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1. 发明申请

US20130030058A1 KIT AND METHOD FOR PRODUCING BONE CEMENT 有权
标题翻译：用于生产骨水泥的套件和方法
公开(公告)号：US20130030058A1
公开(公告)日：2013-01-31
申请号：US13558579
申请日：2012-07-26
申请人： Sebastian VOGT , Hubert BÜCHNER
发明人： Sebastian VOGT , Hubert BÜCHNER
IPC分类号： A61K6/083 , A61P19/00 , A61K47/32
CPC分类号： A61L24/043 , A61K6/005 , A61K6/0073 , A61K6/083 , A61L24/001 , A61L24/0089 , A61L24/06 , A61L27/16 , A61L27/26 , A61L27/50 , A61L2430/02 , C08L33/08 , C08L33/10 , C08L33/14
摘要： A kit for producing bone cement includes at least one paste A and one paste B. Paste A contains at least one monomer (a1) for radical polymerization; at least one polymer (a2) insoluble in monomer (a1); at least one polymer (a3) soluble in monomer (a1); and at least one radical polymerization initiator (a4). The weight ratio of the at least one polymer (a2) to the at least one polymer (a3) is at least 2 to 1. Paste B contains at least one monomer (b1) for radical polymerization; at least one polymer (b2) and at least one accelerator (b3) soluble in monomer (b1); and optionally a polymer (b4) insoluble in monomer (b1). The maximum quantity of polymer (b4) is 5% by weight, relative to the total weight of paste B. The weight ratio of polymer (b4) to the at least one polymer (b2) is no more than 0.2.
摘要翻译：用于生产骨水泥的试剂盒包括至少一种糊剂A和一种糊剂B.糊剂A含有至少一种用于自由基聚合的单体（a1）至少一种不溶于单体（a1）的聚合物（a2）; 至少一种可溶于单体（a1）的聚合物（a3）; 和至少一种自由基聚合引发剂（a4）。至少一种聚合物（a2）与至少一种聚合物（a3）的重量比为至少2:1。糊剂B含有至少一种单体（b1）用于自由基聚合; 至少一种聚合物（b2）和至少一种可溶于单体（b1）的促进剂（b3）; 和任选的不溶于单体（b1）的聚合物（b4）。聚合物（b4）的最大量相对于糊料B的总重量为5重量％。聚合物（b4）与至少一种聚合物（b2）的重量比不大于0.2。

2. 发明申请

US20120164310A1 COATING DEVICE AND COATING METHOD 有权
标题翻译：涂层设备和涂层方法
公开(公告)号：US20120164310A1
公开(公告)日：2012-06-28
申请号：US13332703
申请日：2011-12-21
申请人： Sebastian VOGT , Hubert BÜCHNER
发明人： Sebastian VOGT , Hubert BÜCHNER
IPC分类号： B05D7/00 , B05D1/28 , B05C1/00
CPC分类号： A61L27/54 , A61L31/16 , A61L2300/406 , A61L2420/02 , B05C1/06 , B05C17/00 , B05D1/28
摘要： A device for coating a medical implant includes a container that contains a liquid having at least one pharmaceutically active substance. An elastic head for application of the liquid onto a surface to be coated is connected to an inside of the container through at least one channel.
摘要翻译：用于涂覆医疗植入物的装置包括容纳含有至少一种药物活性物质的液体的容器。用于将液体施加到待涂覆表面上的弹性头部通过至少一个通道连接到容器的内部。

3. 发明申请

US20120026825A1 BONE CEMENT SYSTEM 有权
标题翻译：骨水泥系统
公开(公告)号：US20120026825A1
公开(公告)日：2012-02-02
申请号：US12845885
申请日：2010-07-29
申请人： Sebastian VOGT , Rochus STÖCKLI , Hubert BÜCHNER
发明人： Sebastian VOGT , Rochus STÖCKLI , Hubert BÜCHNER
IPC分类号： B01F5/06 , B01F15/02
CPC分类号： A61B17/8833 , A61B17/8827 , B01F3/2057 , B01F13/003 , B01F2215/0029
摘要： A bone cement system (100) is provided having a mixing facility (10) for mixing and dispensing of bone cement, a reservoir container (112) for a monomer, and a conveyor (122). The mixing facility (10) has a mixing cylinder (20), which stores a bone cement powder. The monomer can be conveyed from the reservoir container (112) into the mixing cylinder (20) by the conveyor (122). A sieve element is (4) is arranged between the reservoir container (112) and the mixing facility (10), in order to preventingress of the bone cement powder from the mixing cylinder (20) into the conveyor (122). The mixing device (10) included a dispensing opening (23) for dispensing a bone cement mixed from the bone cement powder and the monomer. The dispensing opening (23) includes a shield (1) having at least one through-opening (2). The ratio of the area of the through-opening (2) to the area of the sieve element (4) is at least 1 to 3, and the distance between the shield (1) and the sieve element (4) is at least 1 mm.
摘要翻译：提供了一种骨水泥系统（100），其具有用于混合和分配骨水泥的混合设备（10），用于单体的储存容器（112）和输送机（122）。混合设备（10）具有储存骨水泥粉末的混合缸（20）。单体可以通过输送机（122）从储存容器（112）输送到混合缸（20）中。为了将骨水泥粉末从混合缸（20）预防压入输送机（122），在贮存器容器（112）和混合设备（10）之间设有筛子元件（4）。混合装置（10）包括用于分配从骨水泥粉末和单体混合的骨水泥的分配开口（23）。分配开口（23）包括具有至少一个通孔（2）的屏蔽件（1）。通孔（2）的面积与筛子（4）的面积的比例至少为1〜3，护罩（1）和筛子（4）之间的距离为1以上 mm。

