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    • 2. 发明授权
    • Sodium channel inhibitors
    • 钠通道抑制剂
    • US08853250B2
    • 2014-10-07
    • US12669018
    • 2008-07-14
    • Serge BeaudoinMatthew Scott JohnsonBrain Edward MarronMark J. Suto
    • Serge BeaudoinMatthew Scott JohnsonBrain Edward MarronMark J. Suto
    • A01N43/78A61K31/425C07D277/52
    • C07D277/52
    • Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
    • 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物,组合物和方法。 更具体地,本发明提供取代的芳基磺酰胺,包含这些化合物的组合物,以及使用这些化合物或组合物治疗中枢或周围神经系统疾病,特别是疼痛和慢性疼痛的方法,其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物,组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。