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1. 发明申请

US20130276275A1 ROTARY DRUM FOR FIBER-STACKING DEVICE 有权
标题翻译：用于纤维堆叠装置的旋转鼓
公开(公告)号：US20130276275A1
公开(公告)日：2013-10-24
申请号：US13824523
申请日：2011-09-28
申请人： Shinichi Ishikawa , Tomohiro Fujiwara
发明人： Shinichi Ishikawa , Tomohiro Fujiwara
IPC分类号： D04H1/736
CPC分类号： D04H1/736 , A61F13/15617 , A61F13/53 , D04H5/08
摘要： A rotary drum for a fiber-stacking device includes a drum body, pattern plates each having a single fiber-stacking depression, and holding mechanisms each detachably holding a corresponding pattern plate on the outer circumferential surface of the drum body. Each holding mechanism has a fixed hook and a moveable hook. The fixed hook is immovably attached to one side of the drum body and forms a first groove with the drum body. The movable hook is attached to the other side of the drum body to be moveable between a holding position and a release position, forms a second groove with the drum body at the holding position, and opens the second groove at the release position. When the movable hook is at the holding position, the two side parts of the pattern plate are accommodated inside the first and second grooves.
摘要翻译：用于纤维堆叠装置的旋转滚筒包括：滚筒体，每个都具有单个纤维堆叠凹部的图案板;以及保持机构，每个可拆卸地将对应的图案板保持在滚筒本体的外圆周表面上。每个保持机构具有固定钩和可动钩。固定钩不可移动地附接到滚筒主体的一侧，并与滚筒主体形成第一凹槽。可移动钩附接到鼓体的另一侧以在保持位置和释放位置之间移动，在保持位置处形成具有鼓体的第二凹槽，并在释放位置打开第二凹槽。当可动钩处于保持位置时，图案板的两个侧部容纳在第一和第二槽内。

2. 发明授权

US08875359B2 Rotary drum of fiber-stacking device 有权
标题翻译：纤维堆叠装置的旋转鼓
公开(公告)号：US08875359B2
公开(公告)日：2014-11-04
申请号：US13824523
申请日：2011-09-28
申请人： Shinichi Ishikawa , Tomohiro Fujiwara
发明人： Shinichi Ishikawa , Tomohiro Fujiwara
IPC分类号： D04H5/08 , D04H1/736 , A61F13/15 , A61F13/53
CPC分类号： D04H1/736 , A61F13/15617 , A61F13/53 , D04H5/08
摘要： A rotary drum for a fiber-stacking device includes a drum body, pattern plates each having a single fiber-stacking depression, and holding mechanisms each detachably holding a corresponding pattern plate on the outer circumferential surface of the drum body. Each holding mechanism has a fixed hook and a moveable hook. The fixed hook is immovably attached to one side of the drum body and forms a first groove with the drum body. The movable hook is attached to the other side of the drum body to be moveable between a holding position and a release position, forms a second groove with the drum body at the holding position, and opens the second groove at the release position. When the movable hook is at the holding position, the two side parts of the pattern plate are accommodated inside the first and second grooves.
摘要翻译：用于纤维堆叠装置的旋转滚筒包括：滚筒体，每个都具有单个纤维堆叠凹部的图案板;以及保持机构，每个可拆卸地将对应的图案板保持在滚筒本体的外圆周表面上。每个保持机构具有固定钩和可动钩。固定钩不可移动地附接到滚筒主体的一侧，并与滚筒主体形成第一凹槽。可移动钩附接到鼓体的另一侧以在保持位置和释放位置之间移动，在保持位置处形成具有鼓体的第二凹槽，并在释放位置打开第二凹槽。当可动钩处于保持位置时，图案板的两个侧部容纳在第一和第二槽内。