4. 发明申请

US20100159027A1 SPORICIDAL COMPOSITIONS AND USE THEREOF 有权
标题翻译： SPORICIDAL组合物及其用途
公开(公告)号：US20100159027A1
公开(公告)日：2010-06-24
申请号：US12640905
申请日：2009-12-17
申请人： Sebastian VOGT , Hubert BÜCHNER
发明人： Sebastian VOGT , Hubert BÜCHNER
IPC分类号： A01N59/00 , A01P1/00
CPC分类号： A61L24/06 , A61L27/16 , A61L2430/02 , C08L33/12
摘要： What is described are sporicidal compositions, in which hydrogen peroxide and at least one radical stabilizer are homogeneously dissolved in a methacrylate monomer or a mixture of methacrylate monomers, and the quantitative ratio of radical stabilizer to hydrogen peroxide is larger than or equal to 1 to 1. The sporicidal monomer/monomer mixture is usually used for producing single component bone cement pastes; two-component bone cement pastes or monomer solutions for polymethylmethacrylate bone cements that are based on cement powder and monomer liquid. Moreover, a sporicidal cement paste having the following components is proposed: hydrogen peroxide and/or a hydrogen peroxide-releasing substance or mixture of substances; radical stabilizer; low-molecular liquid methacrylate; linear or branched polymethylmethacrylate or linear or branched methylmethacrylate co-polymer; cross-linked polymethylmethacrylate or cross-linked methylmethacrylate copolymer; as well as at least one component of a radical initiator system.
摘要翻译：所描述的是其中过氧化氢和至少一种自由基稳定剂均匀地溶解在甲基丙烯酸酯单体或甲基丙烯酸酯单体的混合物中的杀芽剂组合物，自由基稳定剂与过氧化氢的定量比大于或等于1至1 杀孢子单体/单体混合物通常用于生产单组分骨水泥浆料; 基于水泥粉末和单体液体的聚甲基丙烯酸甲酯骨水泥的双组分骨水泥浆料或单体溶液。此外，提出了具有以下成分的杀芽剂水泥糊剂：过氧化氢和/或过氧化氢释放物质或物质的混合物; 自由基稳定剂低分子液体甲基丙烯酸酯; 直链或支链聚甲基丙烯酸甲酯或直链或支链甲基丙烯酸甲酯共聚物; 交联聚甲基丙烯酸甲酯或交联甲基丙烯酸甲酯共聚物; 以及自由基引发剂体系的至少一种组分。

5. 发明申请

US20110183932A1 THREE-COMPONENT BONE CEMENT 有权
标题翻译：三组分骨水泥
公开(公告)号：US20110183932A1
公开(公告)日：2011-07-28
申请号：US13012909
申请日：2011-01-25
申请人： Sebastian VOGT , Hubert BÜCHNER
发明人： Sebastian VOGT , Hubert BÜCHNER
IPC分类号： A61L24/06 , A61K31/7036 , A61P31/00
CPC分类号： A61L24/0073 , A61L24/0015 , A61L24/06 , A61L27/44 , A61L2300/00 , A61L2430/02 , A61L2430/24 , C08L33/10
摘要： A paste is provided from which bone cement can be formed, which is to the largest extent possible bubble-free and has a high impact strength. The paste includes (i) 15-50 weight percent of at least one mono-functional, hydrophobic methacrylic acid ester, (ii) 40-85 weight percent of at least one filler, (iii) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having at least one peroxide group, (iv) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having no peroxide groups, (v) 0.000001-3 weight percent of at least one accelerator soluble in the methacrylic acid ester (i) and capable of forming radicals from the radical initiators according to (iii) and (iv), (vi) 0.001-5 weight percent of at least one halide salt, and (vii) 0.2-3 weight percent of at least one cross-linking agent.
摘要翻译：提供了可以形成骨粘固剂的浆料，其最大程度上可能是无气泡的并且具有高冲击强度。该糊状物包括（i）15-50重量％的至少一种单官能疏水性甲基丙烯酸酯，（ii）40-85重量％的至少一种填料，（iii）0.01-4重量％的至少一种可溶于甲基丙烯酸酯（i）中并且具有至少一个过氧化物基团的自由基引发剂，（iv）0.01-4重量％的可溶于甲基丙烯酸酯（i）中并且不含过氧化物基团的至少一种自由基引发剂（v ）0.000001-3重量％的可溶于甲基丙烯酸酯（i）中的至少一种促进剂，并能够根据（ⅲ）和（ⅳ），（vi）的自由基引发剂形成自由基，至少0.001-5重量％一种卤化物盐，和（vii）0.2-3％重量的至少一种交联剂。

