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1. 发明授权

US07696174B2 Short bio-active peptides for cellular and immunological modulation 有权
标题翻译：用于细胞和免疫调节的短生物活性肽
公开(公告)号：US07696174B2
公开(公告)日：2010-04-13
申请号：US12005653
申请日：2007-12-27
申请人： Scott M. Harris , Lijuan Zhang , Timothy J. Falla
发明人： Scott M. Harris , Lijuan Zhang , Timothy J. Falla
IPC分类号： A61K38/08 , A61K31/74
CPC分类号： C07K14/43563 , A61K38/00 , C07K5/1024 , C07K7/08
摘要： Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory properties. As keratinocytes are especially sensitive to these effects, the disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.
摘要翻译：披露具有四至十四个残基的肽具有生物活性。这些肽构成肽HB-107（SEQ ID NO：1）的短片段，其本身是抗微生物蛋白质天蚕素B的片段，并且具有细胞刺激性，迁移性和抗炎性质。由于角质形成细胞对这些作用特别敏感，所公开的肽包括用于治疗皮肤损伤（例如糖尿病性溃疡）的有用试剂。这些肽也有效地预防和逆转由各种环境污染引起的皮肤表面损伤。重要的是，肽的治疗效果以等于或大于肽HB-107的浓度表现，因此代表开发有效疗法的较便宜，更通用的手段。还公开了生产和使用这些肽的方法。

2. 发明授权

US08110658B2 Peptide fragments for inducing synthesis of extracellular matrix proteins 有权
标题翻译：用于诱导细胞外基质蛋白合成的肽片段
公开(公告)号：US08110658B2
公开(公告)日：2012-02-07
申请号：US11811876
申请日：2007-06-12
申请人： Scott M. Harris , Timothy J. Falla , Lijuan Zhang
发明人： Scott M. Harris , Timothy J. Falla , Lijuan Zhang
IPC分类号： C07K5/10
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K9/06 , A61K38/00 , A61K2121/00 , A61K2300/00 , A61Q19/00 , A61Q19/08 , C07K5/1002 , C07K5/1008 , C07K5/1024 , C07K14/78
摘要： Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
摘要翻译：公开了由保持G（甘氨酸）和P（脯氨酸）并且x是可变氨基酸的序列GxxG和PxxP组成的短生物活性四肽。肽可单独使用或组合使用以刺激皮肤中细胞外基质蛋白的产生。公开了生产四肽的异源制剂的快速，低成本的方法。

3. 发明授权

US08071555B2 Protective skin care peptides 有权
标题翻译：保护性皮肤护理肽
公开(公告)号：US08071555B2
公开(公告)日：2011-12-06
申请号：US12290236
申请日：2008-10-28
申请人： Lijuan Zhang , Scott M. Harris , Timothy J. Falla
发明人： Lijuan Zhang , Scott M. Harris , Timothy J. Falla
IPC分类号： A61K38/06 , A61K9/00
CPC分类号： C07K5/1024 , A61K8/64 , A61K38/00 , A61K2800/782 , A61Q19/08
摘要： The disclosed invention provides tetrapeptides with the amino acid sequence proline-glutamine-glutamate-X (P-Q-E-X), where X can be either lysine (K) or isoleucine (I). These tetrapeptides inhibit ultraviolet light (UV)-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) by skin epithelial cells and fibroblasts. Furthermore, the tetrapeptides repress the upregulation of matrix metalloproteinase-1 (MMP-1) by skin fibroblasts induced by either direct exposure to UV rays or treatment with media conditioned by UV-treated keratinocytes. The small size and bio-activity of the tetrapeptides render them suitable for use in therapies directed to inflammatory skin disorders and as active ingredients in skin care products.
摘要翻译：所公开的发明提供四肽与氨基酸序列脯氨酸 - 谷氨酰胺 - 谷氨酸酯-X（P-Q-E-X），其中X可以是赖氨酸（K）或异亮氨酸（I）。这些四肽通过皮肤上皮细胞和成纤维细胞抑制紫外线（UV）诱导的促炎细胞因子白细胞介素-6（IL-6）的表达。此外，四肽通过直接暴露于紫外线诱导的皮肤成纤维细胞抑制基质金属蛋白酶-1（MMP-1）的上调或通过经紫外线处理的角质形成细胞调节的培养基来治疗。四肽的小尺寸和生物活性使其适合用于治疗炎症性皮肤病症和作为皮肤护理产品中的活性成分。

