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1. 发明申请

US20060251651A1 Antagonist and agonist which bind to a strong binding site of chemokine receptor 审中-公开
标题翻译：拮抗剂和激动剂，其结合趋化因子受体的强结合位点
公开(公告)号：US20060251651A1
公开(公告)日：2006-11-09
申请号：US10538364
申请日：2003-12-12
申请人： Shiro Shibayama , Kenji Sagawa , Noriki Watanabe , Kazuhiko Takeda , Hideaki Tada , Daikichi Fukushima
发明人： Shiro Shibayama , Kenji Sagawa , Noriki Watanabe , Kazuhiko Takeda , Hideaki Tada , Daikichi Fukushima
IPC分类号： A61K39/395 , G01N33/567 , C07K16/28
CPC分类号： A61K31/49 , A61K31/00 , A61K31/503 , A61K31/5377 , G01N2333/715 , G01N2500/04
摘要： An antagonist or an agonist which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method; an antagonist or an agonist which binds to a strong binding site of a chemokine receptor; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of a chemokine receptor; and a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method. The antagonist or the agonist of the present invention is useful as a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer.
摘要翻译：结合CCR5的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合CCR5的强结合位点的化合物的方法; 包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂; 结合趋化因子受体的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合趋化因子受体的强结合位点的化合物的方法; 以及包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。本发明的拮抗剂或激动剂可用作过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。

2. 发明申请

US20100266539A1 CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF 审中-公开
标题翻译：化疗受体拮抗剂及其医疗用途
公开(公告)号：US20100266539A1
公开(公告)日：2010-10-21
申请号：US12731390
申请日：2010-03-25
申请人： Hiromu HABASHITA , Hiroshi Ochiai , Natsuko Tokuda , Shiro Shibayama , Noriki Watanabe , Takaki Komiya , Kazuhiko Takeda
发明人： Hiromu HABASHITA , Hiroshi Ochiai , Natsuko Tokuda , Shiro Shibayama , Noriki Watanabe , Takaki Komiya , Kazuhiko Takeda
IPC分类号： A61K38/21 , C07D213/76 , A61K31/44 , C07D401/12 , A61K31/444 , C07D241/22 , A61K31/4965 , A61K31/497 , C07D241/44 , A61K31/498 , C07D403/12 , C07D417/12 , A61K31/56 , A61K38/22 , A61P37/06 , A61P37/08 , A61P29/00 , A61P17/00 , A61P11/06 , A61K31/557
CPC分类号： C07D213/82 , C07D213/76 , C07D241/22 , C07D241/44 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc.), and the like], and the like.
摘要翻译：本发明涉及由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或前体药物及其医疗用途（式中的符号如说明书中所述）。由式（I）表示的化合物具有趋化因子受体（特别是CCR4和/或CCR5）拮抗活性。因此，可用于预防和/或治疗趋化因子受体介导的疾病如炎性和/或过敏性疾病[全身炎症反应综合征（SIRS），过敏反应，过敏反应，过敏性血管炎，移植排斥反应，肝炎，肾炎，肾病，胰腺炎，鼻炎，关节炎，炎症性眼病，炎性肠病，脑脊液和/或循环系统疾病，呼吸系统疾病，皮肤病，自身免疫性疾病等），感染[病毒性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷综合征，SARS等）等]等。

3. 发明授权

US07732442B2 Chemokine receptor antagonist and medical use thereof 失效
标题翻译：趋化因子受体拮抗剂及其医疗用途
公开(公告)号：US07732442B2
公开(公告)日：2010-06-08
申请号：US10570813
申请日：2004-09-03
申请人： Hiromu Habashita , Hiroshi Ochiai , Natsuko Tokuda , Shiro Shibayama , Noriki Watanabe , Takaki Komiya , Kazuhiko Takeda
发明人： Hiromu Habashita , Hiroshi Ochiai , Natsuko Tokuda , Shiro Shibayama , Noriki Watanabe , Takaki Komiya , Kazuhiko Takeda
IPC分类号： A61K31/538
CPC分类号： C07D213/82 , C07D213/76 , C07D241/22 , C07D241/44 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc.), and the like], and the like.
摘要翻译：本发明涉及由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或前体药物及其医疗用途（式中的符号如说明书中所述）。由式（I）表示的化合物具有趋化因子受体（特别是CCR4和/或CCR5）拮抗活性。因此，可用于预防和/或治疗趋化因子受体介导的疾病如炎性和/或过敏性疾病[全身炎症反应综合征（SIRS），过敏反应，过敏反应，过敏性血管炎，移植排斥反应，肝炎，肾炎，肾病，胰腺炎，鼻炎，关节炎，炎症性眼病，炎性肠病，脑脊液和/或循环系统疾病，呼吸系统疾病，皮肤病，自身免疫性疾病等），感染[病毒性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷综合征，SARS等）等]等。

