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1. 发明授权

US5622657A Prolonged release microparticle preparation and production of the same 失效
公开(公告)号：US5622657A
公开(公告)日：1997-04-22
申请号：US455546
申请日：1995-05-31
申请人： Shigeyuki Takada , Yoshiaki Uda , Yasuaki Ogawa
发明人： Shigeyuki Takada , Yoshiaki Uda , Yasuaki Ogawa
IPC分类号： A61K9/16 , A61K9/50 , B01J13/04 , B01J13/22
CPC分类号： A61K9/1694 , A61K9/1647 , A61K9/5015 , A61K9/5057 , A61K9/5073 , A61K9/5089 , Y10S514/963 , Y10T428/2984 , Y10T428/2985
摘要： A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are coated with a film of an agent for preventing aggregation of the microparticles is disclosed. The preparation is produced by spraying a solution of a polymer containing a drug and an aqueous solution of an agent for preventing aggregation of the microparticles separately from different nozzles and contacting them with each other in a spray dryer.

2. 发明授权

US5651990A Prolonged release microparticle preparation and production of the same 失效
标题翻译：延长释放微粒的制备和生产相同
公开(公告)号：US5651990A
公开(公告)日：1997-07-29
申请号：US387392
申请日：1995-02-13
申请人： Shigeyuki Takada , Yoshiaki Uda , Yasuaki Ogawa
发明人： Shigeyuki Takada , Yoshiaki Uda , Yasuaki Ogawa
IPC分类号： A61K9/16 , A61K9/50 , A61K9/58 , A61K9/62 , B01J13/04
CPC分类号： A61K9/1694 , A61K9/1647 , A61K9/5015 , A61K9/5057 , A61K9/5073 , A61K9/5089 , Y10S514/963 , Y10T428/2984 , Y10T428/2985
摘要： A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are coated with a film of an agent for preventing aggregation of the microparticles is disclosed. The preparation is produced by spraying a solution of a polymer containing a drug and an aqueous solution of an agent for preventing aggregation of the microparticles separately from different nozzles and contacting them with each other in a spray dryer.
摘要翻译：公开了一种新颖的微粒制剂，其包含含有药物的聚合物的微粒并涂覆有用于防止微粒聚集的试剂的膜。该制剂是通过喷雾含有药物的聚合物的溶液和用于防止微粒聚集的试剂的水溶液与不同的喷嘴分开并在喷雾干燥器中彼此接触来制备的。

3. 发明授权

US5486508A Cyclodextrin composition 失效
标题翻译：环糊精组成
公开(公告)号：US5486508A
公开(公告)日：1996-01-23
申请号：US236699
申请日：1994-04-28
申请人： Yoshiaki Uda , Yoko Nishida , Yasuaki Ogawa
发明人： Yoshiaki Uda , Yoko Nishida , Yasuaki Ogawa
IPC分类号： A61K9/00 , A61K31/216 , A61K31/335 , A61K31/336 , A61K31/546 , A61K31/5513 , A61K47/40 , A61K47/48 , A61K31/715 , A61K47/00
CPC分类号： B82Y5/00 , A61K31/216 , A61K31/335 , A61K31/336 , A61K31/546 , A61K31/5513 , A61K47/40 , A61K47/48969 , A61K9/0019
摘要： A pharmaceutical composition comprising a slightly water-soluble drug, a cyclodextrin and a water-soluble organic solvent is disclosed. The composition improves water-solubility and stability of the slightly water-soluble drug. The pharmaceutical composition is particularly suitable for injection preparations.
摘要翻译：公开了包含微溶于水的药物，环糊精和水溶性有机溶剂的药物组合物。该组合物改善了微溶于水的药物的水溶性和稳定性。药物组合物特别适用于注射制剂。

4. 发明授权

US5554378A Pharmaceutical composition and its mucosal use 失效
标题翻译：药物组合物及其粘膜使用
公开(公告)号：US5554378A
公开(公告)日：1996-09-10
申请号：US379114
申请日：1995-01-27
申请人： Yoshiaki Uda , Shigeyuki Takada , Yukio Fujisawa
发明人： Yoshiaki Uda , Shigeyuki Takada , Yukio Fujisawa
IPC分类号： A61K9/00 , A61K38/04 , A61K38/17 , A61K47/42 , C07K14/245 , A61F13/00
CPC分类号： A61K38/17 , A61K38/04 , A61K47/42 , A61K9/0043 , C07K14/245 , Y10S514/944
摘要： A pharmaceutical composition containing a physiologically active peptide or protein which is poorly absorbable through the gastrointestinal tract and heat-labile enterotoxin B subunit brings an increased absorbability of said peptide or protein into the mammalian body when administered through mucosa.
摘要翻译：含有通过胃肠道难以吸收的生理活性肽或蛋白质和热不稳定肠毒素B亚基的药物组合物当通过粘膜施用时，使所述肽或蛋白质向哺乳动物体内的吸收性提高。

