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1. 发明授权

US4640218A Tablet coating apparatus 失效
标题翻译：片剂涂布装置
公开(公告)号：US4640218A
公开(公告)日：1987-02-03
申请号：US537739
申请日：1983-09-30
申请人： Shimesu Motoyama , Masakazu Gotou , Hiromu Shirakawa , Takamoto Makino
发明人： Shimesu Motoyama , Masakazu Gotou , Hiromu Shirakawa , Takamoto Makino
IPC分类号： A23P1/00 , A23G3/26 , A61J3/00 , A61J3/06 , B01J2/00 , B01J2/12 , B01J2/14 , B05C5/00 , B05C19/00
CPC分类号： A61J3/005 , A23G3/26
摘要： An apparatus for coating pharmaceutical tablets or the like with other material such as sugar or the like. The apparatus includes a cylindrical rotary drum in which the tablets are charged and tumbled, and at least one perforated area for ventilating hot gas or the like so as to dry the sugar coated on the tablets. The perforated area of the drum is covered by a baffle plate. The leading edge of the baffle plate is in contact with the inner surface of the drum, and the trailing edge of the baffle plate forms a ventilating opening through which the hot gas flows. The side edges of the baffle plate is provided with side plates. The ventilating opening is provided with a ventilating plate.
摘要翻译：用其他材料如糖等涂覆药片等的装置。该装置包括一个圆柱形的旋转鼓，其中片剂被装载和翻滚，以及至少一个用于通风热气等的穿孔区域，以便干燥涂在片剂上的糖。滚筒的穿孔区域被挡板覆盖。挡板的前缘与滚筒的内表面接触，挡板的后缘形成热气流过的通风口。挡板的侧边缘设有侧板。通风口设有通风板。

2. 发明授权

US4799449A Coating apparatus 失效
标题翻译：涂装设备
公开(公告)号：US4799449A
公开(公告)日：1989-01-24
申请号：US946135
申请日：1986-12-23
申请人： Katsuaki Miyata , Yutaka Sakuma , Shimesu Motoyama , Masakazu Gotou , Hiromu Shirakawa , Takamoto Makino
发明人： Katsuaki Miyata , Yutaka Sakuma , Shimesu Motoyama , Masakazu Gotou , Hiromu Shirakawa , Takamoto Makino
IPC分类号： A23G3/26 , A61J3/00 , A61J3/06 , F26B11/02 , F26B11/04 , B05C5/00
CPC分类号： A61J3/005 , A23G3/26
摘要： An apparatus for coating pharmaceutical tablets or the like with other material such as sugar or the like. The apparatus includes a cylindrical rotary coating pan in which the tablets are charged and tumbled, and at least one perforated area for ventilating hot gas or the like so as to dry the sugar coated on the tablets. The perforated area of the coating pan is covered by each of baffle members. The baffle members being hollow are provided at positions to cover ventilating areas in the the coating pan, formed to be at least partially increased in width from the leading edge to the trailing edge relative to the rotational direction of the coating pan, and each have a ventilating opening communicated with the ventilating areas. Each of baffle members is formed of a hollow tube polygonal or cylindrical in cross section. A ventilating member for preventing a raw material to be coated from leaking is provided at the ventilating opening of the baffle member.
摘要翻译：用其他材料如糖等涂覆药片等的装置。该装置包括一个圆柱形旋转涂布盘，其中片剂被装入和翻滚，以及至少一个用于通风热气等的穿孔区域，以便干燥涂在片剂上的糖。涂覆盘的穿孔区域被每个挡板构件覆盖。所述挡板构件设置在覆盖所述涂覆盘中的通风区域的位置处，所述通风区域形成为相对于所述涂布盘的旋转方向从所述前缘至所述后缘至少部分地增加宽度，并且每个具有通风口与通风区通信。每个挡板构件由多边形或圆柱形的中空管的横截面形成。在挡板部件的通风口设置有用于防止被涂布原料泄漏的通气部件。

