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1. 发明授权

US07006220B2 Apparatus and method for determining tissue characteristics 有权
标题翻译：用于确定组织特征的装置和方法
公开(公告)号：US07006220B2
公开(公告)日：2006-02-28
申请号：US10611917
申请日：2003-07-03
申请人： Shabbir Bambot , Mark L. Faupel , Glenn Steven Arche
发明人： Shabbir Bambot , Mark L. Faupel , Glenn Steven Arche
IPC分类号： G01N21/00 , A61B1/06
CPC分类号： A61B5/0071 , A61B5/0084 , G01N21/474 , G01N21/49 , G01N21/6486 , G01N2021/6484
摘要： An apparatus and method embodying the invention including utilizing a device with a limited number of interrogation devices to accomplish a large number of measurements on a target tissue. An instrument embodying the invention includes a plurality of detection devices that are arranged in a predetermined pattern on a tissue contacting face of the instrument. The face of the instrument is located adjacent the target tissue, and a plurality of tissue characteristic measurement are simultaneously conducted. The detection devices are moved to a new position, preferably without moving the tissue contacting face, and a second plurality of tissue characteristic measurements are simultaneously conducted. By conducting a series of measurement cycles in this manner, the ultimate resolution of the device is increased, while still obtaining a given resolution, which reduces potential cross-talk errors. Further, a plurality of tissue characteristics are simultaneously obtained from locations spaced across the target tissue during each measurement cycle.
摘要翻译：实施本发明的装置和方法包括利用具有有限数量的询问装置的装置来在目标组织上完成大量的测量。实施本发明的仪器包括以预定图案布置在仪器的组织接触面上的多个检测装置。仪器的表面位于目标组织附近，并且同时进行多个组织特征测量。检测装置移动到新的位置，优选地不移动组织接触面，同时进行第二组织特征测量。通过以这种方式进行一系列测量循环，设备的最终分辨率提高，同时仍然获得给定的分辨率，这降低了潜在的串扰误差。此外，在每个测量周期期间，通过目标组织间隔开的位置同时获得多个组织特征。

2. 发明授权

US07301629B2 Apparatus and method for determining tissue characteristics 有权
标题翻译：用于确定组织特征的装置和方法
公开(公告)号：US07301629B2
公开(公告)日：2007-11-27
申请号：US11351054
申请日：2006-02-09
申请人： Shabbir Bambot , Mark L. Faupel , Glenn Steven Arche
发明人： Shabbir Bambot , Mark L. Faupel , Glenn Steven Arche
IPC分类号： G01N21/00
CPC分类号： A61B5/0071 , A61B5/0084 , G01N21/474 , G01N21/49 , G01N21/6486 , G01N2021/6484
摘要： An apparatus and method embodying the invention include utilizing a device with a limited number of interrogation devices to accomplish a large number of measurements on a target tissue (50). An instrument embodying the invention includes a plurality of detection devices (54) that are arranged in a predetermined pattern on a tissue contacting face of the instrument. The face of the instrument is located adjacent the target tissue (50), and a plurality of tissue characteristic measurement are simultaneously conducted. The detection devices (54) are moved to a new position, preferably without moving the tissue contacting face, and a second plurality of tissue characteristic measurements are simultaneously conducted. By conducting a series of measurements cycles in this manner, the ultimate resolution of the device is increased, while still obtaining a given resolution, which reduces potential cross-talk errors. Further, a plurality of tissue characteristics are simultaneously obtained from locations spaced across the target tissue (50) during each measurement cycle.
摘要翻译：体现本发明的装置和方法包括利用具有有限数量的询问装置的装置来在目标组织（50）上完成大量的测量。实施本发明的仪器包括在仪器的组织接触面上以预定图案布置的多个检测装置（54）。仪器的表面位于目标组织（50）附近，同时进行多个组织特征测量。检测装置（54）移动到新的位置，优选地不移动组织接触面，同时进行第二组织特征测量。通过以这种方式进行一系列测量周期，设备的最终分辨率得到提高，同时仍然获得给定的分辨率，这降低了潜在的串扰误差。此外，在每个测量周期期间，跨越目标组织（50）间隔开的位置同时获得多个组织特征。