5. 发明授权

US3945796A Apparatus for continuous, automatic sterilization of fluid in sealed containers 失效
标题翻译：用于连续自动灭菌密封容器中流体的装置
公开(公告)号：US3945796A
公开(公告)日：1976-03-23
申请号：US375475
申请日：1973-07-02
申请人： Kazuo Nagamatsu , Yoshitsugu Kinoshita , Seizo Kawajiri , Yoshiaki Uda
发明人： Kazuo Nagamatsu , Yoshitsugu Kinoshita , Seizo Kawajiri , Yoshiaki Uda
IPC分类号： F26B15/00 , A61L2/04 , A61L2/24 , A61L3/00 , B65G37/00
CPC分类号： A61L2/24
摘要： An apparatus for sterilization of fluid in sealed containers such as ampoules, the apparatus has a chamber provided with a hot air distributor therein, a magazine conveyor comprising a drum mounted to be rotable about its vertical axis in said chamber having compartment defining means thereon defining a plurality of vertically stacked tiers of compartments for accomodation and transportation of containers to be treated, said chamber having a plurality of bottom walls fixedly mounted therein one being associated with each tier of compartments and constituting the bottoms of said compartments each bottom wall having a gap therein, the gaps being at different circumferential positions, the gaps being for transferring containers inserted and carried in compartments automatically one after the other to the next adjacent lower tier at said positions, one wall of each compartment permitting passage of air therethrough and apparatus for supply and removal of containers to be treated to and from said magazine conveyor, whereby hot air is constantly circulated and recirculated around containers to be treated carried on said magazine conveyor for sterilizing fluid contained in the sealed containers.
摘要翻译：一种用于在密封容器（例如安瓿）中灭菌流体的装置，该装置具有在其中设置有热空气分配器的腔室，包括鼓，其安装成在所述腔室中围绕其垂直轴线旋转，其中隔室限定装置限定一个多个用于容纳待处理容器的垂直层叠的隔间，所述室具有固定地安装在其中的多个底壁，每个底壁与每层隔间相关联并且构成所述隔室的底部，每个底壁在其中具有间隙所述间隙处于不同的周向位置，所述间隙用于将所述隔间中插入和携带的容器自动地一个接一个地自动地移动到所述位置处的下一个相邻的下层，每个隔室的一个壁允许空气通过其中，并且供应装置，取出待处理的容器 m所述杂志传送器，由此热空气不断循环并循环在所述待处理的容器周围，携带在所述料仓输送机上，用于对包含在密封容器中的流体进行灭菌。

6. 发明授权

US5840881A Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility 失效
标题翻译：含有水溶性或水溶性较弱的水溶性化合物的组合物
公开(公告)号：US5840881A
公开(公告)日：1998-11-24
申请号：US437227
申请日：1995-05-08
申请人： Yoshiaki Uda , Takako Yamauchi , Yasushi Nakagawa , Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Yoshiaki Uda , Takako Yamauchi , Yasushi Nakagawa , Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： A23L1/00 , A61K8/73 , A61Q19/00 , C07H7/033 , C07H15/04 , C07H15/256 , C08B30/18 , C08B37/00 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12
CPC分类号： B82Y5/00 , A23P10/30 , A61K8/738 , A61Q19/00 , C07H15/04 , C07H15/24 , C07H7/033 , C08B30/18 , C08B37/0012 , C08B37/0015 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , A61K2800/56
摘要： A composition is disclosed comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid. The branched cyclodextrin-carboxylic acid significantly increases the water-solubility of the compound. Also disclosed is a method of enhancing water-solubility of the compound.
摘要翻译：公开了包含水不溶性或微溶于水的化合物和支链环糊精羧酸的组合物。支链环糊精 - 羧酸显着提高了化合物的水溶性。还公开了提高化合物的水溶性的方法。

7. 发明授权

US5635520A Anti-ulcer compositions suitable for rectal administration 失效
标题翻译：适合于直肠给药的抗溃疡组合物
公开(公告)号：US5635520A
公开(公告)日：1997-06-03
申请号：US298156
申请日：1994-08-30
申请人： Yoshiaki Uda
发明人： Yoshiaki Uda
IPC分类号： A61K9/02 , A61K9/06 , A61K9/107 , A61K31/44 , A61K47/12 , A61K47/32 , A61K47/34 , A61P1/04
CPC分类号： A61K9/02 , A61K31/44 , A61K47/12 , Y10S514/964 , Y10S514/966
摘要： The present invention relates to a composition for rectal administration which comprises a benzimidazole compound having antiulcer activity and a salt of C.sub.6-20 fatty acid, both of which are intermingled with each other in a base for rectal administration.The composition for rectal administration of the present invention is effective for the treatment of gastrointestinal ulcers, is excellent in the stability of the active ingredient therein and the absorption thereof to thereby insure an early attainment of therapeutically effective blood concentration and permits control of the rate of absorption of the drug. Furthermore, the composition for rectal administration of the present invention swells in the intestinal tract, attaches itself to the mucosa, and releases the active ingredient gradually over a long time to supply the drug at a high concentration and with high efficiency. Therefore, the expected therapeutic efficacy can be obtained at a low dosage level with a minimum of side effect.
摘要翻译：本发明涉及一种用于直肠给药的组合物，其包含具有抗溃疡活性的苯并咪唑化合物和C6-20脂肪酸的盐，两者均在用于直肠给药的基质中彼此混合。本发明的直肠给药用组合物对胃肠道溃疡的治疗是有效的，其活性成分的稳定性及其吸收性优异，从而确保早期获得治疗有效的血药浓度，并且可以控制吸收药物。此外，本发明的直肠给药用组合物在肠道中溶胀，粘附于粘膜，并且长时间逐渐释放活性成分以高浓度和高效率地供给药物。因此，可以以最小副作用的低剂量水平获得预期的治疗功效。

