专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08153728B2 PDMS-PVP block copolymers 有权
标题翻译： PDMS-PVP嵌段共聚物
公开(公告)号：US08153728B2
公开(公告)日：2012-04-10
申请号：US12531200
申请日：2008-03-13
申请人： James Parakka , Keith R. McCrea , Robert S. Ward
发明人： James Parakka , Keith R. McCrea , Robert S. Ward
IPC分类号： C08F30/08 , C08F293/00
CPC分类号： C08F293/00 , A61L15/26 , A61L27/18 , C08F8/10 , C08F8/14 , C08F2810/40 , C08G77/442 , C08G77/452 , C08L53/00 , C08L83/10 , G02B1/043 , C08L39/06 , C08L83/06 , C08L83/04 , C08F126/10 , C08L2666/02
摘要： Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
摘要翻译：制备具有可聚合功能的官能化聚乙烯吡咯烷酮的方法。此外，两亲性聚二甲基硅氧烷-PVP嵌段共聚物如（甲基）丙烯酸酯化和（甲基）丙烯酰胺官能化的聚乙烯吡咯烷酮化合物如嵌段共聚物可用作生物医学装置中的生物材料组分。它们为生物医学装置例如眼科镜片提供改善的润湿性，润滑性和材料相容性。

2. 发明授权

US08344090B2 PDMS-PVP block copolymers 有权
标题翻译： PDMS-PVP嵌段共聚物
公开(公告)号：US08344090B2
公开(公告)日：2013-01-01
申请号：US13325584
申请日：2011-12-14
申请人： James Parakka , Keith R. McCrea , Robert S. Ward
发明人： James Parakka , Keith R. McCrea , Robert S. Ward
IPC分类号： C08F30/08 , C08F293/00
CPC分类号： C08F293/00 , A61L15/26 , A61L27/18 , C08F8/10 , C08F8/14 , C08F2810/40 , C08G77/442 , C08G77/452 , C08L53/00 , C08L83/10 , G02B1/043 , C08L39/06 , C08L83/06 , C08L83/04 , C08F126/10 , C08L2666/02
摘要： Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
摘要翻译：制备具有可聚合功能的官能化聚乙烯吡咯烷酮的方法。此外，两亲性聚二甲基硅氧烷-PVP嵌段共聚物如（甲基）丙烯酸酯化和（甲基）丙烯酰胺官能化的聚乙烯吡咯烷酮化合物如嵌段共聚物可用作生物医学装置中的生物材料组分。它们为生物医学装置例如眼科镜片提供改善的润湿性，润滑性和材料相容性。

3. 发明申请

US20120083573A1 NOVEL PDMS-PVP BLOCK COPOLYMERS 有权
标题翻译：新型PDMS-PVP嵌段共聚物
公开(公告)号：US20120083573A1
公开(公告)日：2012-04-05
申请号：US13325584
申请日：2011-12-14
申请人： James PARAKKA , Keith R. McCrea , Robert S. Ward
发明人： James PARAKKA , Keith R. McCrea , Robert S. Ward
IPC分类号： C08G81/02
CPC分类号： C08F293/00 , A61L15/26 , A61L27/18 , C08F8/10 , C08F8/14 , C08F2810/40 , C08G77/442 , C08G77/452 , C08L53/00 , C08L83/10 , G02B1/043 , C08L39/06 , C08L83/06 , C08L83/04 , C08F126/10 , C08L2666/02
摘要： Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
摘要翻译：制备具有可聚合功能的官能化聚乙烯吡咯烷酮的方法。此外，两亲性聚二甲基硅氧烷-PVP嵌段共聚物如（甲基）丙烯酸酯化和（甲基）丙烯酰胺官能化的聚乙烯吡咯烷酮化合物如嵌段共聚物可用作生物医学装置中的生物材料组分。它们为生物医学装置例如眼科镜片提供改善的润湿性，润滑性和材料相容性。

4. 发明授权

US07884171B2 Control of polymer surface molecular architecture via amphipathic endgroups 有权
标题翻译：通过两亲性端基控制聚合物表面分子结构
公开(公告)号：US07884171B2
公开(公告)日：2011-02-08
申请号：US12638371
申请日：2009-12-15
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
IPC分类号： C08G18/00 , C08G77/04 , C08G77/22
CPC分类号： C08G18/6287 , A61L27/18 , A61L29/06 , A61L31/06 , C08G18/0823 , C08G18/12 , C08G18/283 , C08G18/2865 , C08G18/289 , C08G18/5024 , C08G18/5039 , C08G18/6283 , C08G18/6795 , C08L75/04 , C08G18/3228
摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.
摘要翻译：其表面被包括两亲表面改性部分的端基修饰的聚合物。聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于当该重新定位导致界面能量降低时，与身体接触的介质。两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶。在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。还公开了利用这些聚合物的方法和制品。

