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1. 发明申请

US20090274702A1 Method of treatment and Agents useful for same 有权
标题翻译：治疗方法和适用于其的药剂
公开(公告)号：US20090274702A1
公开(公告)日：2009-11-05
申请号：US12499817
申请日：2009-07-09
申请人： John Hamilton , Ian Keith Campbell
发明人： John Hamilton , Ian Keith Campbell
IPC分类号： A61K39/395 , C07K16/18 , A61P3/10
CPC分类号： A61K31/00 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译：本发明一般涉及治疗和预防炎性病症的方法。本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的。本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

2. 发明申请

US20120177654A1 Method of treatment and agents useful for same 审中-公开
标题翻译：治疗方法和对其有用的药剂
公开(公告)号：US20120177654A1
公开(公告)日：2012-07-12
申请号：US13335974
申请日：2011-12-23
申请人： John Hamilton , Gary Peter Anderson , Ian Keith Campbell
发明人： John Hamilton , Gary Peter Anderson , Ian Keith Campbell
IPC分类号： A61K39/395 , A61P19/00 , A61P11/00 , A61P25/00 , A61P17/06 , A61P1/00 , A61K38/02 , A61P3/04
CPC分类号： C07K16/2866 , A61K38/1793 , A61K39/3955 , A61K2039/505 , A61P29/00 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译：本发明一般涉及治疗和预防炎性病症的方法。本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的。本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

3. 发明授权

US08142777B2 Method of treating rheumatoid arthritis with antibodies to M-CSF 有权
标题翻译：用M-CSF抗体治疗类风湿关节炎的方法
公开(公告)号：US08142777B2
公开(公告)日：2012-03-27
申请号：US11856949
申请日：2007-09-18
申请人： John Hamilton , Ian Keith Campbell
发明人： John Hamilton , Ian Keith Campbell
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K31/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译：本发明一般涉及治疗和预防炎性病症的方法。本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的。本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

4. 发明授权

US07455836B2 Method of treatment and agents useful for same 有权
标题翻译：治疗方法和对其有用的药剂
公开(公告)号：US07455836B2
公开(公告)日：2008-11-25
申请号：US09851230
申请日：2001-05-08
申请人： John Hamilton , Gary Peter Anderson , Ian Keith Campbell
发明人： John Hamilton , Gary Peter Anderson , Ian Keith Campbell
IPC分类号： A61K39/40 , A61K39/00
CPC分类号： C07K16/2866 , A61K31/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译：本发明一般涉及治疗和预防炎性病症的方法。本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的。本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

5. 发明授权

US08062637B2 Methods of ameliorating inflammatory disease using an uPA antagonist 有权
标题翻译：使用uPA拮抗剂改善炎性疾病的方法
公开(公告)号：US08062637B2
公开(公告)日：2011-11-22
申请号：US12499817
申请日：2009-07-09
申请人： John Hamilton , Ian Keith Campbell
发明人： John Hamilton , Ian Keith Campbell
IPC分类号： A61K39/40 , A61K39/00
CPC分类号： A61K31/00 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译：本发明一般涉及治疗和预防炎性病症的方法。本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的。本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

6. 发明申请

US20080131424A1 METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME 有权
标题翻译：治疗方法及其用途
公开(公告)号：US20080131424A1
公开(公告)日：2008-06-05
申请号：US11856949
申请日：2007-09-18
申请人： John HAMILTON , Gary Peter Anderson , Ian Keith Campbell
发明人： John HAMILTON , Gary Peter Anderson , Ian Keith Campbell
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： C07K16/2866 , A61K31/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译：本发明一般涉及治疗和预防炎性病症的方法。本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的。本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

7. 发明申请

US20110110934A1 TREATMENT OF UVEITIS 有权
标题翻译：治疗UVEITIS
公开(公告)号：US20110110934A1
公开(公告)日：2011-05-12
申请号：US12900688
申请日：2010-10-08
申请人： Ian Peter Wicks , Ian Keith Campbell , Ann Leckie Cornish
发明人： Ian Peter Wicks , Ian Keith Campbell , Ann Leckie Cornish
IPC分类号： A61K39/395 , A61K39/00 , A61K38/22 , A61K31/7088 , C07K16/26 , A61P27/02 , C07K14/575 , C07H21/00
CPC分类号： C07K16/243 , A61K31/7088 , A61K38/1793 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2866 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present invention relates generally to the use of antagonists of G-CSF, and/or its receptor (G-CSFR) in the treatment of uveitis. The present invention contemplates, therefore, the inhibition of G-CSF or G-CSFR systemically or locally and/or the down-regulation of expression of a G-CSF or G-CSFR in the treatment of uveitis.
摘要翻译：本发明一般涉及G-CSF和/或其受体（G-CSFR）拮抗剂治疗葡萄膜炎的用途。因此，本发明考虑了在治疗葡萄膜炎中G-CSF或G-CSFR的全身或局部抑制和/或下调G-CSF或G-CSFR的表达。

8. 发明授权

US08968731B2 Treatment of uveitis 有权
标题翻译：葡萄膜炎的治疗
公开(公告)号：US08968731B2
公开(公告)日：2015-03-03
申请号：US12900688
申请日：2010-10-08
申请人： Ian Peter Wicks , Ian Keith Campbell , Ann Leckie Cornish
发明人： Ian Peter Wicks , Ian Keith Campbell , Ann Leckie Cornish
IPC分类号： A61K39/395 , A61K39/00 , C07K16/24 , A61K31/7088 , A61K45/06 , C07K16/28 , A61K38/17
CPC分类号： C07K16/243 , A61K31/7088 , A61K38/1793 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2866 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present invention relates generally to the use of antagonists of G-CSF, and/or its receptor (G-CSFR) in the treatment of uveitis. The present invention contemplates, therefore, the inhibition of G-CSF or G-CSFR systemically or locally and/or the down-regulation of expression of a G-CSF or G-CSFR in the treatment of uveitis.
摘要翻译：本发明一般涉及G-CSF和/或其受体（G-CSFR）拮抗剂治疗葡萄膜炎的用途。因此，本发明考虑了在治疗葡萄膜炎中G-CSF或G-CSFR的全身或局部抑制和/或下调G-CSF或G-CSFR的表达。

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