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1. 发明授权

US06951919B1 Fas ligand derivative 失效
标题翻译： Fas配体衍生物
公开(公告)号：US06951919B1
公开(公告)日：2005-10-04
申请号：US09508849
申请日：1998-09-17
申请人： Shigekazu Nagata , Masato Tanaka
发明人： Shigekazu Nagata , Masato Tanaka
IPC分类号： A61K38/00 , C07K14/525 , C07K14/705 , C12N15/12 , C07K1/00 , C07K2/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/70575 , A61K38/00 , C07K14/525
摘要： This invention provides a soluble Fas ligand which functions as a Fas antagonist or an apoptosis regulator, a novel Fas ligand derivative which has excellent apoptosis-inducing activity and cytotoxic activity, and a DNA encoding such peptide.
摘要翻译：本发明提供了作为Fas拮抗剂或凋亡调节剂起作用的可溶性Fas配体，具有优良细胞凋亡诱导活性和细胞毒活性的新型Fas配体衍生物和编码该肽的DNA。

2. 发明授权

US07128905B2 Method of treating graft versus host disease by administration of a Fas antagonist 有权
标题翻译：通过施用Fas拮抗剂治疗移植物抗宿主病的方法
公开(公告)号：US07128905B2
公开(公告)日：2006-10-31
申请号：US10084139
申请日：2002-02-28
申请人： Shigekazu Nagata , Takehiro Yatomi , Takashi Suda
发明人： Shigekazu Nagata , Takehiro Yatomi , Takashi Suda
IPC分类号： A61K39/395 , A61K39/00 , A61K38/00
CPC分类号： C07K14/70578 , A61K38/00 , A61K2039/505 , C07K16/2875 , C07K16/2878 , C07K2319/00 , C07K2319/30
摘要： The present invention is drawn to methods of preventing and treating diseases wherein the involvement of apoptosis has been indicated.
摘要翻译：本发明涉及预防和治疗其中已经指示凋亡参与的疾病的方法。

3. 发明授权

US06348334B1 DNA encoding Fas ligand 失效
标题翻译：编码Fas配体的DNA
公开(公告)号：US06348334B1
公开(公告)日：2002-02-19
申请号：US08339214
申请日：1994-11-10
申请人： Shigekazu Nagata , Takashi Suda , Tomohiro Takahashi , Norio Nakamura
发明人： Shigekazu Nagata , Takashi Suda , Tomohiro Takahashi , Norio Nakamura
IPC分类号： C07H2104
CPC分类号： C07K14/70575 , C07K2319/00
摘要： This invention provides a novel polypeptide useful in the field of medicines, a novel DNA which encodes the novel polypeptide, a recombinant DNA molecule which contains the novel DNA, a transformant transformed with the novel DNA or the recombinant DNA molecule, a process for the purification of the novel polypeptide, a process for the production of the novel polypeptide, an antibody which recognize the novel polypeptide, an oligonucleotide complementary to the novel DNA and a novel screening method. Particularly this invention provides a novel polypeptide which is Fas ligand or a fragment thereof. This novel polypeptide can be used as an effective ingredient of a medicament for regulating the apoptosis in a living body. This novel polypeptide is obtained by identifying a DNA fragment which encodes the novel polpeptide, transforming a desired host with a recombinant DNA molecule which contains the DNA fragment and purifying the novel polypeptide produced by the resulting transformant. This novel polypeptide has a cytoplasmic domain, a transmembrane domain and extracellular domain and takes part in apoptosis.
摘要翻译：本发明提供了可用于药物领域的新型多肽，编码新型多肽的新型DNA，含有新DNA的重组DNA分子，用新型DNA或重组DNA分子转化的转化体，纯化方法的新型多肽的生产方法，识别新多肽的抗体，与新DNA互补的寡核苷酸和新的筛选方法。特别地，本发明提供了一种新的多肽，其是Fas配体或其片段。这种新型多肽可以用作调节活体细胞凋亡的药物的有效成分。通过鉴定编码新型多肽的DNA片段，通过含有该DNA片段的重组DNA分子转化所需宿主并纯化得到的转化体产生的新型多肽来获得该新型多肽。该新型多肽具有胞质结构域，跨膜结构域和细胞外结构域，并参与细胞凋亡。

