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1. 发明授权

US08569691B2 Preconcentrator for analysis instruments 有权
标题翻译：分析仪器预收敛器
公开(公告)号：US08569691B2
公开(公告)日：2013-10-29
申请号：US12953108
申请日：2010-11-23
申请人： Scott Cambron , Thomas J. Roussel , Robert S. Keynton
发明人： Scott Cambron , Thomas J. Roussel , Robert S. Keynton
IPC分类号： H01J49/26
CPC分类号： G01N30/08 , G01N1/405
摘要： An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.
摘要翻译：用于将分析物输送到分析仪器的可互换的预浓缩器组件。组件包括限定内室的壳体。入口与内室流体连通，出口与内室流体连通，用于将流体输送到分析仪器的入口，排气口与内腔流体连通。多个可移除的预浓缩器包装被设置在内室内。每个可移动的预浓缩器包装包括微量预浓缩器。流体流动路径被限定在入口和内部腔室之间。在预浓缩器和排气出口之间限定第一流体流动路径，并且在预浓缩器和出口之间限定第二流体流动路径。可选择操作的阀将流体从内室引导到第一流体流动路径或第二流体流动路径中。

2. 发明申请

US20120132798A1 PRECONCENTRATOR FOR ANALYSIS INSTRUMENTS 有权
标题翻译：分析仪器预处理器
公开(公告)号：US20120132798A1
公开(公告)日：2012-05-31
申请号：US12953108
申请日：2010-11-23
申请人： Scott Cambron , Thomas J. Roussel , Robert S. Keynton
发明人： Scott Cambron , Thomas J. Roussel , Robert S. Keynton
IPC分类号： H01J49/04 , G01N30/02
CPC分类号： G01N30/08 , G01N1/405
摘要： An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.
摘要翻译：用于将分析物输送到分析仪器的可互换的预浓缩器组件。组件包括限定内室的壳体。入口与内室流体连通，出口与内室流体连通，用于将流体输送到分析仪器的入口，排气口与内腔流体连通。多个可移除的预浓缩器包装被设置在内室内。每个可移动的预浓缩器包装包括微量预浓缩器。流体流动路径被限定在入口和内部腔室之间。在预浓缩器和排气出口之间限定第一流体流动路径，并且在预浓缩器和出口之间限定第二流体流动路径。可选择操作的阀将流体从内室引导到第一流体流动路径或第二流体流动路径中。

3. 发明授权

US07988839B2 Capillary electrophoresis systems and methods 失效
标题翻译：毛细管电泳系统及方法
公开(公告)号：US07988839B2
公开(公告)日：2011-08-02
申请号：US11524357
申请日：2006-09-20
申请人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
发明人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
IPC分类号： G01N27/26
CPC分类号： G01N27/447
摘要： An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality of electrodes is configured to induce an electric field across each of the plurality of separation channels sufficient to cause analytes in the samples to migrate along each of the channels. The system further comprises a plurality of detectors configured to detect the analytes.
摘要翻译：本发明的一个实施方案涉及一种包括多个分离微通道的毛细管电泳装置。样本加载通道与多个分离通道中的每一个通信。包括多个电极的驱动器电路被配置为在多个分离通道中的每一个上诱导足够使得样品中的分析物沿着每个通道迁移的电场。该系统还包括被配置成检测分析物的多个检测器。

4. 发明申请

US20110100817A1 MICROFLUIDIC DEVICES AND METHODS OF USING SAME 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US20110100817A1
公开(公告)日：2011-05-05
申请号：US12988713
申请日：2009-04-21
申请人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel, JR. , Carolyn M. Klinge , Wasana Sumanasekera , Gamini Sumanasekera
发明人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel, JR. , Carolyn M. Klinge , Wasana Sumanasekera , Gamini Sumanasekera
IPC分类号： G01N27/447 , B01D57/02 , B81B1/00 , B82Y30/00
CPC分类号： C07K1/26
摘要： The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided are methods of using the same for the electrokinetic separation of one or more molecules of interest from a sample.
摘要翻译：目前公开的主题提供由在微通道内以预定间隔设置的两个或更多个碳纳米管膜组成的微流体装置。还提供了使用其从样品中电动分离一种或多种感兴趣分子的方法。

