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1. 发明申请

US20120165261A1 Alpha-1-antitrypsin compositions 有权
标题翻译： α-1-抗胰蛋白酶组合物
公开(公告)号：US20120165261A1
公开(公告)日：2012-06-28
申请号：US13385642
申请日：2012-02-28
申请人： Scott M. Kee , Paul I. Cook , James R. Smith , Robert Kling , Scott A. Fowler , David Weber
发明人： Scott M. Kee , Paul I. Cook , James R. Smith , Robert Kling , Scott A. Fowler , David Weber
IPC分类号： A61K38/17 , A61P11/00
CPC分类号： A61K38/57 , A61K9/19 , B01D15/327 , B01D15/363 , C07K14/8125 , G01N30/461
摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
摘要翻译：提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。还描述了一种以商业规模提供高产量的药物级AAT的方法。

2. 发明授权

US07777006B2 Method for purification of alpha-1-antitrypsin 有权
标题翻译：纯化α-1-抗胰蛋白酶的方法
公开(公告)号：US07777006B2
公开(公告)日：2010-08-17
申请号：US10334303
申请日：2002-12-31
申请人： Scott M. Kee , Paul I. Cook , James R. Smith , Robert Kling , Scott A. Fowler , David Weber
发明人： Scott M. Kee , Paul I. Cook , James R. Smith , Robert Kling , Scott A. Fowler , David Weber
IPC分类号： A61K35/14
CPC分类号： A61K38/57 , A61K9/19 , B01D15/327 , B01D15/363 , C07K14/8125 , G01N30/461
摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
摘要翻译：提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。还描述了一种以商业规模提供高产量的药物级AAT的方法。

3. 发明授权

US08722624B2 Alpha-1-antitrypsin compositions and methods of use 有权
标题翻译： α-1-抗胰蛋白酶组合物和使用方法
公开(公告)号：US08722624B2
公开(公告)日：2014-05-13
申请号：US13385642
申请日：2012-02-28
申请人： Scott M Kee , Paul I Cook , James R Smith , Robert Kling , Scott A Fowler , David Weber
发明人： Scott M Kee , Paul I Cook , James R Smith , Robert Kling , Scott A Fowler , David Weber
IPC分类号： A61K38/17
CPC分类号： A61K38/57 , A61K9/19 , B01D15/327 , B01D15/363 , C07K14/8125 , G01N30/461
摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
摘要翻译：提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。还描述了一种以商业规模提供高产量的药物级AAT的方法。

4. 发明授权

US08124736B2 Alpha-1-antitrypsin compositions 有权
公开(公告)号：US08124736B2
公开(公告)日：2012-02-28
申请号：US12855721
申请日：2010-08-13
申请人： Scott M Kee , Paul I. Cook , James R Smith , Robert Kling , Scott A Fowler , David Weber
发明人： Scott M Kee , Paul I. Cook , James R Smith , Robert Kling , Scott A Fowler , David Weber
IPC分类号： A61K35/14
CPC分类号： A61K38/57 , A61K9/19 , B01D15/327 , B01D15/363 , C07K14/8125 , G01N30/461
摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

5. 发明授权

US09892372B2 System and a method for data collection and monitoring of a defined space 有权
公开(公告)号：US09892372B2
公开(公告)日：2018-02-13
申请号：US14424590
申请日：2012-08-31
申请人： Gunilla Himmelmann , Johan Lissmats , Andreas Wass , Erik Lärfars , Robert Kling
发明人： Gunilla Himmelmann , Johan Lissmats , Andreas Wass , Erik Lärfars , Robert Kling
IPC分类号： G06Q10/06 , G08B21/24 , H04Q9/00
CPC分类号： G06Q10/0631 , G06Q10/063118 , G08B21/245 , H04Q9/00
摘要： A data collection and monitoring system for a defined space within a public or commercial facility, comprising: a plurality of sensors of which at least one sensor is arranged for monitoring the level of a consumable in connection with said space; and a data collecting unit arranged for wirelessly communicating with said sensors and furthermore arranged for communicating with a central server associated with a storage medium. The storage medium is adapted for storing and monitoring data related to said space. The system is arranged so that said data collecting unit is arranged for minimizing the amount of data transmitted, by transferring data from said sensors to said central server upon a status change of at least one of said sensors.

