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1. 发明授权

US07025877B1 Processing set for processing and treating a biological fluid 有权
标题翻译：加工和处理生物流体的处理装置
公开(公告)号：US07025877B1
公开(公告)日：2006-04-11
申请号：US09325599
申请日：1999-06-03
申请人： Serge de Gheldere , Mahmood Mohiuddin , Peyton S. Metzel , George D. Cimino , Derek J. Hei , Michael S. Clarke
发明人： Serge de Gheldere , Mahmood Mohiuddin , Peyton S. Metzel , George D. Cimino , Derek J. Hei , Michael S. Clarke
IPC分类号： B01D15/00
CPC分类号： A61J1/10 , A61L2/0023 , A61L2/0035 , A61L2/0047 , A61L2/007 , A61L2/0082 , A61L2/24 , A61L2/26 , A61L2202/122 , A61L2202/14 , A61L2202/22 , A61M1/0218 , A61M1/0236 , A61M1/0277 , A61M1/3681 , A61M1/3686 , B01D15/00
摘要： Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.
摘要翻译：公开了用于用光处理生物流体的装置，系统和方法。将生物流体的容器引入到流体处理室中，在该处理室中，与液体处理室附近的一个或多个光源提供的光接触。用于容纳生物流体的抽屉将容器引入腔室。用于保持生物流体的容器由装置标记以指示处理的状态。

2. 发明授权

US07105093B2 Processing set and methods for processing and treating a biological fluid 有权
公开(公告)号：US07105093B2
公开(公告)日：2006-09-12
申请号：US10267566
申请日：2002-10-08
申请人： Serge de Gheldere , Mahmood Mohiuddin , Peyton S. Metzel , George D. Cimino , Derek J. Hei , Michael S. Clarke
发明人： Serge de Gheldere , Mahmood Mohiuddin , Peyton S. Metzel , George D. Cimino , Derek J. Hei , Michael S. Clarke
IPC分类号： A61L2/10 , B01D15/00
CPC分类号： A61J1/10 , A61L2/0023 , A61L2/0035 , A61L2/0047 , A61L2/007 , A61L2/0082 , A61L2/24 , A61L2/26 , A61L2202/122 , A61L2202/14 , A61L2202/22 , A61M1/0218 , A61M1/0236 , A61M1/0277 , A61M1/3681 , A61M1/3686 , B01D15/00
摘要： Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

3. 发明授权

US07425304B2 Processing set and methods for processing and treating a biological fluid 有权
标题翻译：加工和处理生物流体的处理组和方法
公开(公告)号：US07425304B2
公开(公告)日：2008-09-16
申请号：US11353397
申请日：2006-02-13
申请人： Serge de Gheldere , Mahmood Mohiuddin , Peyton S. Metzel , George D. Cimino , Derek J. Hei , Michael S. Clarke
发明人： Serge de Gheldere , Mahmood Mohiuddin , Peyton S. Metzel , George D. Cimino , Derek J. Hei , Michael S. Clarke
IPC分类号： G01N21/00
CPC分类号： A61J1/10 , A61L2/0023 , A61L2/0035 , A61L2/0047 , A61L2/007 , A61L2/0082 , A61L2/24 , A61L2/26 , A61L2202/122 , A61L2202/14 , A61L2202/22 , A61M1/0218 , A61M1/0236 , A61M1/0277 , A61M1/3681 , A61M1/3686 , B01D15/00
摘要： Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.
摘要翻译：公开了用于用光处理生物流体的装置，系统和方法。将生物流体的容器引入到流体处理室中，在该处理室中，与液体处理室附近的一个或多个光源提供的光接触。用于容纳生物流体的抽屉将容器引入腔室。用于保持生物流体的容器由装置标记以指示处理的状态。