5. 发明申请

US20110155575A1 CAPILLARY ELECTROPHORESIS SYSTEMS AND METHODS 失效
标题翻译：毛细管电泳系统和方法
公开(公告)号：US20110155575A1
公开(公告)日：2011-06-30
申请号：US11524357
申请日：2006-09-20
申请人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
发明人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/447
摘要： An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality of electrodes is configured to induce an electric field across each of the plurality of separation channels sufficient to cause analytes in the samples to migrate along each of the channels. The system further comprises a plurality of detectors configured to detect the analytes.
摘要翻译：本发明的一个实施方案涉及一种包括多个分离微通道的毛细管电泳装置。样本加载通道与多个分离通道中的每一个通信。包括多个电极的驱动器电路被配置为在多个分离通道中的每一个上诱导足够使得样品中的分析物沿着每个通道迁移的电场。该系统还包括被配置成检测分析物的多个检测器。

6. 发明授权

US08298392B2 Microfluidic devices and methods of using same 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US08298392B2
公开(公告)日：2012-10-30
申请号：US12988713
申请日：2009-04-21
申请人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel, Jr. , Carolyn M. Klinge , Wasana Sumanasekera , Gamini Sumanasekera
发明人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel, Jr. , Carolyn M. Klinge , Wasana Sumanasekera , Gamini Sumanasekera
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： C07K1/26
摘要： The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided are methods of using the same for the electrokinetic separation of one or more molecules of interest from a sample.
摘要翻译：目前公开的主题提供由在微通道内以预定间隔设置的两个或更多个碳纳米管膜组成的微流体装置。还提供了使用其从样品中电动分离一种或多种感兴趣分子的方法。

7. 发明授权

US07344628B2 Capillary electrophoresis-electrochemical detection microchip device and supporting circuits 失效
标题翻译：毛细管电泳 - 电化学检测微芯片器件和支持电路
公开(公告)号：US07344628B2
公开(公告)日：2008-03-18
申请号：US10364658
申请日：2003-02-10
申请人： Douglas J. Jackson , Thomas J. Roussel, Jr. , Mark M. Crain , Richard P. Baldwin , Robert S. Keynton , John F. Naber , Kevin M. Walsh , John. G. Edelen
发明人： Douglas J. Jackson , Thomas J. Roussel, Jr. , Mark M. Crain , Richard P. Baldwin , Robert S. Keynton , John F. Naber , Kevin M. Walsh , John. G. Edelen
IPC分类号： B01D57/02
CPC分类号： G01N27/44743 , G01N27/4473 , G01N27/44791
摘要： The present invention is a capillary electrophoresis device, comprising a substrate; a first channel in the substrate, and having a buffer arm and a detection arm; a second channel in the substrate intersecting the first channel, and having a sample arm and a waste arm; a buffer reservoir in fluid communication with the buffer arm; a waste reservoir in fluid communication with the waste arm; a sample reservoir in fluid communication with the sample arm; and a detection reservoir in fluid communication with the detection arm. The detection arm and the buffer arm are of substantially equal length.
摘要翻译：本发明是毛细管电泳装置，其特征在于，衬底中的第一通道，并具有缓冲臂和检测臂; 在所述基板中与所述第一通道相交的第二通道，并且具有样品臂和废弃臂; 与缓冲臂流体连通的缓冲容器; 与废物臂流体连通的废物储存器; 与样品臂流体连通的样品容器; 以及与所述检测臂流体连通的检测储存器。检测臂和缓冲臂的长度基本相同。