6. 发明授权

US09089226B2 Support device 有权
标题翻译：支持设备
公开(公告)号：US09089226B2
公开(公告)日：2015-07-28
申请号：US13990460
申请日：2010-12-10
申请人： Robert Kling
发明人： Robert Kling
IPC分类号： A47K10/32 , A47F5/08 , A47G1/17 , A47K5/12 , F16B11/00
CPC分类号： A47F5/08 , A47G1/175 , A47K5/12 , A47K10/32 , A47K2010/3233 , F16B11/006
摘要： A support device includes a base member having a first side adapted to face a flat surface and a second side opposite to the first side, and a cover member adapted to cover at least partially the base member. The base member is adapted to be attached to the flat surface by a fastening system. The fastening system includes a first surface adapted for the application of a stretch releasable adhesive strip on the first side of the base member. The base member has a through opening extending through the base member from the second side to the first side. The through opening is arranged adjacent to the first surface and is adapted for pulling the stretch releasable adhesive strip at least partially therethrough. The cover member in a first position covers the through opening and in a second position exposes the through opening.
摘要翻译：支撑装置包括具有适于面对平坦表面的第一侧和与第一侧相对的第二侧的基部构件，以及适于至少部分地覆盖基部构件的盖构件。基座构件适于通过紧固系统附接到平坦表面。紧固系统包括适于在基部构件的第一侧上施加拉伸可剥离粘合剂条的第一表面。基部构件具有从第二侧延伸穿过基部构件到第一侧的通孔。通孔设置成与第一表面相邻，并且适于至少部分地拉伸拉伸可释放的粘合剂带。第一位置的盖构件覆盖通孔，并且在第二位置使通过开口暴露。

7. 发明授权

US08740132B2 End plug for a paper roll 失效
标题翻译：纸卷端头
公开(公告)号：US08740132B2
公开(公告)日：2014-06-03
申请号：US12280167
申请日：2007-02-01
申请人： Robert Kling , Anders Andersson , Erik Hjort
发明人： Robert Kling , Anders Andersson , Erik Hjort
IPC分类号： B65H75/18
CPC分类号： B65B63/02 , A47K10/38 , A47K10/40 , B65H75/185
摘要： An end plug to be inserted axially into the center of an end of a roll of paper, includes a holding element adapted to hold and/or guide the end of the roll of paper in correct position in a dispenser. The end plug includes an outer sleeve having an outer end and an inner end and the holding element is connected to the sleeve by elements allowing the holding element to be axially moved from a first position to a second position, in which the holding element protrude outwardly from the outer end of the sleeve, the holding element being releasably held in the first position when moved thereto. A roll of tissue paper including such an end plug and a dispenser provided with such a roll are also disclosed.
摘要翻译：轴向插入纸卷端部的中心的端塞包括保持元件，该保持元件适于将纸卷的端部保持和/或引导到分配器中的正确位置。端塞包括外套筒，其具有外端和内端，并且保持元件通过元件连接到套筒，从而允许保持元件从第一位置轴向移动到第二位置，其中保持元件向外突出从套筒的外端开始，当移动到保持元件时，保持元件可释放地保持在第一位置。还公开了一卷包括这种端塞的薄纸和配备有这种卷的分配器。

8. 发明申请

US20130269893A1 STACK OF A PLURALITY OF CELLULOSE-CONTAINING ABSORBENT TOWELS AND A PROCESS FOR MANUFACTURING THE STACK 有权
标题翻译：包含多孔含纤维素的吸收性毛巾和堆叠的方法
公开(公告)号：US20130269893A1
公开(公告)日：2013-10-17
申请号：US13996856
申请日：2010-12-22
申请人： Anna Nelvig , Fredrik Welander , Magnus Falk , Robert Kling , Anders Andersson , Per Möller , Martin Bonnevier
发明人： Anna Nelvig , Fredrik Welander , Magnus Falk , Robert Kling , Anders Andersson , Per Möller , Martin Bonnevier
IPC分类号： D21H27/00 , B65D19/38
CPC分类号： D21H5/00 , A47K10/16 , A47K2010/428 , B65B63/02 , B65B63/026 , B65D19/38 , D21H27/002
摘要： A stack of a plurality of cellulose-containing absorbent towels for a dispenser is provided. The towels are separable upon dispensing. The stack is compressed to a predetermined density dependent on material choice.
摘要翻译：提供了用于分配器的多个含纤维素的吸收性毛巾的堆叠。毛巾在分配后是可分离的。根据材料选择将堆叠压缩至预定密度。

