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1. 发明授权

US07344628B2 Capillary electrophoresis-electrochemical detection microchip device and supporting circuits 失效
标题翻译：毛细管电泳 - 电化学检测微芯片器件和支持电路
公开(公告)号：US07344628B2
公开(公告)日：2008-03-18
申请号：US10364658
申请日：2003-02-10
申请人： Douglas J. Jackson , Thomas J. Roussel, Jr. , Mark M. Crain , Richard P. Baldwin , Robert S. Keynton , John F. Naber , Kevin M. Walsh , John. G. Edelen
发明人： Douglas J. Jackson , Thomas J. Roussel, Jr. , Mark M. Crain , Richard P. Baldwin , Robert S. Keynton , John F. Naber , Kevin M. Walsh , John. G. Edelen
IPC分类号： B01D57/02
CPC分类号： G01N27/44743 , G01N27/4473 , G01N27/44791
摘要： The present invention is a capillary electrophoresis device, comprising a substrate; a first channel in the substrate, and having a buffer arm and a detection arm; a second channel in the substrate intersecting the first channel, and having a sample arm and a waste arm; a buffer reservoir in fluid communication with the buffer arm; a waste reservoir in fluid communication with the waste arm; a sample reservoir in fluid communication with the sample arm; and a detection reservoir in fluid communication with the detection arm. The detection arm and the buffer arm are of substantially equal length.
摘要翻译：本发明是毛细管电泳装置，其特征在于，衬底中的第一通道，并具有缓冲臂和检测臂; 在所述基板中与所述第一通道相交的第二通道，并且具有样品臂和废弃臂; 与缓冲臂流体连通的缓冲容器; 与废物臂流体连通的废物储存器; 与样品臂流体连通的样品容器; 以及与所述检测臂流体连通的检测储存器。检测臂和缓冲臂的长度基本相同。

2. 发明授权

US07988839B2 Capillary electrophoresis systems and methods 失效
标题翻译：毛细管电泳系统及方法
公开(公告)号：US07988839B2
公开(公告)日：2011-08-02
申请号：US11524357
申请日：2006-09-20
申请人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
发明人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
IPC分类号： G01N27/26
CPC分类号： G01N27/447
摘要： An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality of electrodes is configured to induce an electric field across each of the plurality of separation channels sufficient to cause analytes in the samples to migrate along each of the channels. The system further comprises a plurality of detectors configured to detect the analytes.
摘要翻译：本发明的一个实施方案涉及一种包括多个分离微通道的毛细管电泳装置。样本加载通道与多个分离通道中的每一个通信。包括多个电极的驱动器电路被配置为在多个分离通道中的每一个上诱导足够使得样品中的分析物沿着每个通道迁移的电场。该系统还包括被配置成检测分析物的多个检测器。

3. 发明申请

US20110155575A1 CAPILLARY ELECTROPHORESIS SYSTEMS AND METHODS 失效
标题翻译：毛细管电泳系统和方法
公开(公告)号：US20110155575A1
公开(公告)日：2011-06-30
申请号：US11524357
申请日：2006-09-20
申请人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
发明人： Rathissh Dorairaj , Robert S. Keynton , Thomas J. Roussel , Mark M. Crain , Douglas J. Jackson , Kevin M. Walsh , John F. Naber , Richard P. Baldwin , Danielle B. Franco
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/447
摘要： An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality of electrodes is configured to induce an electric field across each of the plurality of separation channels sufficient to cause analytes in the samples to migrate along each of the channels. The system further comprises a plurality of detectors configured to detect the analytes.
摘要翻译：本发明的一个实施方案涉及一种包括多个分离微通道的毛细管电泳装置。样本加载通道与多个分离通道中的每一个通信。包括多个电极的驱动器电路被配置为在多个分离通道中的每一个上诱导足够使得样品中的分析物沿着每个通道迁移的电场。该系统还包括被配置成检测分析物的多个检测器。