5. 发明申请

US20100113711A1 CONTROL OF POLYMER SURFACE MOLECULAR ARCHITECTURE VIA AMPHIPATHIC ENDGROUPS 有权
标题翻译：聚合物表面分子结构的控制通过AMPHIPATHIC ENDGROUPS
公开(公告)号：US20100113711A1
公开(公告)日：2010-05-06
申请号：US12638371
申请日：2009-12-15
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
IPC分类号： C08G69/48 , C08G18/00 , C08G12/12 , C08G63/91 , C08G64/42 , C08G77/38
CPC分类号： C08G18/6287 , A61L27/18 , A61L29/06 , A61L31/06 , C08G18/0823 , C08G18/12 , C08G18/283 , C08G18/2865 , C08G18/289 , C08G18/5024 , C08G18/5039 , C08G18/6283 , C08G18/6795 , C08L75/04 , C08G18/3228
摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.
摘要翻译：其表面被包括两亲表面改性部分的端基修饰的聚合物。聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于当该重新定位导致界面能量降低时，与身体接触的介质。两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶。在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。还公开了利用这些聚合物的方法和制品。

6. 发明申请

US20090258048A1 Self-Assembling Monomers and Oligomers as Surface-Modifying Endgroups for Polymers 审中-公开
标题翻译：自组装单体和低聚物作为表面改性端基用于聚合物
公开(公告)号：US20090258048A1
公开(公告)日：2009-10-15
申请号：US12083927
申请日：2006-12-07
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka , Shanger Wang
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka , Shanger Wang
IPC分类号： A61F2/02 , C08G63/91 , C12M3/00 , B65D71/00
CPC分类号： A61K31/785 , C08G18/0895 , C08G18/2875 , C08G18/288 , C08G18/44 , C08G18/6266
摘要： Polymers having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.
摘要翻译：具有式R（LE）x的聚合物，其中R是数均分子量为5000-7,000,000道尔顿且具有x个端基的聚合物芯，E是通过连接L与聚合物核心R共价连接的端基，L是二价具有至少5个相同重复单元的低聚链，能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x可以彼此相同或不同。单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面修饰该聚合物的端基。使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

7. 发明申请

US20110028661A1 HYBRID POLYURETHANE BLOCK COPOLYMERS WITH THERMOPLASTIC PROCESSABILITY AND THERMOSET PROPERTIES 审中-公开
标题翻译：具有热塑性加工性和热稳定性的混合聚氨酯嵌段共聚物
公开(公告)号：US20110028661A1
公开(公告)日：2011-02-03
申请号：US12809212
申请日：2008-12-18
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , Jim Yang
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , Jim Yang
IPC分类号： C08F283/12
CPC分类号： C08G18/3228 , C08G18/4812 , C08G18/61 , C08G18/6611
摘要： Block copolymers are formulated with multifunctional chain extenders. The block copolymers include a soft segment and a hard segment made from a diisocyanate, an alkylene diamine chain extender, and a multifunctional chain extender which provides delayed crosslinking. The multifunctional chain extenders have a functionality and typically have at least one OH group. The multifunctional chain extenders may be aliphatic or aromatic triols or polyols, or may have other configurations, as described. The resulting block copolymers have improved mechanical properties such as compression set. They may be used in medical applications, or in industrial applications such as seal and gasket applications, including O-rings, window seals, and automotive gaskets. The initially-formed polyurethane resin behaves as a thermoplastic processable material, while the configured end-use product is thermoset.
摘要翻译：嵌段共聚物用多功能扩链剂配制。嵌段共聚物包括软链段和由二异氰酸酯制成的硬链段，亚烷基二胺扩链剂和提供延迟交联的多官能扩链剂。多功能扩链剂具有官能团并且通常具有至少一个OH基团。多官能增链剂可以是脂族或芳族三醇或多元醇，或者可以具有如所述的其它构型。所得的嵌段共聚物具有改进的机械性能，如压缩永久变形。它们可用于医疗应用或工业应用中，例如密封和垫片应用，包括O型圈，窗户密封件和汽车垫圈。初始形成的聚氨酯树脂表现为热塑性可加工材料，而配置的最终用途产品是热固性的。

