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1. 发明授权

US06476482B1 Chip-size integrated circuit package having slits formed in an insulator tape 有权
标题翻译：芯片尺寸的集成电路封装具有形成在绝缘胶带中的狭缝
公开(公告)号：US06476482B1
公开(公告)日：2002-11-05
申请号：US09588189
申请日：2000-06-07
申请人： Shohei Okazaki , Yoshihiro Matsumoto
发明人： Shohei Okazaki , Yoshihiro Matsumoto
IPC分类号： H01L2312
CPC分类号： H01L24/10 , H01L23/3107 , H01L23/3157 , H01L24/13 , H01L2224/05001 , H01L2224/05023 , H01L2224/05568 , H01L2224/13 , H01L2224/13099 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01029 , H01L2924/01033 , H01L2924/01079 , H01L2924/14 , H01L2924/00 , H01L2224/05644 , H01L2924/00014 , H01L2224/05124
摘要： In a chip-size package, an insulator tape is formed with a conductive wire having a wider section which is greater in width than other sections of the wire and a conductive bump connected to the wider section of the wire. The insulator tape is further formed with a first plurality of slits arranged on one side of the wider section of the wire and a second plurality of slits arranged on the other side of the wider section. An integrated circuit chip is provided having a conductive pad connected to the copper bump.
摘要翻译：在芯片尺寸封装中，绝缘胶带形成有导线，该导线具有宽度大于导线的其它部分的宽度，以及连接到导线的较宽部分的导电凸块。绝缘体带还形成有布置在线的较宽部分的一侧上的第一多个狭缝和布置在较宽部分的另一侧上的第二多个狭缝。提供了具有连接到铜凸块的导电焊盘的集成电路芯片。

2. 发明授权

US06373736B1 Isolated converter 有权
公开(公告)号：US06373736B1
公开(公告)日：2002-04-16
申请号：US09880606
申请日：2001-06-13
申请人： Yoshihiro Matsumoto , Tadahiko Matsumoto
发明人： Yoshihiro Matsumoto , Tadahiko Matsumoto
IPC分类号： H02M100
摘要： An isolated converter with a reduced size is disclosed. A small-sized multilayer sheet transformer includes a multilayer circuit board composed of a plurality of sheet substrates, coil patterns of primary and secondary coils disposed coaxially on the sheet substrates, and a core member disposed in a coil pattern unit formed of the coil patterns. In this multilayer sheet transformer, a coil pattern formed on the outer surface of the top layer and a coil pattern formed on the outer surface of the bottom layer are for the same coil on either the primary or secondary side. In the case where the coil patterns formed on the outer surfaces of the top and bottom layers of the multilayer sheet transformer are for the primary coil, an isolation gap is formed between the multilayer sheet transformer and a circuit on the secondary side to prevent an electrical breakdown between the primary and secondary sides. In the case where the coil patterns formed on the outer surfaces of the top and bottom layers of the multilayer sheet transformer are for the secondary coil, an isolation gap is formed between the multilayer sheet transformer and a circuit on the primary side to prevent an electrical breakdown between the primary and secondary sides.

3. 发明授权

US6048972A Recombinant materials for producing humanized anti-IL-8 antibodies 失效
标题翻译：用于产生人源化抗IL-8抗体的重组材料
公开(公告)号：US6048972A
公开(公告)日：2000-04-11
申请号：US880142
申请日：1997-06-20
申请人： Kouji Matsushima , Yoshihiro Matsumoto , Yoshiki Yamada , Koh Sato , Masayuki Tsuchiya , Tatsumi Yamazaki
发明人： Kouji Matsushima , Yoshihiro Matsumoto , Yoshiki Yamada , Koh Sato , Masayuki Tsuchiya , Tatsumi Yamazaki
IPC分类号： A61K39/395 , A61P29/00 , A61P37/02 , C07K16/24 , C12N15/13 , C12P21/08 , C12N5/10
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： Monoclonal antibodies immunospecific for the neutrophil chemotactic factor, IL-8, have been humanized by reshaping the variable regions to conform more closely to human counterparts. These antibodies are useful in immunoassays to detect IL-8 and as ligands on immunoaffinity columns for purification of human IL-8. In addition, the humanized antibodies have an antiinflammatory effect in patients.
摘要翻译：针对嗜中性粒细胞趋化因子IL-8免疫特异性的单克隆抗体已经通过重塑可变区域来更加紧密地与人类对应物进行人源化。这些抗体可用于免疫测定以检测IL-8和作为免疫亲和柱上的配体用于纯化人IL-8。此外，人源化抗体在患者中具有抗炎作用。