9. 发明申请

US20100236956A1 END PLUG FOR A PAPER ROLL 失效
标题翻译：纸卷的最终插入
公开(公告)号：US20100236956A1
公开(公告)日：2010-09-23
申请号：US12280167
申请日：2007-02-01
申请人： Robert Kling , Anders Andersson , Erik Hjort
发明人： Robert Kling , Anders Andersson , Erik Hjort
IPC分类号： B65D85/00 , A47K10/40 , B65H75/18 , B65D30/08 , B65B1/04
CPC分类号： B65B63/02 , A47K10/38 , A47K10/40 , B65H75/185
摘要： An end plug to be inserted axially into the centre of an end of a roll of paper, includes a holding element adapted to hold and/or guide the end of the roll of paper in correct position in a dispenser. The end plug includes an outer sleeve having an outer end and an inner end and the holding element is connected to the sleeve by elements allowing the holding element to be axially moved from a first position to a second position, in which the holding element protrude outwardly from the outer end of the sleeve, the holding element being releasably held in the first position when moved thereto. A roll of tissue paper including such an end plug and a dispenser provided with such a roll are also disclosed.
摘要翻译：轴向插入纸卷端部的中心的端塞包括保持元件，该保持元件适于将纸卷的端部保持和/或引导到分配器中的正确位置。端塞包括外套筒，其具有外端和内端，并且保持元件通过元件连接到套筒，从而允许保持元件从第一位置轴向移动到第二位置，其中保持元件向外突出从套筒的外端开始，当移动到保持元件时，保持元件可释放地保持在第一位置。还公开了一卷包括这种端塞的薄纸和配备有这种卷的分配器。

10. 发明授权

US06649001B2 Method and an arrangement for producing basic fastener tab material, such basic starting material, and fastener tabs 有权
标题翻译：用于生产基本紧固件接头材料，这种基本起始材料和紧固件突片的方法和装置
公开(公告)号：US06649001B2
公开(公告)日：2003-11-18
申请号：US09812857
申请日：2001-03-21
申请人： Anna Heden , Robert Kling , Urban Nilsson , Jose-Maria Mansisidor
发明人： Anna Heden , Robert Kling , Urban Nilsson , Jose-Maria Mansisidor
IPC分类号： B32B3118
CPC分类号： B32B37/144 , A61F13/15577 , A61F13/15699 , A61F13/15756 , A61F13/5622 , A61F13/58 , A61F13/622 , B29C65/086 , B29C66/1122 , B29C66/438 , B29C66/71 , B29C66/72343 , B29C66/727 , B29C66/7294 , B29C66/73921 , B29C66/81427 , B29C66/81463 , B29C66/81465 , B29C66/8161 , B29C66/8221 , B29C66/8286 , B29C66/83411 , B29K2313/00 , B29L2031/4878 , B32B7/02 , B32B7/04 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1082 , Y10T156/1084 , Y10T428/24942 , Y10T428/249923 , Y10T428/27 , Y10T442/60 , Y10T442/601 , Y10T442/602 , Y10T442/647 , Y10T442/659 , Y10T442/66 , Y10T442/674 , Y10T442/681 , B29C65/00 , B29K2023/12
摘要： A method of producing basic starting material for the manufacture of fastener tabs comprises the steps of: stretching a first sheet of elastic material in a first direction; applying a second and a third sheet of material onto respective opposite sides of the first sheet; fastening the three material sheets together in at least two mutually separated zones that extend parallel with each other in one direction perpendicular to the first direction; dividing the first sheet in each region between two zones along a line that lies between the zones, whereby the first sheet in each region between the zones contracts to a non-stretched state, and thereafter fastening the sheets together in each region between the zones.
摘要翻译：制造用于制造紧固件片的基本起始材料的方法包括以下步骤：在第一方向上拉伸第一片弹性材料; 将第二和第三片材料施加到所述第一片材的相应的相对侧上; 将三个材料片材紧固在至少两个相互分离的区域中，该区域在垂直于第一方向的一个方向上彼此平行延伸; 沿着位于区域之间的线将两个区域之间的每个区域中的第一片材分割，由此区域之间的每个区域中的第一片材收缩到非拉伸状态，然后在各区域之间的每个区域中将片材紧固在一起。

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