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1. 发明授权

US06227961B1 HVAC custom control system 失效
标题翻译： HVAC定制控制系统
公开(公告)号：US06227961B1
公开(公告)日：2001-05-08
申请号：US09231050
申请日：1999-01-14
申请人： Scott W. Moore , Terry L. Webb , Michael C. Brown
发明人： Scott W. Moore , Terry L. Webb , Michael C. Brown
IPC分类号： F24F1104
CPC分类号： F04D27/004 , F05D2260/85 , F24F11/77 , F24F2110/30 , F24F2110/40
摘要： A fan control system suitable for use in air moving applications has a pressure sensor responsive to an air pressure in an air duct for supplying a static pressure signal representative of the air pressure. A supply air flow sensor is responsive to an air flow in a supply air duct and supplies a supply air flow signal representative of the air flow in the supply air duct. A return air flow sensor is responsive to an air flow in a return air duct and supplies a return air flow signal representative of the air flow in the return air duct. A supply fan moves air in the supply air duct. The supply fan is driven by a supply fan motor. A return fan moves air in the return air duct. The return fan is driven by a return fan motor. A unitary volumetric air flow controller is connected to the supply fan motor and to the return fan motor. The air flow controller selectively applies a supply drive power signal to the supply fan motor to energize the supply fan motor, and selectively applies a return drive signal to the return fan motor to energize the return fan motor. The power drive signals are responsive to the static pressure signal, supply air flow signal, and return air flow signal.
摘要翻译：适用于空气移动应用的风扇控制系统具有响应于空气管道中的空气压力的压力传感器，用于提供代表空气压力的静压信号。供应空气流量传感器响应于供气管道中的气流，并且供应表示供气管道中的气流的供气流信号。返回空气流量传感器响应于返回空气管道中的气流，并且提供代表返回空气管道中的空气流的返回气流信号。供风扇移动供气管道中的空气。供风扇由供电风扇电机驱动。回风扇在回风管道中移动空气。回风扇由回风机马达驱动。一体式空气流量控制器连接到供气风扇电机和返回风扇电机。空气流量控制器选择性地向供应风扇电机施加供电驱动电力信号，以使供电风扇电动机通电，并且选择性地向返回风扇电动机施加返回驱动信号以给回风扇电动机通电。电力驱动信号响应于静态压力信号，供应气流信号和回气流量信号。

2. 外观设计

USD662528S1 Eyelet setting die set 有权
标题翻译：孔眼设置模具
公开(公告)号：USD662528S1
公开(公告)日：2012-06-26
申请号：US29413486
申请日：2012-02-16
申请人： Michael C. Brown
设计人： Michael C. Brown

3. 发明申请

US20090295009A1 METHOD FOR MANUFACTURING CERAMIC FILTER 有权
标题翻译：制造陶瓷过滤器的方法
公开(公告)号：US20090295009A1
公开(公告)日：2009-12-03
申请号：US12432156
申请日：2009-04-29
申请人： Michael C. Brown , Luiz Eduardo Ferri , Ralph Henry Hagg , Robert Daniel Parker
发明人： Michael C. Brown , Luiz Eduardo Ferri , Ralph Henry Hagg , Robert Daniel Parker
IPC分类号： B29C67/24
CPC分类号： B28B11/006
摘要： Honeycomb ceramic wall flow filters exhibiting reduced plug depth variability, produced by introducing flowable ceramic plugging cements into the ends of selected channels in the honeycombs and wherein the ceramic plugging cements consist of shear-conditioned mixtures exhibiting reduced viscosity differentials.
摘要翻译：通过将可流动的陶瓷堵塞水泥引入蜂窝中的所选通道的端部而产生的具有降低的插塞深度变化性的蜂窝状陶瓷壁流动过滤器，其中陶瓷堵塞水泥由表现出降低的粘度差的剪切调节混合物组成。

