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1. 发明授权

US07364842B2 Methods of identifying modulators of human retrovirus replication 失效
标题翻译：鉴定人类逆转录病毒复制调节剂的方法
公开(公告)号：US07364842B2
公开(公告)日：2008-04-29
申请号：US10849567
申请日：2004-05-18
申请人： Sheng Hao Chao , Jeremy S. Caldwell
发明人： Sheng Hao Chao , Jeremy S. Caldwell
IPC分类号： C12Q1/00 , C12Q1/70 , C12P21/04
CPC分类号： C12Q1/6897 , C12Q1/702
摘要： This invention relates to the discovery that the transcription factors Pbx1 and HMG I are involved in retrovirus, e.g., HIV, replication. Thus, the invention provides methods of identifying modulators of these proteins. Such modulators can be used as reagents in in vitro assays to modulate expression of retroviral sequences and may be used to inhibit HIV replication in vivo.
摘要翻译：本发明涉及转录因子Pbx1和HMG1参与逆转录病毒例如HIV复制的发现。因此，本发明提供鉴定这些蛋白质的调节剂的方法。这种调节剂可用作体外测定中的试剂以调节逆转录病毒序列的表达，并可用于抑制体内HIV复制。

2. 发明授权

US07179619B2 Methods and compositions for inhibiting herpesviral replication 失效
标题翻译：用于抑制疱疹病毒复制的方法和组合物
公开(公告)号：US07179619B2
公开(公告)日：2007-02-20
申请号：US10885862
申请日：2004-07-07
申请人： Sheng-Hao Chao , Jeremy S. Caldwell
发明人： Sheng-Hao Chao , Jeremy S. Caldwell
IPC分类号： C12P21/06
CPC分类号： C12Q1/705
摘要： This invention provides methods of screening for compounds that inhibit herpesviral transcription and replication. The methods comprise screening test compounds for ability to enhance the activity of homeodomain transcription factor PDX1 in repressing transcription of herpesviral genes (e.g., the IE gene of cytomegalovirus). Transcriptional repression by PDX1 can be monitored using an expression vector comprising a reporter gene operably linked to a PDX1-binding, upstream transcription regulatory sequence of the herpesvirus. The invention further provides methods and pharmaceutical compositions for stimulating PDX1-mediated transcriptional repression in a subject and for treating diseases and conditions associated with herpesviral infection.
摘要翻译：本发明提供了筛选抑制疱疹病毒转录和复制的化合物的方法。所述方法包括筛选测试化合物以增强同源异型域转录因子PDX1在抑制疱疹病毒基因（例如，巨细胞病毒的IE基因）的转录中的活性的能力。可以使用包含与疱疹病毒的PDX1结合的上游转录调节序列可操作地连接的报告基因的表达载体来监测PDX1的转录抑制。本发明还提供用于刺激受试者中PDX1介导的转录抑制并用于治疗与疱疹病毒感染相关的疾病和病症的方法和药物组合物。

3. 发明授权

US07344833B2 Methods and compositions for modulating activator protein 1 失效
标题翻译：调节激活蛋白的方法和组合物1
公开(公告)号：US07344833B2
公开(公告)日：2008-03-18
申请号：US10702112
申请日：2003-11-05
申请人： Sumit Chanda , Suhaila White , John B. Hogenesch , Jeremy S. Caldwell
发明人： Sumit Chanda , Suhaila White , John B. Hogenesch , Jeremy S. Caldwell
IPC分类号： C12Q1/68
CPC分类号： G01N33/5023 , G01N33/574 , G01N33/6875 , G01N2500/00
摘要： This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identified modulating agents for modulators of AP-1 transcription factor activities. The invention further provides methods and pharmaceutical compositions for modulating AP-1 transcription factor activities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.
摘要翻译：本发明提供新型AP-1调节多肽。本发明还提供筛选AP-1转录因子活性调节剂的方法。所述方法包括首先筛选AP-1调节多肽的调节剂的测试剂，然后进一步筛选鉴定的调节剂用于AP-1转录因子活性的调节剂。本发明还提供用于调节细胞中AP-1转录因子活性并用于治疗由异常细胞增殖介导的疾病和病症的方法和药物组合物。

