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1. 发明申请

US20110306887A1 SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS 有权
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US20110306887A1
公开(公告)日：2011-12-15
申请号：US13214638
申请日：2011-08-22
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B6/00
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/0091 , A61B5/4312 , A61B5/444 , A61B5/6843 , A61B2562/164 , G01N21/21 , G01N21/49 , G01N21/64 , G01N21/6486 , G01N2021/6484
摘要： A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements. The apparatus and system include a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tissue interface unit configured to perform spectroscopic measurements on a target tissue, a docking unit configured to support the tissue interface when not in use, the docking unit including an illumination source and a processor that processes spectrographic measurements results received from the tissue interface unit, and a pathway coupling the docking unit and the tissue interface unit.
摘要翻译：提供了一种用于询问，接收和分析至少一种荧光激发波长的全发射光谱和至少一种反射测量以确定组织特征的方法和装置。该方法包括用光能照射目标组织的第一部分，形成目标组织的第一图像，用光能照射目标组织的第二部分，对目标反射和/或发射的光能进行光谱测量基于光谱测量的结果确定目标组织的第二部分的光能量的组织，以及确定靶组织的组织特征。该装置和系统包括具有照明，检测和控制子单元的基座单元，照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织界面单元，以及连接基本单元和组织接口单元的路径。系统和装置还可以包括被配置为对目标组织进行光谱测量的组织接口单元，配置成在不使用时支撑组织界面的对接单元，对接单元包括照明源和处理光谱测量结果的处理器从组织接口单元接收的通路，以及连接对接单元和组织接口单元的通路。

2. 发明授权

US6030399A Fluid jet blood sampling device and methods 失效
标题翻译：流体射流采血装置及方法
公开(公告)号：US6030399A
公开(公告)日：2000-02-29
申请号：US869214
申请日：1997-06-04
申请人： Keith D. Ignotz , Mark A. Samuels
发明人： Keith D. Ignotz , Mark A. Samuels
IPC分类号： A61B5/15 , A61B10/00 , A61B17/32
CPC分类号： A61B17/3203 , A61B5/150022 , A61B5/15003 , A61B5/150099 , A61B5/150755 , A61B5/150946 , A61B5/15134 , A61B5/153 , A61B5/155 , A61B10/0045
摘要： A fluid jet blood sampling system and method for obtaining a blood sample from a mammal, utilizes a fluid jet from a disposable jet nozzle to perforate at least the epidermis of the skin and to break at least one blood vessel, thereby allowing a quantity of blood to accumulate on the skin surface of the mammal. A cowling prevents contamination of the local environment with excess fluid, blood, etc. A drying unit may be provided to remove excess fluid, blood, etc. from the skin within the cowling. A sample of blood may be transferred to a test strip, or a collection unit may be used to collect and contain a blood sample from the mammal.
摘要翻译：一种用于从哺乳动物获得血液样本的流体喷射血液采样系统和方法，利用来自一次性喷嘴的流体射流至少穿透皮肤的表皮并破坏至少一个血管，由此允许一定量的血液以积累在哺乳动物的皮肤表面上。整流罩可以防止多余液体，血液等对局部环境的污染。可以提供干燥单元以从整流罩内的皮肤去除多余的液体，血液等。血液样品可以转移到测试条中，或者收集单元可以用于收集和包含来自哺乳动物的血液样品。

3. 发明授权

US5860421A Apparatus and method for calibrating measurement systems 失效
标题翻译：用于校准测量系统的装置和方法
公开(公告)号：US5860421A
公开(公告)日：1999-01-19
申请号：US587949
申请日：1996-01-17
申请人： Jonathan A. Eppstein , Mark A. Samuels , Keith D. Ignotz
发明人： Jonathan A. Eppstein , Mark A. Samuels , Keith D. Ignotz
IPC分类号： G01N21/17 , A61B5/00 , G01N21/27 , A61B8/00
CPC分类号： A61B5/1495 , A61B5/0059 , A61B2560/0233
摘要： A disposable calibration device is used to calibrate a measurement system which transmits radiation or acoustic waves to a material or tissue in order to effect measurements. The disposable calibration device includes a structure with a window through which the radiation or acoustic waves can be transmitted, as well as a removable calibration target arranged on the window and capable of returning a portion of the radiation or acoustic waves for calibrating the measurement system. The removable calibration target can be peeled from window to allow a measurement to be made on the material or tissue. Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the measuring system.
摘要翻译：一次性校准装置用于校准将辐射或声波传输到材料或组织以测量的测量系统。一次性校准装置包括具有透射辐射或声波的窗口的结构以及布置在窗口上并且能够返回一部分辐射或声波以便校准测量系统的可移除校准目标。可移除的校准目标可以从窗口剥离，以便在材料或组织上进行测量。一旦测量完成，可以丢弃一次性校准装置，并且可以在测量系统上插入新的校准装置。

