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1. 发明授权

US07495018B2 Substituted 1,3-thiazole compounds, their production and use 失效
标题翻译：取代的1,3-噻唑化合物，其生产和使用
公开(公告)号：US07495018B2
公开(公告)日：2009-02-24
申请号：US10239692
申请日：2001-03-29
申请人： Shigenori Ohkawa , Ken-ichi Naruo , Seiji Miwatashi , Hiroyuki Kimura
发明人： Shigenori Ohkawa , Ken-ichi Naruo , Seiji Miwatashi , Hiroyuki Kimura
IPC分类号： A61K31/4436 , C07D417/04
CPC分类号： C07D417/04
摘要： (1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.
摘要翻译：（1）5-取代的不具有芳香族基团的取代基的4-吡啶基的1,3-噻唑化合物或（2）取代有5位的1,3-噻唑化合物在与吡啶基的氮原子相邻的位置具有吡啶基的情况下，不含芳香族基团的取代基具有优异的p38MAP激酶抑制活性。

2. 发明申请

US20050080113A1 Medicinal compositions 审中-公开
标题翻译：药用成分
公开(公告)号：US20050080113A1
公开(公告)日：2005-04-14
申请号：US10480551
申请日：2002-06-10
申请人： Shigenori Ohkawa , Ken-ichi Naruo , Shigeru Morimoto , Seiji Miwatashi
发明人： Shigenori Ohkawa , Ken-ichi Naruo , Shigeru Morimoto , Seiji Miwatashi
IPC分类号： A61K31/00 , A61P29/00 , A61P43/00 , C07D417/04 , C07D417/14 , A61K31/426 , A61K31/4439
CPC分类号： C07D417/04 , A61K31/00 , C07D417/14
摘要： The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.
摘要翻译：本发明涉及含有p38 MAP激酶抑制剂和/或TNF-α产生抑制剂的用于预防或治疗疼痛的药剂，用于抑制破骨细胞活化的药剂和破骨细胞形成抑制剂。

3. 发明授权

US06399639B1 Apoptosis inhibitor 失效
标题翻译：凋亡抑制剂
公开(公告)号：US06399639B1
公开(公告)日：2002-06-04
申请号：US09519274
申请日：2000-03-07
申请人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
发明人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
IPC分类号： A61K31427
CPC分类号： A61K31/427 , A61K31/422 , A61K31/425 , A61K31/4439
摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.
摘要翻译：一种凋亡抑制剂，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - ，其中R 3表示可被取代的烷基; m为0或1; n为0,1或2; X表示CH或N; A表示化学键或碳原子数为1〜7的二价脂肪族烃基; Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键; 或其盐，或具有胰岛素敏感性增强活性的化合物。

4. 发明授权

US5804601A Aromatic hydroxamic acid compounds, their production and use 失效
标题翻译：芳香族异羟肟酸化合物，其生产和使用
公开(公告)号：US5804601A
公开(公告)日：1998-09-08
申请号：US629623
申请日：1996-04-09
申请人： Kaneyoshi Kato , Shokyo Miki , Ken-ichi Naruo , Hideki Takahashi
发明人： Kaneyoshi Kato , Shokyo Miki , Ken-ichi Naruo , Hideki Takahashi
IPC分类号： C07C259/06 , C07D215/14 , C07D215/20 , C07D217/14 , C07D235/16 , C07D263/56 , C07D277/64 , C07D513/04 , A61K31/165
CPC分类号： C07D263/56 , C07C259/06 , C07D215/14 , C07D215/20 , C07D217/14 , C07D235/16 , C07D277/64 , C07D513/04
摘要： The present invention relates to a compound of the formula: ##STR1## wherein Ar represents an optionally substituted aromatic group; Q represents a divalent aliphatic hydrocarbon group; R.sub.1 represents hydrogen, cyano, an optionally substituted hydrocarbon group, a group of the formula: ##STR2## wherein R.sup.3 and R.sub.4 independently represent hydrogen, acyl or an optionally substituted hydrocarbon group, or R.sup.3 and R.sup.4 jointly form a ring, or acyl; R.sup.2 represents acyl; ......... represents a single bond or a double bond; m represents 1 or 2 or a salt, a process of producing thereof and an anti-neurodegenerative composition.
摘要翻译：本发明涉及下式的化合物：其中Ar表示任选取代的芳族基团; Q表示二价脂族烃基; R 1表示氢，氰基，任选取代的烃基，下式的基团：其中R 3和R 4独立地表示氢，酰基或任选取代的烃基，或者R 3和R 4共同形成环或酰基; R2代表酰基; + E，ovs ......... + EE表示单键或双键; m表示1或2或其盐，其制备方法和抗神经变性组合物。

