专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080114451A1 RETENTION COATINGS FOR DELIVERY SYSTEMS 审中-公开
标题翻译：用于输送系统的保持涂层
公开(公告)号：US20080114451A1
公开(公告)日：2008-05-15
申请号：US12016343
申请日：2008-01-18
申请人： Sean Stucke , Kimberly Lindsoe , Ralph Chappa , Dale Swan
发明人： Sean Stucke , Kimberly Lindsoe , Ralph Chappa , Dale Swan
IPC分类号： A61L27/34 , A61F2/82 , C09K3/16
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/258 , A61L2300/404 , A61L2300/406 , A61L2300/606 , C08L71/02
摘要： A coating composition, in both its uncrosslinked and crosslinked forms, for use in increasing the static friction of a surface of a delivery system comprising a medical device having a surface in contact with the surface of a delivery component, the static friction of the surface being increased in an amount sufficient to substantially maintain the position of the medical device on the delivery component against forces asserted on the delivery system as it navigates through a vessel of the body. The delivery system may comprise a balloon catheter as the delivery component and a stent as the medical device. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, optionally a photoderivatized monomer, and a hydrophilic monomer such as (meth)acrylamide.
摘要翻译：一种涂料组合物，以其未交联和交联的形式，用于增加递送系统的表面的静摩擦力，其包括具有与输送组分表面接触的表面的医疗装置，表面的静摩擦力增加的量足以基本上保持医疗装置在输送部件上的位置，抵抗在输送系统导航通过身体的血管时所断言的力。输送系统可以包括作为输送部件的气囊导管和作为医疗装置的支架。组合物包括聚醚单体，例如烷氧基聚（亚烷基二醇），含羧酸的单体，例如（甲基）丙烯酸，任选的光衍生单体和亲水性单体如（甲基）丙烯酰胺。

2. 发明申请

US20070292596A1 REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 失效
标题翻译：用于提供表面涂层的试剂和方法
公开(公告)号：US20070292596A1
公开(公告)日：2007-12-20
申请号：US11846955
申请日：2007-08-29
申请人： Ralph Chappa , Sean Stucke , Richard Amos , Terrence Everson , Stephen Chudzik , Dale Swan , Peter Duquette
发明人： Ralph Chappa , Sean Stucke , Richard Amos , Terrence Everson , Stephen Chudzik , Dale Swan , Peter Duquette
IPC分类号： A61L27/28 , A61L2/00
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译：以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体，并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

3. 发明申请

US20060134168A1 Coatings with crystallized active agent(s) and methods 审中-公开
标题翻译：具有结晶活性剂的涂层和方法
公开(公告)号：US20060134168A1
公开(公告)日：2006-06-22
申请号：US11295167
申请日：2005-12-06
申请人： Ralph Chappa , Kimberly Lindsoe
发明人： Ralph Chappa , Kimberly Lindsoe
IPC分类号： A61K6/083 , A61K31/56 , B05D3/02
CPC分类号： A61L31/16 , A61K6/0017 , A61K31/56 , A61L27/34 , A61L27/50 , A61L27/54 , A61L31/10 , A61L31/14 , A61L2300/216 , A61L2300/222 , A61L2300/43 , A61L2300/602 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/06
摘要： The present invention relates to coatings with crystallized active agent(s) and related methods. In an embodiment, the invention includes a method for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, the invention includes an elution control coating disposed on a medical device, the elution control coating including a polymer, and an active agent, wherein the active agent is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, the invention includes a method for enhancing the formation of active agent crystals within a coating layer including forming a coating solution and adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. In an embodiment, the invention includes a method of enhancing crystallization of an active agent, the method including forming a coating solution comprising a polymer, an active agent, and a solvent; applying the coating solution to a substrate; and increasing the rate of active agent nucleation within the coating.
摘要翻译：本发明涉及具有结晶活性剂的涂层和相关方法。在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物，并将所述涂料组合物施用于所述医疗装置。在一个实施方案中，本发明包括设置在医疗装置上的洗脱控制涂层，洗脱控制涂层包括聚合物和活性剂，其中活性剂在被放置在医疗上的一周内至少约80％结晶设备。在一个实施方案中，本发明包括一种用于增强涂层内活性剂晶体形成的方法，包括形成涂层溶液并调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比。在一个实施方案中，本发明包括增强活性剂结晶的方法，所述方法包括形成包含聚合物，活性剂和溶剂的包衣溶液; 将涂布溶液涂布到基材上; 并增加涂层内活性剂成核的速率。

4. 发明申请

US20050244453A1 Composition and method for preparing biocompatible surfaces 有权
标题翻译：用于制备生物相容性表面的组合物和方法
公开(公告)号：US20050244453A1
公开(公告)日：2005-11-03
申请号：US11090655
申请日：2005-03-25
申请人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
发明人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
IPC分类号： A61F2/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
摘要翻译：本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。特别地，本发明提供具有肝素活性的生物相容性涂层。在一些方面，本发明的生物相容性涂层能够释放生物活性剂。可以使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。本发明还提供了通过进行生物相容性涂料组合物的预辐射来提高含生物活性剂的涂层的质量的方法。

5. 发明申请

US20060216324A1 Composition and method for preparing biocompatible surfaces 审中-公开
公开(公告)号：US20060216324A1
公开(公告)日：2006-09-28
申请号：US11440524
申请日：2006-05-25
申请人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
发明人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
IPC分类号： A61K6/083 , A61F13/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.