3. 发明授权

US09314968B2 Pressing apparatus associated with an absorbent article, and pressing method 有权
标题翻译：与吸收性物品相关的按压装置，以及按压方法
公开(公告)号：US09314968B2
公开(公告)日：2016-04-19
申请号：US13819721
申请日：2011-08-22
申请人： Tomohiro Fujiwara , Osamu Ishikawa
发明人： Tomohiro Fujiwara , Osamu Ishikawa
IPC分类号： B29C65/00 , B29C43/28 , B29C43/30 , B29C65/18 , B29C65/48 , B29C65/52 , B32B37/22 , B65H37/04 , B32B37/10 , B29C65/30 , B32B37/06 , A61F13/15 , B29L31/48 , B32B37/12
CPC分类号： B29C66/91631 , A61F13/15699 , A61F13/15739 , B29C43/28 , B29C43/30 , B29C65/18 , B29C65/305 , B29C65/4815 , B29C65/524 , B29C65/526 , B29C66/1122 , B29C66/43 , B29C66/433 , B29C66/45 , B29C66/472 , B29C66/7294 , B29C66/83413 , B29C66/83415 , B29C66/91216 , B29C66/91231 , B29C66/91421 , B29C66/91431 , B29C66/91641 , B29C66/91651 , B29C66/919 , B29C66/93451 , B29C66/961 , B29L2031/4878 , B32B37/06 , B32B37/10 , B32B37/12 , B32B37/22 , B32B2037/1215 , B32B2309/02 , B32B2309/72 , B32B2555/02 , B65H37/04 , B65H2301/43822
摘要： A pressing apparatus associated with an absorbent article, including: a pair of rollers that are driven and rotate with outer circumferential surfaces thereof facing each other, when a fibrous continuous sheet overlapped with an article to be overlapped with a thermoplastic adhesive therebetween is passed in a continuous direction of the fibrous continuous sheet through a roller gap between the pair of rollers, the pressing apparatus sandwiching and pressing the article to be overlapped and the fibrous continuous sheet between the outer circumferential surfaces, and a heating mechanism that heats at least a roller of the pair of rollers that is positioned on a side of the fibrous continuous sheet, the heating mechanism heating the roller so as to keep a temperature of the outer circumferential surface of the roller within a range from 70° C. to 120° C.
摘要翻译：一种与吸收性物品相关的按压装置，包括：一对辊子，当与其间与热塑性粘合剂重叠的物品重叠的纤维状连续片材与其中的热塑性粘合剂重叠的纤维连续片材通过时，被驱动并旋转，其外周面彼此面对纤维连续片的连续方向通过一对辊之间的辊间隙，压制装置夹持并挤压待重叠的制品和外周表面之间的纤维连续片，以及加热机构，其加热至少一个辊一对辊定位在纤维连续片的一侧，加热机构加热辊，以使辊的外圆周表面的温度保持在70℃至120℃的范围内。

4. 发明授权

US09322016B2 MicroRNA-based methods and assays for osteosarcoma 有权
标题翻译：用于骨肉瘤的基于微RNA的方法和测定
公开(公告)号：US09322016B2
公开(公告)日：2016-04-26
申请号：US14240178
申请日：2012-09-07
申请人： Takahiro Ochiya , Tomohiro Fujiwara
发明人： Takahiro Ochiya , Tomohiro Fujiwara
IPC分类号： A61K48/00 , C12N15/113 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/113 , A61B5/055 , A61B5/4504 , A61B6/032 , A61B6/505 , A61B10/025 , C12N2310/113 , C12N2310/141 , C12N2310/3231 , C12N2320/11 , C12N2320/31 , C12Q1/6886 , C12Q2600/178 , G01N33/5011
摘要： Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
摘要翻译：提供了用于诊断，治疗和监测骨肉瘤的方法和组合物。发现与癌症干细胞（CSCs）或肿瘤起始细胞（TIC）相关的某些微小RNA（miRNA）对于骨肉瘤的反义有助于抑制肿瘤生长和转移，延长存活期。 miR-133a的反义寡核苷酸与标准化疗如顺铂联合用于治疗骨肉瘤。

