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1. 发明授权

US6051424A Human cDNAs and proteins encoded thereby 失效
标题翻译：人类cDNA和由此编码的蛋白质
公开(公告)号：US6051424A
公开(公告)日：2000-04-18
申请号：US390207
申请日：1995-02-16
申请人： Seishi Kato , Suwan Oh , Shingo Sekine , Namsoon Kim , Takae Kato , Akiyo Iwahori
发明人： Seishi Kato , Suwan Oh , Shingo Sekine , Namsoon Kim , Takae Kato , Akiyo Iwahori
IPC分类号： C07K14/47 , C12N9/10 , C12N9/14 , C12N15/12 , C07H21/00 , C12N15/63
CPC分类号： C12N9/1007 , C07K14/47 , C12N9/14
摘要： Isolated cDNAs derived from mRNAs expressed in human cells are provided, as are DNAs and RNAs comprising their nucleotide sequences, and vectors for expressing the cDNAs. The cDNAs encode proteins which have functions similar to known proteins.
摘要翻译：提供了源自人细胞中表达的mRNA的分离的cDNA，以及包含其核苷酸序列的DNA和RNA以及用于表达cDNA的载体。 cDNA编码具有与已知蛋白质相似功能的蛋白质。

2. 发明申请

US20050074842A1 Human proteins having transmembrane domains and DNAs encoding these proteins 审中-公开
标题翻译：具有跨膜结构域的人蛋白质和编码这些蛋白质的DNA
公开(公告)号：US20050074842A1
公开(公告)日：2005-04-07
申请号：US10626686
申请日：2003-07-25
申请人： Seishi Kato , Shingo Sekine , Tomoko Kimura
发明人： Seishi Kato , Shingo Sekine , Tomoko Kimura
IPC分类号： C12N15/09 , A61K38/00 , C07H21/04 , C07K14/705 , C12N1/15 , C12N1/19 , C12N5/10 , C12N9/72
CPC分类号： C07K14/705 , A61K38/00 , C12N9/6456
摘要： Proteins comprising any of the amino acid sequences of SEQ ID NOS: 1 to 18 and DNAs encoding said proteins and comprising any of the nucelotide sequences of SEQ ID NOS: 19 to 36 are provided.
摘要翻译：提供了包含SEQ ID NO：1至18的任何氨基酸序列的蛋白质和编码所述蛋白质的DNA并且包含SEQ ID NO：19至36的任一个硝酸苷序列的蛋白质。

3. 发明授权

US06703201B1 Human PEC-60-like protein and DNA encoding this protein 有权
标题翻译：人类PEC-60样蛋白和编码该蛋白的DNA
公开(公告)号：US06703201B1
公开(公告)日：2004-03-09
申请号：US09671483
申请日：2000-09-27
申请人： Seishi Kato , Tomoko Yamaguchi , Shingo Sekine , Kouju Kamata
发明人： Seishi Kato , Tomoko Yamaguchi , Shingo Sekine , Kouju Kamata
IPC分类号： C12Q168
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention provides a human PEC-60-like protein, a gastrointestinal hormone excreted by a stomach tissue and a cDNA encoding this protein. The protein and the gene of the present invention can provide a protein containing the amino acid sequence represented by Sequence No. 1 and a DNA encoding said protein exemplified as a cDNA containing the base sequence represented by Sequence No. 1 as well as a human cDNA encoding a human PEC-60-like protein and said protein by the expression of this human cDNA recombinant.
摘要翻译：本发明提供人类PEC-60样蛋白质，由胃组织排出的胃肠激素和编码该蛋白质的cDNA。本发明的蛋白质和基因可以提供含有序列号1所示的氨基酸序列的蛋白质和编码所述蛋白质的DNA，作为含有序列号1表示的碱基序列的cDNA，以及人cDNA 通过该人cDNA重组体的表达编码人类PEC-60样蛋白和所述蛋白质。

4. 发明申请

US20050053943A1 Human membrane antigen TM4 superfamily protein and DNA encoding this protein 审中-公开
标题翻译：人膜抗原TM4超家族蛋白和编码该蛋白的DNA
公开(公告)号：US20050053943A1
公开(公告)日：2005-03-10
申请号：US10608388
申请日：2003-06-30
申请人： Seishi Kato , Shingo Sekine , Tomoko Yamaguchi
发明人： Seishi Kato , Shingo Sekine , Tomoko Yamaguchi
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12Q1/68 , C07H21/04 , C07K14/74
CPC分类号： C07K14/705 , A61K38/00
摘要： A human membrane antigen TM4 superfamily protein existing on the osteosarcoma cell surface and a cDNA encoding this protein is provided, said protein being useful as a pharmaceutical for treatment and diagnosis of cancers and also as an antigen for preparation of an antibody against said protein.
摘要翻译：提供存在于骨肉瘤细胞表面上的人膜抗原TM4超家族蛋白质和编码该蛋白质的cDNA，所述蛋白质可用作癌症治疗和诊断的药物，也可用作制备针对所述蛋白质的抗体的抗原。