3. 发明授权

US06590651B1 Apparatus and method for determining tissue characteristics 有权
标题翻译：用于确定组织特征的装置和方法
公开(公告)号：US06590651B1
公开(公告)日：2003-07-08
申请号：US09700538
申请日：2000-11-16
申请人： Shabbir Bambot , Mark L. Faupel , Glenn Steven Arche
发明人： Shabbir Bambot , Mark L. Faupel , Glenn Steven Arche
IPC分类号： G01N2100
CPC分类号： A61B5/0071 , A61B5/0084 , G01N21/474 , G01N21/49 , G01N21/6486 , G01N2021/6484
摘要： An apparatus and method embodying the invention include utilizing a device with a limited number of interrogation devices to accomplish a large number of measurements on a target tissue (50). An instrument embodying the invention includes a plurality of detection devices (54) that are arranged in a predetermined pattern on a tissue contacting face of the instrument. The face of the instrument is located adjacent the target tissue (50), and a plurality of tissue characteristic measurement are simultaneously conducted. The detection devices (54) are moved to a new position, preferably without moving the tissue contacting face, and a second plurality of tissue characteristic measurements are simultaneously conducted. By conducting a series of measurements cycles in this manner, the ultimate resolution of the device is increased, while still obtaining a given resolution, which reduces potential cross-talk errors. Further, a plurality of tissue characteristics are simultaneously obtained from locations spaced across the target tissue (50) during each measurement cycle.
摘要翻译：体现本发明的装置和方法包括利用具有有限数量的询问装置的装置来在目标组织（50）上完成大量的测量。实施本发明的仪器包括在仪器的组织接触面上以预定图案布置的多个检测装置（54）。仪器的表面位于目标组织（50）附近，同时进行多个组织特征测量。检测装置（54）移动到新的位置，优选地不移动组织接触面，同时进行第二组织特征测量。通过以这种方式进行一系列测量周期，设备的最终分辨率得到提高，同时仍然获得给定的分辨率，这降低了潜在的串扰误差。此外，在每个测量周期期间，跨越目标组织（50）间隔开的位置同时获得多个组织特征。

4. 发明授权

US6002482A Disposable calibration device 失效
标题翻译：一次性校准装置
公开(公告)号：US6002482A
公开(公告)日：1999-12-14
申请号：US124090
申请日：1998-07-29
申请人： Robert Rothfritz , Scott Kerr , Glenn Steven Arche , Scott Kellogg , Gregory J. Newman , Mark A. Samuels , Richard Lachlan Fowler , Shabbir Bambot
发明人： Robert Rothfritz , Scott Kerr , Glenn Steven Arche , Scott Kellogg , Gregory J. Newman , Mark A. Samuels , Richard Lachlan Fowler , Shabbir Bambot
IPC分类号： A61B5/00 , A61B6/00 , G01B9/02 , G01D18/00 , G01N3/62 , G01N21/27 , G01N21/64
CPC分类号： A61B5/0059 , A61B5/1495 , G01N21/276 , G01N21/278 , G01N21/645 , A61B2560/0233 , G01N2201/0221
摘要： A combined infection shield and calibration or reference target for use with a measuring instrument includes a removable calibration/reference layer. The removable calibration/reference layer has predetermined optical characteristics that can be utilized to calibrate or reference the instrument. The calibration/reference layer may have predetermined reflectance or scattering properties, a predetermined transmissivity to light, or it may have predetermined fluorescence properties. When the calibration/reference layer is removed from the remaining portions of the device, the portion of the calibration/reference layer having the predetermined optical characteristics is irrevocably altered such that the calibration/reference layer cannot be reused. The combined infection shield and target may be attached to a shield holder, which in turn is attached to an instrument. Alternatively, the infection shield and target may be attached directly to an instrument.
摘要翻译：与测量仪器一起使用的组合感染屏蔽和校准或参考目标包括可移除的校准/参考层。可拆卸的校准/参考层具有可用于校准或参考仪器的预定光学特性。校准/参考层可以具有预定的反射率或散射特性，对光的预定透射率，或者可以具有预定的荧光特性。当校准/参考层从设备的其余部分移除时，具有预定光学特性的校准/参考层的部分不可逆转地改变，使得校准/参考层不能被重复使用。组合的感染屏蔽物和靶标可以附着到屏蔽保持器上，屏蔽保持器又连接到仪器上。或者，感染屏蔽物和靶标可以直接附着在仪器上。

