专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100178268A1 BIOCIDIC PACKAGING FOR COSMETICS AND FOODSTUFFS 审中-公开
标题翻译：生物化学包装用于化妆品和食品
公开(公告)号：US20100178268A1
公开(公告)日：2010-07-15
申请号：US12598433
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61K31/74
CPC分类号： A61L2/16 , A01N25/34 , A01N37/08 , A01N37/20 , A01N41/04 , A01N61/00 , A23L3/3463
摘要： The present invention presents a biocidic packaging for cosmetics and/or foodstuffs, comprises at least one insoluble proton sink or source (PSS). The packaging is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of said LTCs' environment. The present invention also discloses a method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC being in a packaging, especially cosmetic or foodstuffs' packaging.
摘要翻译：本发明提出了一种用于化妆品和/或食品的生物杀伤剂包装，包括至少一种不溶性质子沉或源（PSS）。提供的包装用于杀死活的靶细胞（LTC）或以其他方式破坏接触时所述LTC的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持所述LTC的环境的pH。本发明还公开了一种用于杀死活的靶细胞（LTC）或以其它方式破坏所述LTC在包装，特别是化妆品或食品包装中的细胞内过程和/或细胞间相互作用的方法。

2. 发明申请

US20080314751A1 Electrophoretic Separation of Analytes by Molecular Mass 审中-公开
标题翻译：分子质量分析物的电泳分离
公开(公告)号：US20080314751A1
公开(公告)日：2008-12-25
申请号：US11994791
申请日：2006-07-05
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： B01D59/42 , G01N27/447
CPC分类号： G01N27/44747
摘要： The present invention relates to a method and apparatus for the separation of analytes based on their molecular weight, by application of an electric field across a low-friction matrix that includes with a charged separation agent. The matrix comprises charged regions ordered in a monotonous sequence distributed throughout the matrix so as to generate a charge density gradient. When an external electric field is applied, the complex will move through the different charged regions and focusing of different analytes in different charge regions will occur. These systems are suitable for planar, capillary in-tube electrophoresis, as well as multi-channel arrays of capillaries filled with charge gradient gels, serial arrays of discrete compartments with charge density gradient, arrays in a chip format, pre-designed mass focusing arrays for specific protein masses in application for protein and DNA marker diagnostics, and multi compartment trapping devices for specific mass ranges.
摘要翻译：本发明涉及通过在包含带电分离剂的低摩擦基质上施加电场来分离基于其分子量的分析物的方法和装置。矩阵包括以分布在整个矩阵中的单调序列排列的带电区域，以产生电荷密度梯度。当施加外部电场时，复合体将移动穿过不同的充电区域，并且将发生不同分析物在不同电荷区域中的聚焦。这些系统适用于平面，毛细管内电泳，以及填充有电荷梯度凝胶的多通道阵列的毛细管阵列，具有电荷密度梯度的离散隔室的串行阵列，芯片格式的阵列，预先设计的质量聚焦阵列用于蛋白质和DNA标记诊断的特定蛋白质质量，以及用于特定质量范围的多隔室捕获装置。

3. 发明授权

US08697102B2 Compositions and methods for cell killing 失效
标题翻译：细胞杀伤的组合物和方法
公开(公告)号：US08697102B2
公开(公告)日：2014-04-15
申请号：US12823354
申请日：2010-06-25
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A01N25/34 , A61K31/74
CPC分类号： A61L31/16 , A01N25/10 , A01N27/00 , A01N41/08 , A61K31/745 , A61K31/795 , A61L2/232 , A61L15/24 , A61L15/44 , A61L17/005 , A61L17/145 , A61L31/10 , A61L2202/26 , A61L2300/404 , A61L2300/606 , A61L2420/00 , Y02A50/471 , A01N33/12 , A01N37/18 , A01N41/04
摘要： A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H+/(L.pH unit) and further wherein, when said material is in an environment capable of transporting H+ ions, said solid buffer is adapted to cause the death of at least one target cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the solid buffer.
摘要翻译：一种包含一种或多种离子交换材料的固体缓冲液，其中所述固体缓冲液具有大于约20mM H + /（L.pH单位）的体积缓冲能力，此外，当所述材料处于能够输送H +离子的环境中时，所述固体缓冲液适于引起至少一个目标细胞在所述环境中或与所述环境接触中的死亡。可以提供覆盖固体缓冲液的选择性可渗透阻挡层。