4. 发明申请

US20090252757A1 METHODS AND COMPOSITIONS FOR INHIBITING HIV INFECTION 审中-公开
标题翻译：用于抑制HIV感染的方法和组合物
公开(公告)号：US20090252757A1
公开(公告)日：2009-10-08
申请号：US12095867
申请日：2006-12-08
申请人： Deborah Nguyen , Kelli L. Kuhen , Jeremy S. Caldwell
发明人： Deborah Nguyen , Kelli L. Kuhen , Jeremy S. Caldwell
IPC分类号： A61K36/06 , C12Q1/70 , A61K31/553 , A61P31/18 , A61K31/095
CPC分类号： C12Q1/6897 , C12Q1/18 , G01N33/56988 , G01N2333/161 , G01N2500/00
摘要： This invention provides novel HIV-interacting host factors. The invention also provides methods of using the HIV-interacting host factors to screen for compounds that inhibit HIV infection. The methods comprise first screening test compounds for modulators of an HIV interacting host factor disclosed herein, and then further screening the identified modulating compounds for ability to inhibit HIV infection. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with HIV infection.
摘要翻译：本发明提供新颖的HIV相互作用宿主因子。本发明还提供了使用与HIV相互作用的宿主因子筛选抑制HIV感染的化合物的方法。所述方法包括首先筛选本文公开的HIV相互作用宿主因子的调节剂的测试化合物，然后进一步筛选鉴定的调节性化合物以抑制HIV感染的能力。本发明还提供了用于治疗与HIV感染相关的疾病和病症的方法和药物组合物。

5. 发明申请

US20080253927A1 HIGH THROUGHPUT PROCESSING SYSTEM AND METHOD OF USING 审中-公开
标题翻译：高速加工系统及其使用方法
公开(公告)号：US20080253927A1
公开(公告)日：2008-10-16
申请号：US12144573
申请日：2008-06-23
申请人： Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
发明人： Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
IPC分类号： G01N35/10
CPC分类号： B01L9/523 , B01J2219/00587 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/0072 , B01L2300/0829 , B01L2300/0893 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1074 , G01N2015/1006 , G01N2035/00306 , G01N2035/00366 , G01N2035/0405 , G01N2035/0427 , G01N2035/1037 , G01N2500/10 , G01N2500/20 , Y02A50/58 , Y10T436/114165 , Y10T436/2575
摘要： The present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.
摘要翻译：本发明提供一种使用样品保持器进行高通量处理的系统和方法。该系统具有多个工作周边，其中旋转机器人优选地与每个工作周界相关联。在相邻工作周边之间提供至少一个传送站区域，以便将样品架从一个工作周边机器人传送到另一个区域。每个工作周界通常包括多个定义的站位置，其中每个站位置定位成由与该区域相关联的机器人可访问。此外，每个站位置通常被配置为接收诸如自动化仪器或保持嵌套之类的设备。设备组件根据特定的应用要求安排在选定的站位置，以提供灵活，稳健，可靠，准确的高吞吐量处理系统。

6. 发明授权

US07390458B2 High throughput processing system and method of using 有权
标题翻译：高吞吐量处理系统及其使用方法
公开(公告)号：US07390458B2
公开(公告)日：2008-06-24
申请号：US09981313
申请日：2001-10-15
申请人： Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
发明人： Kristina Marie Burow , Jeremy S. Caldwell , Robert Charles Downs , Scott Allan Lesley , James Kevin Mainquist , Andrew J. Meyer , Daniel G. Sipes , Mark Richard Weselak
IPC分类号： G01N35/10 , G01N21/01 , G01N33/50 , B25J15/00 , B01L3/02
CPC分类号： B01L9/523 , B01J2219/00587 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/0072 , B01L2300/0829 , B01L2300/0893 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1074 , G01N2015/1006 , G01N2035/00306 , G01N2035/00366 , G01N2035/0405 , G01N2035/0427 , G01N2035/1037 , G01N2500/10 , G01N2500/20 , Y02A50/58 , Y10T436/114165 , Y10T436/2575
摘要： Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.
摘要翻译：简而言之，本发明提供了一种使用样品保持器进行高通量处理的系统和方法。该系统具有多个工作周边，其中旋转机器人优选地与每个工作周界相关联。在相邻工作周边之间提供至少一个传送站区域，以便将样品架从一个工作周边机器人传送到另一个区域。每个工作周界通常包括多个定义的站位置，其中每个站位置定位成由与该区域相关联的机器人可访问。此外，每个站位置通常被配置为接收诸如自动化仪器或保持嵌套之类的设备。设备组件根据特定的应用要求安排在选定的站位置，以提供灵活，稳健，可靠，准确的高吞吐量处理系统。