4. 发明授权

US06953847B2 Fas antigen derivative 失效
标题翻译： Fas抗原衍生物
公开(公告)号：US06953847B2
公开(公告)日：2005-10-11
申请号：US09949713
申请日：2001-09-12
申请人： Norio Nakamura , Shigekazu Nagata
发明人： Norio Nakamura , Shigekazu Nagata
IPC分类号： A61K38/00 , A61P37/00 , C07K14/705 , C12N1/21 , C12N15/12 , C07H21/04
CPC分类号： C07K14/70578 , A61K38/00
摘要： This invention provides a novel Fas antigen derivative which comprises at least a part or entire portion of Fas antigen extracellular region polypeptide in which at least one amino acid residue is deleted from a group of amino acid residues starting from the N-terminal amino acid residue of the Fas antigen polypeptide to a cysteine residue most close to the N-terminal side (excluding said cysteine residue), as well as a DNA fragment which encodes said Fas antigen derivative, a recombinant DNA molecule which contains said DNA sequence, a transformant in which said recombinant DNA molecule is introduced, a method for the production of said Fas antigen derivative, a medicament which contains said novel Fas antigen derivative as the active ingredient and a method for the improvement of activities and functions of Fas antigen and the like.
摘要翻译：本发明提供了一种新的Fas抗原衍生物，其包含Fas抗原细胞外区域多肽的至少一部分或全部部分，其中至少一个氨基酸残基从氨基酸残基组中缺失，氨基酸残基从N末端氨基酸残基开始 Fas抗原多肽与最接近N端侧的半胱氨酸残基（不包括所述半胱氨酸残基），以及编码所述Fas抗原衍生物的DNA片段，含有所述DNA序列的重组DNA分子，转化体引入所述重组DNA分子，产生所述Fas抗原衍生物的方法，含有所述新型Fas抗原衍生物作为活性成分的药物以及改善Fas抗原等的活性和功能的方法。

5. 发明授权

US06949360B2 DNA coding for human cell surface antigen 失效
标题翻译：编码人细胞表面抗原的DNA
公开(公告)号：US06949360B2
公开(公告)日：2005-09-27
申请号：US09884987
申请日：2001-06-21
申请人： Shigekazu Nagata , Naoto Itoh , Shin Yonehara
发明人： Shigekazu Nagata , Naoto Itoh , Shin Yonehara
IPC分类号： A61K38/00 , C07K14/715 , C07K16/28 , C12N1/21 , C12N15/12 , C12P21/08 , C07H21/04 , C12N15/63
CPC分类号： C07K14/715 , A61K38/00 , C07K16/2878 , C07K2317/73
摘要： DNAs coding for human cell surface antigen (Fas or Fas antigen), vectors for expressing for said DNAs and transformants transfected with said vector are proveded. Fas is a polypeptide that exists in the surfaces of a variety of cells and is considered to be deeply concerned with the apoptosis of cells. The isolated Fas cDNA has an open reading frame that is capable of encoding a protein consisting of 335 amino acids. The mature Fas antigen is a protein consisting of 319 amino acids having a calculated molecular weight of about 36,000 and is constituted by an extracellular domain of 157 amino acids, a membrane-spanning domain of 17 amino acids, and a cytoplasmic domain of 145 amino acids.
摘要翻译：证明编码人细胞表面抗原（Fas或Fas抗原）的DNA，用于表达所述DNA的载体和用所述载体转染的转化体。 Fas是存在于多种细胞表面的多肽，被认为是深入关注细胞的凋亡。分离的Fas cDNA具有能够编码由335个氨基酸组成的蛋白质的开放阅读框。成熟的Fas抗原是由319个氨基酸组成的蛋白质，其计算分子量约为36,000，由157个氨基酸的胞外结构域，17个氨基酸的跨膜结构域和145个氨基酸的胞质结构域。