3. 发明授权

US4472960A Method of and apparatus for testing properties 失效
标题翻译：性能测试方法和设备
公开(公告)号：US4472960A
公开(公告)日：1984-09-25
申请号：US287687
申请日：1981-07-28
申请人： Shimesu Motoyama , Kaoru Kurita , Akira Iwasaki
发明人： Shimesu Motoyama , Kaoru Kurita , Akira Iwasaki
IPC分类号： G01N33/00 , G01N33/15 , G01N35/00 , G01N3/56 , G01N3/40
CPC分类号： G01N33/15 , G01N35/00 , G01N2033/0077
摘要： Method of and apparatus for testing required properties of the specimen solids such as tablets, pills, granules, capsules, etc. automatically and continuously. After nondestructive tests are performed, then destructive tests are performed automatically and continuously. The data obtained by the tests can be processed to record and display the processed data. The nondestructive tests comprise at least one of the tests of the weight, diameter, thickness, color difference, and surface area, etc. which are performed in order or simultaneously. The destructive tests comprise at least one of the tests of the hardness, disintegration, dissolution, abrasion and chemical analysis. The apparatus consists of supply a mechanism for supplying the solids, nondestructive test mechanisms, destructive test mechanisms and a system for transferring solids from one test position to the next test position.
摘要翻译：自动连续地测试样品固体如片剂，丸剂，颗粒剂，胶囊等所需性质的方法和装置。进行非破坏性试验后，自动连续进行破坏性试验。可以处理通过测试获得的数据来记录和显示处理的数据。非破坏性试验包括按顺序或同时进行的重量，直径，厚度，色差和表面积等的试验中的至少一种。破坏性测试包括硬度，分解，溶解，磨损和化学分析的至少一个测试。该设备包括提供用于供应固体的机构，非破坏性测试机构，破坏性测试机构和用于将固体从一个测试位置传递到下一个测试位置的系统。

4. 发明授权

US4027624A Fluid granulating/coating apparatus utilizing suction air current 失效
标题翻译：利用吸入气流的流体造粒/涂布装置
公开(公告)号：US4027624A
公开(公告)日：1977-06-07
申请号：US615123
申请日：1975-09-19
申请人： Shimesu Motoyama
发明人： Shimesu Motoyama
IPC分类号： A61J3/06 , B01J2/16 , B05B17/00
CPC分类号： B01J2/16
摘要： In the fluid granulating/coating apparatus to be worked by utilizing suction air current, a granulating/coating apparatus wherein a receptacle for accommodating bag filters as disposed in the upper part of the apparatus is in the shape of a cylinder with smooth interior, the suction air current is supposed to be discharged by way of one side wall of said cylindrical receptacle, a fan for generating the suction air current and a damper for stopping air suction are installed on the outside of said cylindrical receptacle, and a large-sized safety lid is installed on the upper part of the cylindrical receptacle.
摘要翻译：在通过利用吸入气流加工的流体造粒/涂布装置中，制粒/涂布装置，其中设置在装置的上部的用于容纳袋式过滤器的容器是具有平滑内部的气缸的形状，假设气流通过所述圆筒形容器的一个侧壁排出，用于产生吸入气流的风扇和用于停止吸气的阻尼器安装在所述圆筒形容器的外侧，并且安装有大型安全盖安装在圆柱形容器的上部。

5. 发明授权

US4769945A Delivery unit of plant tissue 失效
标题翻译：植物组织交付单位
公开(公告)号：US4769945A
公开(公告)日：1988-09-13
申请号：US8737
申请日：1987-01-30
申请人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
发明人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
IPC分类号： A01C1/00 , A01G9/10 , A01H4/00 , C12M3/00 , A01C1/06
CPC分类号： A01G9/1033 , A01H4/001
摘要： A delivery unit of plant tissue of the present invention comprises a vessel in which meristematic tissue having the ability to grow into an entire plant body through differentiation is received. The body of the vessel is made of water-soluble substance and the interior thereof is covered with a water-insoluble substance. Hydrogel is charged in the vessel and the meristematic tissue is held by the hydrogel in a state in which its root or rooting portion is embedded therein or it is placed on the hydrogel. The vessel has a structure of a closed type with a cap or an open type. When the delivery unit of plant tissue is seeded in a medium, the water-soluble substance of the vessel body is dissolved by water contained in the medium and the bud and root grown out of the meristematic tissue breaks the thin film made of a water-insoluble substance which is provided in the interior of the vessel so as to further grow out.
摘要翻译：本发明的植物组织的输送单元包括容器，其中具有通过分化生长成整个植物体的能力的分生组织被接收。容器的主体由水溶性物质制成，其内部被水不溶性物质覆盖。将水凝胶装入容器中，分生组织由其根部或生根部分嵌入其中或将其置于水凝胶上的状态下由水凝胶保持。容器具有封闭形式的具有盖或开放型的结构。当植物组织的输送单元接种在培养基中时，容器体的水溶性物质被包含在培养基中的水溶解，并且从分生组织生长的芽和根分解由水 - 不溶物质，其设置在容器的内部以进一步生长。