4. 发明授权

US07357037B2 Strain sensing system 有权
标题翻译：应变传感系统
公开(公告)号：US07357037B2
公开(公告)日：2008-04-15
申请号：US11226023
申请日：2005-09-14
申请人： William P. Hnat , John F. Naber , Kevin M. Walsh
发明人： William P. Hnat , John F. Naber , Kevin M. Walsh
IPC分类号： G01N3/00
CPC分类号： G01D21/00 , A61B5/0031 , A61B5/076 , A61B5/4504 , A61B2090/064 , A61B2560/0219 , A61B2562/0247 , A61B2562/028 , A61B2562/043 , G01D9/005 , G01L1/142 , G01L1/165 , G01L1/22 , G01L1/225 , G01L19/086
摘要： The present invention provides a system 10 for measuring and remotely monitoring strain in an element 1 having a strain sensor 20, a telemetry circuit 40 for transmitting strain data to a remote location, and a reader module 60 for transmitting energy to the telemetry circuit and receiving said data.
摘要翻译：本发明提供了一种用于测量和远程监测具有应变传感器20的元件1中的应变的系统10，用于将应变数据传输到远程位置的遥测电路40以及用于向遥测电路发送能量的读取器模块60 说数据。

5. 发明授权

US08771613B2 Large volume analyte preconcentrator 有权
标题翻译：大容量分析物预浓缩器
公开(公告)号：US08771613B2
公开(公告)日：2014-07-08
申请号：US13056091
申请日：2009-07-31
申请人： Michael Martin , Robert Keynton , Thomas Roussel , Kevin M. Walsh , Douglas J. Jackson , John Naber , Julia W. Abersold , Richard B. Hageman, III , Suraj Alexander , Scott Cambron
发明人： Michael Martin , Robert Keynton , Thomas Roussel , Kevin M. Walsh , Douglas J. Jackson , John Naber , Julia W. Abersold , Richard B. Hageman, III , Suraj Alexander , Scott Cambron
IPC分类号： G01N30/00 , G01N30/08
CPC分类号： G01N1/405 , B01D53/02 , B01D2253/202
摘要： A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuatable damper is disposed within the housing for selectively restricting a collection flow.
摘要翻译：用于浓缩分析物的大容积预浓缩装置。壳体接受分析物蒸汽流，并且多个收集表面设置在壳体内。可选择性致动加热器设置在多个收集表面中的每一个上。至少一个可选择性致动阻尼器设置在壳体内以选择性地限制收集流。

6. 发明申请

US20110214482A1 LARGE VOLUME ANALYTE PRECONCENTRATOR 有权
标题翻译：大容量分析仪预处理器
公开(公告)号：US20110214482A1
公开(公告)日：2011-09-08
申请号：US13056091
申请日：2009-07-31
申请人： Michael Martin , Robert Keynton , Thomas Roussel , Kevin M. Walsh , Douglas J. Jackson , John Naber , Julia W. Abersold , Richard B. Hagemann, III , Suraj Alexander , Scott Cambron
发明人： Michael Martin , Robert Keynton , Thomas Roussel , Kevin M. Walsh , Douglas J. Jackson , John Naber , Julia W. Abersold , Richard B. Hagemann, III , Suraj Alexander , Scott Cambron
IPC分类号： G01N25/00
CPC分类号： G01N1/405 , B01D53/02 , B01D2253/202
摘要： A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuable damper is disposed within the housing for selectively restricting a collection flow.
摘要翻译：用于浓缩分析物的大容积预浓缩装置。壳体接受分析物蒸汽流，并且多个收集表面设置在壳体内。可选择性致动加热器设置在多个收集表面中的每一个上。至少一个可选择性致动阻尼器设置在壳体内以选择性地限制收集流。