8. 发明授权

US4731241A Percutaneous pharmaceuticals preparation for external use 失效
标题翻译：经皮制剂外用
公开(公告)号：US4731241A
公开(公告)日：1988-03-15
申请号：US22515
申请日：1987-03-09
申请人： Masayuki Yamada , Yoshiaki Uda
发明人： Masayuki Yamada , Yoshiaki Uda
IPC分类号： A61K31/19 , A61K9/06 , A61K9/70 , A61K31/045 , A61K31/13 , A61K31/16 , A61K31/20 , A61K31/535 , A61K47/00 , A61K47/10 , A61K47/12 , A61K47/18 , A61P9/08 , C07D271/04
CPC分类号： A61K9/7084 , A61K31/535 , A61K47/10 , A61K47/12 , A61K47/18 , A61K9/0014 , Y10S514/929 , Y10S514/947
摘要： A percutaneous pharmaceutical preparation for external use containing N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) and an absorption promoter selected from the group consisting of aliphatic monoalcohols of 10 to 22 carbon atoms, aliphatic monoamides of 8 to 18 carbon atoms and aliphatic monoamines of 10 to 16 carbon atoms gives a high blood concentration of molsidomine over a long time period when applied onto the human skin.
摘要翻译：含有N-乙氧基羰基-3-吗啉代二亚胺（莫西地利）的外用皮肤药物制剂和选自10-22个碳原子的脂族一元醇，8-18个碳原子的脂族单酰胺和10个脂肪族单胺的吸收促进剂到16个碳原子时，当施用到人的皮肤上时，长时间地产生了高浓度的莫西地丁。

9. 发明授权

US4670419A Pharmaceutical composition and its rectal use 失效
标题翻译：药物组成及其直肠用途
公开(公告)号：US4670419A
公开(公告)日：1987-06-02
申请号：US753816
申请日：1985-07-08
申请人： Yoshiaki Uda , Shin-ichiro Hirai , Takatsuka Yashiki
发明人： Yoshiaki Uda , Shin-ichiro Hirai , Takatsuka Yashiki
IPC分类号： A61K9/02 , A61K38/00 , A61K38/28 , A61K47/40 , A61K47/48 , C08B37/00 , A61K37/24 , A61K37/43
CPC分类号： B82Y5/00 , A61K47/40 , A61K47/48969 , C08B37/0015 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/809 , Y10S930/13
摘要： A pharmaceutical composition containing a hydrophilic drug which is poorly absorbable through the gastrointestinal tract, and cyclodextrin, increases the absorbability of the drug into the mammalian body when administered by a non-oral or non-injection route.
摘要翻译：包含通过胃肠道吸收不良的亲水性药物和环糊精的药物组合物当通过非口服或非注射途径给药时，增加了药物进入哺乳动物体内的吸收性。

10. 发明授权

US4504470A Pharmaceutical preparations containing TRH or its analogue 失效
标题翻译：含TRH或其类似物的药物制剂
公开(公告)号：US4504470A
公开(公告)日：1985-03-12
申请号：US377592
申请日：1982-05-12
申请人： Yoshiaki Uda , Takatsuka Yashiki
发明人： Yoshiaki Uda , Takatsuka Yashiki
IPC分类号： A61K31/401 , A61K9/02 , A61K31/00 , A61K38/04 , A61K38/06 , A61K47/12 , A61K47/14 , A61K37/00 , C07C103/52
CPC分类号： A61K9/02 , A61K38/066 , A61K47/12
摘要： A non-parenteral pharmaceutical preparation containing TRH, its salt, or its analogue is produced by employing the drug and a hydroxycarboxylic acid or polycarboxylic acid of 2 to 8 carbon atoms, and having the pH of the preparation adjusted to 2 to 6.
摘要翻译：含有TRH，其盐或其类似物的非肠胃外药物制剂是通过使用药物和2-8个碳原子的羟基羧酸或多元羧酸制备的，并将制剂的pH值调节至2至6。

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