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1. 发明授权

US6051234A Health diet for preventing diseases caused by life-habit 失效
标题翻译：用于预防因生命习惯引起的疾病的健康饮食
公开(公告)号：US6051234A
公开(公告)日：2000-04-18
申请号：US18437
申请日：1998-02-04
申请人： Shigehiro Kataoka , Akio Obata , Jun Yamakoshi , Yukihiko Iwai , Tatuo Manaka , Toru Izumi , Koichiro Tobe , Nobuyuki Yamaji
发明人： Shigehiro Kataoka , Akio Obata , Jun Yamakoshi , Yukihiko Iwai , Tatuo Manaka , Toru Izumi , Koichiro Tobe , Nobuyuki Yamaji
IPC分类号： C07D311/36 , A23G3/00 , A23G3/36 , A23L1/20 , A23L1/22 , A23L1/238 , A23L1/30 , A61K31/35 , A61K31/352 , A61P3/06 , A61P31/04 , A61P43/00 , C07D311/40 , A61K35/78 , A23L1/28 , A23L1/31
CPC分类号： A23G3/368 , A23G3/362 , A23L11/07 , A23L27/50 , A23L27/72 , A23L33/105
摘要： A health diet for preventing life-habit diseases (adult diseases) is provided.The health diet is prepared by directly encapsulating or tableting an organic solvent extract of soy sauce cakes or an aqueous alkali extract of a soy sauce oil, or blending the extracts with a diet.
摘要翻译：提供了一种用于预防生命习惯疾病（成人疾病）的健康饮食。健康饮食是通过直接包装或压片酱油蛋白的有机溶剂提取物或酱油油的碱性提取物，或者将提取物与饮食混合来制备的。

2. 发明授权

US06333063B2 High-protein food of plate form 失效
标题翻译：高蛋白食品的板状
公开(公告)号：US06333063B2
公开(公告)日：2001-12-25
申请号：US09749769
申请日：2000-12-28
申请人： Toshiaki Ariga , Tatuo Manaka , Emiko Yamazaki , Akio Obata , Norikazu Fujii , Nobuyuki Yamaji , Mamoru Kikuchi , Keizo Tsuruta , Michiko Watanabe
发明人： Toshiaki Ariga , Tatuo Manaka , Emiko Yamazaki , Akio Obata , Norikazu Fujii , Nobuyuki Yamaji , Mamoru Kikuchi , Keizo Tsuruta , Michiko Watanabe
IPC分类号： A23J100
CPC分类号： A23P30/32 , A21D13/48 , A23J3/16 , A23J3/225 , A23P30/10
摘要： A high-protein food of plate form having a protein content of 40% by weight or more and a bulk density of 0.02 to 0.40 g/cm3, which is obtained by puffing-molding a compound protein raw material having a protein content of 40% by weight or more.
摘要翻译：蛋白质含量为40重量％以上，堆积密度为0.02〜0.40g / cm 3的高蛋白质食品，其蛋白质含量为40％以上的复合蛋白质原料，重量以上。

3. 发明授权

US5231193A Process for producing ellagic acid 失效
标题翻译：生产鞣花酸的方法
公开(公告)号：US5231193A
公开(公告)日：1993-07-27
申请号：US854799
申请日：1992-03-25
申请人： Kiyoshi Mizusawa , Yasuhiko Imai , Katsumi Yuasa , Hirokazu Koyama , Nobuyuki Yamaji , Shigehiro Kataoka , Tetsuya Oguma
发明人： Kiyoshi Mizusawa , Yasuhiko Imai , Katsumi Yuasa , Hirokazu Koyama , Nobuyuki Yamaji , Shigehiro Kataoka , Tetsuya Oguma
IPC分类号： C07D493/06
CPC分类号： C07D493/06
摘要： A process for producing ellagic acid comprising reacting a tannin having gallic acid residues attached as constituents with an oxidizing agent at pH 7 or higher.
摘要翻译：一种生产鞣花酸的方法，包括使具有作为成分附着的没食子酸残基的单宁与pH7或更高的氧化剂反应。

