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1. 发明授权

US07353054B2 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US07353054B2
公开(公告)日：2008-04-01
申请号：US10571430
申请日：2004-09-09
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/165
摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.
摘要翻译：提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估该疾病，并且通过应用提取的特征量和存储在存储器中的特征量的特征量之间的相似性的多变量分析来评估疾病单位12.评估结果以条形图表示与各疾病组相似度的分数。

2. 发明申请

US20090118602A1 Disease Diagnosis Support System 有权
标题翻译：疾病诊断支援系统
公开(公告)号：US20090118602A1
公开(公告)日：2009-05-07
申请号：US11916892
申请日：2006-06-08
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/1455
CPC分类号： A61B5/145 , A61B5/14546 , A61B5/14553 , G06F19/00 , G16H50/70
摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.
摘要翻译：提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分，包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为在散点图上进行评估，叠加在散点图上。利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

3. 发明授权

US08386192B2 Disease diagnosis support system 有权
标题翻译：疾病诊断支持系统
公开(公告)号：US08386192B2
公开(公告)日：2013-02-26
申请号：US11916892
申请日：2006-06-08
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
IPC分类号： G01N33/48
CPC分类号： A61B5/145 , A61B5/14546 , A61B5/14553 , G06F19/00 , G16H50/70
摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.
摘要翻译：提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分，包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为在散点图上进行评估，叠加在散点图上。利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

4. 发明申请

US20070055118A1 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US20070055118A1
公开(公告)日：2007-03-08
申请号：US10571430
申请日：2004-09-09
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/165
摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.
摘要翻译：提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估疾病，并且通过在存储的特征量和特征量之间的相似性的多变量分析中应用多变量分析，单位12.评估结果以条形图表示与各疾病组相似度的分数。

5. 发明申请

US20100256468A1 APPARATUS FOR MEASURING BIOLOGICAL LIGHT 审中-公开
标题翻译：用于测量生物光的装置
公开(公告)号：US20100256468A1
公开(公告)日：2010-10-07
申请号：US12600285
申请日：2008-02-01
申请人： Naoki Tanaka , Masashi Kiguchi , Atsushi Maki , Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi
发明人： Naoki Tanaka , Masashi Kiguchi , Atsushi Maki , Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi
IPC分类号： A61B5/1455 , G06N5/02
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/14553
摘要： The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.
摘要翻译：将正常对照受试者与非正常对照受试者分离并将疾病彼此分离的效率提高。使用具有分层结构的多个分类模型，并且获取在多个分类模型中使用的测量数据的区域在分类模型之间不同。

6. 发明授权

US08019399B2 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US08019399B2
公开(公告)日：2011-09-13
申请号：US10578725
申请日：2004-11-01
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
IPC分类号： A61B5/1455
CPC分类号： G06K9/0051 , A61B5/0261 , A61B5/4064 , A61B5/7203 , G06T5/002
摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.
摘要翻译：对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

7. 发明申请

US20070142719A1 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US20070142719A1
公开(公告)日：2007-06-21
申请号：US10578725
申请日：2004-11-01
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
IPC分类号： A61B5/00
CPC分类号： G06K9/0051 , A61B5/0261 , A61B5/4064 , A61B5/7203 , G06T5/002
摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.
摘要翻译：对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

8. 发明申请

US20090054885A1 BIOLOGICAL PHOTOMETRIC DEVICE 有权
标题翻译：生物光学设备
公开(公告)号：US20090054885A1
公开(公告)日：2009-02-26
申请号：US11816452
申请日：2006-02-02
申请人： Shingo Kawasaki , Naoki Tanaka
发明人： Shingo Kawasaki , Naoki Tanaka
IPC分类号： A61B18/18
CPC分类号： A61B5/0059 , A61B5/14546 , A61B5/14553 , G01N21/4795
摘要： A biological photometric device includes a light irradiating unit for irradiating an object to be examined with light having a predetermined wavelength and sympathizing with oxygenated hemoglobin and deoxygenated hemoglobin through an optical fiber, a light detecting unit for detecting and amplifying light passing through a detecting optical fiber and the object as detected signals, a signal processing unit adapted for computing hemoglobin time change information based on oxygenated hemoglobin, deoxygenated hemoglobin and total hemoglobin in the object from the detected signals light detecting unit, and including a noise detector for arithmetically processing the detected signals and determining/detecting whether the time change information is noise attributed to the presence of obstacles to passing of light between the object and the end face of the optical fiber or noise attributed to the damage to the light irradiating unit, and a display unit for displaying the noise signals.
摘要翻译：一种生物测光装置，其特征在于，包括：光照射单元，用于通过光纤对具有预定波长的光进行照射并与氧合血红蛋白和脱氧血红蛋白同步的光进行照射，光检测单元，用于检测和放大通过检测光纤的光所述物体作为检测信号，信号处理单元适于根据来自检测信号光检测单元的所述物体中的氧合血红蛋白，脱氧血红蛋白和总血红蛋白计算血红蛋白时间变化信息，并且包括用于对检测信号进行算术处理的噪声检测器以及确定/检测时间变化信息是否归因于在光纤的物体和端面之间的光通过的障碍物的存在或归因于对光照射单元的损坏的噪声的噪声;以及显示单元，用于显示噪声信号。