4. 发明授权

US5994524A Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same 失效
标题翻译：编码重组的IL-8特异性抗体的多核苷酸及其制备方法
公开(公告)号：US5994524A
公开(公告)日：1999-11-30
申请号：US765783
申请日：1997-03-07
申请人： Kouji Matsushima , Yoshihiro Matsumoto , Yoshiki Yamada , Koh Sato , Masayuki Tsuchiya , Tatsumi Yamazaki
发明人： Kouji Matsushima , Yoshihiro Matsumoto , Yoshiki Yamada , Koh Sato , Masayuki Tsuchiya , Tatsumi Yamazaki
IPC分类号： C07K16/24 , C12N15/13 , C12P21/08 , C07H21/04 , C12N5/10
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： The present invention discloses a reshaped human antibody against human IL-8 comprising:(A) L chains each comprising:(1) a human L chain C region; and,(2) an L chain V region comprising a human Lchain FR, and an L chain CDR of mouse monoclonal antibody against human IL-8; and,(B) H chains each comprising:(1) a human H chain C region; and,(2) an H chain V region comprising a human Hchain FR, and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the majority of this reshaped human antibody originates in human antibody and the CDR has low antigenicity, the reshaped human antibody of the present invention has low antigenicity to humans, and can therefore be expected to be useful in medical treatment. The present invention further discloses polynucleotides which encode reshaped antibodies against IL-8, as well as host cells and methods to produce these antibodies.
摘要翻译： PCT No.PCT / JP95 / 01396 Sec。 371日期1997年3月7日 102（e）1997年3月7日PCT PCT 1995年7月12日PCT公布。出版物WO97 / 02576 日本1996年2月1日本发明公开了针对人IL-8的重构人抗体，其包含：（A）L链，各自包含：（1）人L链C区; 和（2）包含人L链FR的L链V区和针对人IL-8的小鼠单克隆抗体的L链CDR; 和（B）H链，其各自包含：（1）人H链C区; 和（2）包含人H链FR的H链V区和针对人IL-8的小鼠单克隆抗体的H链CDR。由于这种重整人抗体的大部分源于人抗体，CDR具有低抗原性，所以本发明的重构人抗体对人的抗原性低，因此可以预期可用于治疗。本发明进一步公开了编码针对IL-8的重整抗体以及宿主细胞的多核苷酸以及产生这些抗体的方法。

5. 发明授权

US5949575A Binocular telescope 失效
标题翻译：双目望远镜
公开(公告)号：US5949575A
公开(公告)日：1999-09-07
申请号：US517260
申请日：1995-08-22
申请人： Yoshihiro Matsumoto
发明人： Yoshihiro Matsumoto
IPC分类号： G02B7/12 , G02B23/18 , G02B7/06 , G02B7/11
CPC分类号： G02B7/12 , G02B23/18
摘要： A binocular telescope provided with a pair of left and right lens-barrels respectively containing optical systems, a first guide shaft for supporting these lens-barrels in such a manner that the lens-barrels can slide in a direction perpendicular to the optical axes of the optical systems and can rotate, a second guide shaft for restraining the relative tilt of the lens-barrels around this first guide shaft in such a manner that the optical axes of the left and right optical systems become parallel to each other, a first rib for holding both ends of the first guide shaft by fitting upper and lower covers to each other, and a second rib for restraining the tilt of the optical axes of the entire lens-barrels around the first guide shaft.
摘要翻译：一双眼望远镜，设有一对分别容纳光学系统的左右透镜筒，一个用于支撑这些透镜筒的第一引导轴，使得透镜筒能够沿垂直于光学系统的光轴的方向滑动光学系统并且可以旋转;第二引导轴，用于以使得左右光学系统的光轴彼此平行的方式限制透镜套围绕该第一引导轴的相对倾斜;第一肋，用于通过将上盖和下盖彼此嵌合来保持第一引导轴的两端;以及第二肋，用于限制整个透镜套的光轴围绕第一引导轴的倾斜。

