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1. 发明授权

US09108956B2 Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors 有权
标题翻译：环醚DGAT1抑制剂环醚DGAT1抑制剂
公开(公告)号：US09108956B2
公开(公告)日：2015-08-18
申请号：US14396744
申请日：2013-04-26
申请人： Sejal Patel , Justin Mao , Qian Liu , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri
发明人： Sejal Patel , Justin Mao , Qian Liu , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri
IPC分类号： C07D413/12 , C07D417/12
CPC分类号： C07D413/12 , C07D417/12
摘要： The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
摘要翻译：本发明涉及式（I）化合物：可用于治疗由酰基辅酶 - 二酰基甘油酰基转移酶1（DGAT1）介导的病症，例如，代谢紊乱。本发明还提供了治疗这些病症的方法，以及用于治疗的化合物和组合物等。

2. 发明申请

US20150141474A1 CYCLIC ETHER DGAT1 INHIBITORSCYCLIC ETHER DGAT1 INHIBITORS 有权
标题翻译：循环醚DGAT1抑制剂等离子体DGAT1抑制剂
公开(公告)号：US20150141474A1
公开(公告)日：2015-05-21
申请号：US14396744
申请日：2013-04-26
申请人： Sejal Patel , Justin Mao , Qian Liu , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri
发明人： Sejal Patel , Justin Mao , Qian Liu , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri
IPC分类号： C07D413/12
CPC分类号： C07D413/12 , C07D417/12
摘要： The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
摘要翻译：本发明涉及式（I）化合物：可用于治疗由酰基辅酶 - 二酰基甘油酰基转移酶1（DGAT1）介导的病症，例如，代谢紊乱。本发明还提供了治疗这些病症的方法，以及用于治疗的化合物和组合物等。

3. 发明申请

US20150166563A1 CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS 审中-公开
标题翻译：循环桥式加速器DGAT1抑制剂
公开(公告)号：US20150166563A1
公开(公告)日：2015-06-18
申请号：US14628205
申请日：2015-02-20
申请人： Sejal Patel , Justin Mao , Qian Liu , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
发明人： Sejal Patel , Justin Mao , Qian Liu , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
IPC分类号： C07D493/08 , A61K31/4439 , C07D417/14 , A61K31/422 , C07D417/12 , A61K31/433 , C07D413/12 , A61K31/4245 , C07D413/14 , A61K31/506
CPC分类号： C07D493/08 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要： The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
摘要翻译：本发明涉及式（I）化合物：可用于治疗由酰基辅酶 - 二酰基甘油酰基转移酶1（DGAT1）介导的病症，例如，代谢紊乱。本发明还提供了治疗这些病症的方法，以及用于治疗的化合物和组合物等。

4. 发明授权

US08993619B2 Cyclic bridgehead ether DGAT1 inhibitors 有权
标题翻译：循环桥头醚DGAT1抑制剂
公开(公告)号：US08993619B2
公开(公告)日：2015-03-31
申请号：US13871586
申请日：2013-04-26
申请人： Sejal Patel , Justin Mao , Qian Liu , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
发明人： Sejal Patel , Justin Mao , Qian Liu , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
IPC分类号： A01N43/08 , A61K31/34 , A01N43/16 , A61K31/35 , A61K31/505 , A01N43/40 , A61K31/44 , A01N43/82 , A61K31/41 , A01N43/76 , A61K31/42 , C07D401/00 , C07D403/00 , C07D405/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D285/12 , C07D285/14 , C07D513/00 , C07D271/10 , C07D271/12 , C07D498/00 , C07D263/00 , C07D263/34 , C07D493/08 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D413/12 , C07D417/12
CPC分类号： C07D493/08 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要： The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
摘要翻译：本发明涉及式（I）化合物：可用于治疗由酰基辅酶 - 二酰基甘油酰基转移酶1（DGAT1）介导的病症，例如，代谢紊乱。本发明还提供了治疗这些病症的方法，以及用于治疗的化合物和组合物等。

5. 发明申请

US20130289058A1 CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS 有权
公开(公告)号：US20130289058A1
公开(公告)日：2013-10-31
申请号：US13871586
申请日：2013-04-26
申请人： Sejal Patel , Justin Mao , Qian Lui , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
发明人： Sejal Patel , Justin Mao , Qian Lui , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
IPC分类号： C07D493/08 , A61K31/506 , A61K45/06 , A61K31/4245 , A61K31/422 , A61K31/4439 , A61K31/433
CPC分类号： C07D493/08 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要： The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