4. 发明授权

US5246922A N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphates and pharmacutical compositions 失效
标题翻译： N6，N6-二取代 - 环腺苷-3'，5'-单磷酸酯和药物组合物
公开(公告)号：US5246922A
公开(公告)日：1993-09-21
申请号：US571188
申请日：1990-08-23
申请人： Shigehiro Kataoka , Nobuyuki Yamaji , Motohiko Kato , Shoichi Imai
发明人： Shigehiro Kataoka , Nobuyuki Yamaji , Motohiko Kato , Shoichi Imai
IPC分类号： C07H19/213 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P9/04 , C07H19/20
CPC分类号： C07H19/20 , Y02P20/55
摘要： The present invention relates to a N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR1## wherein R represents a linear alkyl group having 3 or more carbon atoms or a branched alkyl group having 4 or more carbon atoms, an aralkyl group or an alkenyl group; A.sup..sym. represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion, an ammonium ion or an organoammonium ion, or a salt thereof, and a cardiac composition comprising it as an effective component, and further includes a process for preparing a compound represented by the formula ##STR2## wherein R.sub.1 represents an alkyl group, an aralkyl group or an alkenyl group and A.sup..sym. has the same meanings as defined above, or a salt thereof, characterized in that a 2'-O-protected-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR3## wherein Y represents a protecting group and A.sup..sym. has the same meanings as defined above, or a salt thereof is reacted with an organic halide represented by the formulaR.sub.1 X (III) wherein X represents a halogen atom and R.sub.1 has the same meanings as defined above, and the protecting group is then removed.
摘要翻译：本发明涉及由式（I）表示的N6，N6-二取代环腺苷-3'，5'-单磷酸酯，其中R表示具有3个或更多个碳原子的直链烷基或支链烷基具有4个或更多个碳原子，芳烷基或烯基; A（+）表示氢离子，碱金属离子，碱土金属离子，铵离子或有机铵离子或其盐，以及包含其作为有效成分的心脏组合物，还包括制备由式（I'）表示的化合物，其中R 1表示烷基，芳烷基或烯基，A（+）具有与上述相同的含义或其盐，其特征在于，或其盐，其中Y表示保护基，A（+）与上述相同的含义，由式（II）表示的2'-O-保护环腺苷-3'，5'-单磷酸与式R1X（III）表示的有机卤化物反应，其中X表示卤素原子，R 1具有与上述相同的含义，然后除去保护基。

5. 发明授权

US4902677A Treatment of heart failure of mammals with N.sup.6 -substituted cyclic adenosine monophosphates 失效
标题翻译：用N6-取代的环状腺苷单磷酸酯治疗哺乳动物的心力衰竭
公开(公告)号：US4902677A
公开(公告)日：1990-02-20
申请号：US159747
申请日：1988-02-24
申请人： Shoichi Imai , Shigehiro Kataoka , Junko Isono , Nobuyuki Yamaji , Motohiko Kato
发明人： Shoichi Imai , Shigehiro Kataoka , Junko Isono , Nobuyuki Yamaji , Motohiko Kato
IPC分类号： C07H19/213 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P9/04 , C07H19/20
CPC分类号： C07H19/20
摘要： A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N.sup.6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following general formula (I) or a physiologically acceptable salt thereof: ##STR1## wherein R represents alkyl or aralkyl group and a pharmaceutically acceptable carrier, as well as a method for treating heart failure of mammals which comprises administering said composition.
摘要翻译：一种用于治疗哺乳动物心力衰竭的组合物，其包含作为其活性成分的由以下通式（I）表示的N 6 - 亚基 - 腺苷-3'，5'-环磷酸酯或其生理学上可接受的盐：其中R表示烷基或芳烷基和药学上可接受的载体，以及用于治疗哺乳动物心力衰竭的方法，其包括施用所述组合物。