6. 发明授权

US5835276A Optical system having compound prism design to reduce ghosts and plares 失效
标题翻译：具有复合棱镜设计的光学系统，以减少重影和复制
公开(公告)号：US5835276A
公开(公告)日：1998-11-10
申请号：US801995
申请日：1997-02-18
申请人： Tetsuhisa Asai , Masashi Hankawa , Yoshihiro Matsumoto
发明人： Tetsuhisa Asai , Masashi Hankawa , Yoshihiro Matsumoto
IPC分类号： G02B23/14 , G02B5/00 , G02B5/04 , G02B17/00 , G02B27/00 , G02B27/14 , G02B27/12
CPC分类号： G02B27/0018
摘要： A prism optical system provided with: a first prism on which a light ray coming from an objective lens is incident; a second prism on which the light ray coming from this first prism is incident, and from which this incident light ray is emitted; and a plate-like member which is interposed between the aforesaid prisms so as to provide a predetermined air space therebetween and which has a diaphragm opening and a light blocking portion. Further, an uneven portion, which consists of depressions and projections and has a serrate section, for preventing light rays, which have been reflected from the surface of the light blocking portion of this plate-like member, from entering a field stop is provided in the light blocking portion thereof. Thereby, occurrences of ghosts and flares due to stray light are prevented. Moreover, ghosts and flares are reduced.
摘要翻译：一种棱镜光学系统，其具有：来自物镜的光线入射的第一棱镜; 来自该第一棱镜的光线入射到其上的第二棱镜，并从该第二棱镜射出该入射光线; 以及设置在上述棱镜之间以在其间提供预定空气空间并且具有光阑开口和遮光部分的板状构件。此外，在该板状构件的遮光部的表面反射的防止光线的凹凸部具有锯齿状的凹凸部不平整部分设置在其遮光部分。因此，防止由于杂散光而发生的鬼影和耀斑。此外，鬼魂和耀斑也减少了。

7. 发明授权

US5734499A Interpupillary distance adjusting mechanism for use in binocular telescope 失效
标题翻译：用于双目望远镜的瞳距调整机构
公开(公告)号：US5734499A
公开(公告)日：1998-03-31
申请号：US510918
申请日：1995-08-03
申请人： Yoshihiro Matsumoto , Fumio Tomikawa
发明人： Yoshihiro Matsumoto , Fumio Tomikawa
IPC分类号： G02B23/18 , G02B7/12 , G02B23/00
CPC分类号： G02B7/12
摘要： An interpupillary distance adjusting mechanism for use in a binocular telescope, having a pair of lens-barrels which contain lens optical systems, respectively, and are placed in parallel with each other. The interpupillary distance adjusting mechanism further has first and second guide shafts, which slidably guide the pair of lens-barrels in a direction substantially perpendicular to the direction of the optical axes of the lens optical systems, interpupillary distance adjusting springs for pushing the pair of lens-barrels in a sliding direction, and an interpupillary distance adjusting cam which can adjust an interpupillary distance by sliding the pair of lens-barrels along the guide shafts as the result of undergoing a pushing force from the interpupillary distance adjusting spring, of converting a part of the pushing force in a direction which intersects the sliding direction, and of moving the pair of lens-barrels by pushing the pair of lens-barrels against the first guide.
摘要翻译：一种用于双目望远镜的瞳孔间距调节机构，具有分别包含透镜光学系统并且彼此平行放置的一对透镜筒。瞳孔间距调节机构还具有第一和第二引导轴，其在基本上垂直于透镜光学系统的光轴的方向的方向上可滑动地引导一对透镜筒，用于推动该对透镜的瞳孔间距调节弹簧以及瞳孔间距调节凸轮，其可以通过从所述瞳孔间距调节弹簧经受推力而沿着所述引导轴滑动所述一对透镜镜筒来调节瞳孔间距离，从而将部件的推力与滑动方向相交的方向，以及通过将一对透镜筒推靠在第一引导件上来移动一对透镜筒。

8. 发明授权

US5371800A Speech detection circuit 失效
标题翻译：语音检测电路
公开(公告)号：US5371800A
公开(公告)日：1994-12-06
申请号：US777184
申请日：1991-10-16
申请人： Noriyoshi Komatsu , Masahiro Aota , Seiji Komatsuda , Toshihiro Ibuka , Yoshihiro Matsumoto
发明人： Noriyoshi Komatsu , Masahiro Aota , Seiji Komatsuda , Toshihiro Ibuka , Yoshihiro Matsumoto
IPC分类号： H04B1/04 , G10L11/02 , G10L5/00
CPC分类号： G10L25/78
摘要： A speech detection circuit includes an amplifier for amplifying an input audio signal and having a variable gain, a rectifying circuit for rectifying an output signal of the amplifier, a comparator for comparing an output signal level of the rectifying circuit with a reference level, and a control circuit for outputting a control signal based on an output signal of the comparator. The control circuit outputs a control signal which indicates a power save mode after a predetermined time elapses from a time when the output signal level of the rectifying circuit becomes less than or equal to the reference level, and outputs a control signal which indicates a normal mode immediately when the output signal level of the rectifying circuit becomes greater than the reference level. The amplifier receives the control signal output from the control circuit and reduces its gain when the control signal indicates the power save mode.
摘要翻译：语音检测电路包括用于放大输入音频信号并具有可变增益的放大器，用于对放大器的输出信号进行整流的整流电路，将整流电路的输出信号电平与参考电平进行比较的比较器，以及控制电路，用于基于比较器的输出信号输出控制信号。控制电路从整流电路的输出信号电平变为小于等于参考电平的时刻起经过了规定时间后，输出表示省电模式的控制信号，并输出表示正常模式的控制信号立即当整流电路的输出信号电平变得大于基准电平时。当控制信号指示省电模式时，放大器接收从控制电路输出的控制信号并降低其增益。