7. 发明授权

US08163153B2 Tool for extracting electrophoretic sample 有权
标题翻译：电泳样品提取工具
公开(公告)号：US08163153B2
公开(公告)日：2012-04-24
申请号：US12158208
申请日：2005-12-20
申请人： Jeremy S. Caldwell , Dale R. Caldwell , Leon C. Clouser, Jr.
发明人： Jeremy S. Caldwell , Dale R. Caldwell , Leon C. Clouser, Jr.
IPC分类号： G01N27/453 , G01N27/447 , B01L3/02
CPC分类号： G01N27/44704 , G01N1/08 , Y10T436/25
摘要： A gel extraction device (10) comprises a hollow cutting member (12) having cutting edge (14) at one end and a squeeze bulb (16) at the other end. In a further embodiment, the air passage between the cutting edge and the bulb has a constriction zone (20) to prevent any extracted gel from being drawn too deeply into the extractor, in another embodiment, a blow-hole in the hollow cutting member or in the squeeze bulb provides for the passage of air displaced by gel through the extractor. The blow-hole may be covered to secure the gel in the receptacle for transfer from the matrix to a sample container.
摘要翻译：凝胶提取装置（10）包括在一端具有切割边缘（14）的中空切割构件（12）和另一端的挤压泡（16）。在另一实施例中，切割边缘和灯泡之间的空气通道具有收缩区（20），以防止任何提取的凝胶被太深地拉入提取器，在另一个实施例中，中空切割构件中的气孔或在挤压灯泡中提供通过凝胶排出的空气通过提取器。可以覆盖吹孔以将凝胶固定在容器中，以从基质转移到样品容器。

8. 发明申请

US20090286326A1 Tool for Extracting Electrophoretic Sample 有权
标题翻译：提取电泳样品的工具
公开(公告)号：US20090286326A1
公开(公告)日：2009-11-19
申请号：US12158208
申请日：2005-12-20
申请人： Jeremy S. Caldwell , Dale R. Caldwell , Leon C. Clouser, JR.
发明人： Jeremy S. Caldwell , Dale R. Caldwell , Leon C. Clouser, JR.
IPC分类号： G01N1/00 , B01L3/00
CPC分类号： G01N27/44704 , G01N1/08 , Y10T436/25
摘要： A gel extraction device (10) comprises a hollow cutting member (12) having cutting edge (14) at one end and a squeeze bulb (16) at the other end. In a further embodiment, the air passage between the cutting edge and the bulb has a constriction zone (20) to prevent any extracted gel from being drawn too deeply into the extractor, in another embodiment, a blow-hole in the hollow cutting member or in the squeeze bulb provides for the passage of air displaced by gel through the extractor. The blow-hole may be covered to secure the gel in the receptacle for transfer from the matrix to a sample container.
摘要翻译：凝胶提取装置（10）包括在一端具有切割边缘（14）的中空切割构件（12）和另一端的挤压泡（16）。在另一实施例中，切割边缘和灯泡之间的空气通道具有收缩区（20），以防止任何提取的凝胶被太深地拉入提取器，在另一个实施例中，中空切割构件中的气孔或在挤压灯泡中提供通过凝胶排出的空气通过提取器。可以覆盖吹孔以将凝胶固定在容器中，以从基质转移到样品容器。

9. 发明授权

US07604977B2 Methods and compositions for inhibiting HIV infection 失效
标题翻译：用于抑制HIV感染的方法和组合物
公开(公告)号：US07604977B2
公开(公告)日：2009-10-20
申请号：US11408551
申请日：2006-04-21
申请人： Kelli L. Kuhen , Jeremy S. Caldwell
发明人： Kelli L. Kuhen , Jeremy S. Caldwell
IPC分类号： C12N7/00 , C07H21/04
CPC分类号： G01N33/573 , G01N33/56988 , G01N2500/10
摘要： This invention provides novel methods for identifying agents that inhibit HIV infection. The anti-HIV agents are identified by screening test compounds for ability to modulate a biological activity of isopeptidase T (IsoT), e.g., its isopeptidase activity or its binding to another molecule such as viral protein R (Vpr). Such IsoT modulators can be further examined for their activity in inhibiting an activity indicative of HIV infection or HIV replication. These novel anti-HIV agents are useful in the prevention or treatment of HIV infection and conditions associated with or caused by HIV infection.
摘要翻译：本发明提供用于鉴定抑制HIV感染的药剂的新方法。通过筛选测试化合物以调节异肽酶T（IsoT）的生物活性的能力，例如其抗肽酶活性或其与另一分子例如病毒蛋白R（Vpr）的结合来鉴定抗HIV剂。可以进一步检查这种IsoT调节剂在抑制表达HIV感染或HIV复制的活性方面的活性。这些新的抗HIV药物可用于预防或治疗HIV感染和与HIV感染有关或与之相关的病症。

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