6. 发明授权

US4751293A Process for preparation of N.sup.6 -substituted 3',5'-cyclic adenosine monophosphate and salt thereof 失效
标题翻译：制备N6-取代的3'，5'-环腺苷一磷酸及其盐的方法
公开(公告)号：US4751293A
公开(公告)日：1988-06-14
申请号：US727062
申请日：1985-04-25
申请人： Shigehiro Kataoka , Ayako Nasu , Nobuyuki Yamaji , Motohiko Kato
发明人： Shigehiro Kataoka , Ayako Nasu , Nobuyuki Yamaji , Motohiko Kato
IPC分类号： C07H19/213 , C07H1/00 , C07H19/20 , C07H15/12 , C07H17/00
CPC分类号： C07H19/20
摘要： A method for the preparation of an N.sup.6 -substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein R.sub.1 represents a straight chain or branched chain alkyl group of 1 to 13 carbon atoms or an aromatic group and B.sym. represents a hydrogen ion or an alkali metal ion, which comprises allowing a 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR2## wherein A.sym. represents a hydrogen ion, alkali metal ion, organic ammonium ion, or ammonium ion, to react with an aldehyde represented by the general formulaR.sub.1 CHO (III)wherein R.sub.1 is as defined above, under the conditions such that pH is 7.0 or below, the temperature is -10.degree. to 120.degree. C., and the molar ratio of the compound (II) to the compound (III) is 1:1-40, and reducing the resulting compound with a metal hydride or nascent hydrogen.
摘要翻译：一种制备由通式（I）表示的N6-取代的3'，5'-环腺苷一磷酸或其盐的方法，其中R 1表示1至13个碳的直链或支链烷基原子或芳基，B（+）表示氢离子或碱金属离子，其包括使通式（II）表示的3'，5'-环腺苷一磷酸或其盐，其中A （+）表示氢离子，碱金属离子，有机铵离子或铵离子，在通式R 1 CHO（III）表示的醛中，其中R 1如上定义，在pH为7.0或温度为-10℃〜120℃，化合物（II）与化合物（III）的摩尔比为1:1-40，用金属氢化物或新生氢还原所得化合物。

7. 发明授权

US4567254A Method for preparing N.sup.6,8-disubstituted 3',5'-cyclic adenosine monophosphate and salt thereof 失效
标题翻译：制备N6,8-二取代的3'，5'-环腺苷单磷酸及其盐的方法
公开(公告)号：US4567254A
公开(公告)日：1986-01-28
申请号：US652093
申请日：1984-09-19
申请人： Shigehiro Kataoka , Takashi Nakamura , Nobuyuki Yamaji , Seiichi Nasuno
发明人： Shigehiro Kataoka , Takashi Nakamura , Nobuyuki Yamaji , Seiichi Nasuno
IPC分类号： C07H19/20 , C07H15/12 , C07H17/00
CPC分类号： C07H19/20
摘要： A method for preparing an N.sup.6,8-disubstituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein X denotes a halogen atom or ##STR2## N.sub.3, OH or OR, R being an alkyl or aralkyl group; A.sup..sym. denotes a hydrogen ion, alkali metal ion, ammonium ion or organic ammonium ion; and R.sub.1 denotes an alkyl or aromatic group, which method comprises reacting an 8-substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula (II) ##STR3## wherein X and A.sup.61 are as defined above, with an aldehyde represented by the general formulaR.sub.1 --CHO (III)wherein R.sub.1 is as defined above, to form an imine compound represented by the general formula ##STR4## wherein X, R.sub.1 and A.sup..sym. are as defined above, as an intermediate, and then reducing the imine compound.
摘要翻译：一种制备由通式（I）表示的N6,8-二取代的3'，5'-环腺苷单磷酸或其盐的方法，其中X表示卤素原子或N 3，OH或OR， R为烷基或芳烷基; A（+）表示氢离子，碱金属离子，铵离子或有机铵离子; 并且R 1表示烷基或芳基，该方法包括使由通式（II）表示的8-取代的3'，5'-环腺苷一磷酸或其盐，其中X和A61为（IV）表示的亚胺化合物，其中X，R 1和A（+）是如上定义的，其中R 1如上所定义，通式为R1-CHO 如上所定义，作为中间体，然后还原亚胺化合物。

