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    • 5. 发明申请
    • Method of treatment and Agents useful for same
    • 治疗方法和适用于其的药剂
    • US20090274702A1
    • 2009-11-05
    • US12499817
    • 2009-07-09
    • John HamiltonIan Keith Campbell
    • John HamiltonIan Keith Campbell
    • A61K39/395C07K16/18A61P3/10
    • A61K31/00A61K2039/505C07K16/241C07K16/243C07K2317/73G01N33/5047
    • The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
    • 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症,特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明,提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞,特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
    • 6. 发明申请
    • TABLE CONSTRUCTION
    • 表结构
    • US20080295745A1
    • 2008-12-04
    • US12128791
    • 2008-05-29
    • John HamiltonKurt HeidmanSteven James BeukemaJay Grandin
    • John HamiltonKurt HeidmanSteven James BeukemaJay Grandin
    • A47B37/00A47B57/00
    • A47B13/06A47B2200/0013
    • A table has two end legs arranged in a parallel, laterally spaced apart relationship for support on a floor surface. Two side rails are arranged in a parallel, laterally spaced apart relationship, and are connected with upper portions of the end legs to retain them in an upright orientation, defining a self-supported table frame without intermediate bracing between the side rails, with a central, vertically extending widow. Top support members are connected with the side rails and protrude outwardly therefrom in a cantilevered fashion. A top member is supported on and connected with the table frame and the top support members, defining a plurality of workstations. A utility module configured to route utilities is positioned within the window of the frame, with opposite sides abuttingly supported on the side rails to removably mount the utility module on the frame and thereby accommodate different utility requirements at the workstations.
    • 桌子具有以平行的横向间隔开的关系布置的两个端部腿,用于支撑在地板表面上。 两个侧轨布置成平行的横向间隔开的关系,并且与端腿的上部连接以将它们保持在直立的方向,从而限定了一个自支撑的桌面框架,而在侧轨之间没有中间支撑, ,垂直延伸的寡妇。 顶部支撑构件与侧轨连接并以悬臂方式向外突出。 顶部构件支撑并与桌子框架和顶部支撑构件连接,定义了多个工作站。 配置为路由公用事业的实用程序模块位于框架的窗口内,相对的侧面邻接支撑在侧轨上,以将可用模块可拆卸地安装在框架上,从而适应工作站的不同的实用要求。
    • 8. 发明申请
    • Table and method
    • 表和方法
    • US20070251428A1
    • 2007-11-01
    • US11412969
    • 2006-04-27
    • Karl MeadJohn HamiltonJames Ludwig
    • Karl MeadJohn HamiltonJames Ludwig
    • A47B37/00
    • A47B83/001A47B13/02E04B2/7422E04B2002/7483E04B2002/7488
    • A table for offices and the like includes an elongate center beam and two center posts having lower ends abuttingly supported on a floor surface and upper ends connected with opposite ends of the center beam. Two outrigger beams are positioned on opposite sides of the center beam in a generally mutually perpendicular relationship therewith, and have inner ends connected with one of the center posts. Two outrigger posts are positioned on opposite sides of the center beam, and have lower ends thereof abutting the floor surface and upper ends connected with the outside ends of the outrigger beams to stabilize the table. Two elongate worksurfaces are positioned along opposite sides of the center beam and have a length generally commensurate with the same. The worksurfaces have inside edges connected with and at least partially supported by the center beam, end segments abutting and at least partially supported by the upper ends of the outrigger posts, and outside edges which protrude outwardly from the outrigger posts in a cantilevered fashion and extend freely therealong to permit unencumbered access to the worksurfaces.
    • 用于办公室等的桌子包括细长的中心束和两个中心柱,其中下端部邻接地支撑在地板表面上,并且上端部与中心梁的相对端连接。 两个支腿梁以与其大致相互垂直的关系定位在中心梁的相对侧上,并且内端与一个中心柱连接。 两个外伸支架位于中心梁的相对侧上,并且其下端邻接地板表面,并且上端与外伸支架梁的外端相连以稳定工作台。 两个细长工件表面沿着中心梁的相对侧定位,并且具有与其相同的长度。 工件表面具有与中心梁连接并且至少部分地由中心梁支撑的内边缘,端部段邻接并且至少部分地由外伸支架柱的上端部支撑,以及从悬臂支柱向外以悬臂方式向外突出的外边缘,并且延伸 自由地允许不受阻碍地访问工作表面。