4. 发明授权

US07407940B2 Antimicrobial hexapeptides 有权
标题翻译：抗菌六肽
公开(公告)号：US07407940B2
公开(公告)日：2008-08-05
申请号：US11350192
申请日：2006-02-08
申请人： Timothy J. Falla , Lijuan Zhang , Scott M. Harris
发明人： Timothy J. Falla , Lijuan Zhang , Scott M. Harris
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K7/06 , A61K38/00 , Y02A50/473
摘要： The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.
摘要翻译：本发明包括由位置2,4和6处的交替的疏水性残基（B），位置1和3的亲水性带电残基（X）和萘丙氨酸（Nal），脂族或芳族残基（O））组成的六肽位置5，通常由式XBXBOB表示，其表现出针对由各种病原体引起的感染的抗微生物活性。这些病原体可以包括革兰氏阳性或阴性细菌，耐酸细菌如分枝杆菌，寄生虫，皮肤真菌或真菌病原体。典型的真菌病原体包括白色念珠菌和典型的皮肤癣菌包括红色毛癣菌和引发毛癣菌。本发明的六肽对接受治疗的哺乳动物具有抗真菌活性，抗菌活性，理想的稳定性和缺乏毒性。

5. 发明授权

US08658764B2 Peptide fragments for inducing synthesis of extracellular matrix proteins 有权
标题翻译：用于诱导细胞外基质蛋白合成的肽片段
公开(公告)号：US08658764B2
公开(公告)日：2014-02-25
申请号：US13339606
申请日：2011-12-29
申请人： Scott M. Harris , Timothy J. Falla , Lijuan Zhang
发明人： Scott M. Harris , Timothy J. Falla , Lijuan Zhang
IPC分类号： C07K5/10
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K9/06 , A61K38/00 , A61K2121/00 , A61K2300/00 , A61Q19/00 , A61Q19/08 , C07K5/1002 , C07K5/1008 , C07K5/1024 , C07K14/78
摘要： Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
摘要翻译：公开了由保持G（甘氨酸）和P（脯氨酸）并且x是可变氨基酸的序列GxxG和PxxP组成的短生物活性四肽。肽可单独使用或组合使用以刺激皮肤中细胞外基质蛋白的产生。公开了生产四肽的异源制剂的快速，低成本的方法。

6. 发明申请

US20120093740A1 PEPTIDE FRAGMENTS FOR INDUCING SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS 有权
标题翻译：诱导细胞基质蛋白合成的肽片段
公开(公告)号：US20120093740A1
公开(公告)日：2012-04-19
申请号：US13339606
申请日：2011-12-29
申请人： Scott M. Harris , Timothy J. Falla , Lijuan Zhang
发明人： Scott M. Harris , Timothy J. Falla , Lijuan Zhang
IPC分类号： A61K38/07 , C07K5/103 , A61P17/02 , C07K5/117 , A61K9/12
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K9/06 , A61K38/00 , A61K2121/00 , A61K2300/00 , A61Q19/00 , A61Q19/08 , C07K5/1002 , C07K5/1008 , C07K5/1024 , C07K14/78
摘要： Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
摘要翻译：公开了由保持G（甘氨酸）和P（脯氨酸）并且x是可变氨基酸的序列GxxG和PxxP组成的短生物活性四肽。肽可单独使用或组合使用以刺激皮肤中细胞外基质蛋白的产生。公开了生产四肽的异源制剂的快速，低成本的方法。