6. 发明授权

US5874546A Fas antigen 失效
标题翻译： Fas抗原
公开(公告)号：US5874546A
公开(公告)日：1999-02-23
申请号：US219237
申请日：1994-03-28
申请人： Shigekazu Nagata , Naoto Itoh , Shin Yonehara
发明人： Shigekazu Nagata , Naoto Itoh , Shin Yonehara
IPC分类号： A61K38/00 , C07K14/715 , C07K16/28 , C12N1/21 , C12N15/12 , C12P21/08 , C07K14/475 , C07K14/435
CPC分类号： C07K14/715 , C07K16/2878 , A61K38/00 , C07K2317/73
摘要： DNAs coding for human cell surface antigen (Fas or Fas antigen), vectors for expressing for said DNAs and transformants transfected with said vector are provided. Fas is a polypeptide that exists in the surfaces of a variety of cells and is considered to be deeply concerned with the apoptosis of cells. The isolated Fas cDNA has an open reading frame that is capable of encoding a protein consisting of 335 amino acids. The mature Fas antigen is a protein consisting of 319 amino acids having a calculated molecular weight of about 36,000 and is constituted by an extracellular domain of 157 amino acids, a membrane-spanning domain of 17 amino acids, and a cytoplasmic domain of 145 amino acids.
摘要翻译：提供编码人细胞表面抗原（Fas或Fas抗原）的DNA，用于表达所述DNA的载体和用所述载体转染的转化体。 Fas是存在于多种细胞表面的多肽，被认为是深入关注细胞的凋亡。分离的Fas cDNA具有能够编码由335个氨基酸组成的蛋白质的开放阅读框。成熟的Fas抗原是由319个氨基酸组成的蛋白质，其计算分子量约为36,000，由157个氨基酸的胞外结构域，17个氨基酸的跨膜结构域和145个氨基酸的胞质结构域。

7. 发明授权

US5574136A DNA encoding granulocyte colony-stimulating factor receptor and protein thereof 失效
标题翻译：编码粒细胞集落刺激因子受体及其蛋白质的DNA
公开(公告)号：US5574136A
公开(公告)日：1996-11-12
申请号：US923976
申请日：1992-09-22
申请人： Shigekazu Nagata , Rikiro Fukunaga
发明人： Shigekazu Nagata , Rikiro Fukunaga
IPC分类号： C07K14/715 , C12N15/12 , C07K14/705
CPC分类号： C07K14/715
摘要： A murine G-CSF receptor cDNA was cloned from a cDNA library prepared from mouse myeloid leukemia cells and the structure analyzed. A human G-CSF receptor cDNA was then cloned from cDNA libraries constructed from human placenta cells or human histocytic lymphoma cells using the murine G-CSF receptor cDNA as a probe, the structure analyzed and expressed in a host cell transformed with it. The stable production of human G-CSF receptor can be accomplished by transforming a host cell with the cloned G-CSF receptor cDNA and making the transformant express the G-CSF receptor.
摘要翻译： PCT No.PCT / JP91 / 00375 Sec。 371日期：1992年9月22日 102（e）日期1992年9月22日PCT 1991年3月22日PCT公布。 WO91 / 14776 PCT出版物日期1991年10月3日从小鼠骨髓性白血病细胞制备的cDNA文库克隆鼠G-CSF受体cDNA，分析结构。然后使用鼠G-CSF受体cDNA作为探针，从由人胎盘细胞或人组织细胞淋巴瘤细胞构建的cDNA文库中克隆人G-CSF受体cDNA，分析并在用其转化的宿主细胞中表达结构。可以通过用克隆的G-CSF受体cDNA转化宿主细胞并使转化体表达G-CSF受体来实现人G-CSF受体的稳定产生。