4. 发明申请

US20130053700A1 ALGORITHM FOR DETECTION OF DIABETES 有权
标题翻译：用于检测糖尿病的算法
公开(公告)号：US20130053700A1
公开(公告)日：2013-02-28
申请号：US13291074
申请日：2011-11-07
申请人： Keith D. IGNOTZ , Dale A. RORABAUGH , Neil M. DAVIS , Vincent F. BRANCACCIO , Paul WILLIAMS , Craig H. MISRACH
发明人： Keith D. IGNOTZ , Dale A. RORABAUGH , Neil M. DAVIS , Vincent F. BRANCACCIO , Paul WILLIAMS , Craig H. MISRACH
IPC分类号： A61B6/00
CPC分类号： A61B3/1173 , A61B5/0068 , A61B5/0071 , A61B5/14546 , A61B5/1455 , A61B5/4842 , G01N21/6486 , G01N21/65 , G01N2800/042
摘要： Methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual.
摘要翻译：用于生物组织的光谱分析方法以将个体分类为糖尿病或非糖尿病，或确定个体中疾病或医学状况的概率，进展或水平。

5. 发明申请

US20080188736A1 SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS 审中-公开
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US20080188736A1
公开(公告)日：2008-08-07
申请号：US12099876
申请日：2008-04-09
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B6/00
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/0091 , A61B5/4312 , A61B5/444 , A61B5/6843 , A61B2562/164 , G01N21/21 , G01N21/49 , G01N21/64 , G01N21/6486 , G01N2021/6484
摘要： A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements. The apparatus and system include a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tissue interface unit configured to perform spectroscopic measurements on a target tissue, a docking unit configured to support the tissue interface when not in use, the docking unit including an illumination source and a processor that processes spectrographic measurements results received from the tissue interface unit, and a pathway coupling the docking unit and the tissue interface unit.
摘要翻译：提供了一种用于询问，接收和分析至少一种荧光激发波长的全发射光谱和至少一种反射测量以确定组织特征的方法和装置。该方法包括用光能照射目标组织的第一部分，形成目标组织的第一图像，用光能照射目标组织的第二部分，对目标反射和/或发射的光能进行光谱测量基于光谱测量的结果确定目标组织的第二部分的光能量的组织，以及确定靶组织的组织特征。该装置和系统包括具有照明，检测和控制子单元的基座单元，照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织界面单元，以及连接基本单元和组织接口单元的路径。系统和装置还可以包括被配置为对目标组织进行光谱测量的组织接口单元，配置成在不使用时支撑组织界面的对接单元，对接单元包括照明源和处理光谱测量结果的处理器从组织接口单元接收的通路，以及连接对接单元和组织接口单元的通路。

6. 发明授权

US08644912B2 System and method for determining tissue characteristics 有权
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US08644912B2
公开(公告)日：2014-02-04
申请号：US13214638
申请日：2011-08-22
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B6/00
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/0091 , A61B5/4312 , A61B5/444 , A61B5/6843 , A61B2562/164 , G01N21/21 , G01N21/49 , G01N21/64 , G01N21/6486 , G01N2021/6484
摘要： An apparatus to interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The apparatus includes a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tube for maintaining the distance between the tissue and units and for surrounding the tissue to prevent patient movement from being transmitted to the tissue.
摘要翻译：用于询问，接收和分析至少一种荧光激发波长的全发射光谱和用于至少一种反射测量以确定组织特征的装置。所述装置包括具有照明，检测和控制子单元的基座单元，所述照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织接口单元，以及连接基部单元和组织接口单元的路径。系统和装置还可以包括用于维持组织和单元之间的距离并围绕组织以防止患者移动被传递到组织的管。