5. 发明授权

US06280968B1 Human PEC-60-like protein and DNA encoding the same 失效
标题翻译：人类PEC-60样蛋白和编码相同的DNA
公开(公告)号：US06280968B1
公开(公告)日：2001-08-28
申请号：US09065019
申请日：1998-04-17
申请人： Seishi Kato , Tomoko Yamaguchi , Shingo Sekine , Kouju Kamata
发明人： Seishi Kato , Tomoko Yamaguchi , Shingo Sekine , Kouju Kamata
IPC分类号： C12P2106
CPC分类号： C07K14/575 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human PEC-60-like protein, a gastrointestinal hormone excreted by a stomach tissue and a cDNA encoding this protein. The protein and the gene of the present invention can provide a protein containing the amino acid sequence represented by Sequence No. 1 and a DNA encoding said protein exemplified as a cDNA containing the base sequence represented by Sequence No. 1. as well as a human cDNA encoding a human PEC-60-like protein and said protein by the expression of this human cDNA recombinant.
摘要翻译：本发明提供人类PEC-60样蛋白质，由胃组织排出的胃肠激素和编码该蛋白质的cDNA。本发明的蛋白质和基因可以提供含有序列号1所示的氨基酸序列的蛋白质和编码所述蛋白质的DNA，该DNA作为含有序列号1表示的碱基序列的cDNA，以及人通过该人cDNA重组体的表达，编码人类PEC-60样蛋白质的cDNA和所述蛋白质。

6. 发明授权

US5597713A Process for producing cDNAs with complete length, process for producing intermediates thereof and process for producing vectors containing cDNAs with complete lengths 失效
标题翻译：用于生产具有完整长度的cDNA的方法，其制备中间体的方法和用于生产含有完整长度的cDNA的载体的方法
公开(公告)号：US5597713A
公开(公告)日：1997-01-28
申请号：US244188
申请日：1994-07-25
申请人： Seishi Kato , Shingo Sekine
发明人： Seishi Kato , Shingo Sekine
IPC分类号： C12N15/09 , C12N15/10 , C12N15/66 , C12N15/11 , C12N15/64 , C12P19/34
CPC分类号： C12N15/1096 , C12N15/66
摘要： A process for providing cDNAs containing full primary structure information of proteins by selectively synthesizing full-length cDNAs containing sequences starting from the capped region of mRNAs is disclosed. The invention provides a process for producing an intermediate for the synthesis of a full-length cDNA, which comprises the steps of treating mRNA extracted from cells to eliminate the phosphate group from the 5' end of an uncapped degraded mRNA; decapping from the 5' end of a capped intact mRNA; and ligating either a DNA oligonucleotide or a DNA-RNA chimeric oligonucleotide represented by the following general formula [I] to the 5' end phosphate group formed in the above step by the action of T4 RNA ligase, thereby selectively adding either the DNA oligonucleotide or the DNA-RNA chimeric oligonucleotide having an arbitrary sequence to the 5' end of the intact mRNA.5'-dN1-dN2- . . . -dNm-N1-N2- . . . -Nn-3' [I]The present invention also provides a process for synthesizing a full-length cDNA, which comprises linking a double-stranded DNA primer having a dT tail by annealing to a poly(A) tail of the 3' end of the intact mRNA having the DNA oligonucleotide or the DNA-RNA chimeric nucleotide added at the 5' end produced by the above-mentioned process, and then synthesizing the first strand cDNA complementary to the intact mRNA by a reverse transcriptase.
摘要翻译： PCT No.PCT / JP93 / 01359 Sec。 371日期：1994年7月25日 102（e）日期1994年7月25日PCT提交1993年9月22日PCT公布。第WO94 / 08001号公报日期1994年04月14日公开了通过选择性地合成含有从mRNA封端区开始的序列的全长cDNA提供含有蛋白质全部一级结构信息的cDNA的方法。本发明提供了一种制备用于合成全长cDNA的中间体的方法，其包括以下步骤：处理从细胞中提取的mRNA，以从未封端的降解的mRNA的5'末端消除磷酸基团; 从覆盖的完整mRNA的5'端开始切割; 并通过T4 RNA连接酶的作用将由以下通式[I]表示的DNA寡核苷酸或DNA-RNA嵌合寡核苷酸与上述步骤中形成的5'端磷酸基结合，从而选择性地添加DNA寡核苷酸或具有与完整mRNA的5'末端任意序列的DNA-RNA嵌合寡核苷酸。 5'-dN1-dN2-。。。 -dNm-N1-N2-。。。 -Nn-3'[I]本发明还提供了一种合成全长cDNA的方法，其包括将具有dT尾的双链DNA引物与3'端的poly（A）末端退火连接的具有通过上述方法制备的5'端加入的DNA寡核苷酸或DNA-RNA嵌合核苷酸的完整mRNA，然后通过逆转录酶合成与完整mRNA互补的第一链cDNA。