8. 发明授权

US5266491A DNA fragment and expression plasmid containing the DNA fragment 失效
标题翻译：含有DNA片段的DNA片段和表达质粒
公开(公告)号：US5266491A
公开(公告)日：1993-11-30
申请号：US757536
申请日：1991-09-11
申请人： Shigekazu Nagata , Seiichi Mizushima
发明人： Shigekazu Nagata , Seiichi Mizushima
IPC分类号： C07K14/47 , C12N15/85 , C12N15/11 , C07H21/04 , C12N15/67 , C12N15/79
CPC分类号： C07K14/47 , C12N15/85 , C12N2830/00 , C12N2830/38 , C12N2830/85
摘要： Novel expression plasmids containing SV40 replication origin and a DNA fragment having a promoter region for a human polypeptide chain elongation factor-1.alpha. gene.The expression plasmids have high applicability to a wide range of host cells with high expression efficiency in transient expression systems.
摘要翻译：含有SV40复制起点的新型表达质粒和具有人多肽链延长因子-1α基因的启动子区的DNA片段。表达质粒在瞬时表达系统中具有高表达效率的广泛范围的宿主细胞的高适用性。

9. 发明申请

US20100196378A1 Removal promoters and inhibitor for apoptosis cells in vivo 有权
标题翻译：体内去除启动子和凋亡细胞抑制剂
公开(公告)号：US20100196378A1
公开(公告)日：2010-08-05
申请号：US12585997
申请日：2009-09-30
申请人： Shigekazu Nagata
发明人： Shigekazu Nagata
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention is to provide a removal promoter for apoptotic cells which is capable of immediately removing apoptotic cells in vivo by macrophages, or a removal inhibitor which inhibits the removal of apoptotic cells in vivo by macrophages. A removal promoter for apoptotic cells in vivo containing the milk fat globule-EGF factor 8-L (MFG-E8-L), MFG-E8-L mutant having removal promotion action for apoptotic cells in vivo by macrophages, or preferably a recombinant human or mouse MFG-E8-L, or a recombinant human or mouse MFG-E8-L mutant as an active ingredient is prepared. Such removal promoters specifically bind to apoptotic cells and promote the phagocytosis of apoptotic cells by macrophages by recognizing aminophospholipids such as phosphatidylserine exposed on apoptotic cell surface. On the other hand, a point mutation (D89E) MFG-E8-L mutant is used as a removal inhibitor.
摘要翻译：本发明提供一种能够通过巨噬细胞在体内立即去除凋亡细胞的凋亡细胞去除启动子，或抑制巨噬细胞在体内去除凋亡细胞的去除抑制剂。含有乳脂肪球-EGF因子8-L（MFG-E8-L），具有由巨噬细胞体内凋亡细胞去除促进作用的MFG-E8-L突变体的凋亡细胞去除启动子，或优选重组人或小鼠MFG-E8-L，或重组人或小鼠MFG-E8-L突变体作为活性成分。这种去除启动子特异性结合凋亡细胞，通过识别暴露于凋亡细胞表面的磷脂酰丝氨酸等氨基磷脂，促进巨噬细胞吞噬细胞凋亡。另一方面，使用点突变（D89E）MFG-E8-L突变体作为去除抑制剂。

10. 发明授权

US6096312A Agent for suppressing a reduction of CD4.sup.+ lymphocytes 失效
标题翻译：用于抑制CD4 +淋巴细胞减少的药剂
公开(公告)号：US6096312A
公开(公告)日：2000-08-01
申请号：US999631
申请日：1998-01-22
申请人： Norio Nakamura , Kamon Shirakawa , Tomokazu Matsusue , Shigekazu Nagata , Man Sung Co , Maximiliano Vasquez
发明人： Norio Nakamura , Kamon Shirakawa , Tomokazu Matsusue , Shigekazu Nagata , Man Sung Co , Maximiliano Vasquez
IPC分类号： A61K38/00 , A61P31/18 , C07K16/28 , A61K39/395 , C07K14/525 , C07K16/00
CPC分类号： C07K16/2875 , C07K16/2878 , A61K2039/505 , A61K38/00 , C07K2317/24
摘要： An agent for preventing or treating AIDS which contains as its effective component an anti-Fas ligand antibody, and the method for preventing and treating AIDS by using such drug.
摘要翻译：用于预防或治疗AIDS的药物，其含有抗Fas配体抗体作为其有效成分，以及通过使用该药物来预防和治疗AIDS的方法。

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