6. 发明授权

US4756922A Powder coating method 失效
标题翻译：粉末涂布法
公开(公告)号：US4756922A
公开(公告)日：1988-07-12
申请号：US47779
申请日：1987-05-08
申请人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
发明人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
IPC分类号： A01G1/06 , A01C1/06 , A01G1/00 , A01H4/00 , C12N5/00 , C12N5/04 , B05D7/24
CPC分类号： A01H4/00 , Y10S47/11
摘要： A method in which a plant meristematic tissues which retain aqueous liquid on their surfaces are mixed with fine powder, thereby forming powder-coated bodies to which fine powder is adhered at the periphery thereof, so that meristematic tissues are separated from each other. A quantity of water or a liquid mainly consisting of water large enough to make fine powder adhere to the surfaces of the meristematic tissues which can grow into entire plant bodies directly or after they have passed through differentiation and organogenesis. The meristematic tissues are mixed with the fine powder which does not indicate adhesiveness at least during the mixing process. This mixing process is effected in such a manner that the powder is adhered to the tissues by gently shaking or agitating them without applying excessive shearing stress to the meristematic tissues.
摘要翻译：将其表面保持水性液体的植物分生组织与细粉末混合，从而在其周围形成附着微细粉末的粉末涂覆体，使分生组织彼此分离。一定量的水或液体主要由足够大的水组成的液体，以使细粉末粘附到分生组织的表面，其可以直接生长到整个植物体内，或者在它们通过分化和器官发生后生长。将分生组织与至少在混合过程中不表示粘合性的细粉末混合。这种混合过程以这样的方式进行：粉末通过轻轻地摇动或搅拌而粘附到组织上，而不对分生组织施加过大的剪切应力。

7. 发明授权

US4623098A Granulating and coating machine 失效
标题翻译：造粒机及涂布机
公开(公告)号：US4623098A
公开(公告)日：1986-11-18
申请号：US542471
申请日：1983-10-17
申请人： Shimesu Motoyama , Kaoru Kurita , Shizuka Sakashita , Narimichi Takei , Shigeru Ohno
发明人： Shimesu Motoyama , Kaoru Kurita , Shizuka Sakashita , Narimichi Takei , Shigeru Ohno
IPC分类号： B01J2/16 , B05B7/14 , B02C23/26
CPC分类号： B05B7/144 , B01J2/10 , B01J2/16 , B05B15/003
摘要： A machine for use in granulation, coating, mixing, drying etc. of powdery or granular raw materials such as medicine or foods etc. The machine is comprised of a casing for containing raw materials, a rotator for tumbling and giving centrifugal force to the material in the casing rotatable horizontally in the casing and at least one disintegrator provided above the rotator for subdividing undesirously large particles. At least one agitator is provided above the rotator for agitating and kneading materials to be granulated or coated. The rotator is movable or fixed in vertical position, and an annular slit is formed between an annular slit forming ring or inner wall of the casing and outer periphery of the rotator. The slit forming ring is movable or fixed in vertical position. At least one ventilating portion is formed on at least one portion of the rotator, and a gas flow rate adjusting mechanism is provided for controlling flow rate of gas passed through the ventilating portion.
摘要翻译：一种用于粉末或颗粒状原料如药物或食品等的造粒，涂布，混合，干燥等的机器。该机器包括用于包含原料的壳体，用于翻转并向材料提供离心力的旋转器在壳体中可水平旋转的壳体和设置在转子上方的至少一个分解器，用于细分不期望的大颗粒。在旋转体上方设置至少一个搅拌器，用于搅拌和捏合待造粒或涂覆的材料。旋转体可移动或固定在垂直位置，并且在环形狭缝形成环或壳体的内壁和旋转体的外周之间形成环形狭缝。狭缝形成环可在垂直位置上移动或固定。在旋转体的至少一部分上形成有至少一个通气部，并且设置有用于控制通过通气部的气体的流量的气体流量调节机构。

