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1. 发明授权

US06436722B1 Device and method for integrated diagnostics with multiple independent flow paths 失效
标题翻译：具有多个独立流路的集成诊断的装置和方法
公开(公告)号：US06436722B1
公开(公告)日：2002-08-20
申请号：US09551496
申请日：2000-04-18
申请人： Scott M. Clark , Robert H. Suva , Michael R. Kepron , Stanislaw Barski, Jr. , Erwin F. Workman, Jr.
发明人： Scott M. Clark , Robert H. Suva , Michael R. Kepron , Stanislaw Barski, Jr. , Erwin F. Workman, Jr.
IPC分类号： G01N33543
CPC分类号： G01N33/558 , G01N33/54366 , Y10T436/11 , Y10T436/12 , Y10T436/255
摘要： Invention performs an assay to determine presence or quantity of specific analyte in fluid sample. Representative device has two separate flow paths established sequentially in device with a single user activation step. First flow path delivers sample, and conjugate soluble binding reagents to solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. Sample volume delivered by first path determined by absorbent capacity of solid phase, and not by amount of sample added to device. User need not measure sample volume. Sample/conjugate mixture is prevented from entering second flow path because capillary and surface energy of second flow path prevent it from being wetted by this mixture. Second flow path allows wash reagent to remove unbound conjugate and sample from solid phase to the absorbant, and optionally deliver detection reagents. Adaptable for many formats including, sandwich immunoassays, colloidal gold, sol particle, heterogeneous generic capture, and competitive assays.
摘要翻译：本发明进行测定以确定流体样品中特定分析物的存在或数量。代表性设备具有在具有单个用户激活步骤的设备中顺序建立的两个单独的流路径。第一流路将样品和可溶性结合试剂结合到固相中。如果存在分析物，则形成并固定分析物：缀合物。由第一路径输送的样品体积由固相的吸收能力确定，而不是通过添加到设备的样品量。用户不需要测量样品量。防止样品/共轭物混合物进入第二流路，因为第二流路的毛细管和表面能阻止其被该混合物润湿。第二流路允许洗涤剂将未结合的结合物和样品从固相除去到吸收剂，并且任选地递送检测试剂。适用于多种形式，包括夹心免疫测定，胶体金，溶胶颗粒，异种通用捕获和竞争性测定。

2. 发明授权

US06060266A Self-contained incubator for growth of microorganism 失效
标题翻译：用于微生物生长的独立孵化器
公开(公告)号：US06060266A
公开(公告)日：2000-05-09
申请号：US43960
申请日：1998-09-28
申请人： Ali Naqui , Erwin F. Workman, Jr. , Haoyi Gu , Mark W. Pierson
发明人： Ali Naqui , Erwin F. Workman, Jr. , Haoyi Gu , Mark W. Pierson
IPC分类号： C12M1/02 , C12M1/12 , C12M1/24 , C12Q1/04 , C12Q1/02 , C12N1/12 , G01N33/53
CPC分类号： C12M23/08 , C12M23/38 , C12M23/54 , C12M41/14 , F24J1/00 , Y10S435/848 , Y10S435/849 , Y10S435/975
摘要： A self-contained incubator for growth of microorganism kit and methods for use of such a kit are provided. The kit and methods may detect the presence of microorganisms and may utilie a microorganism growth and indicator medium provided in a sample container along with a heat source, preferably generating heat through chemical means, and optionally heat shields, allowing for on-site testing of a microorganism present in a sample. The sample container may also include a removable vessel cap that includes a barrier separating the sample from a material capable of disinfecting the sample, thereby preventing contact of the sample and the material for a desired time period. The vessel cap may also be used independently in other applications.
摘要翻译： PCT No.PCT / US96 / 15525 Sec。 371日期：1998年9月28日 102（e）1998年9月28日PCT PCT 1996年9月27日PCT公布。第WO97 / 12029号公报日期1997年4月3日提供了用于生长微生物试剂盒的独立培养箱和使用这种试剂盒的方法。试剂盒和方法可以检测微生物的存在，并且可以利用提供在样品容器中的微生物生长和指示剂介质以及热源，优选通过化学方法产生热量，并且可选地加热屏蔽，允许现场测试存在于样品中的微生物。样品容器还可以包括可移除的容器盖，其包括将样品与能够对样品进行消毒的材料隔离的屏障，从而防止样品和材料在期望的时间段内接触。容器盖也可以在其它应用中独立使用。

3. 发明授权

US4311482A Method and apparatus for collecting blood samples 失效
标题翻译：收集血液样本的方法和装置
公开(公告)号：US4311482A
公开(公告)日：1982-01-19
申请号：US82840
申请日：1979-10-09
申请人： Erwin F. Workman, Jr. , Deborah M. Clark
发明人： Erwin F. Workman, Jr. , Deborah M. Clark
IPC分类号： G01N33/48 , A61K35/14 , G01N33/49 , G01N33/86 , G01N33/16 , C09K3/00
CPC分类号： A61K35/14 , G01N33/86 , Y10T436/108331
摘要： This invention encompasses methods and apparatus for collecting blood samples. It has been discovered that p-aminobenzoyldiethylaminoethanol (procaine) is unexpectedly potent in stabilizing blood samples against platelet release reactions. Methods and apparatus of this invention are particularly useful for collecting blood samples for subsequent platelet factor 4 determination.
摘要翻译：本发明包括用于收集血液样本的方法和装置。已经发现对氨基苯甲酰基二乙基氨基乙醇（普鲁卡因）意外地有效地稳定血液样品以防止血小板释放反应。本发明的方法和装置特别可用于收集用于随后血小板因子4测定的血样。

4. 发明授权

US4195072A Stabilized platelet factor 4 immunoassay standards 失效
标题翻译：稳定的血小板因子4免疫测定标准
公开(公告)号：US4195072A
公开(公告)日：1980-03-25
申请号：US922135
申请日：1978-07-05
申请人： Erwin F. Workman, Jr.
发明人： Erwin F. Workman, Jr.
IPC分类号： G01N33/49 , A61K39/00 , G01N33/53 , G01N33/86 , G01N33/96 , G01N33/16 , A61K43/00
CPC分类号： G01N33/86 , G01N33/96 , G01N2400/40 , Y10S436/804 , Y10S436/826
摘要： The present invention encompasses a stabilized platelet factor 4 immunoassay standard comprising an aqueous solution containing 10 to 100 ng/ml of platelet factor 4, carrier protein, and an effective stabilizing amount of heparin, as well as .sup.125 I labeled platelet factor 4 reagent stabilized in the same manner. These reagents are useful for testing blood plasma for activation of the coagulation system.
摘要翻译：本发明包括稳定的血小板因子4免疫测定标准，其包含含有10-100ng / ml血小板因子4，载体蛋白质和有效稳定量的肝素的水溶液，以及稳定在该溶液中的125I标记的血小板因子4试剂同样的方式这些试剂可用于测试血浆以激活凝血系统。

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