4. 发明授权

US06364864B1 Plastic containers having inner pouches and methods for making such containers 有权
标题翻译：具有内袋的塑料容器和制造这种容器的方法
公开(公告)号：US06364864B1
公开(公告)日：2002-04-02
申请号：US09325436
申请日：1999-06-03
申请人： Mahmood Mohiuddin , George D. Cimino , Derek J. Hei
发明人： Mahmood Mohiuddin , George D. Cimino , Derek J. Hei
IPC分类号： A61B1900
CPC分类号： A61J1/10 , A61M1/1694 , A61M1/3686
摘要： Containers and methods for making containers are disclosed. The containers include a chamber and a pouch fixed within the chamber. During manufacture, the open edges of the pouch are sealed between the walls of the container by a seal defining, in part, the peripheral edge of the chamber.
摘要翻译：公开了制造容器的容器和方法。容器包括固定在腔室内的腔室和小袋。在制造过程中，袋的开口边缘通过限定腔室周边边缘的密封件密封在容器的壁之间。

5. 发明授权

US06951713B2 Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix 有权
标题翻译：用固定在基质中的多孔颗粒吸收病原体灭活化合物
公开(公告)号：US06951713B2
公开(公告)日：2005-10-04
申请号：US10016323
申请日：2001-12-10
申请人： Derek J. Hei , Michael S. Clarke
发明人： Derek J. Hei , Michael S. Clarke
IPC分类号： A61M1/36 , A61L2/00 , A61M1/02 , B01D15/00 , B01D15/08 , B01J20/20 , B01J20/26 , B01J20/28 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/00 , C12N11/08 , C12N11/16 , A01N1/02 , A61K35/14 , C07K1/00 , C12M1/00 , C12N7/06
CPC分类号： B01J20/28026 , A01N1/0205 , A01N1/0236 , A01N1/0242 , A01N1/0278 , A61L2/00 , A61L2/0082 , A61M1/0209 , A61M1/0218 , A61M1/3679 , B01D15/00 , B01J20/20 , B01J20/28004 , B01J20/28019 , B01J20/28028 , B01J20/28057 , B01J20/28078 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/08
摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 1 μm to about 200 μm. The matrix can be fibrous, and the particles can have a surface area greater than 750 m2/g and a pore diameter between about 25 and 800 Å. The device can be used to adsorb and remove a pathogen-inactivating compound that is a nucleic acid-binding compound such as psoralen, an acridine derivative or a dye from a biological composition such as a blood product.
摘要翻译：提供的方法和装置用于降低生物组合物中低分子量化合物的浓度，同时基本维持生物组合物的所需生物活性。该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。含有颗粒的基质包含在壳体中，并且颗粒的直径范围为约1μm至约200μm。基质可以是纤维状的，并且颗粒的表面积可以大于750m 2 / g，孔直径在约25和800之间。该装置可用于从生物组合物如血液制品中吸附和除去作为核酸结合化合物如补骨脂素，吖啶衍生物或染料的病原体灭活化合物。

6. 发明授权

US06544727B1 Methods and devices for the removal of psoralens from blood products 失效
标题翻译：从血液制品中去除补骨脂素的方法和装置
公开(公告)号：US06544727B1
公开(公告)日：2003-04-08
申请号：US08659249
申请日：1996-06-07
申请人： Derek J. Hei
发明人： Derek J. Hei
IPC分类号： A01N102
CPC分类号： A61M1/3686 , A61B90/00 , A61K31/00 , A61K35/00 , A61M37/00
摘要： Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photoproducts. The removal process is particularly suitable for use with platelet concentrates and plasma because the process does not have a significant adverse effect on clotting factor function. The methods and devices can be incorporated with apheresis systems and other devices and procedures currently used to process blood products for transfusion.
摘要翻译：描述了从血液制品中去除补骨脂素和补骨脂素光产物的方法和装置。所述方法包括将补骨脂素和照射处理的血液制品与能够吸附补骨脂素和补骨脂素光产物的树脂接触。除去过程特别适用于血小板浓缩物和血浆，因为该方法对凝血因子功能没有显着的不利影响。方法和装置可以并入采集系统和目前用于处理用于输血的血液制品的其它装置和程序。