5. 发明申请

US20080188736A1 SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS 审中-公开
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US20080188736A1
公开(公告)日：2008-08-07
申请号：US12099876
申请日：2008-04-09
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B6/00
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/0091 , A61B5/4312 , A61B5/444 , A61B5/6843 , A61B2562/164 , G01N21/21 , G01N21/49 , G01N21/64 , G01N21/6486 , G01N2021/6484
摘要： A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements. The apparatus and system include a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tissue interface unit configured to perform spectroscopic measurements on a target tissue, a docking unit configured to support the tissue interface when not in use, the docking unit including an illumination source and a processor that processes spectrographic measurements results received from the tissue interface unit, and a pathway coupling the docking unit and the tissue interface unit.
摘要翻译：提供了一种用于询问，接收和分析至少一种荧光激发波长的全发射光谱和至少一种反射测量以确定组织特征的方法和装置。该方法包括用光能照射目标组织的第一部分，形成目标组织的第一图像，用光能照射目标组织的第二部分，对目标反射和/或发射的光能进行光谱测量基于光谱测量的结果确定目标组织的第二部分的光能量的组织，以及确定靶组织的组织特征。该装置和系统包括具有照明，检测和控制子单元的基座单元，照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织界面单元，以及连接基本单元和组织接口单元的路径。系统和装置还可以包括被配置为对目标组织进行光谱测量的组织接口单元，配置成在不使用时支撑组织界面的对接单元，对接单元包括照明源和处理光谱测量结果的处理器从组织接口单元接收的通路，以及连接对接单元和组织接口单元的通路。

6. 发明授权

US08644912B2 System and method for determining tissue characteristics 有权
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US08644912B2
公开(公告)日：2014-02-04
申请号：US13214638
申请日：2011-08-22
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B6/00
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/0091 , A61B5/4312 , A61B5/444 , A61B5/6843 , A61B2562/164 , G01N21/21 , G01N21/49 , G01N21/64 , G01N21/6486 , G01N2021/6484
摘要： An apparatus to interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The apparatus includes a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tube for maintaining the distance between the tissue and units and for surrounding the tissue to prevent patient movement from being transmitted to the tissue.
摘要翻译：用于询问，接收和分析至少一种荧光激发波长的全发射光谱和用于至少一种反射测量以确定组织特征的装置。所述装置包括具有照明，检测和控制子单元的基座单元，所述照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织接口单元，以及连接基部单元和组织接口单元的路径。系统和装置还可以包括用于维持组织和单元之间的距离并围绕组织以防止患者移动被传递到组织的管。

7. 发明授权

US6055451A Apparatus and method for determining tissue characteristics 失效
标题翻译：用于确定组织特征的装置和方法
公开(公告)号：US6055451A
公开(公告)日：2000-04-25
申请号：US990069
申请日：1997-12-12
申请人： Shabbir Bambot , Mark L. Faupel
发明人： Shabbir Bambot , Mark L. Faupel
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/0086 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： An apparatus and method embodying the invention include utilizing a device intended to be inserted into a patient's body to determine a characteristic of a target tissue. In one apparatus and method, a device illuminates the target tissue with amplitude modulated excitation electromagnetic radiation, and the device senses a returned electromagnetic radiation. A phase shift between the excitation and return electromagnetic radiation is determined, and the phase shift is used to determine characteristics of the target tissue. A demodulation factor, representing ratios of the AC and DC components of the excitation and return electromagnetic radiation may also be calculated and used to determine characteristics of the target tissue. In another apparatus and method embodying the invention, a device illuminates a target tissue with polarized electromagnetic radiation, and a return electromagnetic radiation is sensed. The amplitude of the returned electromagnetic radiation is sensed in mutually perpendicular planes, and this information is used to determine an anisotropy factor. The anisotropy factor, in turn, is used to determine characteristics of the target tissue. In either of the above-described methods, the return radiation could be a portion of the excitation radiation that has been reflected or scattered from the target tissue, or the returned electromagnetic radiation could be fluorescent emissions generated by endogenous or exogenous fluorophores located in the target tissue.
摘要翻译：体现本发明的装置和方法包括利用旨在插入患者体内的装置来确定目标组织的特征。在一种装置和方法中，装置用调幅激励电磁辐射照射目标组织，并且该装置感测到返回的电磁辐射。确定激发和返回电磁辐射之间的相移，并使用相移来确定目标组织的特征。还可以计算表示激励和返回电磁辐射的AC和DC分量的比率的解调因子，并用于确定目标组织的特征。在实施本发明的另一种装置和方法中，装置用极化电磁辐射照射目标组织，并且检测返回电磁辐射。在相互垂直的平面中感测返回的电磁辐射的振幅，并且该信息用于确定各向异性因子。各向异性因子又用于确定靶组织的特征。在上述任一方法中，返回辐射可以是已经从目标组织反射或散射的激发辐射的一部分，或者返回的电磁辐射可以是由位于靶中的内源或外源荧光团产生的荧光发射组织。

