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    • 10. 发明申请
    • One-Step Synthesis Method of 2,9-Dimethyl-4,7-Diphenyl-1,10- Phenanthroline
    • 2,9-二甲基-4,7-二苯基-1,10-菲咯啉的一步合成方法
    • US20120165532A1
    • 2012-06-28
    • US13318716
    • 2010-03-30
    • Lifei CaiWeilong ZhangHongyu ZhaoLei Dai
    • Lifei CaiWeilong ZhangHongyu ZhaoLei Dai
    • C07D471/04
    • C07D471/04
    • This invention, which belongs to the field of organic synthesis, involves “One-step synthetic method of 2,9-dimethyl-1,7-diphenyl-1,10-phenanthroline”. This method uses O-phenylenediamine and formula III to react under the condition of mixed-shrinking agent, the synthesis can be completed in one step, the stated mixed-shrinking agent is mixture of hydrochloric acid and organic acid. The organic acid serves as phase transfer catalyst and shrinking agent, meanwhile, as buffer reagent, organic acid reduces polymerization of III, and side products as well. The products gained are of high purity and the reaction is mild and easy to control. Since there is no polluting material added and generated, the waste is safe to discharge. In the after treatment of reaction, ketone solvent is used to reduce separation step and product lost, thus improving yield.
    • 属于有机合成领域的本发明涉及“2,9-二甲基-1,7-二苯基-1,10-菲咯啉的一步合成方法”。 该方法使用O-苯二胺和式III在混合收缩剂的条件下反应,合成可以一步完成,所述混合收缩剂是盐酸和有机酸的混合物。 有机酸用作相转移催化剂和收缩剂,同时作为缓冲剂,有机酸还可以降低III和侧产物的聚合。 所得产品纯度高,反应温和,易于控制。 由于没有污染物质的添加和生成,废物是安全的排放。 在反应后处理中,使用酮溶剂来减少分离步骤和产物损失,从而提高产率。