5. 发明授权

US5891916A Aromatic hydroxamix acid compounds, their production and use 失效
标题翻译：芳香族异羟肟酸化合物，其生产和使用
公开(公告)号：US5891916A
公开(公告)日：1999-04-06
申请号：US662240
申请日：1996-06-14
申请人： Kaneyoshi Kato , Yoshihiro Sugiura , Ken-ichi Naruo , Hideki Takahashi
发明人： Kaneyoshi Kato , Yoshihiro Sugiura , Ken-ichi Naruo , Hideki Takahashi
IPC分类号： C07C259/06 , C07C271/60 , C07D277/30 , C07C239/08 , A61K31/19 , C07D277/00
CPC分类号： C07C271/60 , C07C259/06
摘要： A compound represented by the formula: ##STR1## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group; Q represents an optionally substituted divalent aliphatic hydrocarbon group optionally containing O or S; R.sup.1 represents H, acyl group, etc.; and X represents an electron-withdrawing group, an optionally substituted aromatic group, a group of the formula: ##STR2## wherein R.sup.2 and R.sup.3 independently represent H, acyl group or an optionally substituted hydrocarbon group, etc., etc.; or salts thereof are useful as an excellent anti-neurodegenerative agent.
摘要翻译：由下式表示的化合物：其中Ar 1和Ar 2独立地表示任选取代的芳基; Q表示任选含有O或S的任选取代的二价脂族烃基; R1代表H，酰基等; X表示吸电子基团，可以具有取代基的芳基，下式的基团：其中R2和R3独立地表示H，酰基或任意取代的烃基等; 或其盐可用作优异的抗神经变性剂。

6. 发明授权

US06555565B2 Apoptosis inhibitor 失效
公开(公告)号：US06555565B2
公开(公告)日：2003-04-29
申请号：US10047816
申请日：2002-01-15
申请人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
发明人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
IPC分类号： A61K31427
CPC分类号： A61K31/427 , A61K31/422 , A61K31/425 , A61K31/4439
摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

7. 发明授权

US6087384A Apoptosis inhibitor 有权
标题翻译：凋亡抑制剂
公开(公告)号：US6087384A
公开(公告)日：2000-07-11
申请号：US272747
申请日：1999-03-15
申请人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
发明人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
IPC分类号： A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/444 , C07D413/02 , C07D413/14 , C07D417/02 , C07D417/14 , A01K31/426 , A01K31/427
CPC分类号： A61K31/427 , A61K31/422 , A61K31/425 , A61K31/4439
摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R.sup.1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R.sup.1 ; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.
摘要翻译：一种凋亡抑制剂，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - ，其中R 3表示可被取代的烷基; m为0或1; n为0,1或2; X表示CH或N; A表示化学键或碳原子数为1〜7的二价脂肪族烃基; Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键; 或其盐，或具有胰岛素敏感性增强活性的化合物。

8. 发明授权

US5622928A Glia activation factor and its production 失效
标题翻译：胶质激活因子及其生产
公开(公告)号：US5622928A
公开(公告)日：1997-04-22
申请号：US593535
申请日：1996-01-24
申请人： Ken-ichi Naruo , Chisako Seko , Tsutomu Kurokawa , Tatsuya Kondo
发明人： Ken-ichi Naruo , Chisako Seko , Tsutomu Kurokawa , Tatsuya Kondo
IPC分类号： A61K38/00 , A61P25/00 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/475 , C07K14/52 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , A61K38/18
CPC分类号： C07K14/4756 , C07K14/475 , A61K38/00
摘要： Disclosed are (1) a novel glia activating factor which has glial cell growth promoting activity; (2) a glia activating factor containing a polypeptide; (3) a DNA coding for a glia activating factor; (4) a host transformed with a vector containing the DNA and (5) a method for producing the above glia activating factor which comprises cultivating the transformant described in a medium, accumulating the glia activating factor in a culture broth, and collecting the resulting glia activating factor.
摘要翻译：公开了（1）具有神经胶质细胞生长促进活性的新型神经胶质激活因子; （2）含有多肽的胶质激活因子; （3）编码神经胶质激活因子的DNA; （4）用含有DNA的载体转化的宿主（5）上述胶原激活因子的制造方法，其特征在于，培养介质中记载的转化体，在培养液中积聚神经胶质细胞活化因子，收集所得到的胶质细胞激活因子。

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