7. 发明授权

US07611831B2 Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix 有权
标题翻译：用固定在基质中的多孔颗粒吸附病原体灭活化合物
公开(公告)号：US07611831B2
公开(公告)日：2009-11-03
申请号：US11243822
申请日：2005-10-04
申请人： Derek J. Hei
发明人： Derek J. Hei
IPC分类号： A01N1/02 , A61K35/14 , C12N7/06 , C12M1/00 , C07K1/22
CPC分类号： A61M1/3679 , A01N1/0215 , A01N1/0231 , A61K35/18 , A61L2/00 , A61L2/0082 , A61L2202/22 , A61M1/0209 , A61M1/0218 , A61M1/3686 , B01J20/20 , B01J20/26 , B01J20/261 , B01J20/28004 , B01J20/28014 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/28057 , B01J20/28064 , B01J20/28066 , B01J20/28078 , B01J20/28083 , B01J20/28085 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/08
摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 μm to about 1500 μm. The device can be used to adsorb and remove a pathogen-inactivating compounds from a biological composition such as a blood product.
摘要翻译：提供的方法和装置用于降低含有细胞的生物组合物中的低分子量化合物的浓度，同时基本保持生物组合物的所需生物活性。该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。含有颗粒的基质包含在壳体中，并且颗粒的直径范围为约100μm至约1500μm。该装置可用于从诸如血液制品的生物组合物中吸附和去除病原体灭活化合物。

8. 发明授权

US06331387B2 Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix 失效
公开(公告)号：US06331387B2
公开(公告)日：2001-12-18
申请号：US09112400
申请日：1998-07-08
申请人： Derek J. Hei
发明人： Derek J. Hei
IPC分类号： A01N102
摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 &mgr;m to about 1500 &mgr;m. The device can be used to adsorb and remove pathogen-inactivating compounds from a biological composition such as a blood product.

9. 发明授权

US09259525B2 Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix 有权
标题翻译：用固定在基质中的多孔颗粒吸附病原体灭活化合物
公开(公告)号：US09259525B2
公开(公告)日：2016-02-16
申请号：US12563958
申请日：2009-09-21
申请人： Derek J. Hei
发明人： Derek J. Hei
IPC分类号： A61M1/36 , A61M1/02 , A01N1/02 , A61L2/00 , B01J20/26 , B01J20/28 , C12N11/08 , C07D493/04 , C07D219/10 , C07D405/12 , C07F9/64 , B01J20/20
CPC分类号： A61M1/3679 , A01N1/0215 , A01N1/0231 , A61K35/18 , A61L2/00 , A61L2/0082 , A61L2202/22 , A61M1/0209 , A61M1/0218 , A61M1/3686 , B01J20/20 , B01J20/26 , B01J20/261 , B01J20/28004 , B01J20/28014 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/28057 , B01J20/28064 , B01J20/28066 , B01J20/28078 , B01J20/28083 , B01J20/28085 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/08
摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 μm to about 1500 μm. The device can be used to adsorb and remove a pathogen-inactivating compounds from a biological composition such as a blood product.
摘要翻译：提供的方法和装置用于降低含有细胞的生物组合物中的低分子量化合物的浓度，同时基本保持生物组合物的所需生物活性。该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。含有颗粒的基质包含在壳体中，并且颗粒的直径范围为约100μm至约1500μm。该装置可用于从诸如血液制品的生物组合物中吸附和去除病原体灭活化合物。

10. 发明授权

US07037642B2 Removing compounds from blood products with porous particles immobilized in a matrix 有权
标题翻译：用固定在基质中的多孔颗粒从血液制品中除去化合物
公开(公告)号：US07037642B2
公开(公告)日：2006-05-02
申请号：US09972323
申请日：2001-10-05
申请人： Derek J. Hei
发明人： Derek J. Hei
IPC分类号： A01N1/02 , A61K35/14 , C12N7/06 , C12M1/00 , C07K1/00
CPC分类号： B01J20/28026 , A01N1/0205 , A01N1/0236 , A01N1/0242 , A01N1/0278 , A61L2/00 , A61L2/0082 , A61M1/0209 , A61M1/0218 , A61M1/3679 , B01D15/00 , B01J20/20 , B01J20/28004 , B01J20/28019 , B01J20/28028 , B01J20/28057 , B01J20/28078 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/08
摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.
摘要翻译：提供的方法和装置用于降低含有细胞的生物组合物中的低分子量化合物的浓度，同时基本保持生物组合物的所需生物活性。该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。

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