7. 发明授权

US6045502A Analyzing system with disposable calibration device 失效
标题翻译：用一次性校准装置分析系统
公开(公告)号：US6045502A
公开(公告)日：2000-04-04
申请号：US904766
申请日：1997-08-01
申请人： Jonathan A. Eppstein , Mark A. Samuels , Keith D. Ignotz , Gregory J. Newman
发明人： Jonathan A. Eppstein , Mark A. Samuels , Keith D. Ignotz , Gregory J. Newman
IPC分类号： A61B5/00 , G01N21/27
CPC分类号： A61B5/0059 , A61B5/0075 , A61B5/1495 , G01J5/02 , G01J5/021 , G01J5/04 , G01J5/048 , G01J5/522 , G01N21/278 , A61B2560/0233
摘要： A system and method for calibrating a measurement instrument prior to making a measurement on a material or tissue includes utilizing a removable calibration device to calibrate the instrument, then removing a target portion of the calibration device so that a measurement may be performed. The calibration device may include an index matching agent, such as a gel, that is to be interposed between the patient's skin and an output end of the measuring instrument. A method embodying the invention may include making a bilirubin concentration measurement on a skin of a patient by measuring the amplitude of light reflected from the patient's skin at first and second wavelengths indicative of a blood content of the patient's skin, and measuring the amplitude of reflected light at a third wavelength indicative of an uncorrected bilirubin concentration, then calculating a corrected bilirubin concentration based on the three measurements. The method may also include taking measurements at fourth and fifth wavelengths indicative of a melanin content of the patient's skin, and calculating the bilirubin concentration based on the fourth and fifth measurements.
摘要翻译：用于在对材料或组织进行测量之前校准测量仪器的系统和方法包括利用可移除的校准装置校准所述仪器，然后移除所述校准装置的目标部分，使得可以执行测量。校准装置可以包括要置于患者皮肤和测量仪器的输出端之间的折射率匹配剂，例如凝胶。体现本发明的方法可以包括通过测量从患者皮肤反射的光的幅度来指示患者皮肤的血液含量的第一和第二波长来测量患者皮肤上的胆红素浓度，并测量反射的指示未校正的胆红素浓度的第三波长的光，然后基于三次测量计算校正的胆红素浓度。该方法还可以包括在指示患者皮肤的黑色素含量的第四和第五波长处进行测量，以及基于第四和第五测量来计算胆红素浓度。

8. 发明授权

US09877647B2 Device for detection of diabetes 有权
公开(公告)号：US09877647B2
公开(公告)日：2018-01-30
申请号：US13291074
申请日：2011-11-07
申请人： Keith D. Ignotz , Dale A. Rorabaugh , Neil M. Davis , Vincent F. Brancaccio , Paul Williams , Craig H. Misrach
发明人： Keith D. Ignotz , Dale A. Rorabaugh , Neil M. Davis , Vincent F. Brancaccio , Paul Williams , Craig H. Misrach
IPC分类号： A61B5/00 , A61B3/117 , A61B5/145 , A61B5/1455 , G01N21/64 , G01N21/65
CPC分类号： A61B3/1173 , A61B5/0068 , A61B5/0071 , A61B5/14546 , A61B5/1455 , A61B5/4842 , G01N21/6486 , G01N21/65 , G01N2800/042
摘要： Methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual.

9. 发明申请

US20140221846A1 SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS 审中-公开
标题翻译：用于确定组织特征的系统和方法
公开(公告)号：US20140221846A1
公开(公告)日：2014-08-07
申请号：US14073304
申请日：2013-11-06
申请人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
发明人： Shabbir Bambot , Mark L. Faupel , Anant Agrawal , Keith D. Ignotz , Andrew Fordham
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/4331
摘要： An apparatus to interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The apparatus includes a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tube for maintaining the distance between the tissue and units and for surrounding the tissue to prevent patient movement from being transmitted to the tissue.
摘要翻译：用于询问，接收和分析至少一种荧光激发波长的全发射光谱和用于至少一种反射测量以确定组织特征的装置。所述装置包括具有照明，检测和控制子单元的基座单元，所述照明子单元提供用于照射目标组织的照明光能和检测目标组织的组织特征的检测子单元，单独的组织接口单元，以及连接基部单元和组织接口单元的路径。系统和装置还可以包括用于维持组织和单元之间的距离并围绕组织以防止患者移动被传递到组织的管。

10. 发明授权

US06882873B2 Method and system for determining bilirubin concentration 有权
标题翻译：测定胆红素浓度的方法和系统
公开(公告)号：US06882873B2
公开(公告)日：2005-04-19
申请号：US10303832
申请日：2002-11-26
申请人： Mark A. Samuels , Keith D. Ignotz , Gregory J. Newman , Jonathan A. Eppstein , Fan Xu
发明人： Mark A. Samuels , Keith D. Ignotz , Gregory J. Newman , Jonathan A. Eppstein , Fan Xu
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B2560/0233 , A61B2562/247
摘要： A system and method embodying the invention can be used to detect a characteristic or condition of a patient. A method embodying the invention may include the steps of illuminating a portion of a skin of the patient with light, detecting a frequency spectrum of light scattered from the skin, determining, from first and second portions of the spectrum, a first parameter indicative of a blood content of the skin and a second parameter indicative of a melanin content of the skin, determining, from a third portion of the spectrum, a third parameter indicative of an uncorrected bilirubin concentration, and calculating a corrected bilirubin concentration based on the first, second and third parameters.
摘要翻译：体现本发明的系统和方法可用于检测患者的特征或状况。体现本发明的方法可以包括以下步骤：用光照射患者皮肤的一部分，检测从皮肤散射的光的频谱，从频谱的第一和第二部分确定指示一个皮肤的血液含量和指示皮肤黑色素含量的第二参数，从光谱的第三部分确定指示未校正的胆红素浓度的第三参数，以及基于第一，第二和第三个参数。

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