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1. 发明申请

US20100267782A1 SODIUM CHANNEL INHIBITORS 有权
标题翻译：钠通道抑制剂
公开(公告)号：US20100267782A1
公开(公告)日：2010-10-21
申请号：US12669018
申请日：2008-07-14
申请人： Serge Beaudoin , Matthew Scott Johnson , Brain Edward Marron , Mark J. Suto
发明人： Serge Beaudoin , Matthew Scott Johnson , Brain Edward Marron , Mark J. Suto
IPC分类号： A61K31/425 , C07D277/52 , A61P25/00
CPC分类号： C07D277/52
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
摘要翻译：提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或指示条件复发。本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

2. 发明授权

US08853250B2 Sodium channel inhibitors 有权
标题翻译：钠通道抑制剂
公开(公告)号：US08853250B2
公开(公告)日：2014-10-07
申请号：US12669018
申请日：2008-07-14
申请人： Serge Beaudoin , Matthew Scott Johnson , Brain Edward Marron , Mark J. Suto
发明人： Serge Beaudoin , Matthew Scott Johnson , Brain Edward Marron , Mark J. Suto
IPC分类号： A01N43/78 , A61K31/425 , C07D277/52
CPC分类号： C07D277/52
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
摘要翻译：提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或指示条件复发。本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

3. 发明申请

US20090023740A1 SODIUM CHANNEL INHIBITORS 有权
标题翻译：钠通道抑制剂
公开(公告)号：US20090023740A1
公开(公告)日：2009-01-22
申请号：US12173012
申请日：2008-07-14
申请人： Alan Bradley Fulp , Matthew Scott Johnson , Christopher John Markworth , Brian Edward Marron , Darrick Conway Seconi , Christopher William West , Xiaodong Wang , Shulan Zhou
发明人： Alan Bradley Fulp , Matthew Scott Johnson , Christopher John Markworth , Brian Edward Marron , Darrick Conway Seconi , Christopher William West , Xiaodong Wang , Shulan Zhou
IPC分类号： A61K31/502 , C07D409/12 , A61K31/427 , A61K31/4439 , C07D409/14
CPC分类号： C07D417/12 , C07D413/12
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
摘要翻译：提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。更具体地说，本发明提供取代磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢性或周围神经系统疾病，特别是通过阻断与发作或复发有关的钠通道的疼痛和慢性疼痛的方法的指示条件。本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

4. 发明授权

US06962365B2 Inflation gas generation devices and methods utilizing joule-thomson heating 失效
标题翻译：膨胀气体发生装置和方法利用焦耳汤加热
公开(公告)号：US06962365B2
公开(公告)日：2005-11-08
申请号：US10379054
申请日：2003-03-04
申请人： Karl K. Rink , Matthew Scott Johnson
发明人： Karl K. Rink , Matthew Scott Johnson
IPC分类号： B60R21/26 , F17C1/00
CPC分类号： F17C1/00 , B60R21/26 , F17C2201/0104 , F17C2201/0109 , F17C2201/0119 , F17C2201/0166 , F17C2201/0171 , F17C2201/058 , F17C2203/0617 , F17C2205/0311 , F17C2205/0314 , F17C2205/0323 , F17C2205/0326 , F17C2205/035 , F17C2205/0391 , F17C2205/0394 , F17C2205/0397 , F17C2209/22 , F17C2209/221 , F17C2221/013 , F17C2221/015 , F17C2221/017 , F17C2221/03 , F17C2223/0123 , F17C2223/0153 , F17C2223/036 , F17C2223/043 , F17C2225/0123 , F17C2225/035 , F17C2225/043 , F17C2227/0304 , F17C2227/0332 , F17C2227/036 , F17C2227/0372 , F17C2260/017 , F17C2260/025 , F17C2260/042 , F17C2270/0181 , F17C2270/0189
摘要： The invention provides apparatus for inflating an inflatable safety restraint cushion and associated methods for producing an inflation gas for inflating an inflatable safety restraint cushion which rely, at least in part, on Joule-Thomson heating.
摘要翻译：本发明提供了用于充气可充气安全约束垫的装置和用于产生充气气体的相关方法，所述膨胀气体用于充气至少部分依赖焦耳 - 汤姆森加热的可充气安全约束垫。

5. 发明授权

US08124610B2 Sodium channel inhibitors 有权
标题翻译：钠通道抑制剂
公开(公告)号：US08124610B2
公开(公告)日：2012-02-28
申请号：US12173012
申请日：2008-07-14
申请人： Alan Bradley Fulp , Matthew Scott Johnson , Christopher John Markworth , Brian Edward Marron , Darrick Conway Seconi , Christopher William West , Xiaodong Wang , Shulan Zhou
发明人： Alan Bradley Fulp , Matthew Scott Johnson , Christopher John Markworth , Brian Edward Marron , Darrick Conway Seconi , Christopher William West , Xiaodong Wang , Shulan Zhou
IPC分类号： C07D409/12 , A61K31/44
CPC分类号： C07D417/12 , C07D413/12
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
摘要翻译：提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。更具体地说，本发明提供取代磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢性或周围神经系统疾病，特别是通过阻断与发作或复发有关的钠通道的疼痛和慢性疼痛的方法的指示条件。本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

6. 发明授权

US06726243B2 Tuning the performance of compressed gas-containing inflators 失效
标题翻译：调整压缩气体充气机的性能
公开(公告)号：US06726243B2
公开(公告)日：2004-04-27
申请号：US10159992
申请日：2002-05-31
申请人： Charles Paul Dinsdale , Matthew Scott Johnson , Linda M. Rink , Karl K. Rink
发明人： Charles Paul Dinsdale , Matthew Scott Johnson , Linda M. Rink , Karl K. Rink
IPC分类号： B60R2126
CPC分类号： B60R21/268 , C06D5/04
摘要： An inflator apparatus wherein the molecular weight of the gas mixture therein contained is manipulated by varying the relative amounts of the various constituents thereof. Through such manipulation and tight control of gas mixture molecular weight, the performance of the inflator can be properly tuned such as to desirably control or influence the speed of deployment of an associated airbag cushion and minimize or reduce damage to an associated airbag cushion caused by excessive deployment speeds, as well as satisfy the relatively onerous inflation demands required for proper or desired operation of various close proximity airbag cushions or inflatable restraint devices.
摘要翻译：其中通过改变其中各种成分的相对量来操纵其中含有的气体混合物的分子量的充气机装置。通过这种操作和气体混合物分子量的严格控制，可以适当地调节充气机的性能，以便期望地控制或影响相关联的气囊垫的展开速度，并且最小化或减少由过度的部署速度以及满足各种紧邻气囊垫或充气式约束装置的正确或期望操作所需的相对繁重的充气要求。

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