4. 发明申请

US20100136077A1 BIOCIDIC HOUSEHOLD CLEANSING MATERIALS 审中-公开
标题翻译：生物化学家用清洁材料
公开(公告)号：US20100136077A1
公开(公告)日：2010-06-03
申请号：US12598428
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A01N61/00 , A01N25/00 , C08F112/08
CPC分类号： A01N61/00 , A61L2/22 , C11D3/48 , C11D17/049 , Y10T442/10 , Y10T442/60
摘要： The present invention discloses household cleaning materials comprising at least one insoluble proton sink or source (PSS) and to method for utilizing the PSS as a biocidic agent. The household cleaning materials are provided useful for killing living target cells (LTCs) or otherwise inhibiting LTCs growth, disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The household cleaning materials consisting of at least one PSS, comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of said LTC and/or disrupting vital intercellular interactions of said LTCs while efficiently preserving the pH of said LTCs' environment.
摘要翻译：本发明公开了包含至少一种不溶性质子沉或源（PSS）的家用清洁材料以及将PSS用作生物杀伤剂的方法。家用清洁材料可用于杀死活细胞（LTC）或以其他方式抑制LTC的生长，破坏LTC在接触时的重要细胞内过程和/或细胞间相互作用。由至少一个PSS组成的家用清洁材料尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏所述LTC的限定体积内的pH稳态和/或电平衡和/或破坏所述LTC的重要细胞间相互作用，同时有效地保持所述LTC的环境的pH。

5. 发明申请

US20100087769A1 BIOCIDIC MEDICAL DEVICES, IMPLANTS AND WOUND DRESSINGS 审中-公开
标题翻译：生物医疗器械，植入物和创新衣服
公开(公告)号：US20100087769A1
公开(公告)日：2010-04-08
申请号：US12598429
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61F13/00 , A61L27/50 , A61L15/42 , A61L2/00
CPC分类号： A61L27/54 , A61L15/44 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/404
摘要： The present invention discloses a medical device selected from a group consisting of medical devices, implants wound dressings, comprises at least one insoluble proton sink or source (PSS). The medical device is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
摘要翻译：本发明公开了一种从包括医疗装置，植入物伤口敷料组成的组中选择的医疗装置，其包括至少一个不溶性质子沉或源（PSS）。提供的医疗装置可用于杀死活细胞（LTC），或以其他方式破坏LTC在接触时的重要的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。

6. 发明授权

US07794698B2 Composition and methods for cell killing 有权
标题翻译：细胞杀伤的组成和方法
公开(公告)号：US07794698B2
公开(公告)日：2010-09-14
申请号：US11590756
申请日：2006-11-01
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61K31/74
CPC分类号： A61L2/16 , A01N25/00 , A01N25/10 , A61L2/23 , A61L2/232
摘要： A method of generating a change in a cellular process of a target cell is disclosed. The method comprises contacting the target cell with a solid buffer, so as to alter an intracellular pH value in at least a portion of the cell, thereby generating the change in a cellular process of a target cell of a multicellular organism. The method may be used to kill either eukaryotic or prokaryotic cells. Pharmaceutical compositions and devices are also enclosed.
摘要翻译：公开了一种产生目标单元的蜂窝过程变化的方法。该方法包括使靶细胞与固体缓冲液接触，以便改变细胞的至少一部分中的细胞内pH值，由此产生多细胞生物体的靶细胞的细胞过程的变化。该方法可用于杀死真核细胞或原核细胞。药物组合物和装置也被封闭。

7. 发明申请

US20100133114A1 BIOFILM DETERRENCE IN WATER SUPPLY SYSTEMS 审中-公开
标题翻译：水供应系统中的生物灭绝
公开(公告)号：US20100133114A1
公开(公告)日：2010-06-03
申请号：US12598431
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： C02F1/461 , A61L2/16
CPC分类号： A61L2/16 , A01N25/34 , A01N37/08 , A01N41/04 , A01N61/00 , C02F1/50 , C02F2303/20
摘要： Means and methods for deterring biofilm in water supply systems, comprising at least one insoluble proton sink or source (PSS). The means and methods for deterring biofilm is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
摘要翻译：在供水系统中阻止生物膜的方法和方法，包括至少一种不溶性质子沉或源（PSS）。用于阻止生物膜的方法和方法可用于杀死活细胞（LTC）或以其他方式破坏LTC在接触时的重要的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS正在有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持LTC的环境的pH。