6. 发明申请

US20050232970A1 Process and systems for biocompatible surfaces 有权
标题翻译：用于生物相容表面的方法和系统
公开(公告)号：US20050232970A1
公开(公告)日：2005-10-20
申请号：US11090517
申请日：2005-03-25
申请人： Sean Stucke , Ralph Chappa , Joseph Chinn
发明人： Sean Stucke , Ralph Chappa , Joseph Chinn
IPC分类号： A61F2/00 , A61K31/4745 , A61K31/727 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61K31/4745 , A61K31/727 , A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed using biostable or biodegradable polymeric material and photoreactive groups.
摘要翻译：本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。特别地，本发明提供具有能够释放生物活性剂的肝素活性的生物相容性涂层，其中使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。

7. 发明申请

US20050170427A1 Target molecule attachment to surfaces 审中-公开
标题翻译：目标分子附着于表面
公开(公告)号：US20050170427A1
公开(公告)日：2005-08-04
申请号：US11101271
申请日：2005-04-06
申请人： Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
发明人： Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
IPC分类号： G01N33/53 , C07B61/00 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12Q1/6834 , C40B40/06 , C40B60/14 , G01N1/28 , G01N21/78 , G01N33/566 , G01N37/00 , C07H21/04 , C12M1/34
CPC分类号： B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
摘要： Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.
摘要翻译：用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。试剂组合物包括能够共价结合靶分子的基团。任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。

8. 发明申请

US20050281857A1 Methods and reagents for preparing biomolecule-containing coatings 审中-公开
标题翻译：制备含生物分子的涂料的方法和试剂
公开(公告)号：US20050281857A1
公开(公告)日：2005-12-22
申请号：US11138733
申请日：2005-05-25
申请人： Toni Heyer , Dale Swan , Stephen Chudzik , Joseph Chinn , Ralph Chappa
发明人： Toni Heyer , Dale Swan , Stephen Chudzik , Joseph Chinn , Ralph Chappa
IPC分类号： A61L2/00 , A61L27/00 , A61L27/34 , A61L33/00 , B05D3/00
CPC分类号： A61L27/34 , A61L33/0029 , C08L33/06
摘要： Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.
摘要翻译：包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。

9. 发明申请

US20060165872A1 Advanced coating apparatus and method 有权
标题翻译：先进的涂装设备及方法
公开(公告)号：US20060165872A1
公开(公告)日：2006-07-27
申请号：US11388478
申请日：2006-03-24
申请人： Ralph Chappa , Mark Carlson
发明人： Ralph Chappa , Mark Carlson
IPC分类号： A61L33/00 , B05D3/00 , B05D7/00
CPC分类号： B05B7/0807 , B05B7/0861 , B05B7/0869 , B05B13/0207 , B05B13/0228 , B05B13/0436 , B05B13/0442 , B05D1/002 , B05D1/02
摘要： A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.
摘要翻译：描述了一种包括具有一对辊和喷嘴的装置旋转器的可卷绕装置的方法。喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。

10. 发明申请

US20050196424A1 Medical devices and methods for producing the same 有权
标题翻译：医疗器械及其制造方法
公开(公告)号：US20050196424A1
公开(公告)日：2005-09-08
申请号：US11102465
申请日：2005-04-08
申请人： Ralph Chappa
发明人： Ralph Chappa
IPC分类号： A61K9/00 , A61K31/58 , A61L2/00 , A61F2/00 , A61M31/00
CPC分类号： A61L31/10 , A61F9/0017 , A61K9/0051 , A61K31/58 , C08L31/04 , C08L33/10
摘要： Embodiments of the invention include coated medical devices that can elute one or more bioactive agents within the body, and methods for producing the same. In an embodiment, the invention includes a method of forming a coated medical device including depositing a coated composition onto a medical device having a roughened segment and a smooth segment. In an embodiment, the invention includes a method of forming a coated implantable medical device including depositing a coated composition onto a medical device having a body segment and a piercing segment. In an embodiment, the invention includes a medical device, a coated composition provided on the substrate surface, the composition including a bioactive agent and a polymer. The medical device includes an uncoated component wherein the edge of the coated composition is within 0.5 mm of the uncoated component. In an embodiment, the invention includes a method for disposing a coated composition on a medical device with an ultrasonically atomized spray stream including moving a spray stream in a pattern having a plurality of transverse sweeps and a plurality of longitudinal movements.
摘要翻译：本发明的实施方案包括可以洗脱身体内的一种或多种生物活性剂的涂覆的医疗装置及其制备方法。在一个实施方案中，本发明包括形成涂覆的医疗装置的方法，包括将涂覆的组合物沉积在具有粗糙部分和平滑部分的医疗装置上。在一个实施方案中，本发明包括形成涂覆的可植入医疗装置的方法，包括将涂覆的组合物沉积到具有身体部分和刺穿部分的医疗装置上。在一个实施方案中，本发明包括医疗装置，设置在基材表面上的涂布组合物，所述组合物包含生物活性剂和聚合物。医疗装置包括未涂覆的组分，其中涂覆组合物的边缘在未涂覆组分的0.5mm以内。在一个实施方案中，本发明包括用超声波雾化喷雾流将医用装置上的涂覆组合物设置为包括使具有多个横向扫描和多个纵向移动的图案移动喷雾流的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式