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1. 发明授权

US08338608B2 Inhibitors of ion channels 失效
标题翻译：离子通道抑制剂
公开(公告)号：US08338608B2
公开(公告)日：2012-12-25
申请号：US12729193
申请日：2010-03-22
申请人： Xiaodong Wang , Alan Fulp , Brian Marron , Serge Beaudoin , Darrick Seconi , Mark Suto
发明人： Xiaodong Wang , Alan Fulp , Brian Marron , Serge Beaudoin , Darrick Seconi , Mark Suto
IPC分类号： C07D417/12 , A61K31/4436
CPC分类号： C07D277/52 , C07D417/12 , C07D417/14
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
摘要翻译：提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或指示条件复发。本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

2. 发明申请

US20100197655A1 SULFONAMIDE DERIVATIVES 有权
标题翻译：磺酰胺衍生物
公开(公告)号：US20100197655A1
公开(公告)日：2010-08-05
申请号：US12685913
申请日：2010-01-12
申请人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： A61K31/505 , C07D417/12 , A61K31/433 , A61K31/427 , C07D285/08 , C07D263/50 , A61K31/421 , A61K31/4439 , A61K31/506 , C07D261/16 , A61K31/42 , C07D239/69 , A61K31/4245 , C07D401/12 , A61K31/454 , A61K31/44 , C07D213/84 , C07D403/14 , A61K31/501 , C07D405/12 , A61P29/00
CPC分类号： C07D417/12 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D263/50 , C07D275/03 , C07D277/18 , C07D285/08 , C07D401/12 , C07D413/12 , C07D417/14 , C07F9/6539
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
摘要翻译：本发明涉及下式的化合物及其药学上可接受的盐，溶剂合物或互变异构体，其制备方法，用于制备的中间体和含有这些化合物的组合物，以及这些化合物的用途，特别是用于治疗疼痛。

3. 发明申请

US20070135493A1 INHIBITORS OF ION CHANNELS 失效
标题翻译：离子通道的抑制剂
公开(公告)号：US20070135493A1
公开(公告)日：2007-06-14
申请号：US11555977
申请日：2006-11-02
申请人： Xiaodong Wang , Alan Fulp , Brian Marron , Serge Beaudoin , Darrick Seconi , Mark Suto
发明人： Xiaodong Wang , Alan Fulp , Brian Marron , Serge Beaudoin , Darrick Seconi , Mark Suto
IPC分类号： A61K31/513 , A61K31/497 , A61K31/4439 , A61K31/426 , C07D417/02
CPC分类号： C07D277/52 , C07D417/12 , C07D417/14
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
摘要翻译：提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与发作相关的钠通道或指示条件复发。本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

4. 发明申请

US20060014792A1 Heterocyclo inhibitors of potassium channel function 有权
标题翻译：钾通道功能的杂环抑制剂
公开(公告)号：US20060014792A1
公开(公告)日：2006-01-19
申请号：US11186991
申请日：2005-07-21
申请人： John Lloyd , Yoon Jeon , Heather Finlay , Lin Yan , Michael Gross , Serge Beaudoin
发明人： John Lloyd , Yoon Jeon , Heather Finlay , Lin Yan , Michael Gross , Serge Beaudoin
IPC分类号： C07D211/26 , A61K31/445
CPC分类号： C07D211/26 , C07D211/34 , C07D211/62 , C07D211/64 , C07D211/96 , C07D223/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
摘要翻译：可用作钾通道功能抑制剂的新型杂环化合物（特别是电压门控K +通道的K 1亚族的抑制剂，特别是抑制剂K > 1.5，其与超快速活化延迟整流器K +电流I K连接），使用这些化合物在预防和治疗心律失常中的方法，相关条件和含有这些化合物的药物组合物。

5. 发明授权

US06858611B2 Potassium channel inhibitors 有权
标题翻译：钾通道抑制剂
公开(公告)号：US06858611B2
公开(公告)日：2005-02-22
申请号：US10390597
申请日：2003-03-19
申请人： Aimee Dolores Reed , Michael Francis Gross , Serge Beaudoin
发明人： Aimee Dolores Reed , Michael Francis Gross , Serge Beaudoin
IPC分类号： A61P9/06 , C07D213/40 , C07D233/54 , C07D239/26 , C07D239/42 , C07D241/12 , C07D409/12 , C07D417/12 , A61K31/4709 , A61K31/517 , C07D401/12 , C07D403/12
CPC分类号： C07D213/40 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D409/12 , C07D417/12
摘要： Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
摘要翻译：描述了可用作钾通道抑制剂并且由于其缓慢脱落率的化合物特别可用于治疗心律失常。