7. 发明申请

US20080206160A1 Short bio-active peptides for cellular and immunological modulation 有权
标题翻译：用于细胞和免疫调节的短生物活性肽
公开(公告)号：US20080206160A1
公开(公告)日：2008-08-28
申请号：US12005653
申请日：2007-12-27
申请人： Scott M. Harris , Lijuan Zhang , Timothy J. Falla
发明人： Scott M. Harris , Lijuan Zhang , Timothy J. Falla
IPC分类号： A61K9/12 , C07K2/00 , C07K7/06 , A61K38/02 , A61K38/08 , A61P17/02 , A61K38/10
CPC分类号： C07K14/43563 , A61K38/00 , C07K5/1024 , C07K7/08
摘要： Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory properties. As keratinocytes are especially sensitive to these effects, the disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.
摘要翻译：披露具有四至十四个残基的肽具有生物活性。这些肽构成肽HB-107（SEQ ID NO：1）的短片段，其本身是抗微生物蛋白质天蚕素B的片段，并且具有细胞刺激性，迁移性和抗炎性质。由于角质形成细胞对这些作用特别敏感，所公开的肽包括用于治疗皮肤损伤（例如糖尿病性溃疡）的有用试剂。这些肽也有效地预防和逆转由各种环境污染引起的皮肤表面损伤。重要的是，肽的治疗效果以等于或大于肽HB-107的浓度表现，因此代表开发有效疗法的较便宜，更通用的手段。还公开了生产和使用这些肽的方法。

8. 发明授权

US5799650A Femoral compression device and method 失效
标题翻译：股骨压缩装置及方法
公开(公告)号：US5799650A
公开(公告)日：1998-09-01
申请号：US826222
申请日：1997-03-27
申请人： Scott M. Harris
发明人： Scott M. Harris
IPC分类号： A61B17/132 , A61F5/058 , A61F5/34 , A61F5/24
CPC分类号： A61F5/34 , A61B17/1325 , A61F5/05841
摘要： A femoral compression device for preventing post-catheterization wound bleeding includes a rigid restraining member strapped in fixed position to a patient to prevent hip flexion. A compression strap connected to the restraining member urges a discrete compression element toward the wound site. The compression strap cooperates with the discrete compression element to form a general ball and socket joint therebetween, whereby slight movement of the compression strap relative to the compression element will not cause a corresponding movement of the compression element.
摘要翻译：用于防止导管后伤口出血的股骨压缩装置包括以固定位置捆绑到患者以防止髋部屈曲的刚性约束构件。连接到限制构件的压缩带将离散的压缩元件推向伤口部位。压缩带与分立的压缩元件配合以在它们之间形成一般的球窝接头，由此压缩带相对于压缩元件的轻微移动不会引起压缩元件的相应移动。

9. 发明授权

US6008208A Compositions and methods for treating bone deficit conditions 失效
公开(公告)号：US6008208A
公开(公告)日：1999-12-28
申请号：US878868
申请日：1997-06-19
申请人： Charles Petrie , Mark W. Orme , Nand Baindur , Kirk G. Robbins , Scott M. Harris , Maria Kontoyianni , Gregory R. Mundy
发明人： Charles Petrie , Mark W. Orme , Nand Baindur , Kirk G. Robbins , Scott M. Harris , Maria Kontoyianni , Gregory R. Mundy
IPC分类号： A61K31/47 , A61K31/549 , A61K31/655 , A61K31/35 , A61K31/495
CPC分类号： A61K31/47 , A61K31/549 , A61K31/655
摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

10. 发明授权

US5990169A Compositions and methods for treating bone deficit conditions 失效
公开(公告)号：US5990169A
公开(公告)日：1999-11-23
申请号：US806771
申请日：1997-02-26
申请人： Charles Petrie , Mark W. Orme , Nand Baindur , Kirk G. Robbins , Scott M. Harris , Gregory R. Mundy
发明人： Charles Petrie , Mark W. Orme , Nand Baindur , Kirk G. Robbins , Scott M. Harris , Gregory R. Mundy
IPC分类号： A61K31/196 , A61K31/445 , A61K31/16 , A61K31/18
CPC分类号： A61K31/196
摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

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