7. 发明授权

US08525279B2 Single element three terminal piezoresistive pressure sensor 有权
标题翻译：单元三端压阻式压力传感器
公开(公告)号：US08525279B2
公开(公告)日：2013-09-03
申请号：US12794288
申请日：2010-06-04
申请人： Usha R. Gowrishetty , Kevin M. Walsh
发明人： Usha R. Gowrishetty , Kevin M. Walsh
IPC分类号： G01R29/22 , H01L21/302
CPC分类号： G01L9/0055 , G01L1/2293
摘要： Embodiments of the invention provide for three-terminal pressure sensors (“3-TPS”), a method of measuring a pressure with a 3-TPS, and a method of manufacturing a 3-TPS. In some embodiments, the 3-TPS includes a semiconducting layer with cavity and a 3-TPS element having at least one piezoresistive layer overlapping at least a portion of the cavity and oriented at an angle selected to provide a desired sensitivity for the 3-TPS. The method of measuring a pressure with a 3-TPS is performed with a 3-TPS that includes an input terminal, first and second output terminals, and a 3-TPS element, the 3-TPS element overlapping at least a portion of a cavity at a predetermined angle. The method comprises providing an input signal to the input terminal of the 3-TPS, determining a difference between two output signals from the respective output terminals of the 3-TPS, and correlating the determined difference to a pressure.
摘要翻译：本发明的实施例提供三端压力传感器（“3-TPS”），使用3-TPS测量压力的方法和制造3-TPS的方法。在一些实施例中，3-TPS包括具有空腔的半导体层和具有至少一个压阻层的3-TPS元件，该至少一个压阻层与空腔的至少一部分重叠并且以选定的角度定向以为3-TPS提供期望的灵敏度。使用3-TPS测量压力的方法是使用包括输入端子，第一和第二输出端子以及3-TPS元件的3-TPS进行的，所述3-TPS元件与空腔的至少一部分重叠以预定角度。该方法包括向3-TPS的输入端提供输入信号，确定来自3-TPS的相应输出端的两个输出信号之间的差值，并将所确定的差与压力相关。

8. 发明授权

US5614722A Radiation detector based on charge amplification in a gaseous medium 失效
标题翻译：基于气体介质中电荷放大的辐射检测器
公开(公告)号：US5614722A
公开(公告)日：1997-03-25
申请号：US551472
申请日：1995-11-01
申请人： Keith Solberg , William K. Pitts , Kevin M. Walsh
发明人： Keith Solberg , William K. Pitts , Kevin M. Walsh
IPC分类号： G01T1/185 , G01T1/85
CPC分类号： G01T1/185
摘要： A radiation detector includes a substrate having a cavity defined therein, an anode surface positioned in the bottom of the cavity and a cathode positioned adjacent the cavity opening. A drift electrode is juxtaposed over the substrate opposite the cavity and defines a region containing a gaseous medium. As ionized charge pairs are established in the gaseous medium due to radiation provided by an external radiation source, electrons drift toward the anode under the influence of a first electric field established between the anode and drift electrode. Thereafter, the electron undergoes avalanche multiplication with the gaseous medium in an avalanche region defined by a second intense electric field established between the anode and cathode. The structure of the present invention provides an electric field gradient geometry which permits optimal design of the avalanche region geometry, and which further minimizes photon feedback from the cathode.
摘要翻译：辐射检测器包括具有限定在其中的腔的衬底，位于空腔底部的阳极表面和邻近腔开口定位的阴极。漂移电极并置在与空腔相对的衬底上，并限定含有气体介质的区域。由于由外部辐射源提供的辐射而在气体介质中建立电离电荷对，在阳极和漂移电极之间建立的第一电场的影响下，电子向阳极漂移。此后，电子在由在阳极和阴极之间建立的第二强电场限定的雪崩区域中与气态介质进行雪崩倍增。本发明的结构提供电场梯度几何形状，其允许雪崩区域几何的最佳设计，并进一步使来自阴极的光子反馈最小化。