6. 发明授权

US09255093B2 Polycyclic HERG activators 有权
标题翻译：多环HERG激活剂
公开(公告)号：US09255093B2
公开(公告)日：2016-02-09
申请号：US14688397
申请日：2015-04-16
申请人： Gregory Raymond Bebernitz , Emma Cody , Tajesh Patel , Ming Qian , Lewis Whitehead , Thomas Zabawa , Frederic Zecri
发明人： Gregory Raymond Bebernitz , Emma Cody , Tajesh Patel , Ming Qian , Lewis Whitehead , Thomas Zabawa , Frederic Zecri
IPC分类号： C07D405/04 , A61K31/41 , C07D417/12 , C07D405/14 , C07D307/85 , A61K31/343 , C07D407/12 , A61K31/357 , A61K31/443 , A61K31/428
CPC分类号： C07D405/04 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/41 , A61K31/428 , A61K31/443 , A61K31/4439 , A61K31/5377 , C07D307/85 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，其中R 1，R 2，X和R 3在发明概述中定义。制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

7. 发明申请

US20090156556A1 AMINOPROPANOL DERIVATIVES 失效
标题翻译：氨基酚类衍生物
公开(公告)号：US20090156556A1
公开(公告)日：2009-06-18
申请号：US12391298
申请日：2009-02-24
申请人： Rainer Albert , Eric Francotte , Frederic Zecri , Markus Zollinger
发明人： Rainer Albert , Eric Francotte , Frederic Zecri , Markus Zollinger
IPC分类号： A61K31/675 , C07F9/547 , C07F9/06 , A61K31/66
CPC分类号： C07F9/5728 , C07D209/46 , C07D263/14 , C07F9/094 , C07F9/653 , Y10T436/163333
摘要： Compounds of formula I: wherein R1, R2, n and m are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
摘要翻译：式I化合物：其中R1，R2，n和m如说明书中所定义，其制备方法及其用途和含有它们的药物组合物。

8. 发明授权

US09683019B2 Cyclic polypeptides for the treatment of heart failure 有权
公开(公告)号：US09683019B2
公开(公告)日：2017-06-20
申请号：US14963391
申请日：2015-12-09
申请人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Guimaraes
发明人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Guimaraes
IPC分类号： A61K38/12 , C07K7/64 , C07K16/46 , A61K45/06 , C07K14/47 , A61K47/48 , C07K14/765
CPC分类号： C07K14/47 , A61K38/12 , A61K38/1709 , A61K45/06 , A61K47/542 , A61K47/60 , A61K47/643 , A61K47/6811 , C07K7/64 , C07K14/765 , C07K16/461 , C07K2319/30 , C07K2319/31
摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

9. 发明授权

US09340582B2 Bioconjugates of synthetic apelin polypeptides 有权
标题翻译：合成apelin多肽的生物缀合物
公开(公告)号：US09340582B2
公开(公告)日：2016-05-17
申请号：US14336290
申请日：2014-07-21
申请人： Jun Yuan , Frederic Zecri , Philipp Grosche , Hongjuan Zhao , Eric Peters , Shari Lynn Caplan , Changgang Lou
发明人： Jun Yuan , Frederic Zecri , Philipp Grosche , Hongjuan Zhao , Eric Peters , Shari Lynn Caplan , Changgang Lou
IPC分类号： C07K14/47 , C07K7/08 , A61K47/48 , A61K45/06 , A61K38/10 , C07K16/00 , A61K39/395
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , A61K47/542 , A61K47/643 , A61K47/68 , A61K47/6811 , C07K14/47 , C07K14/765 , C07K2319/30 , C07K2319/31
摘要： The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供包含式I'（SEQ ID NO：1）的合成多肽的生物缀合物或其酰胺，其酯或其盐，其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，X 8，X 9 ，X10，X11，X12和X13在本文中定义并且半衰期延长部分，其中肽和半衰期延长部分任选地经由连接体共价连接或融合。多肽是APJ受体的激动剂。本发明还涉及本发明的生物缀合物的制备方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，布鲁加达综合征，室性心动过速，动脉粥样硬化，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（包括晒伤）和先兆子痫。本发明还提供药理活性剂和药物组合物的组合。

10. 发明申请

US20100144729A1 COUMARIN DERIVATIVES 审中-公开
标题翻译： COUMARIN衍生物
公开(公告)号：US20100144729A1
公开(公告)日：2010-06-10
申请号：US12524943
申请日：2008-01-31
申请人： Rolf Baenteli , Nigel Graham Cooke , Frederic Zecri , Alexander Baxter Smith
发明人： Rolf Baenteli , Nigel Graham Cooke , Frederic Zecri , Alexander Baxter Smith
IPC分类号： A61K31/5377 , C07D311/02 , A61K31/366 , C07D405/12 , A61K31/4025 , A61K31/453 , C07D413/12
CPC分类号： C07D311/16 , C07D311/18
摘要： A compound of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译：其中R 1，R 2，R 3和R 4如说明书中所定义的式（I）化合物，其制备方法，用途，特别是在移植中，以及含有它们的药物组合物。

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