8. 发明授权

US5789581A Process for obtaining malonyl isoflavone glycosides and obtaining isoflavone glycosides or isoflavone aglycons from malonyl isoflavone glycosides 失效
标题翻译：获得丙二酰异黄酮糖苷并从丙二酰异黄酮糖苷获得异黄酮糖苷或异黄酮苷酸的方法
公开(公告)号：US5789581A
公开(公告)日：1998-08-04
申请号：US630347
申请日：1996-04-10
申请人： Masaru Matsuura , Akio Obata , Kouichiro Tobe , Nobuyuki Yamaji
发明人： Masaru Matsuura , Akio Obata , Kouichiro Tobe , Nobuyuki Yamaji
IPC分类号： C12P17/06 , A61K36/48 , C07D311/36 , C07H1/08 , C07H17/07 , C07G3/00 , C07H17/00
CPC分类号： C07H17/07
摘要： A malonylisoflavone glycoside present in soybean is obtained efficiently. In addition, the corresponding isoflavone glycoside and aglycone are obtained from the malonylisoflavone glycoside. An aqueous extract of soybean is adsorbed on an adsorbent, and eluted with an aqueous alcohol solution.
摘要翻译：有效地获得存在于大豆中的丙二酰基异黄酮糖苷。此外，相应的异黄酮糖苷和糖苷配基由丙二酰基异黄酮糖苷获得。将大豆的水提物吸附在吸附剂上，并用醇水溶液洗脱。

9. 发明授权

US5693480A Method and reagent for determinng exo-type saccharide hydrolase activity 失效
标题翻译：测定外型糖水解酶活性的方法和试剂
公开(公告)号：US5693480A
公开(公告)日：1997-12-02
申请号：US501870
申请日：1995-07-13
申请人： Yasuhiko Imai , Shoichi Tokutake , Masaru Suzuki , Nobuyuki Yamaji
发明人： Yasuhiko Imai , Shoichi Tokutake , Masaru Suzuki , Nobuyuki Yamaji
IPC分类号： C07H3/04 , C12Q1/34 , C12Q1/40 , C07G3/00
CPC分类号： C07H3/04 , C12Q1/34 , C12Q1/40 , C12Q2334/00 , C12Q2334/10 , G01N2333/924
摘要： According to this invention are provided a method for determining an exo-type saccharide hydrolase activity which comprises adding to a sample a .beta.-maltoside derivative represented by the general formula ##STR1## wherein R is a chromophoric organic group, as a substrate, conducting reaction in the presence of a coupled enzyme, and optically determining the substance liberated, and a method for differentially determining glucoamylase and .alpha.-glucosidase activities which comprises adding, to a sample, the above .beta.-maltoside derivative as the first substrate and a coupled enzyme, and an .alpha.-glucoside derivative represented by the general formula ##STR2## wherein R' is a chromophoric organic group, as the second substrate, subjecting the mixtures to separate enzymatic reactions, and then optically quantitatively determine the substances liberated.
摘要翻译：根据本发明提供了一种测定外型糖水解酶活性的方法，其包括向样品中加入由通式“IMAGE”表示的β-麦芽糖衍生物，其中R是发色有机基团，作为底物，进行反应在偶联酶的存在下，并光学测定释放的物质，以及差异测定葡糖淀粉酶和α-葡糖苷酶活性的方法，其包括向样品中加入上述β-麦芽糖衍生物作为第一底物和偶联酶，和由通式表示的α-葡萄糖苷衍生物，其中R'是发色有机基团，作为第二底物，使混合物分离酶反应，然后光学定量地测定释放的物质。

10. 发明授权

US5494804A Differential determination process of .alpha.-amylase isoenzyme activities 失效
标题翻译： α-淀粉酶同工酶活性的差异测定方法
公开(公告)号：US5494804A
公开(公告)日：1996-02-27
申请号：US305917
申请日：1994-09-16
申请人： Riichiro Uchida , Shoichi Tokutake , Nobuyuki Yamaji , Yoshinori Motoyama , Kenji Hosoi
发明人： Riichiro Uchida , Shoichi Tokutake , Nobuyuki Yamaji , Yoshinori Motoyama , Kenji Hosoi
IPC分类号： C12N9/99 , C12Q1/00 , C12Q1/34 , C12Q1/40 , C07G3/00
CPC分类号： C12Q1/007
摘要： A process for differentially determining .alpha.-amylase isoenzyme activities by the inhibitor method, in which 6.sup.3 -deoxymaltotriose (DOG3) represented by the formula ##STR1## is used as an inhibitor.
摘要翻译：通过抑制剂方法差异测定α-淀粉酶同工酶活性的方法，其中由式（IMAGE）表示的63-脱氧麦芽三糖（DOG3）用作抑制剂。

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