9. 发明申请

US20060206017A1 Living body photometric device 有权
标题翻译：生命体测光装置
公开(公告)号：US20060206017A1
公开(公告)日：2006-09-14
申请号：US10526893
申请日：2003-09-05
申请人： Shingo Kawasaki , Naoki Tanaka
发明人： Shingo Kawasaki , Naoki Tanaka
IPC分类号： A61B5/00
CPC分类号： A61B5/1455
摘要： By making use of a set of loading of stimulation and no loading, variation signals in time of hemoglobin density at a plurality of measurement points of a subject attached of an optical measurement probe and corresponding to a plurality of channels are detected, and for the respective detected hemoglobin variation signals principal component analysis is performed as well as a representative signal having a higher contribution rate is extracted and the extracted representative signal is displayed on a monitor. A correlation between the representative signal and a task reference and response waveform representing a response pattern of a living body in response to a stimulation task is calculated, and a representative signal having the highest correlation value as calculated is displayed in a discriminable manner from the other signals as a task related signal which responds most to the stimulation given to the subject. From weights of the respective channels for the representative signal displayed as the task related signal, an optical measurement point or region, which responds most to the task is identified and displayed in discriminable manner.
摘要翻译：通过利用一组刺激负荷和无载荷，检测在光学测量探针附着并对应于多个通道的受试者的多个测量点处的血红蛋白密度的变化信号，并且对于相应的检测出的血红蛋白变化信号进行主成分分析，并提取具有较高贡献率的代表信号，并将提取的代表信号显示在监视器上。计算代表信号和表示响应于刺激任务的生物体的响应模式的任务参考和响应波形之间的相关性，并且以可计算的方式从其他方式显示具有计算的相关值最高的代表信号信号作为对给予对象的刺激最响应的任务相关信号。从显示为任务相关信号的代表信号的相应通道的权重中，以可区分的方式识别和显示对该任务最响应的光学测量点或区域。

10. 发明授权

US07725145B2 Biological photometric device 有权
标题翻译：生物测光装置
公开(公告)号：US07725145B2
公开(公告)日：2010-05-25
申请号：US11816452
申请日：2006-02-02
申请人： Shingo Kawasaki , Naoki Tanaka
发明人： Shingo Kawasaki , Naoki Tanaka
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/14546 , A61B5/14553 , G01N21/4795
摘要： A biological photometric device includes a light irradiating unit for irradiating an object to be examined with light having a predetermined wavelength and sympathizing with oxygenated hemoglobin and deoxygenated hemoglobin through an optical fiber, a light detecting unit for detecting and amplifying light passing through a detecting optical fiber and the object as detected signals, a signal processing unit adapted for computing hemoglobin time change information based on oxygenated hemoglobin, deoxygenated hemoglobin and total hemoglobin in the object from the detected signals light detecting unit, and including a noise detector for arithmetically processing the detected signals and determining/detecting whether the time change information is noise attributed to the presence of obstacles to passing of light between the object and the end face of the optical fiber or noise attributed to the damage to the light irradiating unit, and a display unit for displaying the noise signals.
摘要翻译：一种生物测光装置，其特征在于，包括：光照射单元，用于通过光纤对具有预定波长的光进行照射并与氧合血红蛋白和脱氧血红蛋白同步的光进行照射，光检测单元，用于检测和放大通过检测光纤的光所述物体作为检测信号，信号处理单元适于根据来自检测信号光检测单元的所述物体中的氧合血红蛋白，脱氧血红蛋白和总血红蛋白计算血红蛋白时间变化信息，并且包括用于对检测信号进行算术处理的噪声检测器以及确定/检测时间变化信息是否归因于在光纤的物体和端面之间的光通过的障碍物的存在或归因于对光照射单元的损坏的噪声的噪声;以及显示单元，用于显示噪声信号。

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