7. 发明授权

US06500939B1 cDNAs coding for human proteins having transmembrane domains 失效
标题翻译：编码具有跨膜结构域的人蛋白质的cDNA
公开(公告)号：US06500939B1
公开(公告)日：2002-12-31
申请号：US09529157
申请日：2000-08-21
申请人： Seishi Kato , Shingo Sekine
发明人： Seishi Kato , Shingo Sekine
IPC分类号： C07H2102
CPC分类号： C07K14/705
摘要： The invention provides cDNAs coding for human proteins having transmembrane domains and eucaryotic cells expressing said cDNAs. The cDNAs of the invention can be utilized as probes for the gene diagnosis and gene sources for the gene therapy. Furthermore, the cDNAs can be utilized for large-scale expression of said proteins. Cells, wherein these membrane protein genes are introduced and membrane proteins are expressed in large amounts, can be utilized for detection of the corresponding ligands, screening of novel low-molecular pharmaceuticals, and so on.
摘要翻译：本发明提供了编码具有跨膜结构域的人蛋白质和表达所述cDNA的真核细胞的cDNA。本发明的cDNA可用作基因诊断的探针和基因治疗的基因来源。此外，cDNA可用于大规模表达所述蛋白质。其中引入这些膜蛋白基因和大量表达膜蛋白的细胞可用于检测相应的配体，筛选新的低分子药物等。

8. 发明授权

US06180602B2 Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent 失效
标题翻译：人类新型cDNA，由此编码的TGF-β超家族蛋白和使用免疫抑制剂
公开(公告)号：US06180602B2
公开(公告)日：2001-01-30
申请号：US08775882
申请日：1997-01-02
申请人： Seishi Kato , Suwan Oh , Shingo Sekine , Mihoro Saeki , Midori Kobayashi , Mika Yada , Tomoko Tsuji , Hitoshi Ohmori
发明人： Seishi Kato , Suwan Oh , Shingo Sekine , Mihoro Saeki , Midori Kobayashi , Mika Yada , Tomoko Tsuji , Hitoshi Ohmori
IPC分类号： A61K3818
CPC分类号： C12N9/1007 , C07K14/47 , C12N9/14 , Y10S530/868
摘要： Isolated cDNAs derived from mRNAs expressed in human cells are provided, as are DNAs and RNAs comprising their nucleotide sequences, and vectors for expressing the cDNAs. The cDNAs encode proteins which have functions similar to known proteins.
摘要翻译：提供了源自人细胞中表达的mRNA的分离的cDNA，以及包含其核苷酸序列的DNA和RNA以及用于表达cDNA的载体。 cDNA编码具有与已知蛋白质相似功能的蛋白质。

9. 发明申请

US20080312435A1 Imine Compound 审中-公开
标题翻译：亚胺化合物
公开(公告)号：US20080312435A1
公开(公告)日：2008-12-18
申请号：US11667728
申请日：2005-10-31
申请人： Shiuji Saito , Hiroshi Ohta , Tomoko Ishizaki , Mitsukane Yoshinaga , Makoto Tatsuzuki , Yuji Yokobori , Yasumitsu Tomishima , Aki Morita , Yoshihisa Toda , Kimiko Tokugawa , Ayaka Kaku , Tomomi Murakami , Hiromitsu Yoshimura , Shingo Sekine , Takao Yoshimizu
发明人： Shiuji Saito , Hiroshi Ohta , Tomoko Ishizaki , Mitsukane Yoshinaga , Makoto Tatsuzuki , Yuji Yokobori , Yasumitsu Tomishima , Aki Morita , Yoshihisa Toda , Kimiko Tokugawa , Ayaka Kaku , Tomomi Murakami , Hiromitsu Yoshimura , Shingo Sekine , Takao Yoshimizu
IPC分类号： C07D417/12 , C07D213/75 , C07D277/46 , C07D231/40 , C07D263/48
CPC分类号： C07D417/12 , C07D213/75 , C07D231/40 , C07D401/12 , C07D409/12 , C07D413/12
摘要： An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C3-10 cycloalkyl group, a C1-6 haloalkyl group, a C1-10 alkoxy group, etc.; R4 represents an optionally substituted C1-10 alkyl, C2-6 alkenyl, or aryl group; R5 represents a hydrogen atom, a C1-10 alkoxy group, a C1-6 haloalkyl group, an optionally substituted C1-10 alkyl or C2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO2—, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.
摘要翻译：由下式表示的亚胺化合物：其中A表示杂环基; R 1，R 2，R 3各自表示氢原子，卤素原子，任选被被卤素原子取代的芳基取代的C 1-10烷基，C 3-10环烷基， 6卤代烷基，C1-10烷氧基等; R 4表示任选取代的C 1-10烷基，C 2-6烯基或芳基; R5表示氢原子，C1-10烷氧基，C1-6卤代烷基，任选取代的C 1-10烷基或C 2-6烯基，任选取代的芳基或杂环基等; W表示-CO-，-CO-CO-，-CO-NH-，-CS-NH-或-SO 2 - 或包含所述亚胺化合物作为活性成分的大麻素受体激动剂。本发明的亚胺化合物具有大麻素受体激动剂作用，可用作疼痛和自身免疫疾病的治疗或预防药物。

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