5. 发明申请

US20130220541A1 PRESSING APPARATUS ASSOCIATED WITH AN ABSORBENT ARTICLE, AND PRESSING METHOD 有权
标题翻译：与吸收制品相关的压制装置和压制方法
公开(公告)号：US20130220541A1
公开(公告)日：2013-08-29
申请号：US13819721
申请日：2011-08-22
申请人： Tomohiro Fujiwara , Osamu Ishikawa
发明人： Tomohiro Fujiwara , Osamu Ishikawa
IPC分类号： B32B37/10
CPC分类号： B29C66/91631 , A61F13/15699 , A61F13/15739 , B29C43/28 , B29C43/30 , B29C65/18 , B29C65/305 , B29C65/4815 , B29C65/524 , B29C65/526 , B29C66/1122 , B29C66/43 , B29C66/433 , B29C66/45 , B29C66/472 , B29C66/7294 , B29C66/83413 , B29C66/83415 , B29C66/91216 , B29C66/91231 , B29C66/91421 , B29C66/91431 , B29C66/91641 , B29C66/91651 , B29C66/919 , B29C66/93451 , B29C66/961 , B29L2031/4878 , B32B37/06 , B32B37/10 , B32B37/12 , B32B37/22 , B32B2037/1215 , B32B2309/02 , B32B2309/72 , B32B2555/02 , B65H37/04 , B65H2301/43822
摘要： A pressing apparatus associated with an absorbent article, including: a pair of rollers that are driven and rotate with outer circumferential surfaces thereof facing each other, when a fibrous continuous sheet overlapped with an article to be overlapped with a thermoplastic adhesive therebetween is passed in a continuous direction of the fibrous continuous sheet through a roller gap between the pair of rollers, the pressing apparatus sandwiching and pressing the article to be overlapped and the fibrous continuous sheet between the outer circumferential surfaces, and a heating mechanism that heats at least a roller of the pair of rollers that is positioned on a side of the fibrous continuous sheet, the heating mechanism heating the roller so as to keep a temperature of the outer circumferential surface of the roller within a range from 70° C. to 120° C.
摘要翻译：一种与吸收性物品相关的按压装置，包括：一对辊子，当与其间与热塑性粘合剂重叠的物品重叠的纤维状连续片材与其中的热塑性粘合剂重叠的纤维连续片材通过时，被驱动并旋转，其外周面彼此面对。纤维连续片的连续方向通过一对辊之间的辊间隙，压制装置夹持并挤压待重叠的制品和外周表面之间的纤维连续片，以及加热机构，其加热至少一个辊一对辊定位在纤维连续片的一侧，加热机构加热辊，以使辊的外圆周表面的温度保持在70℃至120℃的范围内。

6. 发明申请

US20140243392A1 MicroRNA-Based Methods and Assays for Osteosarcoma 有权
标题翻译：基于微RNA的骨肉瘤的方法和测定
公开(公告)号：US20140243392A1
公开(公告)日：2014-08-28
申请号：US14240178
申请日：2012-09-07
申请人： Takahiro Ochiya , Tomohiro Fujiwara
发明人： Takahiro Ochiya , Tomohiro Fujiwara
IPC分类号： C12N15/113 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/113 , A61B5/055 , A61B5/4504 , A61B6/032 , A61B6/505 , A61B10/025 , C12N2310/113 , C12N2310/141 , C12N2310/3231 , C12N2320/11 , C12N2320/31 , C12Q1/6886 , C12Q2600/178 , G01N33/5011
摘要： Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
摘要翻译：提供了用于诊断，治疗和监测骨肉瘤的方法和组合物。发现与癌症干细胞（CSCs）或肿瘤起始细胞（TIC）相关的某些微小RNA（miRNA）对于骨肉瘤的反义有助于抑制肿瘤生长和转移，延长存活期。 miR-133a的反义寡核苷酸与标准化疗如顺铂联合用于治疗骨肉瘤。

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