8. 发明申请

US20100016704A1 METHOD AND SYSTEM FOR MONITORING A CONDITION OF AN EYE 审中-公开
标题翻译：用于监测眼睛状况的方法和系统
公开(公告)号：US20100016704A1
公开(公告)日：2010-01-21
申请号：US12174458
申请日：2008-07-16
申请人： John F. Naber , Douglas J. Jackson , Henry J. Kaplan , Julia Aebersold , Kevin Walsh , Robert S. Keynton , Thomas Roussel , Paul van der Pol
发明人： John F. Naber , Douglas J. Jackson , Henry J. Kaplan , Julia Aebersold , Kevin Walsh , Robert S. Keynton , Thomas Roussel , Paul van der Pol
IPC分类号： A61B3/16
CPC分类号： A61B3/16 , A61B5/0002 , A61B5/4839
摘要： A method, system, and computer-readable medium are provided which monitor a condition of an eye. The system includes a communication interface and a processor operably coupled to the communication interface. The communication interface is configured to receive an intraocular pressure measurement datum and a time datum associated with the time the intraocular pressure measurement was measured using an eye measurement system. The processor is configured to receive the intraocular pressure measurement datum and the time datum, to receive a dispensed amount datum associated with an amount of a drug administered to an eye of a user and a second time datum associated with the time the drug was administered, and to store the received intraocular pressure measurement datum, the received time datum, the received dispensed amount datum, and the received second time datum to monitor a condition of the eye.
摘要翻译：提供了监测眼睛状况的方法，系统和计算机可读介质。该系统包括可操作地耦合到通信接口的通信接口和处理器。通信接口被配置为接收眼压测量数据和与使用眼睛测量系统测量的眼内压测量的时间相关联的时间数据。处理器被配置为接收眼内压测量数据和时间数据，以接收与给药到用户的眼睛的药物的量相关联的分配量数据和与给药时间相关联的第二时间数据，并且存储所接收的眼内压测量数据，接收的时间数据，接收到的分配量数据和接收到的第二时间数据，以监视眼睛的状况。

9. 发明授权

US09409023B2 Spinal stimulator systems for restoration of function 有权
标题翻译：用于恢复功能的脊柱刺激器系统
公开(公告)号：US09409023B2
公开(公告)日：2016-08-09
申请号：US14007262
申请日：2012-03-26
申请人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca , Yangshen Chen
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca , Yangshen Chen
IPC分类号： A61N1/37 , A61N1/36 , A61N1/05 , A61B5/00 , A61B5/0492 , A61B5/11
CPC分类号： A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要： Described are devices including stimulation assemblies connectable to a plurality of electrodes. The plurality of electrodes can be configured to connect to a spinal cord at a location below a lesion of the spinal cord. The stimulation assembly can be configured to deliver stimulation to selected ones of the plurality of electrodes when the stimulation assembly is connected to the plurality of electrodes when located below the lesion of the spinal cord. Methods of using the devices are also described.
摘要翻译：描述了包括可连接到多个电极的刺激组件的装置。多个电极可以被配置为在脊髓损伤下方的位置处连接到脊髓。刺激组件可以被配置为当刺激组件连接到多个电极时位于脊髓的损伤下方时将刺激递送到多个电极中的选定的电极。还描述了使用装置的方法。

10. 发明申请

US20170216068A1 ANTI-MIGRATION STENT DEPLOYMENT DELIVERY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20170216068A1
公开(公告)日：2017-08-03
申请号：US15501306
申请日：2015-08-05
申请人： Amy C. Dwyer , Alex Isham , Scott D. Cambron , Robert S. Keynton
发明人： Amy C. Dwyer , Alex Isham , Scott D. Cambron , Robert S. Keynton
IPC分类号： A61F2/966 , A61F2/97 , A61F2/958
CPC分类号： A61F2/966 , A61F2/86 , A61F2/958 , A61F2/97 , A61F2002/9505 , A61F2002/9665
摘要： The present invention relates to devices, systems and methods for implanting a radially expandable endoluminal stent. In certain aspects, the devices, systems, and methods of the present invention include a radially expandable endoluminal stent mounted on a delivery tube and having a distal end and a proximal end. A first retention element is also mounted on the delivery tube at or adjacent to the distal end of the expandable endoluminal device, and a second retention element is mounted on the delivery tube at or adjacent to the proximal end of the expandable endoluminal device. Expansion of the first and/or second retention elements reduces or prevents migration of the stent during and immediately after stent deployment.

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