4. 发明授权

US5292636A Therapeutic and diagnostic methods using soluble T cell surface molecules 失效
标题翻译：使用可溶性T细胞表面分子的治疗和诊断方法
公开(公告)号：US5292636A
公开(公告)日：1994-03-08
申请号：US434398
申请日：1989-11-09
申请人： Patrick C. Kung , Stephen H. Ip , Michael C. Brown , Linda A. MacKeen
发明人： Patrick C. Kung , Stephen H. Ip , Michael C. Brown , Linda A. MacKeen
IPC分类号： C07K16/28 , G01N33/564 , G01N33/566 , G01N33/569 , G01N33/571 , G01N33/574 , G01N33/68 , G01N33/543 , G01N33/577
CPC分类号： C07K16/2812 , C07K16/2815 , G01N33/564 , G01N33/566 , G01N33/56972 , G01N33/56977 , G01N33/56983 , G01N33/56988 , G01N33/571 , G01N33/57407 , G01N33/57423 , G01N33/57488 , G01N33/6869 , G01N33/6893 , G01N2333/71 , G01N2333/715 , G01N2800/102 , G01N2800/245 , Y10S435/974 , Y10S435/975 , Y10S436/811 , Y10S436/813
摘要： The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis, staging, and therapy of diseases and disorders. Specific embodiments involve the diagnosis and monitoring of therapy using absolute values of such soluble molecules. Further embodiments involve detecting a change in the levels of such soluble molecules, in the diagnosis and therapy of diseases and disorders. In specific embodiments, measurements of interleukin-2 receptor levels can be made to detect lung cancer, or to stage squamous cell lung carcinoma. In other embodiments, detection of increases in both soluble IL2R and creatinine in the body fluid of a transplant patient can be used to differentially diagnose renal allograft rejection from infection. The invention is also directed to methods for measurement of soluble CD4 antigens, which measurements can be used, in a specific embodiment, to diagnose a state of immune activation, to diagnose rheumatoid arthritis, to monitor therapeutic efficacy (e.g. of AIDS treatments), or to stage adult T cell leukemia in a patient. In another aspect, the invention relates to the detection, staging, and monitoring of therapy of diseases and disorders by measuring a plurality of soluble T cell markers.
摘要翻译：本发明涉及可溶性T细胞生长因子受体，可溶性T细胞分化抗原或相关的可溶性分子或其片段的测量，以及在疾病和病症的诊断，分期和治疗中使用这些测量。具体实施方案涉及使用这种可溶性分子的绝对值来诊断和监测治疗。进一步的实施方案涉及在疾病和病症的诊断和治疗中检测这些可溶性分子的水平的变化。在具体实施方案中，可以测量白细胞介素-2受体水平以检测肺癌或鳞状细胞肺癌。在其它实施方案中，检测移植患者的体液中可溶性IL2R和肌酐的增加可用于差异性诊断感染的肾同种异体移植排斥反应。本发明还涉及用于测量可溶性CD4抗原的方法，在具体实施方案中可以使用测量来诊断免疫激活的状态，诊断类风湿性关节炎，以监测治疗功效（例如AIDS治疗）或在患者中分期成年T细胞白血病。另一方面，本发明涉及通过测量多种可溶性T细胞标记来检测，分期和监测疾病和病症的治疗。

5. 发明授权

US09314239B2 Methods and devices for securing suture to tissue 有权
标题翻译：用于将缝合线固定到组织的方法和装置
公开(公告)号：US09314239B2
公开(公告)日：2016-04-19
申请号：US13478537
申请日：2012-05-23
申请人： Michael C. Brown
发明人： Michael C. Brown
IPC分类号： A61B17/04 , A61F2/08
CPC分类号： A61B17/0401 , A61B2017/044 , A61F2002/0852 , A61F2002/087
摘要： Methods and devices are provided for securing suture to tissue. In one exemplary embodiment, the implant can include an intermediate portion, a first radially expandable portion extending from the intermediate portion, and a second radially expandable portion extending from the intermediate portion. The implant can be configured to be inserted through a delivery device in a first configuration and deployed into a hole formed in tissue in a second configuration such that the intermediate portion is positioned within the hole. A suture can be inserted through a passageway of the intermediate portion positioned within the hole, and the suture can be tensioned to secure the tissue to bone.
摘要翻译：提供了用于将缝合线固定到组织上的方法和装置。在一个示例性实施例中，植入物可以包括中间部分，从中间部分延伸的第一可径向扩张部分和从中间部分延伸的第二可径向扩张部分。植入物可以构造成以第一构型插入通过输送装置，并且以第二构造部署到组织中形成的孔中，使得中间部分位于孔内。缝合线可以穿过定位在孔内的中间部分的通道插入，缝合线可以被张紧以将组织固定在骨头上。

6. 发明授权

US08734500B2 Distal detachment mechanisms for vascular devices 有权
标题翻译：血管装置的远端分离机制
公开(公告)号：US08734500B2
公开(公告)日：2014-05-27
申请号：US13246343
申请日：2011-09-27
申请人： Thomas Boden , Michael C. Brown
发明人： Thomas Boden , Michael C. Brown
IPC分类号： A61F2/82
CPC分类号： A61F2/966 , A61F2002/9505 , A61F2002/9534 , A61F2002/9665 , A61F2230/0091
摘要： A system for delivering an expandable implant into the vasculature of a patient, including an elongated core element having a proximal end accessible exterior to the patient and a distal end including at least one feature for engaging a proximal portion of the implant in a collapsed state. The system further includes an expansion limiter having an inner diameter and a length sufficient to cover the proximal portion of the implant and to retain the proximal portion in the collapsed state, and at least one elongated member having a distal end connected to the expansion limiter and a proximal end accessible exterior to the patient to enable proximal movement of the expansion limiter to release the implant.
摘要翻译：一种用于将可扩张植入物递送到患者的脉管系统中的系统，包括细长的芯元件，其具有可触及病人外部的近端，以及包括至少一个特征的远端，用于在塌缩状态下接合植入物的近端部分。所述系统还包括膨胀限制器，其具有足够的内径和长度以覆盖植入物的近端部分并且将近端部分保持在折叠状态，以及至少一个细长构件，其远端连接到膨胀限制器，近端可触及患者的外部，以使扩张限制器近端移动以释放植入物。