8. 发明申请

US20090221985A1 SYSTEM FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF POLYMERIC AGENTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于聚合物的绝缘超导传输系统及其使用方法
公开(公告)号：US20090221985A1
公开(公告)日：2009-09-03
申请号：US12090675
申请日：2006-10-19
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61N1/30 , A61K38/02 , A61K31/728 , A61K38/39
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： A system for iontophoretic transdermal delivery of a non-peptidic polymeric cosmetic or therapeutic agent or of a polypeptide useful for delivery of high molecular weight cosmetic or therapeutic agents. Particularly, the present invention relates to a system that includes an iontophoresis device and a pharmaceutical composition of a non-peptidic polymeric cosmetic or therapeutic agent together with a peptide, polypeptide or protein and a pharmaceutically acceptable carrier having a pH below or above the isoelectric pH of the peptide, polypeptide or protein.
摘要翻译：用于离子电渗透皮递送非肽性聚合物化妆品或治疗剂或可用于递送高分子量化妆品或治疗剂的多肽的系统。特别地，本发明涉及一种系统，其包括离子电渗疗法装置和非肽聚合物化妆品或治疗剂的药物组合物以及肽，多肽或蛋白质以及pH低于或高于等电pH的药学上可接受的载体的肽，多肽或蛋白质。

9. 发明授权

US07354733B2 Method for sorting and separating living cells 有权
标题翻译：活细胞分选分离方法
公开(公告)号：US07354733B2
公开(公告)日：2008-04-08
申请号：US10105628
申请日：2002-03-26
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： C12Q1/28
CPC分类号： G01N1/4044 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2400/0454 , B82Y30/00 , G01N15/1475 , G01N21/6456 , G01N2001/2826 , G01N2015/1006 , G01N2015/149 , G01N2021/6439 , G01N2021/6441 , Y10S435/96 , Y10S435/968 , Y10S436/801 , Y10S436/905
摘要： We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a photosensitive metal compound to form metal grains, particles or crystals. The metal adheres to the cells and forms the basis for sorting or separating different cell types. Photophoric labels may include chemiluminescent agents such as peroxidase enzymes activated with peroxidase substrates capable of luminescence. Photosensitive metal compounds may be present in a light-sensitive matrix or emulsion containing photosensitizable metal compounds, which form metal grains, particles or crystals upon exposure to a developer solution. Developer solutions are formulated to substantially allow living cells to remain viable after exposure to the developing solution. Our methods are useful in flow cytometry and fluorescence activated cell sorting (FACS) methods, microdissection methods, and for attracting, sedimenting, depositing, layering, attaching, adhering, bonding, binding, trapping or suspending cells on surfaces.
摘要翻译：我们公开了分选或分离活细胞混合物（例如真核，原核，哺乳动物，致病菌，细菌，病毒等）的方法。我们通过激活细胞选择性光斑标记来执行我们的方法，光敏标记光敏化学和化学还原感光金属化合物以形成金属颗粒，颗粒或晶体。金属粘附到细胞并形成用于分选或分离不同细胞类型的基础。光致标记可以包括化学发光剂，例如能够发光的过氧化物酶底物活化的过氧化物酶。感光金属化合物可以存在于含有可光敏化的金属化合物的光敏基质或乳液中，其在暴露于显影剂溶液中时形成金属颗粒，颗粒或晶体。将显影剂溶液配制成基本上允许活细胞在暴露于显影溶液之后保持活性。我们的方法可用于流式细胞术和荧光激活细胞分选（FACS）方法，显微切割方法，以及用于在表面上吸引，沉淀，沉积，分层，附着，粘附，粘合，结合，捕获或悬浮细胞。

10. 发明申请

US20130040026A1 EXTENDED SHELF-LIFE LIQUIDS AND METHOD THEREOF 审中-公开
标题翻译：延长寿命的液体及其方法
公开(公告)号：US20130040026A1
公开(公告)日：2013-02-14
申请号：US13512969
申请日：2010-12-02
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A23L2/44 , A01N41/04 , A01P1/00 , A01N61/00
CPC分类号： A01N25/10 , A01N33/12 , A01N41/04 , A23L2/44 , A23L3/3463 , A23L3/3526 , A23L3/3535
摘要： A method of producing a liquid substantially free of beverage spoiling microorganisms, characterized in that said method comprises steps of: (a) obtaining a liquid; (b) obtaining a bioactive material that does not affect a predetermined set of organoleptic parameters of said liquid upon contact with said concentrate for a predetermined length of time; and, (c) treating said liquid with said bioactive material until the concentration of beverage-spoiling microorganism falls below a predetermined threshold.
摘要翻译：一种生产基本上不含饮料破坏微生物的液体的方法，其特征在于所述方法包括以下步骤：（a）获得液体; （b）获得生物活性材料，所述生物活性材料在与所述浓缩物接触预定长度的时间后不影响所述液体的预定组感官参数; 和（c）用所述生物活性材料处理所述液体，直到饮料破坏微生物的浓度降到预定阈值以下。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式