8. 发明申请

US20110306887A1 SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS 有权
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US20110306887A1
公开(公告)日：2011-12-15
申请号：US13214638
申请日：2011-08-22
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B6/00
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/0091 , A61B5/4312 , A61B5/444 , A61B5/6843 , A61B2562/164 , G01N21/21 , G01N21/49 , G01N21/64 , G01N21/6486 , G01N2021/6484
摘要： A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements. The apparatus and system include a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tissue interface unit configured to perform spectroscopic measurements on a target tissue, a docking unit configured to support the tissue interface when not in use, the docking unit including an illumination source and a processor that processes spectrographic measurements results received from the tissue interface unit, and a pathway coupling the docking unit and the tissue interface unit.
摘要翻译：提供了一种用于询问，接收和分析至少一种荧光激发波长的全发射光谱和至少一种反射测量以确定组织特征的方法和装置。该方法包括用光能照射目标组织的第一部分，形成目标组织的第一图像，用光能照射目标组织的第二部分，对目标反射和/或发射的光能进行光谱测量基于光谱测量的结果确定目标组织的第二部分的光能量的组织，以及确定靶组织的组织特征。该装置和系统包括具有照明，检测和控制子单元的基座单元，照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织界面单元，以及连接基本单元和组织接口单元的路径。系统和装置还可以包括被配置为对目标组织进行光谱测量的组织接口单元，配置成在不使用时支撑组织界面的对接单元，对接单元包括照明源和处理光谱测量结果的处理器从组织接口单元接收的通路，以及连接对接单元和组织接口单元的通路。

9. 发明申请

US20140221846A1 SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS 审中-公开
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US20140221846A1
公开(公告)日：2014-08-07
申请号：US14073304
申请日：2013-11-06
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/4331
摘要： An apparatus to interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The apparatus includes a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tube for maintaining the distance between the tissue and units and for surrounding the tissue to prevent patient movement from being transmitted to the tissue.
摘要翻译：用于询问，接收和分析至少一种荧光激发波长的全发射光谱和用于至少一种反射测量以确定组织特征的装置。所述装置包括具有照明，检测和控制子单元的基座单元，所述照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织接口单元，以及连接基部单元和组织接口单元的路径。系统和装置还可以包括用于维持组织和单元之间的距离并围绕组织以防止患者移动被传递到组织的管。

10. 发明申请

US20070161876A1 Method and apparatus for rapid detection and diagnosis of tissue abnormalities 审中-公开
标题翻译：快速检测和诊断组织异常的方法和装置
公开(公告)号：US20070161876A1
公开(公告)日：2007-07-12
申请号：US11601904
申请日：2006-11-20
申请人： Shabbir Bambot , Mark Faupel , David Mongin
发明人： Shabbir Bambot , Mark Faupel , David Mongin
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/4331 , A61B5/0059 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0077 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0229 , G01J3/0232 , G01J3/0262 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/28 , G01J3/4406 , G01J2003/1213 , G01J2003/2866 , G01N21/274 , G01N21/31 , G01N21/474 , G01N21/645 , G01N2021/6417 , G01N2021/6423 , G01N2021/6484 , G01N2201/0221
摘要： A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics and correlate same to photographic images. Further, the system and method accomplish this measurement rapidly by increasing the light throughput by integrating optics into a hand held unit and avoiding the need for a coherent fiber optic bundle being used. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements.
摘要翻译：提供了一种方法和装置，用于询问，接收和分析至少一种荧光激发波长的全发射光谱，以及至少一次反射测量以确定组织特征并将其与摄影图像相关联。此外，该系统和方法通过将光学器件集成到手持式单元中并且避免对使用的相干光纤束的需要而增加光通量而快速地完成该测量。该方法包括用光能照射目标组织的第一部分，形成目标组织的第一图像，用光能照射目标组织的第二部分，对目标反射和/或发射的光能进行光谱测量基于光谱测量的结果确定目标组织的第二部分的光能量的组织，以及确定靶组织的组织特征。

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