7. 外观设计

USD663330S1 Eyelet removal die set 有权
标题翻译：孔眼去除模具
公开(公告)号：USD663330S1
公开(公告)日：2012-07-10
申请号：US29413485
申请日：2012-02-16
申请人： Michael C. Brown
设计人： Michael C. Brown

8. 发明授权

US07189520B2 Compositions and methods for detecting animal byproduct in feed 失效
标题翻译：用于检测饲料中动物副产物的组合物和方法
公开(公告)号：US07189520B2
公开(公告)日：2007-03-13
申请号：US10734654
申请日：2003-12-12
申请人： Mark T. Muldoon , Dale V. Onisk , Michael C. Brown , Christina Straughen , James W. Stave
发明人： Mark T. Muldoon , Dale V. Onisk , Michael C. Brown , Christina Straughen , James W. Stave
IPC分类号： G01N33/53
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/02
摘要： Analytes and ligands for detecting animal byproduct in agricultural samples such as animal feed to minimize the transmission of prion pathogens into food products consumed by humans. The analyte is a component of rendered animal byproduct such as meat and bone meal (MBM). An antibody specific for the analyte is produced by immunizing an animal with MBM or an immunogenic component of MBM that is found in rendered animal product.
摘要翻译：用于检测农业样品如动物饲料中的动物副产物的分析物和配体，以最小化朊病毒病原体向食物消费的食物的传播。分析物是呈现的动物副产物如肉和骨粉（MBM）的组分。对分析物特异性的抗体是通过用生物动物产品中发现的MBM或MBM的免疫原性成分免疫动物产生的。

9. 发明授权

US4637986A Flow cytometry lysing reagent with leukoprotective agent for producing a 3-part WBC count 失效
标题翻译：流式细胞仪用白细胞保护剂溶解试剂，产生3份WBC计数
公开(公告)号：US4637986A
公开(公告)日：1987-01-20
申请号：US525575
申请日：1983-08-22
申请人： Michael C. Brown , Stefan J. Kirchanski
发明人： Michael C. Brown , Stefan J. Kirchanski
IPC分类号： G01N33/49 , G01N15/14 , G01N33/48 , G01N33/483 , G01N33/50 , G01N31/00
CPC分类号： G01N33/5094 , G01N15/1404 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331
摘要： Lysing reagents for use in flow cytometry instruments. Lysing reagents suitable for lysing red blood cells are provided thereby permitting 3-part differential counting of white blood cells. The reagents comprise a leukoprotective agent for preserving the lymphocyte cellular integrity during analysis, and buffers adjusted to provide the correct pH environment for optimal lysis and activity. Preferred embodiments will additionally incorporate non-ionic preservatives in very low concentrations.
摘要翻译：用于流式细胞仪器的溶解试剂。提供适于裂解红细胞的裂解试剂，从而允许白细胞的3部分差异计数。试剂包含用于在分析期间保持淋巴细胞完整性的白细胞保护剂，并调节缓冲液以提供用于最佳溶解和活性的正确pH环境。优选的实施方案将额外地掺入非常低浓度的非离子防腐剂。

10. 发明申请

US20130317546A1 Methods and Devices for Securing Suture to Tissue 有权
标题翻译：用于将缝合线固定到组织的方法和装置
公开(公告)号：US20130317546A1
公开(公告)日：2013-11-28
申请号：US13478537
申请日：2012-05-23
申请人： Michael C. Brown
发明人： Michael C. Brown
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/044 , A61F2002/0852 , A61F2002/087
摘要： Methods and devices are provided for securing suture to tissue. In one exemplary embodiment, the implant can include an intermediate portion, a first radially expandable portion extending from the intermediate portion, and a second radially expandable portion extending from the intermediate portion. The implant can be configured to be inserted through a delivery device in a first configuration and deployed into a hole formed in tissue in a second configuration such that the intermediate portion is positioned within the hole. A suture can be inserted through a passageway of the intermediate portion positioned within the hole, and the suture can be tensioned to secure the tissue to bone.
摘要翻译：提供了用于将缝合线固定到组织上的方法和装置。在一个示例性实施例中，植入物可以包括中间部分，从中间部分延伸的第一可径向扩张部分和从中间部分延伸的第二可径向扩张部分。植入物可以构造成以第一构型插入通过输送装置，并且以第二构造部署到组织中形成的孔中，使得中间部分位于孔内。可以将缝合线插入位于孔内的中间部分的通道中，并且缝合线可以被张紧以将组织固定在骨头上。

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