9. 发明授权

US5602397A Optical imaging system utilizing a charge amplification device 失效
标题翻译：利用电荷放大装置的光学成像系统
公开(公告)号：US5602397A
公开(公告)日：1997-02-11
申请号：US551556
申请日：1995-11-01
申请人： William K. Pitts , Kevin M. Walsh , Keith Solberg
发明人： William K. Pitts , Kevin M. Walsh , Keith Solberg
IPC分类号： H01J47/02
CPC分类号： H01J47/02
摘要： An optical imaging system includes an array of optical imaging devices each comprising a device for providing charge amplification in a gaseous medium. A preferred embodiment of such a charge amplification device includes a substrate having a cavity defined therein, an anode surface positioned in the bottom of the cavity and a cathode positioned adjacent the cavity opening. A drift electrode is juxtaposed over the substrate opposite the cavity and defines a region containing a gaseous medium. As ionized charge pairs are established in the gaseous medium due to radiation provided by an external radiation source, electrons are attracted toward the anode where they undergo avalanche multiplication with the gaseous medium under the influence of an intense electric field established between the anode and cathode. As a result of the avalanche process, the gaseous medium within the avalanche region emits photons, predominately in the UV region, which are collected by the substrate and provided to a photon detector coupled thereto. The substrate is preferably provided with a wavelength shifting material operable to shift the UV light to the visible region, where it is thereafter imaged by the photon detector using, for example, conventional CCD camera technology.
摘要翻译：光学成像系统包括一组光学成像装置，每个光学成像装置包括用于在气体介质中提供电荷放大的装置。这种电荷放大装置的优选实施例包括其中限定有空腔的基板，位于空腔底部的阳极表面和邻近腔开口定位的阴极。漂移电极并置在与空腔相对的衬底上，并限定含有气体介质的区域。由于由外部辐射源提供的辐射而在气体介质中建立了电离电荷对，电子被吸引到阳极，在阳极处，在阳极和阴极之间建立的强电场的影响下，电子对与气体介质进行雪崩倍增。作为雪崩过程的结果，雪崩区域内的气体介质发射主要在UV区域中的光子，其由衬底收集并提供给耦合到其上的光子检测器。衬底优选地设置有波长移动材料，其可操作以将UV光移动到可见光区域，此后，其使用例如常规CCD照相机技术由光子检测器成像。

10. 发明申请

US20100308791A1 SINGLE ELEMENT THREE TERMINAL PIEZORESISTIVE PRESSURE SENSOR 有权
标题翻译：单元三端式压力传感器
公开(公告)号：US20100308791A1
公开(公告)日：2010-12-09
申请号：US12794288
申请日：2010-06-04
申请人： Usha R. Gowrishetty , Kevin M. Walsh
发明人： Usha R. Gowrishetty , Kevin M. Walsh
IPC分类号： G01R29/22 , H01L21/302
CPC分类号： G01L9/0055 , G01L1/2293
摘要： Embodiments of the invention provide for three-terminal pressure sensors (“3-TPS”), a method of measuring a pressure with a 3-TPS, and a method of manufacturing a 3-TPS. In some embodiments, the 3-TPS includes a semiconducting layer with cavity and a 3-TPS element having at least one piezoresistive layer overlapping at least a portion of the cavity and oriented at an angle selected to provide a desired sensitivity for the 3-TPS. The method of measuring a pressure with a 3-TPS is performed with a 3-TPS that includes an input terminal, first and second output terminals, and a 3-TPS element, the 3-TPS element overlapping at least a portion of a cavity at a predetermined angle. The method comprises providing an input signal to the input terminal of the 3-TPS, determining a difference between two output signals from the respective output terminals of the 3-TPS, and correlating the determined difference to a pressure.
摘要翻译：本发明的实施例提供三端压力传感器（“3-TPS”），使用3-TPS测量压力的方法和制造3-TPS的方法。在一些实施例中，3-TPS包括具有空腔的半导体层和具有至少一个压阻层的3-TPS元件，该至少一个压阻层与空腔的至少一部分重叠并且以选定的角度定向以为3-TPS提供期望的灵敏度。使用3-TPS测量压力的方法是使用包括输入端子，第一和第二输出端子以及3-TPS元件的3-TPS进行的，所述3-TPS元件与空腔的至少一部分重叠以预定角度。该方法包括向3-TPS的输入端提供输入信号，确定来自3-TPS的相应输出端的两个输出信号之间的差值，并将所确定的差与压力相关。

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