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    • 10. 发明授权
    • Antagonistic human LIGHT-specific human monoclonal antibodies
    • 拮抗人类LIGHT特异性人单克隆抗体
    • US08461307B2
    • 2013-06-11
    • US13240356
    • 2011-09-22
    • Steven W. GrangerShinichiro KatoCarl F. Ware
    • Steven W. GrangerShinichiro KatoCarl F. Ware
    • C12P21/08
    • C07K16/24A61K2039/505C07K16/2875C07K2317/21C07K2317/34C07K2317/56C07K2317/565C07K2317/76
    • Provided herein are antibodies that immunospecifically bind to an hLIGHT polypeptide; isolated nucleic acids encoding the antibodies; vectors and host cells comprising nucleic acids encoding the antibodies; methods of making the antibodies; and a method of treating a hLIGHT-mediated disease in a subject comprising administering to the subject the antibodies. In preferred embodiments, the anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo (e.g., the hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
    • 本文提供了免疫特异性结合于hLIGHT多肽的抗体; 编码抗体的分离的核酸; 载体和宿主细胞,其包含编码抗体的核酸; 制备抗体的方法; 以及治疗受试者中的hLIGHT介导的疾病的方法,包括向受试者施用抗体。 在优选的实施方案中,本文提供的抗hLIGHT抗体可改善,中和或抑制体内的hLIGHT生物活性(例如,hLIGHT介导的来自表达hLIGHT受体的细胞的CCL20,IL-8或RANTES的产生或分泌)。 本文还提供了用于检测样品中的hLIGHT的方法以及用于改善,中和或抑制hLIGHT活性的方法,例如在患有hLIGHT活性有害的病症的人类受试者中。