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1. 发明授权

US08461307B2 Antagonistic human LIGHT-specific human monoclonal antibodies 有权
标题翻译：拮抗人类LIGHT特异性人单克隆抗体
公开(公告)号：US08461307B2
公开(公告)日：2013-06-11
申请号：US13240356
申请日：2011-09-22
申请人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
发明人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
IPC分类号： C12P21/08
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Provided herein are antibodies that immunospecifically bind to an hLIGHT polypeptide; isolated nucleic acids encoding the antibodies; vectors and host cells comprising nucleic acids encoding the antibodies; methods of making the antibodies; and a method of treating a hLIGHT-mediated disease in a subject comprising administering to the subject the antibodies. In preferred embodiments, the anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo (e.g., the hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
摘要翻译：本文提供了免疫特异性结合于hLIGHT多肽的抗体; 编码抗体的分离的核酸; 载体和宿主细胞，其包含编码抗体的核酸; 制备抗体的方法; 以及治疗受试者中的hLIGHT介导的疾病的方法，包括向受试者施用抗体。在优选的实施方案中，本文提供的抗hLIGHT抗体可改善，中和或抑制体内的hLIGHT生物活性（例如，hLIGHT介导的来自表达hLIGHT受体的细胞的CCL20，IL-8或RANTES的产生或分泌）。本文还提供了用于检测样品中的hLIGHT的方法以及用于改善，中和或抑制hLIGHT活性的方法，例如在患有hLIGHT活性有害的病症的人类受试者中。

2. 发明授权

US08058402B2 Antagonistic human LIGHT-specific human monoclonal antibodies 有权
标题翻译：拮抗人类LIGHT特异性人单克隆抗体
公开(公告)号：US08058402B2
公开(公告)日：2011-11-15
申请号：US12439518
申请日：2007-08-24
申请人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
发明人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
IPC分类号： C12P21/08
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Provided herein are antibodies, such as fully human antibodies that immunospecifically bind to an hLIGHT polypeptide. Also provided are isolated nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Further provided are vectors and host cells comprising nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided are methods of making antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided herein is a method of treating a hLIGHT-mediated disease in a subject comprising administering to the subject an antibody, such as a fully human antibody, that immunospecifically binds to a hLIGHT polypeptide. In preferred embodiments, that anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo (e.g., the hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
摘要翻译：本文提供了抗体，例如免疫特异性结合hLIGHT多肽的完全人抗体。还提供了编码抗体的分离的核酸，例如免疫特异性结合于hLIGHT多肽的完全人抗体。还提供了载体和宿主细胞，其包含免疫特异性结合hLIGHT多肽的编码抗体（例如完全人抗体）的核酸。还提供了制备免疫特异性结合hLIGHT多肽的抗体（例如完全人抗体）的方法。本文还提供了治疗受试者中的hLIGHT介导的疾病的方法，包括向受试者施用免疫特异性结合hLIGHT多肽的抗体，例如完全人抗体。在优选实施方案中，本文提供的抗-HLIGHT抗体将改善，中和或抑制体内的hLIGHT生物活性（例如，hLIGHT介导的来自表达hLIGHT受体的细胞的CCL20，IL-8或RANTES的产生或分泌）。本文还提供了用于检测样品中的hLIGHT的方法以及用于改善，中和或抑制hLIGHT活性的方法，例如在患有hLIGHT活性有害的病症的人类受试者中。

3. 发明申请

US20100021466A1 Antagonistic Human LIGHT-Specific Human Monoclonal Antibodies 有权
标题翻译：拮抗人类LIGHT特异性人类单克隆抗体
公开(公告)号：US20100021466A1
公开(公告)日：2010-01-28
申请号：US12439518
申请日：2007-08-24
申请人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
发明人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , A61P1/00 , C12N5/02
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Provided herein are antibodies, such as fully human antibodies that immunospecifically bind to an hLIGHT polypeptide. Also provided are isolated nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Further provided are vectors and host cells comprising nucleic acids encoding antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided are methods of making antibodies, such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide. Also provided herein is a method of treating a hLIGHT-mediated disease in a subject comprising administering to the subject an antibody, such as a fully human antibody, that immunospecifically binds to a hLIGHT polypeptide. In preferred embodiments, that anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo (e.g., the hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
摘要翻译：本文提供了抗体，例如免疫特异性结合hLIGHT多肽的完全人抗体。还提供了编码抗体的分离的核酸，例如免疫特异性结合于hLIGHT多肽的完全人抗体。还提供了载体和宿主细胞，其包含免疫特异性结合hLIGHT多肽的编码抗体（例如完全人抗体）的核酸。还提供了制备免疫特异性结合hLIGHT多肽的抗体（例如完全人抗体）的方法。本文还提供了治疗受试者中的hLIGHT介导的疾病的方法，包括向受试者施用免疫特异性结合hLIGHT多肽的抗体，例如完全人抗体。在优选实施方案中，本文提供的抗-HLIGHT抗体将改善，中和或抑制体内的hLIGHT生物活性（例如，hLIGHT介导的来自表达hLIGHT受体的细胞的CCL20，IL-8或RANTES的产生或分泌）。本文还提供了用于检测样品中的hLIGHT的方法以及用于改善，中和或抑制hLIGHT活性的方法，例如在患有hLIGHT活性有害的病症的人类受试者中。

4. 发明申请

US20120076798A1 Antagonistic Human LIGHT-Specific Human Monoclonal Antibodies 有权
标题翻译：拮抗人类LIGHT特异性人类单克隆抗体
公开(公告)号：US20120076798A1
公开(公告)日：2012-03-29
申请号：US13240356
申请日：2011-09-22
申请人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
发明人： Steven W. Granger , Shinichiro Kato , Carl F. Ware
IPC分类号： A61K39/395 , C12N15/13 , C12N1/21 , C12P21/00 , C12N5/16 , C07K16/24 , C12N5/10
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Provided herein are antibodies that immunospecifically bind to an hLIGHT polypeptide; isolated nucleic acids encoding the antibodies; vectors and host cells comprising nucleic acids encoding the antibodies; methods of making the antibodies; and a method of treating a hLIGHT-mediated disease in a subject comprising administering to the subject the antibodies. In preferred embodiments, the anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo (e.g., the hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
摘要翻译：本文提供了免疫特异性结合于hLIGHT多肽的抗体; 编码抗体的分离的核酸; 载体和宿主细胞，其包含编码抗体的核酸; 制备抗体的方法; 以及治疗受试者中的hLIGHT介导的疾病的方法，包括向受试者施用抗体。在优选的实施方案中，本文提供的抗hLIGHT抗体将改善，中和或抑制体内的hLIGHT生物活性（例如，hLIGHT介导的来自表达hLIGHT受体的细胞的CCL20，IL-8或RANTES的产生或分泌）。本文还提供了用于检测样品中的hLIGHT的方法以及用于改善，中和或抑制hLIGHT活性的方法，例如在患有hLIGHT活性有害的病症的人类受试者中。

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