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1. 发明授权

US09551706B2 Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids 有权
标题翻译：用于分离材料的基于密度的方法，监测固体支持的反应和测量小液体体积和固体的密度
公开(公告)号：US09551706B2
公开(公告)日：2017-01-24
申请号：US12666132
申请日：2008-06-30
申请人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
发明人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
IPC分类号： G01N33/553 , G01N33/543 , B01L3/00 , G01R33/12 , B01D35/06
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译：描述了使用非均匀磁场悬浮在含有顺磁性阳离子的溶液中的反磁性颗粒悬浮，分离和检测密度变化的能力。这种分离装置的主要优点是：i）不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）它与简单的光学检测（只要透明材料用于制造分离发生的容器/通道）兼容; iii）收集分离的颗粒进行进一步处理是简单的; iv）不需要对颗粒/材料进行磁性标记; 和v）它是小，便携。所提供的方法和试剂盒用于分离和收集不同密度的材料，用于检测感兴趣的分析物的诊断，固体支持的化学反应的监测和固体和液体混合物的密度的测定。

2. 发明申请

US20100285606A1 DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 有权
标题翻译：用于分离材料的基于密度的方法，监测固体支持反应和测量小液体和固体的浓度
公开(公告)号：US20100285606A1
公开(公告)日：2010-11-11
申请号：US12666132
申请日：2008-06-30
申请人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
发明人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
IPC分类号： G01N33/553 , G01N33/44 , G01N33/53 , G01N33/20 , G01N33/14
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译：描述了使用非均匀磁场悬浮在含有顺磁性阳离子的溶液中的反磁性颗粒悬浮，分离和检测密度变化的能力。这种分离装置的主要优点是：i）不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）它与简单的光学检测（只要透明材料用于制造分离发生的容器/通道）兼容; iii）收集分离的颗粒进行进一步处理是简单的; iv）不需要对颗粒/材料进行磁性标记; 和v）它是小，便携。所提供的方法和试剂盒用于分离和收集不同密度的材料，用于检测感兴趣的分析物的诊断，固体支持的化学反应的监测和固体和液体混合物的密度的测定。

3. 发明授权

US08628729B2 Three-dimensional microfluidic devices 有权
标题翻译：三维微流体装置
公开(公告)号：US08628729B2
公开(公告)日：2014-01-14
申请号：US12934499
申请日：2009-03-27
申请人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
发明人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
IPC分类号： G01N21/75
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括多个图案化的多孔亲水层和设置在每两个相邻的图案化的多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定图案化的多孔亲水层内的一个或多个亲水区域的边界。流体不可渗透层具有与至少一个相邻的图案化的多孔亲水层内的亲水区域的至少一部分对准的开口。还描述了微流控测定装置，微流体混合器，微流控流量控制装置。

4. 发明授权

US08377710B2 Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same 有权
公开(公告)号：US08377710B2
公开(公告)日：2013-02-19
申请号：US12425121
申请日：2009-04-16
申请人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
发明人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
IPC分类号： G01N21/77
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/12 , B01L2300/06 , B01L2300/0848 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386 , G06F3/005
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.

5. 发明申请

US20110123398A1 THREE-DIMENSIONAL MICROFLUIDIC DEVICES 有权
标题翻译：三维微流体装置
公开(公告)号：US20110123398A1
公开(公告)日：2011-05-26
申请号：US12934499
申请日：2009-03-27
申请人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
发明人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
IPC分类号： G01N33/00
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括多个图案化的多孔亲水层和设置在每两个相邻的图案化的多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定图案化的多孔亲水层内的一个或多个亲水区域的边界。流体不可渗透层具有与至少一个相邻的图案化的多孔亲水层内的亲水区域的至少一部分对准的开口。还描述了微流控测定装置，微流体混合器，微流控流量控制装置。

6. 发明申请

US20130034869A1 DEVICES AND METHODS FOR MULTIPLEXED ASSAYS 有权
标题翻译：多重测试的设备和方法
公开(公告)号：US20130034869A1
公开(公告)日：2013-02-07
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
IPC分类号： C12M1/34 , G01N21/78 , G01N33/53
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译：本公开提供了用于执行多重测定的低成本便携式三维装置。这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

7. 发明授权

US08821810B2 Devices and methods for multiplexed assays 有权
标题翻译：多重测定的装置和方法
公开(公告)号：US08821810B2
公开(公告)日：2014-09-02
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
IPC分类号： G01N33/52 , B01L3/00
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译：本公开提供了用于执行多重测定的低成本便携式三维装置。这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

8. 发明授权

US09023458B2 Patterning of ionic polymers 有权
标题翻译：离子聚合物图案化
公开(公告)号：US09023458B2
公开(公告)日：2015-05-05
申请号：US12311811
申请日：2007-10-18
申请人： Michal Lahav , Adam Winkleman , Max Narovlyansky , Raquel Perez-Castillejos , Emily A. Weiss , Leonard N. J. Rodriguez , George M. Whitesides
发明人： Michal Lahav , Adam Winkleman , Max Narovlyansky , Raquel Perez-Castillejos , Emily A. Weiss , Leonard N. J. Rodriguez , George M. Whitesides
IPC分类号： B32B3/00 , B05D3/06 , B82Y10/00 , B82Y40/00 , G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL-PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone-novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与解决方案。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的暴露区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

9. 发明申请

US20100233434A1 PATTERNING OF IONIC POLYMERS 有权
标题翻译：离子聚合物的构图
公开(公告)号：US20100233434A1
公开(公告)日：2010-09-16
申请号：US12311811
申请日：2007-10-18
申请人： Michal Lahav , Adam Winkleman , Max Narovlyansky , Raquel Perez-Castillejos , Emily A. Weiss , Leonard N.J. Rodriguez , George M. Whitesides
发明人： Michal Lahav , Adam Winkleman , Max Narovlyansky , Raquel Perez-Castillejos , Emily A. Weiss , Leonard N.J. Rodriguez , George M. Whitesides
IPC分类号： B01J41/12 , B32B3/00 , B05D3/06 , G03F7/20
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL-PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone-novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与解决方案。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的暴露区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

10. 发明授权

US09409265B2 Three dimensional assembly of diamagnetic materials using magnetic levitation 有权
标题翻译：使用磁悬浮的抗磁材料三维组装
公开(公告)号：US09409265B2
公开(公告)日：2016-08-09
申请号：US13994595
申请日：2011-12-20
申请人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
发明人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
IPC分类号： C30B30/04 , B23P19/04 , B03C1/01 , B03C1/28 , B81C3/00
CPC分类号： B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
摘要： The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
摘要翻译：描述了使用悬浮在含有顺磁阳离子的溶液中的反磁性颗粒组装三维结构的能力。这种分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）组装的结构可以在固定结构之后从顺磁溶液中除去以进一步处理; iii）装配快速; 和iv）它是小，便携式。

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