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    • 5. 发明授权
    • Dinuclear metal complex and pyrophosphate assay using the same
    • 双核金属络​​合物和焦磷酸盐测定使用相同
    • US07279588B2
    • 2007-10-09
    • US10855940
    • 2004-05-27
    • Jong-In HongDong Hoon LeeJa Hyun ImSeung Uk SonYoung Keun Chung
    • Jong-In HongDong Hoon LeeJa Hyun ImSeung Uk SonYoung Keun Chung
    • C07F1/00C07F15/00D06L1/00
    • C07F17/02
    • A novel coordination complex formed by dinuclear metal complexation is provided. The complex is a dinuclear metal complex of a compound, wherein the compound comprises a conjugation ring system substituted with: a) an electron donating group selected from —OH, —SH and —NH2; b) an indicating group selected from a chromogenic group, a fluorescent group and an electrochemical group; and c) two binding auxiliary groups, in combination with the electron donating group each of which being coordinated with the metal to provide an anion bonding site, wherein as the complex binds to a anion, the coordination of the electron donating group with the metal is weakened and electron donation of the electron donating group to the conjugation ring system is reinforced such that the reinforced electron donation by the electron donating group is transferred through the conjugation ring system to the indicating group to produce an indicating signal concomitant with the change of its electronic density. The coordination complex shows high sensitivity and high selectivity for pyrophosphate over other anions in an aqueous solvent over a wide pH range. Therefore, the complex is useful for pyrophosphate assay as a pyrophosphate sensor.
    • 提供了由双核金属络​​合形成的新型配位络合物。 络合物是化合物的双核金属络​​合物,其中所述化合物包含被以下物质取代的共轭环体系:a)选自-OH,-SH和-NH 2的给电子基团; b)选自显色基团,荧光基团和电化学基团的指示基团; 和c)两个结合的辅助基团,与供体基团组合,每个与金属配位以提供阴离子结合位点,其中当络合物与阴离子结合时,给电子基团与金属的配位是 电子给体基团向共轭环体系的弱化和电子供体被加强,使得电子给予基团的增强电子给体通过共轭环系统转移到指示基团,以产生指示信号,伴随其电子变化 密度。 配位络合物在宽pH范围内,在水性溶剂中显示出高灵敏度和高焦磷酸盐选择性。 因此,该复合物可用于焦磷酸盐测定作为焦磷酸盐传感器。
    • 6. 发明申请
    • Novel dinuclear metal complex and pyrophosphate assay using the same
    • 新型双核金属络​​合物和焦磷酸盐测定使用相同
    • US20050119497A1
    • 2005-06-02
    • US10855940
    • 2004-05-27
    • Jong-In HongDong Hoon LeeJa Hyun ImSeung Uk SonYoung Keun Chung
    • Jong-In HongDong Hoon LeeJa Hyun ImSeung Uk SonYoung Keun Chung
    • C07F17/02C07F1/00D06L1/00
    • C07F17/02
    • A novel coordination complex formed by dinuclear metal complexation is provided. The complex is a dinuclear metal complex of a compound, wherein the compound comprises a conjugation ring system substituted with: a) an electron donating group selected from —OH, —SH and —NH2; b) an indicating group selected from a chromogenic group, a fluorescent group and an electrochemical group; and c) two binding auxiliary groups, in combination with the electron donating group each of which being coordinated with the metal to provide an anion bonding site, wherein as the complex binds to a anion, the coordination of the electron donating group with the metal is weakened and electron donation of the electron donating group to the conjugation ring system is reinforced such that the reinforced electron donation by the electron donating group is transferred through the conjugation ring system to the indicating group to produce an indicating signal concomitant with the change of its electronic density. The coordination complex shows high sensitivity and high selectivity for pyrophosphate over other anions in an aqueous solvent over a wide pH range. Therefore, the complex is useful for pyrophosphate assay as a pyrophosphate sensor.
    • 提供了由双核金属络​​合形成的新型配位络合物。 络合物是化合物的双核金属络​​合物,其中所述化合物包含被以下物质取代的共轭环体系:a)选自-OH,-SH和-NH 2的给电子基团; b)选自显色基团,荧光基团和电化学基团的指示基团; 和c)两个结合的辅助基团,与供体基团组合,每个与金属配位以提供阴离子结合位点,其中当络合物与阴离子结合时,给电子基团与金属的配位是 电子给体基团向共轭环体系的弱化和电子供体被加强,使得电子给予基团的增强电子给体通过共轭环系统转移到指示基团,以产生指示信号,伴随其电子变化 密度。 配位络合物在宽pH范围内,在水性溶剂中显示出高灵敏度和高焦磷酸盐选择性。 因此,该复合物可用于焦磷酸盐测定作为焦磷酸盐传感器。
    • 10. 发明授权
    • Method of purifying organic compounds using an enantioselective receptor
    • 使用对映选择性受体纯化有机化合物的方法
    • US5571911A
    • 1996-11-05
    • US296814
    • 1994-08-26
    • W. Clark StillJulian A. SimonJong-In Hong
    • W. Clark StillJulian A. SimonJong-In Hong
    • C07B57/00C07B63/00C07B63/04C07D487/18C07D487/22C07D498/18C07D513/18
    • C07D487/18C07B57/00C07B63/00C07B63/04C07D487/22C07D498/18C07D513/18Y02P20/55
    • The present invention relates to a composition having the general formula: ##STR1## wherein each of A, B, C, X, Y, and Z is independently O, NH, N(CH.sub.2).sub.m CH.sub.3, N(C.dbd.O) (CH.sub.2).sub.m CH.sub.3, CH.sub.2, S, or Se; each of R.sub.1, R.sub.2, and R.sub.3 is independently phenyl, 4-hydroxyphenyl, pyridyl, pyrrolyl, indolyl, naphthyl, thiophenyl, (C.dbd.O) (CH.sub.2).sub.p CH.sub.3, NH(C.dbd.O) (CH.sub.2).sub.p CH.sub.3, OH, COOH, NH.sub.2, or SH; and m, n, and p are integers between 0 and 5. The composition is a chiral receptor molecule useful for the purification of enantiomers of derivatives of amino acids and of compounds able to form hydrogen bonds. The preparation of the composition involves coupling a trifunctional aromatic molecule with three protected chiral molecules at the three aromatic groups, cleaving protecting groups, and joining adjacent chiral groups by multiple lactamizations. The receptor may be used in a form either bound to a solid support or dissolved in an immiscible phase to effect convenient purification of enantiomers or other compounds of interest.
    • 本发明涉及具有以下通式的组合物:其中A,B,C,X,Y和Z各自独立地为O,NH,N(CH 2)m CH 3,N(C = O) )mCH 3,CH 2,S或Se; R 1,R 2和R 3各自独立地为苯基,4-羟基苯基,吡啶基,吡咯基,吲哚基,萘基,噻吩基,(C = O)(CH 2)pCH 3,NH(C = O)(CH 2)p CH 3,OH,COOH ,NH2或SH; 并且m,n和p是0和5之间的整数。该组合物是可用于纯化氨基酸衍生物和能够形成氢键的化合物的对映异构体的手性受体分子。 组合物的制备包括将三官能芳族分子与三个芳族基团上的三个受保护的手性分子偶联,切割保护基团,并通过多次内酰胺化连接相邻的手性基团。 受体可以以与固体支持物结合或溶解在不混溶相中的形式使用,以实现对映异构体或其它目的化合物的方便的纯化。