6. 发明申请

US20110015673A1 SURGICAL SUTURE MATERIAL WITH AN ANTIMICROBIAL SURFACE AND PROCESS FOR PROVIDING AN ANTIMICROBIAL COATING ON SURGICAL SUTURE MATERIAL 有权
标题翻译：具有抗微生物表面的外科手术材料和用于在外科手术材料上提供抗微生物涂层的方法
公开(公告)号：US20110015673A1
公开(公告)日：2011-01-20
申请号：US12889550
申请日：2010-09-24
申请人： Sebastian VOGT , Klaus-Dieter Kühn , Hubert Büchner
发明人： Sebastian VOGT , Klaus-Dieter Kühn , Hubert Büchner
IPC分类号： A61L17/00 , A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/145 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A61L2300/802 , B05D1/18 , B05D2256/00
摘要： A surgical suture material with an antimicrobial surface is described, the surface exhibiting a coating containing a) at least one fatty acid, b) octenidine dichloride and/or dequalinium chloride and c) optionally oligomeric lactic acid esters. In addition, a process for coating surgical suture material is described which is characterized by the fact that the thread material is wetted with a homogeneous methanolic solution of octenidine dichloride and/or dequalinium chloride and subsequently the methanol is evaporated, a coating forming on the thread surface.
摘要翻译：描述了具有抗微生物表面的外科缝合材料，所述表面显示包含a）至少一种脂肪酸，b）二氯化奥立芬和/或氯化脱氯化物的涂层，以及c）任选的低聚乳酸酯。另外，描述了用于涂覆外科缝合材料的方法，其特征在于螺纹材料被二氯化二苯胺和/或氯化金合金的均匀甲醇溶液润湿，随后甲醇蒸发，在螺纹上形成涂层表面。

7. 发明申请

US20100160483A1 POLYMETHYLMETHACRYLATE BONE CEMENT COMPOSITION FOR CONTROLLED HYPERTHERMIA TREATMENT 审中-公开
标题翻译：用于控制高血压治疗的聚甲基丙烯酸甲酯骨水泥组合物
公开(公告)号：US20100160483A1
公开(公告)日：2010-06-24
申请号：US12641895
申请日：2009-12-18
申请人： Sebastian VOGT , Hubert Büchner
发明人： Sebastian VOGT , Hubert Büchner
IPC分类号： C08L33/12
CPC分类号： A61L27/50 , A61L27/16 , A61L27/446 , A61L2430/02 , C08L33/12
摘要： The invention relates to a polymethylmethacrylate bone cement composition that contains polymethylmethacrylate, radio-opaquer, methylmethacrylate and/or alkylmethacrylates, and an initiator system and comprises, in addition, ferromagnetic and/or superparamagnetic particles of a particle size of up to maximally 500 μm—which allows it to be heated by alternating magnetic fields—and further contains at least one biodegradable or biocompatible crystalline substance having a melting point in the range of 43-46° C. The cured cement can be used for local over-heating (hyperthermia) therapy in the absence of undesired temperature peaks.
摘要翻译：本发明涉及一种聚甲基丙烯酸甲酯骨水泥组合物，其包含聚甲基丙烯酸甲酯，无光乳剂，甲基丙烯酸甲酯和/或甲基丙烯酸烷基酯，以及引发剂体系，此外还包含粒径达最大为500μm- 其允许其通过交变磁场加热 - 并且还包含至少一种具有在43-46℃范围内的熔点的可生物降解或生物相容的结晶物质。固化的水泥可用于局部过热（热疗）在没有不希望的温度峰值的情况下进行治疗。