4. 发明申请

US20070254886A1 Chemokine Receptor Antagonist and Medical Use Thereof 失效
标题翻译：趋化因子受体拮抗剂及其用途
公开(公告)号：US20070254886A1
公开(公告)日：2007-11-01
申请号：US10570813
申请日：2004-09-03
申请人： Hiromu Habashita , Hiroshi Ochiai , Natsuko Tokuda , Shiro Shibayama , Noriki Watanabe , Takaki Komiya , Kazuhiko Takeda
发明人： Hiromu Habashita , Hiroshi Ochiai , Natsuko Tokuda , Shiro Shibayama , Noriki Watanabe , Takaki Komiya , Kazuhiko Takeda
IPC分类号： A61K31/4412 , A61K31/444 , A61K31/4965 , A61K31/498 , A61P11/06 , A61P17/00 , A61P31/00 , A61P9/00 , C07D213/72 , C07D241/22 , C07D241/44
CPC分类号： C07D213/82 , C07D213/76 , C07D241/22 , C07D241/44 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc.), and the like], and the like.
摘要翻译：本发明涉及由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或前体药物及其医疗用途（式中的符号如说明书中所述）。由式（I）表示的化合物具有趋化因子受体（特别是CCR4和/或CCR5）拮抗活性。因此，可用于预防和/或治疗趋化因子受体介导的疾病如炎性和/或过敏性疾病[全身炎症反应综合征（SIRS），过敏反应，过敏反应，过敏性血管炎，移植排斥反应，肝炎，肾炎，肾病，胰腺炎，鼻炎，关节炎，炎症性眼病，炎性肠病，脑脊液和/或循环系统疾病，呼吸系统疾病，皮肤病，自身免疫性疾病等），感染[病毒性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷综合征，SARS等）等]等。

5. 发明授权

US08246955B2 Substance specific to human PD-1 有权
标题翻译：人PD-1特异性物质
公开(公告)号：US08246955B2
公开(公告)日：2012-08-21
申请号：US13169278
申请日：2011-06-27
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译：本发明涉及对人PD-1特异性的物质，其包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头。由于对人PD-1特异性的物质可以选择性地识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它可用于治疗和/或预防免疫病引起的疾病。

6. 发明申请

US20090263865A1 Substance Specific to Human PD-1 有权
标题翻译：人类PD-1特异性物质
公开(公告)号：US20090263865A1
公开(公告)日：2009-10-22
申请号：US12469188
申请日：2009-05-20
申请人： Tasuku HONJO , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku HONJO , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： C12P21/02 , C07K16/46 , C07H21/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译：本发明涉及对人PD-1特异性的物质，其包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头。由于对人PD-1特异性的物质可以选择性地识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它可用于治疗和/或预防免疫病引起的疾病。

7. 发明申请

US20130164294A1 SUBSTANCE SPECIFIC TO HUMAN PD-1 有权
公开(公告)号：US20130164294A1
公开(公告)日：2013-06-27
申请号：US13548807
申请日：2012-07-13
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.

8. 发明授权

US08951518B2 Substance specific to human PD-1 有权
公开(公告)号：US08951518B2
公开(公告)日：2015-02-10
申请号：US13548807
申请日：2012-07-13
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.

9. 发明授权

US07998479B2 Substance specific to human PD-1 有权
标题翻译：人PD-1特异性物质
公开(公告)号：US07998479B2
公开(公告)日：2011-08-16
申请号：US12469188
申请日：2009-05-20
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译：本发明涉及对人PD-1特异性的物质，其包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头。由于对人PD-1特异性的物质可以选择性地识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它可用于治疗和/或预防免疫病引起的疾病。

10. 发明授权

US07563869B2 Substance specific to human PD-1 有权
标题翻译：人PD-1特异性物质
公开(公告)号：US07563869B2
公开(公告)日：2009-07-21
申请号：US10543323
申请日：2004-01-22
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： C07K14/47 , C07K16/00 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译：本发明涉及对人PD-1特异性的物质，其包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头。由于对人PD-1特异性的物质可以选择性地识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它可用于治疗和/或预防免疫病引起的疾病。

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