表示可以与R1和R2相同或不同的单环芳基，多环芳基或杂环基，或具有或选自由单键，O，CH2，S，SO2，CH2OCH2，OCH2，OCH2CH2OCH2，OCH2OCH2CH2和CH2OCH2CH2组成的组中的一个基团键合的单环芳基，多环芳基或杂环基，或其盐，以及用于控制细胞内钙浓度的组合物，其包含其化合物或其盐作为活性成分。

7. 发明授权

US5091549A Synthesis of D-myoinositol-1-phosphate 失效
标题翻译： D-木糖醇-1-磷酸酯的合成
公开(公告)号：US5091549A
公开(公告)日：1992-02-25
申请号：US575615
申请日：1990-08-31
申请人： Shoichiro Ozaki , Takahiko Akiyama , Naoto Takechi , Kunio Kageyama , Morihisa Machida
发明人： Shoichiro Ozaki , Takahiko Akiyama , Naoto Takechi , Kunio Kageyama , Morihisa Machida
IPC分类号： C07F7/18 , C07F9/117 , C07F9/6574
CPC分类号： C07F9/117 , Y02P20/55
摘要： A method of synthesizing D-myoinositol-1-phosphate from 1,2-(R.sup.1)-3-R.sup.2 -myoinositol compounds of the formula ##STR1## wherein R.sup.1 is a bridging type protective group bonded to two oxygen atoms at the 1- and 2-position, and R.sup.2 is a protective group coupled to the oxygen atom at the 3-position. D-Myoinositol-1-phosphate is useful as an intermediate for the production of inositol-1,4,5-triphosphate.
摘要翻译：由式（IMA）的1,2-（R1）-3-R2-肌醇化合物合成D-肌醇-1-磷酸的方法，其中R 1是在1位上与两个氧原子键合的桥连型保护基， 2位，R2是与3位上的氧原子连接的保护基。 D-肌醇-1-磷酸可用作生产肌醇-1,4,5-三磷酸的中间体。

8. 发明授权

US4032524A 1-Carbamoyl-5-fluorouracil derivatives 失效
标题翻译： 1-CARBAMOYL-5-FLUOROURACIL DORIVATIVES
公开(公告)号：US4032524A
公开(公告)日：1977-06-28
申请号：US726196
申请日：1976-09-24
申请人： Shoichiro Ozaki , Haruki Mori
发明人： Shoichiro Ozaki , Haruki Mori
IPC分类号： A61K31/505 , C07D239/54 , C07D239/553 , C07D239/10
CPC分类号： C07D239/553 , A61K31/505 , C07D239/54 , Y10S514/908
摘要： 1-Carbamoyl-5-fluorouracil derivatives represented by the formula ##STR1## wherein R.sub.1 represents methyl, ethyl, phenyl or cyclohexyl and R.sub.2 represents hydrogen or is the same as R.sub.1 are effective anti-metabolites useful in treating lymphatic leukemia L1210, sarcoma 180A and Ehrlich ascites carcinoma in mice.

9. 发明授权

US08853424B2 Protein cross-linking inhibitor 有权
标题翻译：蛋白质交联抑制剂
公开(公告)号：US08853424B2
公开(公告)日：2014-10-07
申请号：US13058647
申请日：2009-08-11
申请人： Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
发明人： Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
IPC分类号： C07D333/00 , A61K31/67 , C07F5/02 , A61K31/69
CPC分类号： C07F5/025 , A61K31/69
摘要： The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (1) R3—[—X—B(ZR1)—Y—]n—R4, (2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4, (3) R3—[—X—B(ZR1)—]n—R4, (4) R3—[—B(ZR2)—W—]n—R4, (5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2, (6) R3—B(OH)2, (7) R3—B(ZR1)—X—B(ZR2)—R4, (8) R3—B(R1)—O—B(R2)—R4, (9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4, (10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4, (11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (12) [R3—X—B(ZR1)—Y]2B(ZR2), (13) wherein each symbol is as defined in the DESCRIPTION.
摘要翻译：本发明提供一种蛋白质交联抑制剂，其含有下述式（1） - （13）中任一项所示的化合物或其药学上可接受的盐：R3 - [ - X-B（ZR1）-Y-B ZR2）-W-] n-R4，（1）R3 - [ - X-B（ZR1）-Y-] n-R4，（2）R3 - [ - B（ZR1）-Y-B（ZR2） - W - ] n-R4，（3）R3 - [ - X-B（ZR1） - ] n-R4，（4）R3 - [ - B（ZR2）-W-] n-R4，（5） X-B（ZR1）-T [B（ZR2）-W-R4] 2，（6）R3-B（OH）2，（7）R3-B（ZR1）-X-B（ZR2）-R4，（8）R3-B（R1）-O-B（R2）-R4，（9）R3 - [ - X-B（ZR1）-Y-B（ZR2） - ] n-R4，（10） [-X-B（ZR1）-Y-B（ZR2）-WQ-] n-R4，（11）R3 - [ - P-X-B（ZR1）-Y-B（ZR2）-W-] n -R4，（12）[R3-X-B（ZR1）-Y] 2B（ZR2），（13）其中每个符号如说明书中所定义。

10. 发明授权

US4376119A Benzothiazine derivative 失效
标题翻译：苯并噻嗪衍生物
公开(公告)号：US4376119A
公开(公告)日：1983-03-08
申请号：US274209
申请日：1981-06-16
申请人： Shoichiro Ozaki , Hideya Kobayashi , Haruki Mori , Hiroshi Kawazura , Yutaka Okazaki , Takafumi Kitano , Mikio Kumakura , Takuo Nakano
发明人： Shoichiro Ozaki , Hideya Kobayashi , Haruki Mori , Hiroshi Kawazura , Yutaka Okazaki , Takafumi Kitano , Mikio Kumakura , Takuo Nakano
IPC分类号： C07D417/12 , A61K31/54 , A61P29/00 , C07D213/73
CPC分类号： C07D213/73
摘要： N-(6-fluoro-2-pyridyl)-3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide that is a novel benzothiazine derivative. The compound is characterized by a low degree of toxicity and a low incidence of gastric disorders and useful as an anti-inflammatory agent.
摘要翻译：作为新的苯并噻嗪衍生物的N-（6-氟-2-吡啶基）-3,4-二氢-2-甲基-4-氧代-2H-1,2-苯并噻嗪-3-甲酰胺1,1-二氧化物。该化合物的特征在于毒性低，胃疾病发生率低，可用作抗炎剂。

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