8. 发明申请

US20120164311A1 COATING METHOD AND COATING DEVICE 有权
标题翻译：涂料方法和涂料装置
公开(公告)号：US20120164311A1
公开(公告)日：2012-06-28
申请号：US13331351
申请日：2011-12-20
申请人： Sebastian VOGT , Hubert Büchner
发明人： Sebastian VOGT , Hubert Büchner
IPC分类号： B05D5/00 , B05C11/00 , B05C3/02 , B05D1/18 , B05D3/12
CPC分类号： B05C19/06 , A61L2/18 , A61L27/32 , A61L27/54 , A61L2300/112 , A61L2300/406 , A61L2300/412 , A61L2420/02 , A61L2420/06 , A61L2430/24 , B05C1/00 , B05C3/02 , B05D1/28 , C23C24/00
摘要： A device for coating at least regions of a medical implant including a powder having at least one pharmaceutically active substance or one bone growth-promoting substance such that the powder can be transferred to the medical implant when the medical implant is contacted.
摘要翻译：一种用于涂覆至少包括具有至少一种药物活性物质或一种骨生长促进物质的粉末的医用植入物的区域的装置，使得当所述医疗植入物接触时，所述粉末可以转移到所述医疗植入物。

9. 发明申请

US20110287064A1 ANTIBIOTIC COATING 审中-公开
标题翻译：抗生素涂料
公开(公告)号：US20110287064A1
公开(公告)日：2011-11-24
申请号：US13110096
申请日：2011-05-18
申请人： Sebastian VOGT , Hubert BÜCHNER , Klaus-Dieter KÜHN
发明人： Sebastian VOGT , Hubert BÜCHNER , Klaus-Dieter KÜHN
IPC分类号： A61K9/00 , B05D3/02 , B05D7/00 , A61K31/7036
CPC分类号： A61L27/54 , A61L27/28 , A61L2300/406
摘要： An implant is provided having an antibiotic coating that is inexpensive and easy to manufacture. The antibiotic coating adheres well and in stable manner to the surface of the implant, can be degraded by the body without forming toxic products, prevents the crystallization of the antibiotics in the coating, and ensures a high immediate locally-effective antibiotic concentration at the implant site. A coating solution useful for making the implant and a method for the manufacture of the implant are also described.
摘要翻译：提供具有廉价且易于制造的抗生素涂层的植入物。抗生素涂层很好地并且稳定地粘附到植入物的表面，可以被身体降解而不形成有毒产物，防止涂层中的抗生素结晶，并且确保在植入物中高度立即局部有效的抗生素浓度现场。还描述了可用于制造植入物的涂布溶液和用于制造植入物的方法。

10. 发明申请

US20110313078A1 PASTE-LIKE BONE CEMENT 有权
公开(公告)号：US20110313078A1
公开(公告)日：2011-12-22
申请号：US13162735
申请日：2011-06-17
申请人： Sebastian VOGT , Hubert BUECHNER
发明人： Sebastian VOGT , Hubert BUECHNER
IPC分类号： A61L24/06
CPC分类号： A61L24/001 , A61L24/0094 , A61L24/06 , A61L27/50 , A61L2400/06 , A61L2430/02
摘要： A kit is provided based on two pastes designed to produce bone cement with high initial stability and therefore low post-cure. The kit includes a paste A and a paste B, wherein paste A contains (a1) a polymerizable monomer having a pH in water in the range of 5-9, (a2) a filling agent insoluble in (a1), and (a3) a barbituric acid derivative selected from the group consisting of 1,5-disubstituted barbiturates, 1,3,5-trisubstituted barbiturates, and 1,3,5-tetrasubstituted barbiturates, and paste B contains (b1) a polymerizable monomer having a pH in water in the range of 5-9, (b2) a filling agent insoluble in (b1), (b3) a peroxide soluble in (b1), (b4) a heavy metal compound insoluble in (b1) and selected from the group consisting of heavy metal salts and heavy metal complexes, and wherein at least one of the pastes A and B contains a halide salt.
摘要翻译：提供了一种基于两种浆料的试剂盒，其设计用于生产具有高初始稳定性和因此低固化后的骨水泥。试剂盒包括糊剂A和糊剂B，其中糊剂A含有（a1）水中pH值在5-9范围内的可聚合单体，（a2）不溶于（a1）的填充剂和（a3）选自1,5-二取代巴比妥酸盐，1,3,5-三取代巴比妥酸盐和1,3,5-四取代巴比妥酸盐的巴比土酸衍生物，糊剂B含有（b1）具有pH值的可聚合单体（b2）不溶于（b1）的填充剂，（b3）可溶于（b1）的过氧化物，（b4）不溶于（b1）的重金属化合物，并且选自的重金属盐和重金属络合物，并且其中至少一种糊状物A和B含有卤化物盐。

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