8. 发明申请

US20110086077A1 SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS 审中-公开
标题翻译：用于组织粘合剂和组织粘合应用的硅胶水凝胶
公开(公告)号：US20110086077A1
公开(公告)日：2011-04-14
申请号：US12745509
申请日：2008-11-21
申请人： Keith R. McCrea , Robert S. Ward , Yuan Tian
发明人： Keith R. McCrea , Robert S. Ward , Yuan Tian
IPC分类号： A61L15/22 , A61K38/39 , A61P17/02
CPC分类号： A61L15/60 , A61L15/225 , A61L15/26 , A61L26/0019 , A61L26/0076 , A61L26/008 , C08L83/04
摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).
摘要翻译：硅氧烷水凝胶制剂可以含有无规和/或嵌段共聚物或低聚物或大分子单体。硅氧烷共聚物与其它聚合物或单体或大分子单体共聚或共混以获得最终配方。硅氧烷水凝胶可以含有交联基团以提供完全或部分交联的最终结构。硅氧烷水凝胶制剂可以预先形成为膜或其它结构，或者可以在使用时聚合，如在粘合剂制剂的情况下。一种伤口敷料，其包含在施加到伤口之前或原位在伤口上形成的膜的硅酮水凝胶，该膜具有透气性，透湿性和高含水量，其中所述硅氧水凝胶由可聚合硅氧烷形成例如甲基丙烯酸二官能聚二甲基硅氧烷和N，N-二甲基丙烯酰胺（DMA），甲基丙烯酸2-羟乙酯（HEMA）和三甲基甲硅烷氧基硅烷（TRIS）等交联剂。

9. 发明授权

US07671162B2 Control of polymer surface molecular architecture via amphipathic endgroups 有权
标题翻译：通过两亲性端基控制聚合物表面分子结构
公开(公告)号：US07671162B2
公开(公告)日：2010-03-02
申请号：US11211734
申请日：2005-08-26
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
IPC分类号： C08G18/00 , C08G77/04 , C08G77/22
CPC分类号： C08G18/6287 , A61L27/18 , A61L29/06 , A61L31/06 , C08G18/0823 , C08G18/12 , C08G18/283 , C08G18/2865 , C08G18/289 , C08G18/5024 , C08G18/5039 , C08G18/6283 , C08G18/6795 , C08L75/04 , C08G18/3228
摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.
摘要翻译：其表面被包括两亲表面改性部分的端基修饰的聚合物。聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于当该重新定位导致界面能量降低时，与身体接触的介质。两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶。在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。还公开了利用这些聚合物的方法和制品。

10. 发明申请

US20110124772A1 ANTIMICROBIAL POLYMERS AND THEIR USES 审中-公开
标题翻译：抗微生物聚合物及其用途
公开(公告)号：US20110124772A1
公开(公告)日：2011-05-26
申请号：US12994836
申请日：2009-05-26
申请人： Shanger Wang , Robert S. Ward , Yuan Tian , Li Li , Keith Mccrea , James Parakka , Robert L. Jones, JR.
发明人： Shanger Wang , Robert S. Ward , Yuan Tian , Li Li , Keith Mccrea , James Parakka , Robert L. Jones, JR.
IPC分类号： C09D175/04 , C08G71/04
CPC分类号： A01N33/12 , A01N47/44 , A01N25/10 , A01N2300/00
摘要： Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.
摘要翻译：具有非浸出抗菌活性的聚合物及其用作医疗器械的表面涂层或体积树脂。抗微生物聚合物通过共价键合到聚合物链末端的抗微生物部分或在侧链末端与聚合物主链一起制备。含抗微生物部分的端基包括表面活性（或表面组装）部分，其促进抗微生物端基在聚合物表面的富集，从而形成抗微生物活性表面。具有内置抗微生物端基的聚合物可用作散装树脂，作为抗微生物添加剂，或作为医疗器械制造中的感染预防性涂层（例如，导管，血管通路装置，外围线，IV部位，下水道，胃饲和管，和其他可植入装置）。在需要控制生物膜形成的环境中，例如海产品，这些材料也可用作与微生物接触的结构上的抗微生物和防污涂料。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式