9. 发明授权

US4839823A Automatic trouble analysis apparatus and method thereof 失效
标题翻译：自动故障分析装置及其方法
公开(公告)号：US4839823A
公开(公告)日：1989-06-13
申请号：US230723
申请日：1988-08-10
申请人： Yoshihiro Matsumoto
发明人： Yoshihiro Matsumoto
IPC分类号： H02H6/00 , G06F9/44 , G06F11/30 , G06F17/00 , G06N5/04 , G06N7/02
CPC分类号： G05B23/024 , Y10S706/90 , Y10S706/907 , Y10S706/911
摘要： In a trouble analysis apparatus, a cause of an accident which is empirically and statistically obtained, and a plurality of effects corresponding to the cause are entered in advance at a keyboard and stored as a data base in a magnetic disk unit. In this case, a sum of basic probabilities of the plurality of effects for the cause is set to be 1. A pre-processor calculates as upper (or lower) probability of a subset of the result by using the Dempster & Shafer probability theory. The pre-processor uses the upper or lower probability to create Fuzzy membership functions, and also creates a hypothetical proposition for corresponding the Fuzzy membership function and the cause. An inference engine matches accident phenomena with the effects when an accident occurs and infers the cause by a modified Fuzzy inference method using the hypothetical proposition.
摘要翻译：在故障分析装置中，预先在键盘输入根据经验和统计学获得的事故原因以及与原因相对应的多种效果，作为数据库存储在磁盘单元中。在这种情况下，将原因的多个效果的基本概率之和设置为1.预处理器通过使用Dempster＆Shafer概率理论计算结果子集的高（或更低）概率。预处理器使用上限或更低的概率来创建模糊隶属函数，并且还为相应的模糊隶属函数和原因创建了假设命题。推理引擎将事故现象与发生事故的效果相匹配，并通过使用假设命题的改进的模糊推理方法推理出原因。

10. 发明授权

US08912117B2 Cellulose gel for purification of immunoglobulin 有权
标题翻译：用于纯化免疫球蛋白的纤维素凝胶
公开(公告)号：US08912117B2
公开(公告)日：2014-12-16
申请号：US13201647
申请日：2010-02-18
申请人： Yoshihiro Matsumoto , Yasuto Umeda , Shigeyuki Aoyama , Masami Todokoro
发明人： Yoshihiro Matsumoto , Yasuto Umeda , Shigeyuki Aoyama , Masami Todokoro
IPC分类号： A61L15/60 , B01J20/24 , A61K38/00 , C07K1/18 , C07K1/22 , B01J20/32 , B01J41/20 , B01J39/26 , C07K1/16 , B01J20/286 , B01D15/38 , B01D15/36
CPC分类号： C07K1/16 , B01D15/362 , B01D15/3804 , B01J20/286 , B01J20/328 , B01J39/26 , B01J41/20
摘要： The present invention provides a chromatography packing material having improved flow rate characteristics and adsorption characteristics. In particular, the present invention provides a chromatography packing material suitable for separation and purification of immunoglobulin in the manufacture of antibody preparations. A porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry weight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles, is used. By adding a predetermined amount of polysaccharides having a predetermined limiting viscosity to porous cellulose particles, flow rate characteristics and adsorption characteristics can be improved.
摘要翻译：本发明提供具有改善的流速特性和吸附特性的色谱填充材料。特别地，本发明提供了适用于制备抗体制剂中免疫球蛋白分离和纯化的色谱填充材料。通过向多孔纤维素颗粒加入特性粘度为0.21〜0.90dL / g的多糖制成的多孔纤维素凝胶，多孔纤维素凝胶的每单位体积的干重为每单位体积的干重的1.06〜1.40倍使用多孔纤维素颗粒。通过向多孔纤维素颗粒添加预定量的具有预定极限粘度的多糖，可以提高流速特性和吸附特性。

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