8. 发明授权

US4540602A Process for the preparation of activated pharmaceutical compositions 失效
标题翻译：活性药物组合物的制备方法
公开(公告)号：US4540602A
公开(公告)日：1985-09-10
申请号：US420384
申请日：1982-09-20
申请人： Shimesu Motoyama , Satashi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Suto , Yuko Takasaka , Takuichi Tsujino
发明人： Shimesu Motoyama , Satashi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Suto , Yuko Takasaka , Takuichi Tsujino
IPC分类号： A61K9/14 , A61K9/50 , B01J13/02
CPC分类号： A61K9/5047 , A61K9/14 , A61K9/5031 , A61K9/5036
摘要： Disclosed is a process for the preparation of an activated pharmaceutical composition containing a solid drug that is scarcely soluble in water, the pharmaceutical composition being characterized in that, when it is administered orally, the drug is readily absorbed to attain its high blood concentration quickly. This process is carried out by providing a solid drug that is scarcely soluble in water, dispersing the drug in water in the presence of a water-soluble high-molecular substance to form a disperse system containing the drug in the form of finely divided particles substantially not greater than 10.mu. in diameter, and then removing the water from the disperse system.
摘要翻译：公开了一种制备含有几乎不溶于水的固体药物的活性药物组合物的方法，该药物组合物的特征在于，口服给药时，药物容易被吸收以迅速达到高血药浓度。该方法通过提供几乎不溶于水的固体药物，在水溶性高分子物质的存在下将药物分散在水中，形成含有基本上细碎颗粒形式的药物的分散体系直径不大于10微米，然后从分散体系中除去水分。

9. 发明授权

US4310108A Aerosol sprayer with pressure reservoir 失效
标题翻译：气压喷雾器带压力贮存器
公开(公告)号：US4310108A
公开(公告)日：1982-01-12
申请号：US176448
申请日：1980-08-08
申请人： Shimesu Motoyama , Shuri Yamada , Kaoru Kurita , Akira Iwasaki
发明人： Shimesu Motoyama , Shuri Yamada , Kaoru Kurita , Akira Iwasaki
IPC分类号： B65D83/14 , G05D16/06 , B65D83/00
CPC分类号： B65D83/663 , G05D16/0655 , Y10T137/7808
摘要： An aerosol sprayer, which comprises a can for accommodating an aerosol material which is provided with a spray nozzle and connected with a pressure regulator, and a small-sized bomb which is charged with a highly compressed gas and connected with said pressure regulator.
摘要翻译：一种气溶胶喷雾器，其包括用于容纳设置有喷嘴并与压力调节器连接的气溶胶材料的罐，以及装有高压缩气体并与所述压力调节器连接的小型炸弹。

10. 发明授权

US4154636A Method of film-coating medicines 失效
标题翻译：薄膜包衣药方法
公开(公告)号：US4154636A
公开(公告)日：1979-05-15
申请号：US848741
申请日：1977-11-04
申请人： Shimesu Motoyama , Takuichi Tsujino
发明人： Shimesu Motoyama , Takuichi Tsujino
IPC分类号： A61J3/00 , A61K9/28 , A61K9/48 , B65B9/04 , B29C6/02
CPC分类号： A61K9/4833 , A61J3/005 , A61K9/28 , B30B11/34 , B65B9/045
摘要： A method of film-coating medicines which comprises either putting a prescribed dose of a medicine between two sheets capable of releasing the medicine wrapped therein within the digestive organs or putting a prescribed dose of a medicine in a tablet-shaped or capsule-shaped receptacle consisting of said film, and subsequently putting the films together so as to wrap the medicine therein.
摘要翻译：一种薄膜包衣药物的方法，其包括将规定剂量的药物放在两片能够释放消化器官内包裹的药物之间或将规定剂量的药物放入片状或胶囊形容器中的组合物的胶片，然后将胶片放在一起以将药物包裹在其中。

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