6. 发明授权

US07582654B2 Heterocyclo inhibitors of potassium channel function 有权
标题翻译：钾通道功能的杂环抑制剂
公开(公告)号：US07582654B2
公开(公告)日：2009-09-01
申请号：US11186991
申请日：2005-07-21
申请人： John Lloyd , Yoon T. Jeon , Heather Finlay , Lin Yan , Michael F. Gross , Serge Beaudoin
发明人： John Lloyd , Yoon T. Jeon , Heather Finlay , Lin Yan , Michael F. Gross , Serge Beaudoin
IPC分类号： C07D401/02 , A61K31/445
CPC分类号： C07D211/26 , C07D211/34 , C07D211/62 , C07D211/64 , C07D211/96 , C07D223/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
摘要翻译：可用作钾通道功能抑制剂的新型杂环化合物（特别是电压门控K +通道的Kv1亚族抑制剂，特别是与超快速活化延迟整流剂K +当前IKur连接的抑制剂Kv1.5），使用这些化合物的方法在预防和治疗心律失常和IKur相关病症中，以及含有这些化合物的药物组合物。

7. 发明申请

US20070142333A1 CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION 审中-公开
标题翻译：钾离子通道功能的CYCLOALKYL抑制剂
公开(公告)号：US20070142333A1
公开(公告)日：2007-06-21
申请号：US11670482
申请日：2007-02-02
申请人： John Lloyd , Yoon Jeon , Heather Finlay , Lin Yan , Michael Gross , Serge Beaudoin
发明人： John Lloyd , Yoon Jeon , Heather Finlay , Lin Yan , Michael Gross , Serge Beaudoin
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/426 , A61K31/421 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D213/40 , A61K45/06 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/65 , C07C235/06 , C07C235/34 , C07C235/46 , C07C235/60 , C07C279/16 , C07C279/24 , C07C279/28 , C07C307/02 , C07C307/04 , C07C307/08 , C07C307/10 , C07C311/16 , C07C311/29 , C07C311/55 , C07C311/59 , C07C311/64 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2603/66 , C07D213/69 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/48 , C07D233/56 , C07D233/64 , C07D233/76 , C07D235/14 , C07D239/42 , C07D239/94 , C07D239/95 , C07D241/06 , C07D249/04 , C07D249/08 , C07D251/44 , C07D251/46 , C07D261/08 , C07D261/14 , C07D271/06 , C07D295/13 , C07D295/185 , C07D295/215 , C07D295/26 , C07D307/68 , C07D309/04 , C07D309/08 , C07D333/20 , C07D333/28 , C07D333/38 , C07D333/58 , C07D333/62 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
摘要翻译：可用作钾通道功能抑制剂的新型环烷基化合物（特别是电压门控K +通道抑制剂，尤其是抑制剂K + > 1.5，其与超快速活化延迟整流器K +电流I K连接），使用这些化合物在预防和治疗心律失常中的方法，相关条件和含有这些化合物的药物组合物。

8. 发明授权

US08853250B2 Sodium channel inhibitors 有权
标题翻译：钠通道抑制剂
公开(公告)号：US08853250B2
公开(公告)日：2014-10-07
申请号：US12669018
申请日：2008-07-14
申请人： Serge Beaudoin , Matthew Scott Johnson , Brain Edward Marron , Mark J. Suto
发明人： Serge Beaudoin , Matthew Scott Johnson , Brain Edward Marron , Mark J. Suto
IPC分类号： A01N43/78 , A61K31/425 , C07D277/52
CPC分类号： C07D277/52
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
摘要翻译：提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或指示条件复发。本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

9. 发明申请

US20120149679A1 Sulfonamide Derivatives 有权
标题翻译：磺酰胺衍生物
公开(公告)号：US20120149679A1
公开(公告)日：2012-06-14
申请号：US13400356
申请日：2012-02-20
申请人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： A61K31/433 , A61K31/427 , C07D285/08 , C07D263/50 , A61K31/421 , C07D277/52 , A61K31/426 , C07D275/03 , A61K31/425 , A61K31/4439 , A61K31/506 , A61K31/497 , A61K31/501 , C07D401/12 , A61K31/454 , A61P29/00 , C07D417/12
CPC分类号： C07D417/12 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D263/50 , C07D275/03 , C07D277/18 , C07D285/08 , C07D401/12 , C07D413/12 , C07D417/14 , C07F9/6539
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
摘要翻译：本发明涉及下式的化合物及其药学上可接受的盐，溶剂合物或互变异构体，其制备方法，用于制备的中间体和含有这些化合物的组合物，以及这些化合物的用途，特别是用于治疗疼痛。

10. 发明授权

US08153814B2 Sulfonamide derivatives 有权
标题翻译：磺酰胺衍生物
公开(公告)号：US08153814B2
公开(公告)日：2012-04-10
申请号：US12685913
申请日：2010-01-12
申请人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： C07D277/00 , A61K31/425
CPC分类号： C07D417/12 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D263/50 , C07D275/03 , C07D277/18 , C07D285/08 , C07D401/12 , C07D413/12 , C07D417/14 , C07F9/6539
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
摘要翻译：本发明涉及下式的化合物及其药学上可接受的盐，溶剂合物或互变异构体，其制备方法，用于制备的中间体和含有这些化合物的组合物，以及这些化合物的用途，特别是用于治疗疼痛。

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